ATE275559T1 - Aromatische amin-derivate verwendbar als pharmazeutische mittel - Google Patents
Aromatische amin-derivate verwendbar als pharmazeutische mittelInfo
- Publication number
- ATE275559T1 ATE275559T1 AT99925183T AT99925183T ATE275559T1 AT E275559 T1 ATE275559 T1 AT E275559T1 AT 99925183 T AT99925183 T AT 99925183T AT 99925183 T AT99925183 T AT 99925183T AT E275559 T1 ATE275559 T1 AT E275559T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- aromatic amine
- pharmaceutical agents
- amine derivatives
- derivatives usable
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9811969.6A GB9811969D0 (en) | 1998-06-03 | 1998-06-03 | Chemical compounds |
PCT/GB1999/001741 WO1999062901A1 (en) | 1998-06-03 | 1999-06-03 | Aromatic amine derivatives as pharmaceutical agents |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE275559T1 true ATE275559T1 (de) | 2004-09-15 |
Family
ID=10833164
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99925183T ATE275559T1 (de) | 1998-06-03 | 1999-06-03 | Aromatische amin-derivate verwendbar als pharmazeutische mittel |
Country Status (10)
Country | Link |
---|---|
US (2) | US6110945A (de) |
EP (1) | EP1084119B1 (de) |
JP (1) | JP2002517391A (de) |
AT (1) | ATE275559T1 (de) |
AU (1) | AU765979B2 (de) |
CA (1) | CA2331791A1 (de) |
DE (1) | DE69920010T2 (de) |
ES (1) | ES2228050T3 (de) |
GB (1) | GB9811969D0 (de) |
WO (1) | WO1999062901A1 (de) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6939855B2 (en) * | 1997-07-31 | 2005-09-06 | Elan Pharmaceuticals, Inc. | Anti-inflammatory compositions and method |
US6455734B1 (en) | 2000-08-09 | 2002-09-24 | Magnesium Diagnostics, Inc. | Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states |
NZ518886A (en) | 1999-12-28 | 2004-02-27 | Pfizer Prod Inc | Non-peptidyl inhibitors of VLA-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases |
US6740654B2 (en) | 2000-07-07 | 2004-05-25 | Celltech R & D Limited | Squaric acid derivatives |
SE0102299D0 (sv) * | 2001-06-26 | 2001-06-26 | Astrazeneca Ab | Compounds |
SE0102764D0 (sv) * | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
JPWO2003024933A1 (ja) | 2001-09-12 | 2004-12-24 | 科研製薬株式会社 | 2−フェニル−3−ヘテロアリールプロピオン酸誘導体またはその塩、それを用いた医薬 |
GB0226930D0 (en) | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
GB0325402D0 (en) * | 2003-10-31 | 2003-12-03 | Astrazeneca Ab | Compounds |
GB0327761D0 (en) * | 2003-11-29 | 2003-12-31 | Astrazeneca Ab | Compounds |
GB0328178D0 (en) * | 2003-12-05 | 2004-01-07 | Astrazeneca Ab | Compounds |
WO2005080360A1 (en) * | 2004-02-18 | 2005-09-01 | Astrazeneca Ab | Compounds |
AU2005214132B9 (en) * | 2004-02-18 | 2009-06-25 | Astrazeneca Ab | Benzamide derivatives and their use as glucokinae activating agents |
EP1574511A1 (de) * | 2004-03-03 | 2005-09-14 | Bayer CropScience S.A. | 2-Pyridinylethylcarboxamid-Derivate und ihre Verwendung als Fungizide |
CN106075435A (zh) | 2004-06-04 | 2016-11-09 | 健泰科生物技术公司 | 用于治疗多发性硬化的方法 |
TW200600086A (en) * | 2004-06-05 | 2006-01-01 | Astrazeneca Ab | Chemical compound |
GB0423043D0 (en) * | 2004-10-16 | 2004-11-17 | Astrazeneca Ab | Compounds |
KR20070085371A (ko) | 2004-10-16 | 2007-08-27 | 아스트라제네카 아베 | 페녹시 벤즈아미드 화합물의 제조 방법 |
GB0423044D0 (en) * | 2004-10-16 | 2004-11-17 | Astrazeneca Ab | Compounds |
TW200714289A (en) * | 2005-02-28 | 2007-04-16 | Genentech Inc | Treatment of bone disorders |
JP2008542247A (ja) * | 2005-05-24 | 2008-11-27 | アストラゼネカ アクチボラグ | グルコキナーゼモジュレーターとしての2−フェニル置換イミダゾール[4,5b]ピリジン/ピラジンおよびプリン誘導体 |
TW200714597A (en) * | 2005-05-27 | 2007-04-16 | Astrazeneca Ab | Chemical compounds |
US20080234273A1 (en) * | 2005-07-09 | 2008-09-25 | Mckerrecher Darren | Heteroaryl Benzamide Derivatives for Use as Glk Activators in the Treatment of Diabetes |
EP2301929A1 (de) * | 2005-07-09 | 2011-03-30 | AstraZeneca AB (Publ) | Heteroarylbenzamidderivate zur Verwendung als GLK-Aktivatoren bei der Behandlung von Diabetes |
US20110053910A1 (en) * | 2005-07-09 | 2011-03-03 | Mckerrecher Darren | 2 -heterocyclyloxybenzoyl amino heterocyclyl compounds as modulators of glucokinase for the treatment of type 2 diabetes |
US9202182B2 (en) * | 2005-08-11 | 2015-12-01 | International Business Machines Corporation | Method and system for analyzing business architecture |
MY149159A (en) | 2005-11-15 | 2013-07-31 | Hoffmann La Roche | Method for treating joint damage |
TW200738621A (en) * | 2005-11-28 | 2007-10-16 | Astrazeneca Ab | Chemical process |
TW200825063A (en) * | 2006-10-23 | 2008-06-16 | Astrazeneca Ab | Chemical compounds |
TW200825060A (en) * | 2006-10-26 | 2008-06-16 | Astrazeneca Ab | Chemical compounds |
UY30822A1 (es) * | 2006-12-21 | 2008-07-31 | Astrazeneca Ab | Fnueva forma cristalina de 3-{[5-azetidin-1-ylcabonyl)pyrazin-2-yl]oxy}-5-[1-methylethyloxy]-n-1h-pyrazol-3-ylbenzamida, composiciones conteniéndola, procesos de preparacion y aplicaciones |
LT2494993T (lt) * | 2007-05-04 | 2018-12-27 | Marina Biotech, Inc. | Aminorūgščių lipidai ir jų panaudojimas |
KR20110052676A (ko) * | 2008-08-04 | 2011-05-18 | 아스트라제네카 아베 | 피라졸로[3,4]피리미딘-4-일 유도체 및 당뇨병 및 비만을 치료하기 위한 이의 용도 |
TW201014605A (en) * | 2008-09-16 | 2010-04-16 | Genentech Inc | Methods for treating progressive multiple sclerosis |
WO2010075249A2 (en) | 2008-12-22 | 2010-07-01 | Genentech, Inc. | A method for treating rheumatoid arthritis with b-cell antagonists |
GB0902406D0 (en) * | 2009-02-13 | 2009-04-01 | Astrazeneca Ab | Crystalline polymorphic form |
GB0902434D0 (en) * | 2009-02-13 | 2009-04-01 | Astrazeneca Ab | Chemical process |
WO2010116176A1 (en) * | 2009-04-09 | 2010-10-14 | Astrazeneca Ab | Pyrazolo [4, 5-e] pyrimidine derivative and its use to treat diabetes and obesity |
WO2010116177A1 (en) | 2009-04-09 | 2010-10-14 | Astrazeneca Ab | A pyrazolo [4,5-e] pyrimidine derivative and its use to treat diabetes and obesity |
WO2013101771A2 (en) | 2011-12-30 | 2013-07-04 | Genentech, Inc. | Compositions and method for treating autoimmune diseases |
US20130243750A1 (en) | 2012-01-31 | 2013-09-19 | Genentech, Inc. | Anti-ige antibodies and methods using same |
US20170002077A1 (en) | 2014-03-13 | 2017-01-05 | Prothena Biosciences Limited | Combination treatment for multiple sclerosis |
JP2018529747A (ja) | 2015-10-06 | 2018-10-11 | ジェネンテック, インコーポレイテッド | 多発性硬化症を治療するための方法 |
TWI773657B (zh) | 2015-12-18 | 2022-08-11 | 美商亞德利克斯公司 | 作爲非全身tgr5促效劑之經取代之4-苯基吡啶化合物 |
US11174256B2 (en) | 2018-10-30 | 2021-11-16 | Gilead Sciences, Inc. | Imidazopyridine derivatives |
AU2019373242B2 (en) | 2018-10-30 | 2023-07-13 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
WO2020092401A1 (en) | 2018-10-30 | 2020-05-07 | Gilead Sciences, Inc. | COMPOUNDS FOR INHIBITION OF ALPHA 4β7 INTEGRIN |
CN112969687A (zh) | 2018-10-30 | 2021-06-15 | 吉利德科学公司 | 作为α4β7整合素抑制剂的喹啉衍生物 |
CA3148613A1 (en) | 2019-08-14 | 2021-02-18 | Gilead Sciences, Inc. | Phenylalanine derived compounds and their use as inhinitors of alpha 4 beta 7 integrin |
Family Cites Families (76)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1437781A (en) * | 1972-04-04 | 1976-06-03 | Beecham Group Ltd | Pyridine derivatives having hypoglycaemic activity |
JPS609718B2 (ja) | 1977-08-25 | 1985-03-12 | 塩野義製薬株式会社 | チアジアゾリルチオセフアロスポリン類縁抗生物質 |
JPS5683483A (en) * | 1979-12-13 | 1981-07-08 | Santen Pharmaceut Co Ltd | Thiazolidine compound |
JPS5690045A (en) | 1979-12-25 | 1981-07-21 | Tokuyama Soda Co Ltd | Alpha*alpha**di substituted amino phenylenediacetic acid |
JPS56139455A (en) * | 1980-04-02 | 1981-10-30 | Santen Pharmaceut Co Ltd | Sulfur-containing acylaminoacid |
US4470973A (en) | 1982-07-19 | 1984-09-11 | E. R. Squibb & Sons, Inc. | Substituted peptide compounds |
FR2540871B1 (fr) | 1983-02-16 | 1986-01-10 | Lipha | Amino-2 phenyl-5 benzodiazepines-1,3; procede de preparation et medicaments les contenant |
GB8332704D0 (en) * | 1983-12-07 | 1984-01-11 | Pfizer Ltd | Growth promotants for animals |
IT1176983B (it) * | 1984-10-16 | 1987-08-26 | Zambon Spa | Dipeptidi ad attivita' farmacologica |
CN1030415A (zh) * | 1987-02-20 | 1989-01-18 | 山之内制药株式会社 | 饱和的杂环碳酰胺衍生物和它的制备方法 |
JPH0784424B2 (ja) | 1987-04-15 | 1995-09-13 | 味の素株式会社 | チロシン誘導体及びその用途 |
US5510346A (en) | 1987-12-07 | 1996-04-23 | Hoechst Marion Roussel, Inc. | 4-heteroaryl-1,3-benzodiazepines and 2-substituted-gamma-(heteroaryl)benzeneethanamines |
IT1223565B (it) * | 1987-12-21 | 1990-09-19 | Zambon Spa | Derivati dell'acido tiazolidin 4 carbossilico ad attivita' farmaceutica |
US5256812A (en) | 1989-01-31 | 1993-10-26 | Hoffmann-La Roche Inc. | Carboxamides and sulfonamides |
US5164372A (en) * | 1989-04-28 | 1992-11-17 | Fujisawa Pharmaceutical Company, Ltd. | Peptide compounds having substance p antagonism, processes for preparation thereof and pharmaceutical composition comprising the same |
JPH07121917B2 (ja) * | 1989-07-31 | 1995-12-25 | 四国化成工業株式会社 | 4(5)―チオカルバモイル―イミダゾール化合物及びその合成方法 |
US5260277A (en) * | 1990-09-10 | 1993-11-09 | Tanabe Seiyaku Co., Ltd. | Guanidinyl and related cell adhesion modulation compounds |
IT1244548B (it) * | 1991-02-06 | 1994-07-15 | Poli Ind Chimica Spa | Derivati della 5-oxo-l-prolina e loro applicazioni farmaceutiche |
ES2190428T3 (es) | 1991-06-28 | 2003-08-01 | Smithkline Beecham Corp | Antagonistas biciclicos de fibrinogeno. |
US5296486A (en) * | 1991-09-24 | 1994-03-22 | Boehringer Ingelheim Pharmaceuticals, Inc. | Leukotriene biosynthesis inhibitors |
US5250679A (en) | 1991-10-18 | 1993-10-05 | Genentech, Inc. | Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor |
US5352667A (en) * | 1991-11-22 | 1994-10-04 | Ofer Lider | Non-peptidic surrogates of the Arg-Gly-Asp sequence and pharmaceutical compositions comprising them |
US5227490A (en) | 1992-02-21 | 1993-07-13 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
AU686115B2 (en) * | 1992-11-02 | 1998-02-05 | Fujisawa Pharmaceutical Co., Ltd. | Imidazo (I,2-a) pyridine derivatives as bradykinin antagonists, pharmaceuticals and processes for their preparation |
FR2700168B1 (fr) * | 1993-01-07 | 1995-02-03 | Rhone Poulenc Rorer Sa | Dérivés de thiazolidine, leur préparation et les médicaments les contenant. |
FR2700167B1 (fr) * | 1993-01-07 | 1995-02-03 | Rhone Poulenc Rorer Sa | Dérivés de pyrrolidine et thiazolidine, leur préparation et les médicaments les contenant. |
GB9311661D0 (en) * | 1993-06-05 | 1993-07-21 | Smithkline Beecham Plc | Novel compounds |
AU678503B2 (en) | 1993-09-24 | 1997-05-29 | Takeda Chemical Industries Ltd. | Condensed heterocyclic compounds and their use as squalene synthetase inhibitors |
AU8107694A (en) * | 1993-11-17 | 1995-06-06 | Byk Nederland Bv | Use of substituted thiazolidine derivatives in the treatment of raised intraocular pressure |
AU693143B2 (en) * | 1993-12-06 | 1998-06-25 | Cytel Corporation | CS-1 peptidomimetics, compositions and methods of using the same |
JP2973271B2 (ja) | 1994-01-18 | 1999-11-08 | 参天製薬株式会社 | エンドペプチダーゼ24.15阻害剤 |
FR2721608B1 (fr) * | 1994-06-22 | 1996-07-19 | Rhone Poulenc Rorer Sa | Dérivés de thiazolidine, leur préparation et les médicaments les contenant. |
ATE237342T1 (de) * | 1994-07-11 | 2003-05-15 | Athena Neurosciences Inc | Inhibitoren der leukozytenadhäsion |
TW403748B (en) * | 1994-11-02 | 2000-09-01 | Takeda Chemical Industries Ltd | An oxazolidinedione derivative, its production and a pharmaceutical composition for lowering blood sugar and lipid in blood comprising the same |
ES2123889T3 (es) * | 1994-11-02 | 1999-01-16 | Merck Patent Gmbh | Antagonistas de receptores de adhesion. |
US6306840B1 (en) * | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
WO1996026190A1 (en) | 1995-02-22 | 1996-08-29 | Smithkline Beecham Corporation | Integrin receptor antagonists |
US6248713B1 (en) * | 1995-07-11 | 2001-06-19 | Biogen, Inc. | Cell adhesion inhibitors |
US6028223A (en) | 1995-08-30 | 2000-02-22 | G. D. Searle & Co. | Meta-guanidine, urea, thiourea or azacyclic amino benzoic acid compounds and derivatives thereof |
US5714488A (en) * | 1995-10-03 | 1998-02-03 | Abbott Laboratories | Bis-heteroarylylmethoxyphenyl ketone derivatives as inhibitors of leukotriene biosynthesis |
WO1997024124A1 (en) | 1995-12-29 | 1997-07-10 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
GB9604242D0 (en) * | 1996-02-28 | 1996-05-01 | Glaxo Wellcome Inc | Chemical compounds |
DK0891325T3 (da) * | 1996-03-29 | 2002-05-21 | Searle & Co | Para-substituerede phenylpropansyrederivater som integrinantagonister |
WO1997036862A1 (en) | 1996-03-29 | 1997-10-09 | G.D. Searle & Co. | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS |
WO1998000395A1 (de) * | 1996-06-28 | 1998-01-08 | Merck Patent Gmbh | Phenylalanin-derivate als integrin-inhibitoren |
DE19654483A1 (de) * | 1996-06-28 | 1998-01-02 | Merck Patent Gmbh | Phenylalanin-Derivate |
PL190866B1 (pl) * | 1996-07-25 | 2006-02-28 | Biogen | Inhibitor adhezji komórek, sposób jego wytwarzania i jego zastosowanie oraz kompozycja farmaceutyczna i sposób jej wytwarzania |
DE19647381A1 (de) * | 1996-11-15 | 1998-05-20 | Hoechst Ag | Neue Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten |
DE19647380A1 (de) * | 1996-11-15 | 1998-05-20 | Hoechst Ag | 5-Ring-Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten |
US6034136A (en) * | 1997-03-20 | 2000-03-07 | Novartis Ag | Certain cyclic thio substituted acylaminoacid amide derivatives |
JP2002501537A (ja) * | 1997-05-29 | 2002-01-15 | メルク エンド カンパニー インコーポレーテッド | 細胞接着阻害薬としてのスルホンアミド類 |
EP1001764A4 (de) * | 1997-05-29 | 2005-08-24 | Merck & Co Inc | Heterozyklische amide als zelladhäsionshemmern |
EP1017382B1 (de) * | 1997-05-29 | 2006-03-01 | Merck & Co., Inc. (a New Jersey corp.) | Biarylalkansäuren in der verwendung als zelladhäsionsinhibitoren |
JP2002501518A (ja) * | 1997-05-30 | 2002-01-15 | セルテック セラピューティックス リミテッド | 抗炎症性チロシン誘導体 |
JP2001517246A (ja) * | 1997-06-23 | 2001-10-02 | 田辺製薬株式会社 | α▲下4▼β▲下1▼媒介細胞接着の阻止剤 |
IL133635A0 (en) * | 1997-07-31 | 2001-04-30 | Elan Pharm Inc | Benzyl compounds which inhibit leukocyte adhesion mediated by vla-4 |
CN1265672A (zh) * | 1997-07-31 | 2000-09-06 | 伊兰药品公司 | 能抑制由vla-4介导的白细胞粘连的磺酰化二肽化合物 |
KR20010022412A (ko) * | 1997-07-31 | 2001-03-15 | 진 엠. 듀발 | Vla-4에 의해 매개되는 백혈구 유착을 억제하는디펩티드 화합물 |
CN1265669A (zh) * | 1997-07-31 | 2000-09-06 | 伊兰药品公司 | 抑制由vla-4介导的白细胞粘着的化合物 |
ZA986837B (en) * | 1997-07-31 | 2000-05-02 | Anthena Neurosciences Inc | 4-amino-phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4. |
JP2001512134A (ja) * | 1997-07-31 | 2001-08-21 | エラン・ファーマシューティカルズ・インコーポレーテッド | Vla−4仲介性白血球付着を阻害する置換フェニルアラニン型化合物 |
IL133639A0 (en) * | 1997-07-31 | 2001-04-30 | Elan Pharm Inc | Dipeptide and related compounds which inhibit leukocyte adhesion mediated by vla-4 |
AR016133A1 (es) * | 1997-07-31 | 2001-06-20 | Wyeth Corp | Compuesto de carbamiloxi que inhiben la adhesion de leucocitos mediada por vla-4, compuestos que son prodrogas de dichos compuestos, composicionfarmaceutica, metodo para fijar vla-4 a una muestra biologica, metodo para el tratamiento de una condicion inflamatoria |
DK1005446T3 (da) * | 1997-08-22 | 2004-06-07 | Hoffmann La Roche | N-aroylphenylalaninderivater |
EP1005445B1 (de) * | 1997-08-22 | 2004-05-26 | F. Hoffmann-La Roche Ag | N-alkanoylphenylalaninderivate |
AU1361499A (en) * | 1997-10-21 | 1999-05-10 | Merck & Co., Inc. | Azapeptide acids as cell adhesion inhibitors |
WO1999030709A1 (en) | 1997-12-17 | 1999-06-24 | Merck & Co., Inc. | Integrin receptor antagonists |
US6197794B1 (en) * | 1998-01-08 | 2001-03-06 | Celltech Therapeutics Limited | Phenylalanine derivatives |
US6329372B1 (en) * | 1998-01-27 | 2001-12-11 | Celltech Therapeutics Limited | Phenylalanine derivatives |
ES2226413T3 (es) * | 1998-02-26 | 2005-03-16 | Celltech Therapeutics Limited | Derivados de fenilalanina como inhibidores de alfa-4 integrinas. |
US6521626B1 (en) * | 1998-03-24 | 2003-02-18 | Celltech R&D Limited | Thiocarboxamide derivatives |
GB9811159D0 (en) | 1998-05-22 | 1998-07-22 | Celltech Therapeutics Ltd | Chemical compounds |
GB9821406D0 (en) | 1998-10-01 | 1998-11-25 | Celltech Therapeutics Ltd | Chemical compounds |
GB9825652D0 (en) | 1998-11-23 | 1999-01-13 | Celltech Therapeutics Ltd | Chemical compounds |
AU2357600A (en) | 1998-12-14 | 2000-07-03 | American Home Products Corporation | 3,4-diamino-3-cyclobutene-1,2-dione derivatives which inhibit leukocyte adhesionmediated by vla-4 |
US6518283B1 (en) | 1999-05-28 | 2003-02-11 | Celltech R&D Limited | Squaric acid derivatives |
-
1998
- 1998-06-03 GB GBGB9811969.6A patent/GB9811969D0/en not_active Ceased
-
1999
- 1999-06-02 US US09/323,966 patent/US6110945A/en not_active Expired - Fee Related
- 1999-06-03 CA CA002331791A patent/CA2331791A1/en not_active Abandoned
- 1999-06-03 EP EP99925183A patent/EP1084119B1/de not_active Expired - Lifetime
- 1999-06-03 WO PCT/GB1999/001741 patent/WO1999062901A1/en active IP Right Grant
- 1999-06-03 AT AT99925183T patent/ATE275559T1/de not_active IP Right Cessation
- 1999-06-03 DE DE69920010T patent/DE69920010T2/de not_active Expired - Fee Related
- 1999-06-03 AU AU41566/99A patent/AU765979B2/en not_active Ceased
- 1999-06-03 JP JP2000552112A patent/JP2002517391A/ja active Pending
- 1999-06-03 ES ES99925183T patent/ES2228050T3/es not_active Expired - Lifetime
-
2000
- 2000-03-30 US US09/538,918 patent/US6369229B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US6369229B1 (en) | 2002-04-09 |
EP1084119A1 (de) | 2001-03-21 |
CA2331791A1 (en) | 1999-12-09 |
WO1999062901A1 (en) | 1999-12-09 |
DE69920010D1 (de) | 2004-10-14 |
JP2002517391A (ja) | 2002-06-18 |
US6110945A (en) | 2000-08-29 |
AU4156699A (en) | 1999-12-20 |
DE69920010T2 (de) | 2005-09-15 |
EP1084119B1 (de) | 2004-09-08 |
AU765979B2 (en) | 2003-10-09 |
ES2228050T3 (es) | 2005-04-01 |
GB9811969D0 (en) | 1998-07-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE275559T1 (de) | Aromatische amin-derivate verwendbar als pharmazeutische mittel | |
ATE273273T1 (de) | Phenylalaninderivate als inhibitoren von alpha4 integrinen | |
DE60316779D1 (de) | Thiadiazolylpiperazinderivate geeignet für die behandlung bzw. prävention von schmerzen | |
DE122006000051I1 (de) | Ester der 5-Aminolevulins{ure als Mittel zur Photosensibillisierung in der Chemotherapie | |
BR0212042A (pt) | Composto, composição farmacêutica, método de tratamento ou prevenção de doenças, e, uso de um composto | |
MA28012A1 (fr) | Derives de pyridyle et utilisation de ceux-ci en tant qu'agents therapeutiques | |
DE60134874D1 (de) | Benzodiazepin-derivate als gamma-secretase inhibitoren | |
MA25809A1 (fr) | Derives d'arylmethylamine pour usage comme inhibiteurs de tryptase | |
ATE360630T1 (de) | Azabicyclische heterocyclen als modulatoren des cannabinoidrezeptors | |
RS20060190A (en) | Bicyclic /3.1.0/ derivatives as glycine transporter inhibitors | |
TW200614983A (en) | 5-substituted-2-phenylamino benzamides as MEK inhibitors | |
ATE386028T1 (de) | Zyklohexylsulfone als gamma-sekretase-inhibitoren | |
MA31873B1 (fr) | Inhibiteurs de la peptide déformylase | |
CY1109037T1 (el) | Πιπεραζινες χρησιμες για θεραπεια πονου | |
TN2011000252A1 (fr) | Lactames servant d'inhibiteurs de beta-secretase | |
HUP0002272A2 (hu) | Piperazinszármazékok, eljárás előállításukra, e vegyületeket tartalmazó gyógyászati készítmények és alkalmazásuk | |
DK0694545T3 (da) | Substituerede dibenzoxazepinforbindelser, farmaceutiske sammensætninger og anvendelsesmetoder | |
TR199802060T2 (xx) | Aminoisokinolinler ve aminopiridin t�revlerinin iltihap �nleyiciler olarak kullan�m�. | |
DK0738269T3 (da) | Piperidinderivater med PAF-antagonistaktivitet | |
DE69429328T2 (de) | N-(3-piperidinylcarbonyl)-b-alanin derivate als paf-antagonisten | |
ATE181731T1 (de) | Isothioharnstoff-derivate als no synthase hemmer | |
YU86701A (sh) | Jedinjenja i formulacije za inhibiciju agregacije proteina i snimanje amiloidnih naslaga | |
NO924949D0 (no) | Piperidylsubstituerte indoler | |
DE69214587T2 (de) | Methanoanthracene als Dopaminantagonisten | |
SE9902267D0 (sv) | New compounds |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |