DE69429328T2 - N-(3-piperidinylcarbonyl)-b-alanin derivate als paf-antagonisten - Google Patents
N-(3-piperidinylcarbonyl)-b-alanin derivate als paf-antagonistenInfo
- Publication number
- DE69429328T2 DE69429328T2 DE69429328T DE69429328T DE69429328T2 DE 69429328 T2 DE69429328 T2 DE 69429328T2 DE 69429328 T DE69429328 T DE 69429328T DE 69429328 T DE69429328 T DE 69429328T DE 69429328 T2 DE69429328 T2 DE 69429328T2
- Authority
- DE
- Germany
- Prior art keywords
- alanine derivatives
- piperidinylcarbonyl
- inhibitor
- paf antagonists
- blood platelets
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939319561A GB9319561D0 (en) | 1993-09-22 | 1993-09-22 | Beta-alanine derivative and a process for preparation thereof |
| GB9413936A GB9413936D0 (en) | 1994-07-11 | 1994-07-11 | Beta-Alanine derivative and a process for the preparation thereof |
| PCT/JP1994/001550 WO1995008536A1 (en) | 1993-09-22 | 1994-09-21 | N-(3-piperidinylcarbonyl)-beta-alanine derivatives as paf antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69429328D1 DE69429328D1 (de) | 2002-01-17 |
| DE69429328T2 true DE69429328T2 (de) | 2002-06-13 |
Family
ID=26303555
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69429328T Expired - Lifetime DE69429328T2 (de) | 1993-09-22 | 1994-09-21 | N-(3-piperidinylcarbonyl)-b-alanin derivate als paf-antagonisten |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6380215B1 (de) |
| EP (2) | EP1106606A3 (de) |
| CN (1) | CN1041919C (de) |
| AT (1) | ATE210118T1 (de) |
| AU (1) | AU684547B2 (de) |
| CA (1) | CA2157792C (de) |
| DE (1) | DE69429328T2 (de) |
| DK (1) | DK0669912T3 (de) |
| ES (1) | ES2164109T3 (de) |
| HK (1) | HK1004985A1 (de) |
| HU (1) | HUT73174A (de) |
| IL (3) | IL126825A (de) |
| PT (1) | PT669912E (de) |
| RU (1) | RU2161155C2 (de) |
| TW (1) | TW401414B (de) |
| WO (1) | WO1995008536A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010051730A1 (en) * | 1993-09-22 | 2001-12-13 | Fujisawa Pharmaceutical Co., Ltd. | Beta-alanine derivative and a process for the preparation thereof |
| KR19980703107A (ko) * | 1995-03-17 | 1998-10-15 | 후지야마 아키라 | N-아실피페리디닐카보닐아미노카복실산 및 당단백질 IIB/IIa 길항제와 피브리노겐-혈소판 결합 억제제로서의 이의 용도 |
| JP2000506524A (ja) * | 1996-03-13 | 2000-05-30 | 藤沢薬品工業株式会社 | フィブリノーゲン受容体拮抗剤であるＮ―［（Ｒ）―１―｛３―（４―ピペリジル）プロピオニル｝―３―ピペリジルカルボニル］―２（Ｓ）―アセチルアミノ―β―アラニン |
| DK0923555T3 (da) * | 1996-05-01 | 2005-08-15 | Ortho Mcneil Pharm Inc | pyrrolidin, piperidin og hexahydroazepin til behandling af trombotiske lidelser |
| EP1184374B1 (de) * | 1996-05-01 | 2009-01-28 | Ortho-McNeil Pharmaceutical, Inc. | Carboxamidderivate von Pyrrolidin, Piperidin und Hexahydropiperizin für Behandlung von Thrombosen |
| AU8334498A (en) * | 1997-07-14 | 1999-02-10 | Phytera Symbion Aps | Piperidine oligomers and combinatorial libraries thereof |
| US6066651A (en) | 1997-10-29 | 2000-05-23 | Ortho-Mcneil Pharmaceutical, Inc. | Orally-active nipecotamide glycolamide esters for the treatment of thrombosis disorders |
| US6020347A (en) * | 1997-11-18 | 2000-02-01 | Merck & Co., Inc. | 4-substituted-4-piperidine carboxamide derivatives |
| WO1999025685A1 (en) * | 1997-11-18 | 1999-05-27 | Merck & Co., Inc. | 4-substituted-4-piperidine carboxamide derivatives |
| AU769718B2 (en) * | 1998-10-12 | 2004-02-05 | Fujisawa Pharmaceutical Co., Ltd. | New processes for producing beta-alanine derivative |
| AUPP646598A0 (en) * | 1998-10-12 | 1998-11-05 | Fujisawa Pharmaceutical Co., Ltd. | New processes for producing alpha-alanine derivative |
| WO2000056730A1 (en) * | 1999-03-22 | 2000-09-28 | Ortho-Mcneil Pharmaceutical, Inc. | PROCESS FOR PREPARING [S-(R*,S*)] -β -[[[1-[1-OXO-3- (4-PIPERIDINYL) PROPYL] -3-PIPERIDINYL] CARBONYL] AMINO] -3- PYRIDINEPROPANOIC ACID AND DERIVATIVES |
| ES2244474T3 (es) | 1999-09-29 | 2005-12-16 | Ortho-Mcneil Pharmaceutical, Inc. | Isonipecotamida para el tratamiento de trastornos mediados por integrina. |
| AUPQ570100A0 (en) * | 2000-02-17 | 2000-03-09 | Fujisawa Pharmaceutical Co., Ltd. | Beta-alanine derivatives and their use as receptor antagonists |
| DE60208186T2 (de) | 2001-04-09 | 2006-08-24 | Ortho-Mcneil Pharmaceutical Research Inc. | Chinazolin- und chinazolinähnliche verbindungen zur behandlung von integrin-vermittelten erkrankungen |
| JP4910695B2 (ja) | 2004-02-25 | 2012-04-04 | アステラス製薬株式会社 | 血栓造影剤 |
| RU2597425C2 (ru) | 2011-08-17 | 2016-09-10 | Пирамаль Имэджинг Са | Соединения для связывания со специфическим для тромбоцитов гликопротеином iib/iiia и их применение для визуализации тромбов |
| JP2016508507A (ja) | 2013-02-12 | 2016-03-22 | バイエル・ファルマ・アクティエンゲゼルシャフト | 血小板特異的糖タンパク質ＩＩｂ／ＩＩＩａに結合するための金属キレート化合物 |
| KR102548998B1 (ko) | 2020-03-31 | 2023-06-29 | 재단법인 아산사회복지재단 | 혈전영상을 위한 방사성의약품 및 조성물 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03257624A (ja) * | 1990-03-08 | 1991-11-18 | Fujitsu Ltd | 画面言語方式 |
| CA2037153A1 (en) * | 1990-03-09 | 1991-09-10 | Leo Alig | Acetic acid derivatives |
| CA2054627A1 (en) * | 1991-02-13 | 1992-08-14 | Yea-Shun Cheng | Polypeptide skeletal muscle relaxants |
| WO1992019595A1 (en) * | 1991-05-07 | 1992-11-12 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| US5770575A (en) * | 1994-03-16 | 1998-06-23 | Ortho Pharmaceutical Corporation | Nipecotic acid derivatives as antithrombotic compounds |
-
1994
- 1994-09-21 AU AU76657/94A patent/AU684547B2/en not_active Ceased
- 1994-09-21 HU HU9501845A patent/HUT73174A/hu unknown
- 1994-09-21 TW TW083108696A patent/TW401414B/zh not_active IP Right Cessation
- 1994-09-21 DE DE69429328T patent/DE69429328T2/de not_active Expired - Lifetime
- 1994-09-21 ES ES94927076T patent/ES2164109T3/es not_active Expired - Lifetime
- 1994-09-21 RU RU95112456/04A patent/RU2161155C2/ru not_active IP Right Cessation
- 1994-09-21 DK DK94927076T patent/DK0669912T3/da active
- 1994-09-21 AT AT94927076T patent/ATE210118T1/de not_active IP Right Cessation
- 1994-09-21 CA CA002157792A patent/CA2157792C/en not_active Expired - Lifetime
- 1994-09-21 WO PCT/JP1994/001550 patent/WO1995008536A1/en active IP Right Grant
- 1994-09-21 EP EP01102827A patent/EP1106606A3/de not_active Withdrawn
- 1994-09-21 CN CN94190981A patent/CN1041919C/zh not_active Expired - Fee Related
- 1994-09-21 US US08/495,572 patent/US6380215B1/en not_active Expired - Lifetime
- 1994-09-21 PT PT94927076T patent/PT669912E/pt unknown
- 1994-09-21 EP EP94927076A patent/EP0669912B1/de not_active Expired - Lifetime
- 1994-09-22 IL IL12682594A patent/IL126825A/xx not_active IP Right Cessation
- 1994-09-22 IL IL11103694A patent/IL111036A/xx not_active IP Right Cessation
-
1998
- 1998-05-01 HK HK98103726A patent/HK1004985A1/xx not_active IP Right Cessation
- 1998-10-30 IL IL12682598A patent/IL126825A0/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1106606A3 (de) | 2003-10-22 |
| ATE210118T1 (de) | 2001-12-15 |
| EP0669912A1 (de) | 1995-09-06 |
| CN1041919C (zh) | 1999-02-03 |
| AU7665794A (en) | 1995-04-10 |
| IL111036A0 (en) | 1994-11-28 |
| TW401414B (en) | 2000-08-11 |
| EP1106606A2 (de) | 2001-06-13 |
| AU684547B2 (en) | 1997-12-18 |
| ES2164109T3 (es) | 2002-02-16 |
| WO1995008536A1 (en) | 1995-03-30 |
| CN1116847A (zh) | 1996-02-14 |
| HK1004985A1 (en) | 1998-12-18 |
| PT669912E (pt) | 2002-03-28 |
| HU9501845D0 (en) | 1995-08-28 |
| RU2161155C2 (ru) | 2000-12-27 |
| CA2157792C (en) | 2005-05-24 |
| IL126825A (en) | 1999-09-22 |
| RU95112456A (ru) | 1997-04-20 |
| EP0669912B1 (de) | 2001-12-05 |
| IL111036A (en) | 1999-07-14 |
| CA2157792A1 (en) | 1995-03-30 |
| HUT73174A (en) | 1996-06-28 |
| DK0669912T3 (da) | 2002-03-04 |
| DE69429328D1 (de) | 2002-01-17 |
| IL126825A0 (en) | 1999-08-17 |
| US6380215B1 (en) | 2002-04-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: ASTELLAS PHARMA INC., TOKIO/TOKYO, JP |