FI954609A - 1-amidinofenyyli-pyrrolidoneja, -piperidinoneja ja -atsetinoneja verihiutaleiden kasaantumisen inhibiittoreina - Google Patents
1-amidinofenyyli-pyrrolidoneja, -piperidinoneja ja -atsetinoneja verihiutaleiden kasaantumisen inhibiittoreina Download PDFInfo
- Publication number
- FI954609A FI954609A FI954609A FI954609A FI954609A FI 954609 A FI954609 A FI 954609A FI 954609 A FI954609 A FI 954609A FI 954609 A FI954609 A FI 954609A FI 954609 A FI954609 A FI 954609A
- Authority
- FI
- Finland
- Prior art keywords
- platelet aggregation
- pct
- amidinophenylpyrrolidones
- acetetinones
- piperidinones
- Prior art date
Links
- 208000010110 spontaneous platelet aggregation Diseases 0.000 title abstract 3
- BZGJHAKVSTWVMW-UHFFFAOYSA-N C1CCC(=O)N1C1(C(=N)N)CC=CC=C1 Chemical class C1CCC(=O)N1C1(C(=N)N)CC=CC=C1 BZGJHAKVSTWVMW-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- XUWHAWMETYGRKB-UHFFFAOYSA-N piperidin-2-one Chemical class O=C1CCCCN1 XUWHAWMETYGRKB-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4143393A | 1993-03-31 | 1993-03-31 | |
| US4143393 | 1993-03-31 | ||
| PCT/US1994/003259 WO1994022820A1 (en) | 1993-03-31 | 1994-03-30 | 1-amidinophenyl-pyrrolidones piperidinones azetinones as platelet aggregation inhibitors |
| US9403259 | 1994-03-30 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI954609A0 FI954609A0 (fi) | 1995-09-28 |
| FI954609A true FI954609A (fi) | 1995-10-23 |
| FI111007B FI111007B (fi) | 2003-05-15 |
Family
ID=21916489
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI954609A FI111007B (fi) | 1993-03-31 | 1995-09-28 | Menetelmä terapeuttisesti aktiivisten 1-amidinofenyyli-pyrrolidonien, -piperidinonien ja -atsetinonien valmistamiseksi |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5721366A (fi) |
| EP (1) | EP0691953B1 (fi) |
| JP (1) | JP3034046B2 (fi) |
| KR (1) | KR100257837B1 (fi) |
| CN (1) | CN1054842C (fi) |
| AT (1) | ATE195117T1 (fi) |
| AU (1) | AU681396B2 (fi) |
| CA (1) | CA2159450C (fi) |
| DE (1) | DE69425431T2 (fi) |
| DK (1) | DK0691953T3 (fi) |
| ES (1) | ES2150489T3 (fi) |
| FI (1) | FI111007B (fi) |
| GR (1) | GR3034520T3 (fi) |
| NO (1) | NO305950B1 (fi) |
| PT (1) | PT691953E (fi) |
| WO (1) | WO1994022820A1 (fi) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5314902A (en) * | 1993-01-27 | 1994-05-24 | Monsanto Company | Urea derivatives useful as platelet aggregation inhibitors |
| US5614539A (en) * | 1993-03-15 | 1997-03-25 | G. D. Searle & Co. | Urea compounds which are useful as platelet aggregation inhibitors |
| US5610296A (en) * | 1994-12-05 | 1997-03-11 | G. D. Searle & Co. | Process for the preparation of amidino phenyl pyrrolidine beta-alanine urea analogs |
| TW448172B (en) * | 1996-03-08 | 2001-08-01 | Pharmacia & Upjohn Co Llc | Novel hydroxamic acid derivatives useful for the treatment of diseases related to connective tissue degradation |
| CA2253402A1 (en) * | 1996-05-15 | 1997-11-20 | G.D. Searle & Co. | Method and reagent for monitoring blood levels of antiplatelet compounds |
| PL190866B1 (pl) * | 1996-07-25 | 2006-02-28 | Biogen | Inhibitor adhezji komórek, sposób jego wytwarzania i jego zastosowanie oraz kompozycja farmaceutyczna i sposób jej wytwarzania |
| US5872122A (en) * | 1997-10-16 | 1999-02-16 | Monsanto Company | Pyrimidinylamidino β-amino acid derivatives useful as inhibitors of platelet aggregation |
| US5986107A (en) * | 1998-04-08 | 1999-11-16 | G. D. Searle & Co. | Process for the preparation of a 2-oxopyrrolidine compound |
| HUP0101419A3 (en) | 1998-04-16 | 2002-08-28 | Texas Biotechnology Corp Houst | Compounds that inhibit the binding of integrins to their receptors and pharmaceutical compositions containing them |
| DE19822912A1 (de) * | 1998-05-22 | 1999-11-25 | Degussa | Verfahren zur Herstellung von 3-Amino-2-oxo-pyrrolidinen, neue Zwischenprodukte und deren Verwendung |
| US6025358A (en) * | 1998-06-11 | 2000-02-15 | G. D. Searle & Co. | Double prodrugs of potent GP IIb/IIIa antagonists |
| US6335324B1 (en) | 1998-06-25 | 2002-01-01 | Bristol-Myers Squibb Co. | Beta lactam compounds and their use as inhibitors of tryptase |
| EP1105389A4 (en) * | 1998-08-13 | 2001-10-17 | Merck & Co Inc | INTEGRIN RECEPTOR ANTAGONISTS |
| DE19841895A1 (de) * | 1998-09-11 | 2000-03-23 | Degussa | Neues Verfahren zur Herstellung von 3-Amino-2-oxo-pyrrolidinen, neue Zwischenprodukte und deren Verwendung |
| US6037365A (en) * | 1998-09-25 | 2000-03-14 | G.D. Searle & Co. | Aminobenzamidinosuccinyl lactone derivatives useful as inhibitors of platelet aggregation |
| WO2000059285A2 (en) | 1999-04-02 | 2000-10-12 | Du Pont Pharmaceuticals Company | NOVEL LACTAM INHIBITORS OF MATRIX METALLOPROTEINASES, TNF-α, AND AGGRECANASE |
| WO2000067746A1 (en) * | 1999-05-07 | 2000-11-16 | Texas Biotechnology Corporation | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors |
| AU782616B2 (en) * | 1999-05-07 | 2005-08-11 | Encysive Pharmaceuticals Inc. | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors |
| US6972296B2 (en) * | 1999-05-07 | 2005-12-06 | Encysive Pharmaceuticals Inc. | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors |
| US6723711B2 (en) | 1999-05-07 | 2004-04-20 | Texas Biotechnology Corporation | Propanoic acid derivatives that inhibit the binding of integrins to their receptors |
| US6849639B2 (en) * | 1999-12-14 | 2005-02-01 | Amgen Inc. | Integrin inhibitors and their methods of use |
| SI21096B (sl) * | 2001-10-09 | 2012-05-31 | Encysive Pharmaceuticals Inc | Derivati karboksilne kisline ki inhibirajo vezavo integrinov na njihove receptorje |
| CN103073476B (zh) * | 2013-01-29 | 2015-03-04 | 西北师范大学 | 一种n-芳基-5-三氟甲基-2-吡咯烷酮和n-芳基-6-三氟甲基-2-吡啶烷酮的合成方法 |
| CN103356678A (zh) * | 2013-06-24 | 2013-10-23 | 丁圣雨 | Houttuynoid C在抗血小板聚集药物中的应用 |
| CN103356672B (zh) * | 2013-06-24 | 2015-08-19 | 丁圣雨 | Houttuynoid B在制备扩血管药物中的应用 |
| CN103381174B (zh) * | 2013-06-24 | 2015-08-19 | 丁圣雨 | Houttuynoid E在制备治疗缺血性脑损伤药物中的应用 |
| CN103356679A (zh) * | 2013-06-24 | 2013-10-23 | 丁圣雨 | Houttuynoid A在抗血小板聚集药物中的应用 |
| CN103393704B (zh) * | 2013-06-24 | 2015-08-19 | 丁圣雨 | Houttuynoid E在制备治疗动脉粥样硬化药物中的应用 |
| CN103356669B (zh) * | 2013-06-24 | 2015-08-19 | 丁圣雨 | Houttuynoid A在制备治疗或预防急性心衰的药物中的应用 |
| CN103356674A (zh) * | 2013-06-24 | 2013-10-23 | 丁圣雨 | Houttuynoid E在抗缺氧药物中的应用 |
| CN103356682B (zh) * | 2013-06-24 | 2015-08-19 | 丁圣雨 | Houttuynoid D在制备抗血小板聚集药物中的应用 |
| CN103381176B (zh) * | 2013-06-24 | 2015-04-29 | 丁圣雨 | Houttuynoid C在制备治疗动脉粥样硬化药物中的应用 |
| CN103381179B (zh) * | 2013-06-24 | 2015-08-19 | 丁圣雨 | Houttuynoid D在制备治疗缺血性脑损伤药物中的应用 |
| CN103462967A (zh) * | 2013-09-22 | 2013-12-25 | 南京广康协生物医药技术有限公司 | Incarviatone A在抗疱疹病毒的药物中的应用 |
| DE102014108210A1 (de) | 2014-06-11 | 2015-12-17 | Dietrich Gulba | Rodentizid |
| CN105130965A (zh) * | 2015-10-08 | 2015-12-09 | 侯方杰 | 一种可用于制备治疗心血管疾病药物的化合物及其制备方法、用途 |
| CN112312910A (zh) * | 2018-04-12 | 2021-02-02 | 莫菲克医疗股份有限公司 | 人整合素α4β7拮抗剂 |
| US11104661B1 (en) | 2019-10-16 | 2021-08-31 | Morphic Therapeutic, Inc. | Inhibiting human integrin (α-4) (β-7) |
| EP4070658A1 (de) | 2021-04-06 | 2022-10-12 | BIORoxx GmbH | Verwendung von blutgerinnungshemmenden verbindungen als rodentizide |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3474093A (en) * | 1966-05-03 | 1969-10-21 | American Home Prod | Enamine adducts of n-acyloxy-n-acylaminoacetanilide |
| DE4035961A1 (de) * | 1990-11-02 | 1992-05-07 | Thomae Gmbh Dr K | Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| WO1993008164A1 (en) * | 1991-10-15 | 1993-04-29 | G.D. Searle & Co. | Substituted heterocyclic derivatives useful as platelet aggregation inhibitors |
| DE4213919A1 (de) * | 1992-04-28 | 1993-11-04 | Thomae Gmbh Dr K | Cyclische iminoderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE4213931A1 (de) * | 1992-04-28 | 1993-11-04 | Thomae Gmbh Dr K | Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
-
1994
- 1994-03-30 DE DE69425431T patent/DE69425431T2/de not_active Expired - Fee Related
- 1994-03-30 EP EP94913308A patent/EP0691953B1/en not_active Expired - Lifetime
- 1994-03-30 CN CN94192290A patent/CN1054842C/zh not_active Expired - Fee Related
- 1994-03-30 KR KR1019950704253A patent/KR100257837B1/ko not_active IP Right Cessation
- 1994-03-30 CA CA002159450A patent/CA2159450C/en not_active Expired - Fee Related
- 1994-03-30 US US08/436,404 patent/US5721366A/en not_active Expired - Fee Related
- 1994-03-30 AU AU65522/94A patent/AU681396B2/en not_active Ceased
- 1994-03-30 AT AT94913308T patent/ATE195117T1/de not_active IP Right Cessation
- 1994-03-30 ES ES94913308T patent/ES2150489T3/es not_active Expired - Lifetime
- 1994-03-30 JP JP6522208A patent/JP3034046B2/ja not_active Expired - Fee Related
- 1994-03-30 WO PCT/US1994/003259 patent/WO1994022820A1/en active IP Right Grant
- 1994-03-30 PT PT94913308T patent/PT691953E/pt unknown
- 1994-03-30 DK DK94913308T patent/DK0691953T3/da active
-
1995
- 1995-09-28 NO NO953844A patent/NO305950B1/no unknown
- 1995-09-28 FI FI954609A patent/FI111007B/fi not_active IP Right Cessation
-
2000
- 2000-09-29 GR GR20000402210T patent/GR3034520T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| FI111007B (fi) | 2003-05-15 |
| WO1994022820A1 (en) | 1994-10-13 |
| CN1124957A (zh) | 1996-06-19 |
| AU6552294A (en) | 1994-10-24 |
| FI954609A0 (fi) | 1995-09-28 |
| NO953844D0 (no) | 1995-09-28 |
| CA2159450C (en) | 2002-01-08 |
| NO305950B1 (no) | 1999-08-23 |
| JP3034046B2 (ja) | 2000-04-17 |
| KR100257837B1 (ko) | 2000-07-01 |
| PT691953E (pt) | 2001-01-31 |
| US5721366A (en) | 1998-02-24 |
| CN1054842C (zh) | 2000-07-26 |
| JPH08508732A (ja) | 1996-09-17 |
| DK0691953T3 (da) | 2000-09-04 |
| CA2159450A1 (en) | 1994-10-13 |
| ES2150489T3 (es) | 2000-12-01 |
| DE69425431D1 (en) | 2000-09-07 |
| ATE195117T1 (de) | 2000-08-15 |
| DE69425431T2 (de) | 2001-02-08 |
| EP0691953B1 (en) | 2000-08-02 |
| AU681396B2 (en) | 1997-08-28 |
| EP0691953A1 (en) | 1996-01-17 |
| GR3034520T3 (en) | 2000-12-29 |
| NO953844L (no) | 1995-11-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MA | Patent expired |