DE69429328D1 - N-(3-piperidinylcarbonyl)-b-alanin derivate als paf-antagonisten - Google Patents
N-(3-piperidinylcarbonyl)-b-alanin derivate als paf-antagonistenInfo
- Publication number
- DE69429328D1 DE69429328D1 DE69429328T DE69429328T DE69429328D1 DE 69429328 D1 DE69429328 D1 DE 69429328D1 DE 69429328 T DE69429328 T DE 69429328T DE 69429328 T DE69429328 T DE 69429328T DE 69429328 D1 DE69429328 D1 DE 69429328D1
- Authority
- DE
- Germany
- Prior art keywords
- alanine derivatives
- piperidinylcarbonyl
- inhibitor
- paf antagonists
- blood platelets
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939319561A GB9319561D0 (en) | 1993-09-22 | 1993-09-22 | Beta-alanine derivative and a process for preparation thereof |
| GB9413936A GB9413936D0 (en) | 1994-07-11 | 1994-07-11 | Beta-Alanine derivative and a process for the preparation thereof |
| PCT/JP1994/001550 WO1995008536A1 (en) | 1993-09-22 | 1994-09-21 | N-(3-piperidinylcarbonyl)-beta-alanine derivatives as paf antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69429328D1 true DE69429328D1 (de) | 2002-01-17 |
| DE69429328T2 DE69429328T2 (de) | 2002-06-13 |
Family
ID=26303555
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69429328T Expired - Lifetime DE69429328T2 (de) | 1993-09-22 | 1994-09-21 | N-(3-piperidinylcarbonyl)-b-alanin derivate als paf-antagonisten |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6380215B1 (de) |
| EP (2) | EP1106606A3 (de) |
| CN (1) | CN1041919C (de) |
| AT (1) | ATE210118T1 (de) |
| AU (1) | AU684547B2 (de) |
| CA (1) | CA2157792C (de) |
| DE (1) | DE69429328T2 (de) |
| DK (1) | DK0669912T3 (de) |
| ES (1) | ES2164109T3 (de) |
| HK (1) | HK1004985A1 (de) |
| HU (1) | HUT73174A (de) |
| IL (3) | IL126825A (de) |
| PT (1) | PT669912E (de) |
| RU (1) | RU2161155C2 (de) |
| TW (1) | TW401414B (de) |
| WO (1) | WO1995008536A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010051730A1 (en) * | 1993-09-22 | 2001-12-13 | Fujisawa Pharmaceutical Co., Ltd. | Beta-alanine derivative and a process for the preparation thereof |
| AU4954296A (en) * | 1995-03-17 | 1996-10-08 | Fujisawa Pharmaceutical Co., Ltd. | N-acylpiperidinylcarbonylaminocarboxylic acids and their use as glycoprotein iib/iia antagonists and fibrinogen-blood platelets binding inhibitors |
| CA2248809A1 (en) * | 1996-03-13 | 1997-09-18 | Fujisawa Pharmaceutical Co., Ltd. | N-[(r)-1-{3-(4-piperidyl)propionyl}-3-piperidylcarbonyl]-2(s)-acetylamino-beta-alanine as fibrinogen receptor antagonist |
| EP1184374B1 (de) * | 1996-05-01 | 2009-01-28 | Ortho-McNeil Pharmaceutical, Inc. | Carboxamidderivate von Pyrrolidin, Piperidin und Hexahydropiperizin für Behandlung von Thrombosen |
| PL190796B1 (pl) * | 1996-05-01 | 2006-01-31 | Ortho Mcneil Pharm Inc | Karboksyamidowe pochodne piperydyny do leczenia zaburzeń zakrzepicowych |
| WO1999003832A1 (en) * | 1997-07-14 | 1999-01-28 | Phytera Symbion Aps | Piperidine oligomers and combinatorial libraries thereof |
| US6066651A (en) * | 1997-10-29 | 2000-05-23 | Ortho-Mcneil Pharmaceutical, Inc. | Orally-active nipecotamide glycolamide esters for the treatment of thrombosis disorders |
| AU1415099A (en) * | 1997-11-18 | 1999-06-07 | Merck & Co., Inc. | 4-substituted-4-piperidine carboxamide derivatives |
| US6020347A (en) * | 1997-11-18 | 2000-02-01 | Merck & Co., Inc. | 4-substituted-4-piperidine carboxamide derivatives |
| AUPP646598A0 (en) * | 1998-10-12 | 1998-11-05 | Fujisawa Pharmaceutical Co., Ltd. | New processes for producing alpha-alanine derivative |
| AU769718B2 (en) * | 1998-10-12 | 2004-02-05 | Fujisawa Pharmaceutical Co., Ltd. | New processes for producing beta-alanine derivative |
| JP2002540108A (ja) | 1999-03-22 | 2002-11-26 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | ［Ｓ−（Ｒ＊，Ｓ＊）］−β−［［［１−［１−オキソ−３−（４−ピペリジニル）プロピル］−３−ピペリジニル］カルボニル］アミノ］−３−ピリジンプロパン酸及び誘導体を製造する方法 |
| CN1352641A (zh) | 1999-09-29 | 2002-06-05 | 奥索-麦克尼尔药品公司 | 用于治疗整联蛋白介导的疾病的异哌啶甲酰胺 |
| AUPQ570100A0 (en) * | 2000-02-17 | 2000-03-09 | Fujisawa Pharmaceutical Co., Ltd. | Beta-alanine derivatives and their use as receptor antagonists |
| US7081460B2 (en) | 2001-04-09 | 2006-07-25 | Ortho-Mcneil Pharmaceutical, Inc. | Quinazoline and quinazoline-like compounds for the treatment of integrin-mediated disorders |
| EP2404899A1 (de) | 2004-02-25 | 2012-01-11 | Astellas Pharma Inc. | Kontrastmittel für Thrombusentdeckung |
| PT2744802T (pt) | 2011-08-17 | 2017-03-15 | Piramal Imaging Sa | Compostos para ligação às glicoproteínas iib/iiia específicas de plaquetas e a sua utilização em imagiologia de trombos |
| US20160008490A1 (en) | 2013-02-12 | 2016-01-14 | Bayer Pharma Aktiengesellschaft | Metal chelate compounds for binding to the platelet specific glycoprotein iib/iiia |
| KR102548998B1 (ko) | 2020-03-31 | 2023-06-29 | 재단법인 아산사회복지재단 | 혈전영상을 위한 방사성의약품 및 조성물 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03257624A (ja) * | 1990-03-08 | 1991-11-18 | Fujitsu Ltd | 画面言語方式 |
| CA2037153A1 (en) * | 1990-03-09 | 1991-09-10 | Leo Alig | Acetic acid derivatives |
| CA2054627A1 (en) * | 1991-02-13 | 1992-08-14 | Yea-Shun Cheng | Polypeptide skeletal muscle relaxants |
| HUT68769A (en) * | 1991-05-07 | 1995-07-28 | Merck & Co Inc | FIBRINOGéN RECEPTOR ANTAGONIST COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AS EFFECTIVE SUBSTANCE |
| US5770575A (en) * | 1994-03-16 | 1998-06-23 | Ortho Pharmaceutical Corporation | Nipecotic acid derivatives as antithrombotic compounds |
-
1994
- 1994-09-21 EP EP01102827A patent/EP1106606A3/de not_active Withdrawn
- 1994-09-21 AT AT94927076T patent/ATE210118T1/de not_active IP Right Cessation
- 1994-09-21 HU HU9501845A patent/HUT73174A/hu unknown
- 1994-09-21 AU AU76657/94A patent/AU684547B2/en not_active Ceased
- 1994-09-21 CN CN94190981A patent/CN1041919C/zh not_active Expired - Fee Related
- 1994-09-21 CA CA002157792A patent/CA2157792C/en not_active Expired - Lifetime
- 1994-09-21 RU RU95112456/04A patent/RU2161155C2/ru not_active IP Right Cessation
- 1994-09-21 DK DK94927076T patent/DK0669912T3/da active
- 1994-09-21 WO PCT/JP1994/001550 patent/WO1995008536A1/en active IP Right Grant
- 1994-09-21 ES ES94927076T patent/ES2164109T3/es not_active Expired - Lifetime
- 1994-09-21 DE DE69429328T patent/DE69429328T2/de not_active Expired - Lifetime
- 1994-09-21 US US08/495,572 patent/US6380215B1/en not_active Expired - Lifetime
- 1994-09-21 EP EP94927076A patent/EP0669912B1/de not_active Expired - Lifetime
- 1994-09-21 TW TW083108696A patent/TW401414B/zh not_active IP Right Cessation
- 1994-09-21 PT PT94927076T patent/PT669912E/pt unknown
- 1994-09-22 IL IL12682594A patent/IL126825A/xx not_active IP Right Cessation
- 1994-09-22 IL IL11103694A patent/IL111036A/xx not_active IP Right Cessation
-
1998
- 1998-05-01 HK HK98103726A patent/HK1004985A1/xx not_active IP Right Cessation
- 1998-10-30 IL IL12682598A patent/IL126825A0/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL126825A0 (en) | 1999-08-17 |
| AU7665794A (en) | 1995-04-10 |
| WO1995008536A1 (en) | 1995-03-30 |
| US6380215B1 (en) | 2002-04-30 |
| EP0669912B1 (de) | 2001-12-05 |
| CN1116847A (zh) | 1996-02-14 |
| AU684547B2 (en) | 1997-12-18 |
| ATE210118T1 (de) | 2001-12-15 |
| CN1041919C (zh) | 1999-02-03 |
| EP0669912A1 (de) | 1995-09-06 |
| EP1106606A2 (de) | 2001-06-13 |
| HUT73174A (en) | 1996-06-28 |
| ES2164109T3 (es) | 2002-02-16 |
| DE69429328T2 (de) | 2002-06-13 |
| TW401414B (en) | 2000-08-11 |
| CA2157792A1 (en) | 1995-03-30 |
| HK1004985A1 (en) | 1998-12-18 |
| HU9501845D0 (en) | 1995-08-28 |
| DK0669912T3 (da) | 2002-03-04 |
| IL111036A0 (en) | 1994-11-28 |
| IL126825A (en) | 1999-09-22 |
| IL111036A (en) | 1999-07-14 |
| PT669912E (pt) | 2002-03-28 |
| RU95112456A (ru) | 1997-04-20 |
| CA2157792C (en) | 2005-05-24 |
| RU2161155C2 (ru) | 2000-12-27 |
| EP1106606A3 (de) | 2003-10-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: ASTELLAS PHARMA INC., TOKIO/TOKYO, JP |