ATE386028T1 - Zyklohexylsulfone als gamma-sekretase-inhibitoren - Google Patents
Zyklohexylsulfone als gamma-sekretase-inhibitorenInfo
- Publication number
- ATE386028T1 ATE386028T1 AT04731659T AT04731659T ATE386028T1 AT E386028 T1 ATE386028 T1 AT E386028T1 AT 04731659 T AT04731659 T AT 04731659T AT 04731659 T AT04731659 T AT 04731659T AT E386028 T1 ATE386028 T1 AT E386028T1
- Authority
- AT
- Austria
- Prior art keywords
- cyclohexylsulphones
- gamma secretase
- secretase inhibitors
- gamma
- inhibitors
- Prior art date
Links
- 239000003540 gamma secretase inhibitor Substances 0.000 title 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 abstract 1
- 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0311341A GB0311341D0 (en) | 2003-05-16 | 2003-05-16 | Therapeutic agents |
GB0327055A GB0327055D0 (en) | 2003-11-20 | 2003-11-20 | Therapeutic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE386028T1 true ATE386028T1 (de) | 2008-03-15 |
Family
ID=33420897
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04731659T ATE386028T1 (de) | 2003-05-16 | 2004-05-07 | Zyklohexylsulfone als gamma-sekretase-inhibitoren |
Country Status (16)
Country | Link |
---|---|
US (3) | US7410964B2 (de) |
EP (2) | EP1644346A1 (de) |
JP (1) | JP4818114B2 (de) |
KR (1) | KR20060013404A (de) |
AT (1) | ATE386028T1 (de) |
AU (1) | AU2004238607B2 (de) |
BR (1) | BRPI0409969A (de) |
CA (1) | CA2525841C (de) |
DE (1) | DE602004011767T2 (de) |
IL (1) | IL171977A (de) |
IS (1) | IS8058A (de) |
MX (1) | MXPA05012323A (de) |
NO (1) | NO20055979L (de) |
NZ (1) | NZ542797A (de) |
RU (1) | RU2334743C2 (de) |
WO (2) | WO2004101539A1 (de) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0108591D0 (en) | 2001-04-05 | 2001-05-23 | Merck Sharp & Dohme | Therapeutic agents |
GB0120347D0 (en) | 2001-08-21 | 2001-10-17 | Merck Sharp & Dohme | Therapeutic agents |
GB0223039D0 (en) | 2002-10-04 | 2002-11-13 | Merck Sharp & Dohme | Therapeutic compounds |
US7521481B2 (en) | 2003-02-27 | 2009-04-21 | Mclaurin Joanne | Methods of preventing, treating and diagnosing disorders of protein aggregation |
ATE386028T1 (de) * | 2003-05-16 | 2008-03-15 | Merck Sharp & Dohme | Zyklohexylsulfone als gamma-sekretase-inhibitoren |
EP1812007B1 (de) | 2004-11-02 | 2011-09-07 | Northwestern University | Pyridazinverbindungen und verfahren |
ES2382814T3 (es) | 2005-05-17 | 2012-06-13 | Merck Sharp & Dohme Ltd. | Ácido cis-4-[(4-clorofenil)sulfonil]-4-(2,5-difluorofenil)ciclohexanopropanoico para el tratamiento del cáncer |
WO2006123183A2 (en) * | 2005-05-17 | 2006-11-23 | Merck Sharp & Dohme Limited | Sulphone derivatives for treatment of cancer |
GB0512049D0 (en) * | 2005-06-14 | 2005-07-20 | Merck Sharp & Dohme | Chemical process |
PE20071321A1 (es) * | 2006-01-20 | 2007-12-29 | Schering Corp | Bencensulfonil-cromano, tiocromano, tetrahidronaftaleno e inhibidores de gamma secretasa relacionados |
JP5379692B2 (ja) | 2006-11-09 | 2013-12-25 | プロビオドルグ エージー | 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての3−ヒドロキシ−1,5−ジヒドロ−ピロール−2−オン誘導体 |
US9126987B2 (en) | 2006-11-30 | 2015-09-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
JP2010518064A (ja) | 2007-02-12 | 2010-05-27 | メルク・シャープ・エンド・ドーム・コーポレイション | Adおよび関連状態の治療のためのピペラジン誘導体 |
CN101668525A (zh) | 2007-03-01 | 2010-03-10 | 前体生物药物股份公司 | 谷氨酰胺酰环化酶抑制剂的新用途 |
DK2142514T3 (da) | 2007-04-18 | 2015-03-23 | Probiodrug Ag | Thioureaderivater som glutaminylcyclase-inhibitorer |
CA2691542A1 (en) | 2007-07-05 | 2009-01-15 | Schering Corporation | Tetrahydropyranochromene gamma secretase inhibitors |
PE20090447A1 (es) * | 2007-07-17 | 2009-04-18 | Schering Corp | Bencensulfonil-cromano, tiocromano, tetrahidronaftaleno e inhibidores relacionados de la gamma secretasa |
WO2009128057A2 (en) | 2008-04-18 | 2009-10-22 | UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN et al | Psycho-pharmaceuticals |
EP2375895A4 (de) * | 2008-12-11 | 2012-05-30 | Merck Sharp & Dohme | Verfahren zur behandlung von morbus alzheimer und damit verwandten leiden |
WO2010114780A1 (en) | 2009-04-01 | 2010-10-07 | Merck Sharp & Dohme Corp. | Inhibitors of akt activity |
JP5934645B2 (ja) | 2009-09-11 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体 |
US8859776B2 (en) | 2009-10-14 | 2014-10-14 | Merck Sharp & Dohme Corp. | Substituted piperidines that increase p53 activity and the uses thereof |
EP2528890A1 (de) * | 2010-01-29 | 2012-12-05 | Pfizer Inc. | Aminocyclohexane und aminotetrahydropyrane sowie zugehörige verbindungen als gamma-sekretase-modulatoren |
JP6026284B2 (ja) | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
CN102791704B (zh) | 2010-03-10 | 2015-11-25 | 前体生物药物股份公司 | 谷氨酰胺酰环化酶(qc, ec 2.3.2.5)的杂环抑制剂 |
EP2560953B1 (de) | 2010-04-21 | 2016-01-06 | Probiodrug AG | Hemmer der glutaminylzyklase |
EP2584903B1 (de) | 2010-06-24 | 2018-10-24 | Merck Sharp & Dohme Corp. | Neue heterozyklische verbindungen als erk-hemmer |
JP6043285B2 (ja) | 2010-08-02 | 2016-12-14 | サーナ・セラピューティクス・インコーポレイテッドSirna Therapeutics,Inc. | 低分子干渉核酸(siNA)を用いたカテニン(カドヘリン結合型タンパク質)β1(CTNNB1)遺伝子発現のRNA干渉媒介性阻害 |
RU2624045C2 (ru) | 2010-08-17 | 2017-06-30 | Сирна Терапьютикс,Инк | ОПОСРЕДУЕМОЕ РНК-ИНТЕРФЕРЕНЦИЕЙ ИНГИБИРОВАНИЕ ЭКСПРЕССИИ ГЕНОВ ВИРУСА ГЕПАТИТА B (HBV) С ПРИМЕНЕНИЕМ МАЛОЙ ИНТЕРФЕРИРУЮЩЕЙ НУКЛЕИНОВОЙ КИСЛОТЫ (миНК) |
EP2613782B1 (de) | 2010-09-01 | 2016-11-02 | Merck Sharp & Dohme Corp. | Indazolderivate als erk-hemmer |
US9242981B2 (en) | 2010-09-16 | 2016-01-26 | Merck Sharp & Dohme Corp. | Fused pyrazole derivatives as novel ERK inhibitors |
EP2632472B1 (de) | 2010-10-29 | 2017-12-13 | Sirna Therapeutics, Inc. | Durch rna-interferenz vermittelte inhibition einer genexpression unter verwendung von short-interfering-nukleinsäuren (sina) |
WO2012087772A1 (en) | 2010-12-21 | 2012-06-28 | Schering Corporation | Indazole derivatives useful as erk inhibitors |
JP6050264B2 (ja) | 2011-03-16 | 2016-12-21 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体 |
US9023865B2 (en) | 2011-10-27 | 2015-05-05 | Merck Sharp & Dohme Corp. | Compounds that are ERK inhibitors |
US20150299696A1 (en) | 2012-05-02 | 2015-10-22 | Sirna Therapeutics, Inc. | SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS |
CA2882950A1 (en) | 2012-09-28 | 2014-04-03 | Merck Sharp & Dohme Corp. | Novel compounds that are erk inhibitors |
RU2660349C2 (ru) | 2012-11-28 | 2018-07-05 | Мерк Шарп И Доум Корп. | Композиции и способы для лечения злокачественной опухоли |
WO2014100065A1 (en) | 2012-12-20 | 2014-06-26 | Merck Sharp & Dohme Corp. | Substituted imidazopyridines as hdm2 inhibitors |
WO2014120748A1 (en) | 2013-01-30 | 2014-08-07 | Merck Sharp & Dohme Corp. | 2,6,7,8 substituted purines as hdm2 inhibitors |
EP3041938A1 (de) | 2013-09-03 | 2016-07-13 | Moderna Therapeutics, Inc. | Kreisförmige polynukleotide |
DK3461819T3 (da) | 2017-09-29 | 2020-08-10 | Probiodrug Ag | Inhibitorer af glutaminylcyklase |
EP3706742B1 (de) | 2017-11-08 | 2023-03-15 | Merck Sharp & Dohme LLC | Prmt5-inhibitoren |
US20210309688A1 (en) | 2018-08-07 | 2021-10-07 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
WO2020033282A1 (en) | 2018-08-07 | 2020-02-13 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
KR20220123229A (ko) | 2019-12-17 | 2022-09-06 | 머크 샤프 앤드 돔 엘엘씨 | Prmt5 억제제 |
WO2022015670A1 (en) * | 2020-07-14 | 2022-01-20 | Nikang Therapeutics, Inc. | Pyrido[2,3-d]pyrimidin-7(8h)-one derivatives as cyclin-dependent kinase 2 inhibitors |
US20240116945A1 (en) | 2022-09-02 | 2024-04-11 | Merck Sharp & Dohme Llc | Exatecan-derived topoisomerase-1 inhibitors pharmaceutical compositions, and uses thereof |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2833776A (en) * | 1958-05-06 | Aryl-substituted psperidylpropanols | ||
US3992536A (en) * | 1972-11-11 | 1976-11-16 | Boehringer Ingelheim Gmbh | Pharmaceutical compositions containing a 1-phenyl-2,2,4,4-C1 -C2 alkyl-3-[4-phenyl of pyridyl)-piperazino]-cyclobutanol-(1) and method of use |
US3869434A (en) * | 1973-11-19 | 1975-03-04 | Phillips Petroleum Co | Soluble arylene sulfide polymers |
DE2528285A1 (de) * | 1975-06-25 | 1977-01-20 | Basf Ag | Verfahren zur herstellung von 1,2,4-dihydrotriazin-4-oxid-spiro- (3,1')- eckige klammer auf oximino- (2')-cycloalkanen eckige klammer zu |
DE3347126A1 (de) * | 1983-12-22 | 1985-07-11 | Schering AG, 1000 Berlin und 4709 Bergkamen | 11ss-aryl-estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate |
DE4035961A1 (de) * | 1990-11-02 | 1992-05-07 | Thomae Gmbh Dr K | Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
MXPA01008606A (es) | 1999-02-26 | 2003-05-05 | Merck & Co Inc | Compuestos de sulfonamida novedosos y uso de los mismos. |
CA2404125C (en) * | 2000-03-20 | 2011-01-25 | Merck Sharp & Dohme Limited | Sulphonamido-substituted bridged bicycloalkyl derivatives |
FR2812291B1 (fr) * | 2000-07-28 | 2002-12-13 | Adir | Nouveaux derives de benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
DE60112957T2 (de) | 2000-11-02 | 2006-05-18 | Merck Sharp & Dohme Ltd., Hoddesdon | Sulfamide als gamma-secretase-inhibitoren |
GB0108592D0 (en) * | 2001-04-05 | 2001-05-23 | Merck Sharp & Dohme | Therapeutic agents |
GB0108591D0 (en) | 2001-04-05 | 2001-05-23 | Merck Sharp & Dohme | Therapeutic agents |
AU2002367147A1 (en) | 2001-12-27 | 2003-07-15 | Daiichi Pharmaceutical Co., Ltd. | Beta-AMYLOID PROTEIN PRODUCTION/SECRETION INHIBITORS |
ATE386028T1 (de) | 2003-05-16 | 2008-03-15 | Merck Sharp & Dohme | Zyklohexylsulfone als gamma-sekretase-inhibitoren |
-
2004
- 2004-05-07 AT AT04731659T patent/ATE386028T1/de not_active IP Right Cessation
- 2004-05-07 CA CA2525841A patent/CA2525841C/en not_active Expired - Fee Related
- 2004-05-07 WO PCT/GB2004/002013 patent/WO2004101539A1/en not_active Application Discontinuation
- 2004-05-07 DE DE602004011767T patent/DE602004011767T2/de active Active
- 2004-05-07 WO PCT/GB2004/001973 patent/WO2004101538A1/en active IP Right Grant
- 2004-05-07 NZ NZ542797A patent/NZ542797A/en not_active IP Right Cessation
- 2004-05-07 EP EP04731671A patent/EP1644346A1/de not_active Withdrawn
- 2004-05-07 US US10/555,034 patent/US7410964B2/en active Active
- 2004-05-07 JP JP2006530479A patent/JP4818114B2/ja not_active Expired - Fee Related
- 2004-05-07 EP EP04731659A patent/EP1638951B1/de active Active
- 2004-05-07 KR KR1020057021877A patent/KR20060013404A/ko not_active Application Discontinuation
- 2004-05-07 RU RU2005139398/04A patent/RU2334743C2/ru not_active IP Right Cessation
- 2004-05-07 BR BRPI0409969-9A patent/BRPI0409969A/pt not_active IP Right Cessation
- 2004-05-07 MX MXPA05012323A patent/MXPA05012323A/es active IP Right Grant
- 2004-05-07 AU AU2004238607A patent/AU2004238607B2/en not_active Ceased
- 2004-05-14 US US10/845,833 patent/US7342009B2/en active Active
-
2005
- 2005-09-30 IS IS8058A patent/IS8058A/is unknown
- 2005-11-15 IL IL171977A patent/IL171977A/en not_active IP Right Cessation
- 2005-12-15 NO NO20055979A patent/NO20055979L/no not_active Application Discontinuation
-
2007
- 2007-08-01 US US11/888,450 patent/US20080045515A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
MXPA05012323A (es) | 2006-01-30 |
US20040230054A1 (en) | 2004-11-18 |
AU2004238607B2 (en) | 2010-05-27 |
JP2006528961A (ja) | 2006-12-28 |
RU2334743C2 (ru) | 2008-09-27 |
WO2004101538A1 (en) | 2004-11-25 |
BRPI0409969A (pt) | 2006-04-25 |
CA2525841C (en) | 2012-10-16 |
US7410964B2 (en) | 2008-08-12 |
US20080045515A1 (en) | 2008-02-21 |
US20060281737A1 (en) | 2006-12-14 |
KR20060013404A (ko) | 2006-02-09 |
IS8058A (is) | 2005-09-30 |
NZ542797A (en) | 2007-12-21 |
EP1638951A1 (de) | 2006-03-29 |
CA2525841A1 (en) | 2004-11-25 |
JP4818114B2 (ja) | 2011-11-16 |
EP1644346A1 (de) | 2006-04-12 |
WO2004101539A1 (en) | 2004-11-25 |
AU2004238607A1 (en) | 2004-11-25 |
IL171977A0 (en) | 2006-04-10 |
NO20055979L (no) | 2006-02-15 |
RU2005139398A (ru) | 2006-04-10 |
DE602004011767D1 (de) | 2008-03-27 |
IL171977A (en) | 2010-12-30 |
EP1638951B1 (de) | 2008-02-13 |
DE602004011767T2 (de) | 2009-02-19 |
US7342009B2 (en) | 2008-03-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |