DE69315699T2 - Inhibitoren gegen die aggregation von blutplättchen - Google Patents
Inhibitoren gegen die aggregation von blutplättchenInfo
- Publication number
- DE69315699T2 DE69315699T2 DE69315699T DE69315699T DE69315699T2 DE 69315699 T2 DE69315699 T2 DE 69315699T2 DE 69315699 T DE69315699 T DE 69315699T DE 69315699 T DE69315699 T DE 69315699T DE 69315699 T2 DE69315699 T2 DE 69315699T2
- Authority
- DE
- Germany
- Prior art keywords
- inhibitors against
- against aggregation
- blood plates
- compounds
- platelet aggregation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
- C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/75—Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/940,569 US5354738A (en) | 1992-09-04 | 1992-09-04 | Platelet aggregation inhibitors |
PCT/US1993/007975 WO1994005694A1 (en) | 1992-09-04 | 1993-08-27 | Platelet aggregation inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69315699D1 DE69315699D1 (de) | 1998-01-22 |
DE69315699T2 true DE69315699T2 (de) | 1998-04-09 |
Family
ID=25475067
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69315699T Expired - Fee Related DE69315699T2 (de) | 1992-09-04 | 1993-08-27 | Inhibitoren gegen die aggregation von blutplättchen |
Country Status (11)
Country | Link |
---|---|
US (1) | US5354738A (de) |
EP (1) | EP0659193B1 (de) |
JP (1) | JP3489628B2 (de) |
AT (1) | ATE161017T1 (de) |
AU (1) | AU5090393A (de) |
CA (1) | CA2140927C (de) |
DE (1) | DE69315699T2 (de) |
DK (1) | DK0659193T3 (de) |
ES (1) | ES2110115T3 (de) |
GR (1) | GR3025764T3 (de) |
WO (1) | WO1994005694A1 (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993018058A1 (en) * | 1992-03-06 | 1993-09-16 | G.D. Searle & Co. | Peptides mimics useful as platelet aggregation inhibitors |
HUT63609A (en) * | 1992-03-10 | 1993-09-28 | Sandoz Ag | Process for producing new derivatives and isosters of beta-amino acids and pharmaceutical compositions comprising such compounds |
US5314902A (en) * | 1993-01-27 | 1994-05-24 | Monsanto Company | Urea derivatives useful as platelet aggregation inhibitors |
US5409939A (en) * | 1993-02-12 | 1995-04-25 | G. D. Searle & Co. | Phenyl amidine thio derivatives useful as platelet aggregation inhibitors |
US6268380B1 (en) * | 1993-02-19 | 2001-07-31 | G. D. Searle & Co. | Urea derivatives useful as platelet aggregation inhibitors |
US5614539A (en) * | 1993-03-15 | 1997-03-25 | G. D. Searle & Co. | Urea compounds which are useful as platelet aggregation inhibitors |
PT729362E (pt) * | 1993-11-19 | 2000-06-30 | Searle & Co | Composicao transdermica de n-¬n-¬5-¬4-(aminoiminometil)fenil|-1oxopentil|-l-alfa-aspartil|-l-fenillalanina ou esteres e seus sais farmaceuticamente aceitaveis |
US5561146A (en) * | 1994-06-10 | 1996-10-01 | Bristol-Myers Squibb Company | Modified guanidino and amidino thrombin inhibitors |
US6387880B1 (en) | 1994-10-24 | 2002-05-14 | G.D. Searle & Co. | Transdermal N-[N-[5-[4-(aminoiminomethly)phenyl]-1-oxopentyl]-L-α-aspartyl]-L-phenylalainine or its esters and their pharmaceutically acceptable salts |
US5674894A (en) * | 1995-05-15 | 1997-10-07 | G.D. Searle & Co. | Amidine derivatives useful as platelet aggregation inhibitors and vasodilators |
US6132697A (en) * | 1996-06-10 | 2000-10-17 | G. D. Searle & Co. | Radiopharmaceutical compositions capable of localizing at sites of thrombus |
US6087332A (en) * | 1997-12-23 | 2000-07-11 | Galler; Lawrence Isaac | Streptokinase derivatives with high affinity for activated platelets and methods of their production and use in thrombolytic therapy |
WO2003077656A1 (en) * | 2002-03-15 | 2003-09-25 | Ciba Specialty Chemicals Holding Inc. | 4-aminopyrimidines and their use for the antimicrobial treatment of surfaces |
US11043823B2 (en) * | 2017-04-06 | 2021-06-22 | Tesla, Inc. | System and method for facilitating conditioning and testing of rechargeable battery cells |
CN113959911A (zh) * | 2020-07-20 | 2022-01-21 | 深圳迈瑞生物医疗电子股份有限公司 | 抗血小板聚集干扰的检测方法、试剂及其应用 |
CN113959912A (zh) * | 2020-07-20 | 2022-01-21 | 深圳迈瑞生物医疗电子股份有限公司 | 抗血小板聚集干扰的白细胞检测方法、试剂及其应用 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3134933A1 (de) * | 1981-09-03 | 1983-03-31 | Hoechst Ag, 6230 Frankfurt | "harnstoffderivate, verfahren zu ihrer herstellung und diese enthaltende medikamente sowie deren verwendung" |
DE3601398A1 (de) * | 1986-01-18 | 1987-07-23 | Fresenius Ag | Verwendung von oligopeptiden zur behandlung von cerebralen stoerungen |
US5093367A (en) * | 1988-06-15 | 1992-03-03 | Montefiore Medical Center | Method of synthesis and novel compounds for pharmaceutical uses |
US5084466A (en) * | 1989-01-31 | 1992-01-28 | Hoffmann-La Roche Inc. | Novel carboxamide pyridine compounds which have useful pharmaceutical utility |
CA2037153A1 (en) * | 1990-03-09 | 1991-09-10 | Leo Alig | Acetic acid derivatives |
IE920710A1 (en) * | 1991-03-06 | 1992-09-09 | Searle & Co | Phenyl amidines derivatives useful as platelet aggregation¹inhibitors |
ATE142641T1 (de) * | 1991-05-13 | 1996-09-15 | Fujisawa Pharmaceutical Co | Neue peptid-verbindungen und verfahren zur herstellung davon |
-
1992
- 1992-09-04 US US07/940,569 patent/US5354738A/en not_active Expired - Fee Related
-
1993
- 1993-08-27 JP JP50727694A patent/JP3489628B2/ja not_active Expired - Fee Related
- 1993-08-27 CA CA002140927A patent/CA2140927C/en not_active Expired - Fee Related
- 1993-08-27 EP EP93920318A patent/EP0659193B1/de not_active Expired - Lifetime
- 1993-08-27 WO PCT/US1993/007975 patent/WO1994005694A1/en active IP Right Grant
- 1993-08-27 ES ES93920318T patent/ES2110115T3/es not_active Expired - Lifetime
- 1993-08-27 DK DK93920318.8T patent/DK0659193T3/da active
- 1993-08-27 DE DE69315699T patent/DE69315699T2/de not_active Expired - Fee Related
- 1993-08-27 AT AT93920318T patent/ATE161017T1/de not_active IP Right Cessation
- 1993-08-27 AU AU50903/93A patent/AU5090393A/en not_active Abandoned
-
1997
- 1997-12-23 GR GR970403415T patent/GR3025764T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
GR3025764T3 (en) | 1998-03-31 |
US5354738A (en) | 1994-10-11 |
JP3489628B2 (ja) | 2004-01-26 |
ATE161017T1 (de) | 1997-12-15 |
AU5090393A (en) | 1994-03-29 |
CA2140927C (en) | 2003-12-30 |
EP0659193A1 (de) | 1995-06-28 |
DE69315699D1 (de) | 1998-01-22 |
EP0659193B1 (de) | 1997-12-10 |
JPH08501099A (ja) | 1996-02-06 |
DK0659193T3 (da) | 1998-01-26 |
ES2110115T3 (es) | 1998-02-01 |
WO1994005694A1 (en) | 1994-03-17 |
CA2140927A1 (en) | 1994-03-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |