ATE161017T1 - Inhibitoren gegen die aggregation von blutplättchen - Google Patents

Inhibitoren gegen die aggregation von blutplättchen

Info

Publication number
ATE161017T1
ATE161017T1 AT93920318T AT93920318T ATE161017T1 AT E161017 T1 ATE161017 T1 AT E161017T1 AT 93920318 T AT93920318 T AT 93920318T AT 93920318 T AT93920318 T AT 93920318T AT E161017 T1 ATE161017 T1 AT E161017T1
Authority
AT
Austria
Prior art keywords
platelet aggregation
aggregation inhibitors
compounds
mammals
inhibition
Prior art date
Application number
AT93920318T
Other languages
English (en)
Inventor
Jeffery Alan Zablocki
Foe Siong Tjoeng
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Application granted granted Critical
Publication of ATE161017T1 publication Critical patent/ATE161017T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT93920318T 1992-09-04 1993-08-27 Inhibitoren gegen die aggregation von blutplättchen ATE161017T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/940,569 US5354738A (en) 1992-09-04 1992-09-04 Platelet aggregation inhibitors

Publications (1)

Publication Number Publication Date
ATE161017T1 true ATE161017T1 (de) 1997-12-15

Family

ID=25475067

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93920318T ATE161017T1 (de) 1992-09-04 1993-08-27 Inhibitoren gegen die aggregation von blutplättchen

Country Status (11)

Country Link
US (1) US5354738A (de)
EP (1) EP0659193B1 (de)
JP (1) JP3489628B2 (de)
AT (1) ATE161017T1 (de)
AU (1) AU5090393A (de)
CA (1) CA2140927C (de)
DE (1) DE69315699T2 (de)
DK (1) DK0659193T3 (de)
ES (1) ES2110115T3 (de)
GR (1) GR3025764T3 (de)
WO (1) WO1994005694A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993018058A1 (en) * 1992-03-06 1993-09-16 G.D. Searle & Co. Peptides mimics useful as platelet aggregation inhibitors
HUT63609A (en) * 1992-03-10 1993-09-28 Sandoz Ag Process for producing new derivatives and isosters of beta-amino acids and pharmaceutical compositions comprising such compounds
US5314902A (en) * 1993-01-27 1994-05-24 Monsanto Company Urea derivatives useful as platelet aggregation inhibitors
US5409939A (en) * 1993-02-12 1995-04-25 G. D. Searle & Co. Phenyl amidine thio derivatives useful as platelet aggregation inhibitors
US6268380B1 (en) * 1993-02-19 2001-07-31 G. D. Searle & Co. Urea derivatives useful as platelet aggregation inhibitors
AU6395094A (en) * 1993-03-15 1994-10-11 G.D. Searle & Co. Urea derivatives useful as platelet aggregation inhibitors
JPH09505290A (ja) * 1993-11-19 1997-05-27 ジー．ディー．サール アンド カンパニー Ｎ‐［Ｎ‐［５‐［４‐（アミノイミノメチル）フェニル］‐１‐オキソペンチル］‐Ｌ‐α‐アスパルチル］‐Ｌ‐フェニルアラニンまたはそのエステル並びにそれらの医薬的に許容される塩類の経皮的組成物
US5561146A (en) * 1994-06-10 1996-10-01 Bristol-Myers Squibb Company Modified guanidino and amidino thrombin inhibitors
US6387880B1 (en) 1994-10-24 2002-05-14 G.D. Searle & Co. Transdermal N-[N-[5-[4-(aminoiminomethly)phenyl]-1-oxopentyl]-L-α-aspartyl]-L-phenylalainine or its esters and their pharmaceutically acceptable salts
US5674894A (en) * 1995-05-15 1997-10-07 G.D. Searle & Co. Amidine derivatives useful as platelet aggregation inhibitors and vasodilators
EP0910416A2 (de) * 1996-06-10 1999-04-28 G.D. Searle & Co. Radiomarkierte verbindungen zur thrombus-bilderzeugung
US6087332A (en) * 1997-12-23 2000-07-11 Galler; Lawrence Isaac Streptokinase derivatives with high affinity for activated platelets and methods of their production and use in thrombolytic therapy
ATE366045T1 (de) * 2002-03-15 2007-07-15 Ciba Sc Holding Ag Verwendung von 4-aminopyrimidinen zur antimikrobiellen behandlung von oberflächen
US11043823B2 (en) * 2017-04-06 2021-06-22 Tesla, Inc. System and method for facilitating conditioning and testing of rechargeable battery cells
CN113959912B (zh) * 2020-07-20 2024-06-21 深圳迈瑞生物医疗电子股份有限公司 抗血小板聚集干扰的白细胞检测方法、试剂及其应用
CN113959911B (zh) * 2020-07-20 2024-06-18 深圳迈瑞生物医疗电子股份有限公司 抗血小板聚集干扰的检测方法、试剂及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3134933A1 (de) * 1981-09-03 1983-03-31 Hoechst Ag, 6230 Frankfurt "harnstoffderivate, verfahren zu ihrer herstellung und diese enthaltende medikamente sowie deren verwendung"
DE3601398A1 (de) * 1986-01-18 1987-07-23 Fresenius Ag Verwendung von oligopeptiden zur behandlung von cerebralen stoerungen
US5093367A (en) * 1988-06-15 1992-03-03 Montefiore Medical Center Method of synthesis and novel compounds for pharmaceutical uses
US5084466A (en) * 1989-01-31 1992-01-28 Hoffmann-La Roche Inc. Novel carboxamide pyridine compounds which have useful pharmaceutical utility
CA2037153A1 (en) * 1990-03-09 1991-09-10 Leo Alig Acetic acid derivatives
DE69200766T2 (de) * 1991-03-06 1995-05-04 G.D. Searle & Co., Chicago, Ill. Phenylamidinderivate als plättchenaggregationsinhibitoren.
EP0513675B1 (de) * 1991-05-13 1996-09-11 Fujisawa Pharmaceutical Co., Ltd. Neue Peptid-Verbindungen und Verfahren zur Herstellung davon

Also Published As

Publication number Publication date
JP3489628B2 (ja) 2004-01-26
GR3025764T3 (en) 1998-03-31
ES2110115T3 (es) 1998-02-01
DE69315699T2 (de) 1998-04-09
CA2140927A1 (en) 1994-03-05
DK0659193T3 (da) 1998-01-26
JPH08501099A (ja) 1996-02-06
CA2140927C (en) 2003-12-30
EP0659193B1 (de) 1997-12-10
AU5090393A (en) 1994-03-29
DE69315699D1 (de) 1998-01-22
US5354738A (en) 1994-10-11
WO1994005694A1 (en) 1994-03-17
EP0659193A1 (de) 1995-06-28

Similar Documents

Publication Publication Date Title
DK0715623T3 (da) Blodpladeaggregationsinhibitorer
FI954609A (fi) 1-amidinofenyyli-pyrrolidoneja, -piperidinoneja ja -atsetinoneja verihiutaleiden kasaantumisen inhibiittoreina
WO1992015607A3 (en) Phenyl amidines derivatives useful as platelet aggregation inhibitors
ATE161017T1 (de) Inhibitoren gegen die aggregation von blutplättchen
LV12209A (lv) Ar fenilgrupu aizvietoti heterocikli ka ciklooksigenazes-2 inhibitori
ES2160949T3 (es) Derivados de fenilen-sulfonamida sustituidos en meta.
ATE202337T1 (de) Cyclopropylalkansäurederivate
RU95101048A (ru) Производные пролинамида, фармкомпозиция на их основе
DK0804418T3 (da) Platelataggregationshæmmere
MD1560F2 (en) Cyclic compounds, pharmaceutical compositions on base thereof and methods of treatment of infections or diseases provoked by retroviruses.
EE03488B1 (et) Meetod anhüdroekgoniini estrite valmistamiseks
DE59304359D1 (de) Ketorolac-Derivat mit wesentlich geringerer gastrointestinaler Reizung und Ulzeration
ES2181879T3 (es) Inhibidores de la agkytubacuib de las plaquetas que contienen restos de aminoacidos con cadenas laterales de c-terminal aminergicos.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee