DE69315699D1 - Inhibitoren gegen die aggregation von blutplättchen - Google Patents

Inhibitoren gegen die aggregation von blutplättchen

Info

Publication number
DE69315699D1
DE69315699D1 DE69315699T DE69315699T DE69315699D1 DE 69315699 D1 DE69315699 D1 DE 69315699D1 DE 69315699 T DE69315699 T DE 69315699T DE 69315699 T DE69315699 T DE 69315699T DE 69315699 D1 DE69315699 D1 DE 69315699D1
Authority
DE
Germany
Prior art keywords
inhibitors against
against aggregation
blood plates
compounds
platelet aggregation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69315699T
Other languages
English (en)
Other versions
DE69315699T2 (de
Inventor
Jeffery Zablocki
Foe Tjoeng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Publication of DE69315699D1 publication Critical patent/DE69315699D1/de
Application granted granted Critical
Publication of DE69315699T2 publication Critical patent/DE69315699T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69315699T 1992-09-04 1993-08-27 Inhibitoren gegen die aggregation von blutplättchen Expired - Fee Related DE69315699T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/940,569 US5354738A (en) 1992-09-04 1992-09-04 Platelet aggregation inhibitors
PCT/US1993/007975 WO1994005694A1 (en) 1992-09-04 1993-08-27 Platelet aggregation inhibitors

Publications (2)

Publication Number Publication Date
DE69315699D1 true DE69315699D1 (de) 1998-01-22
DE69315699T2 DE69315699T2 (de) 1998-04-09

Family

ID=25475067

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69315699T Expired - Fee Related DE69315699T2 (de) 1992-09-04 1993-08-27 Inhibitoren gegen die aggregation von blutplättchen

Country Status (11)

Country Link
US (1) US5354738A (de)
EP (1) EP0659193B1 (de)
JP (1) JP3489628B2 (de)
AT (1) ATE161017T1 (de)
AU (1) AU5090393A (de)
CA (1) CA2140927C (de)
DE (1) DE69315699T2 (de)
DK (1) DK0659193T3 (de)
ES (1) ES2110115T3 (de)
GR (1) GR3025764T3 (de)
WO (1) WO1994005694A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993018058A1 (en) * 1992-03-06 1993-09-16 G.D. Searle & Co. Peptides mimics useful as platelet aggregation inhibitors
HUT63609A (en) * 1992-03-10 1993-09-28 Sandoz Ag Process for producing new derivatives and isosters of beta-amino acids and pharmaceutical compositions comprising such compounds
US5314902A (en) * 1993-01-27 1994-05-24 Monsanto Company Urea derivatives useful as platelet aggregation inhibitors
US5409939A (en) * 1993-02-12 1995-04-25 G. D. Searle & Co. Phenyl amidine thio derivatives useful as platelet aggregation inhibitors
US6268380B1 (en) * 1993-02-19 2001-07-31 G. D. Searle & Co. Urea derivatives useful as platelet aggregation inhibitors
US5614539A (en) * 1993-03-15 1997-03-25 G. D. Searle & Co. Urea compounds which are useful as platelet aggregation inhibitors
WO1995013825A1 (en) * 1993-11-19 1995-05-26 G.D. Searle & Co. TRANSDERMAL COMPOSITION OF N-[N-[5-[4-(AMINOIMINOMETHYL)PHENYL]-1-OXOPENTYL]-L-α-ASPARTYL]-L-PHENYLALANINE OR ITS ESTERS AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS
US5561146A (en) * 1994-06-10 1996-10-01 Bristol-Myers Squibb Company Modified guanidino and amidino thrombin inhibitors
US6387880B1 (en) 1994-10-24 2002-05-14 G.D. Searle & Co. Transdermal N-[N-[5-[4-(aminoiminomethly)phenyl]-1-oxopentyl]-L-α-aspartyl]-L-phenylalainine or its esters and their pharmaceutically acceptable salts
US5674894A (en) * 1995-05-15 1997-10-07 G.D. Searle & Co. Amidine derivatives useful as platelet aggregation inhibitors and vasodilators
JP2001504801A (ja) * 1996-06-10 2001-04-10 ジー．ディー．サール アンド カンパニー 血栓サイトに局在化可能な放射性医薬組成物
US6087332A (en) * 1997-12-23 2000-07-11 Galler; Lawrence Isaac Streptokinase derivatives with high affinity for activated platelets and methods of their production and use in thrombolytic therapy
CN1642422A (zh) * 2002-03-15 2005-07-20 西巴特殊化学品控股有限公司 4－氨基嘧啶及其在表面抗菌处理中的应用
US11043823B2 (en) * 2017-04-06 2021-06-22 Tesla, Inc. System and method for facilitating conditioning and testing of rechargeable battery cells
CN113959911A (zh) * 2020-07-20 2022-01-21 深圳迈瑞生物医疗电子股份有限公司 抗血小板聚集干扰的检测方法、试剂及其应用
CN113959912A (zh) * 2020-07-20 2022-01-21 深圳迈瑞生物医疗电子股份有限公司 抗血小板聚集干扰的白细胞检测方法、试剂及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3134933A1 (de) * 1981-09-03 1983-03-31 Hoechst Ag, 6230 Frankfurt "harnstoffderivate, verfahren zu ihrer herstellung und diese enthaltende medikamente sowie deren verwendung"
DE3601398A1 (de) * 1986-01-18 1987-07-23 Fresenius Ag Verwendung von oligopeptiden zur behandlung von cerebralen stoerungen
US5093367A (en) * 1988-06-15 1992-03-03 Montefiore Medical Center Method of synthesis and novel compounds for pharmaceutical uses
US5084466A (en) * 1989-01-31 1992-01-28 Hoffmann-La Roche Inc. Novel carboxamide pyridine compounds which have useful pharmaceutical utility
CA2037153A1 (en) * 1990-03-09 1991-09-10 Leo Alig Acetic acid derivatives
DE69200766T2 (de) * 1991-03-06 1995-05-04 Searle & Co Phenylamidinderivate als plättchenaggregationsinhibitoren.
DK0513675T3 (da) * 1991-05-13 1996-09-30 Fujisawa Pharmaceutical Co Hidtil ukendt peptidforbindelse samt fremgangsmåde til fremstilling deraf

Also Published As

Publication number Publication date
CA2140927A1 (en) 1994-03-05
DK0659193T3 (da) 1998-01-26
EP0659193A1 (de) 1995-06-28
ATE161017T1 (de) 1997-12-15
CA2140927C (en) 2003-12-30
GR3025764T3 (en) 1998-03-31
WO1994005694A1 (en) 1994-03-17
AU5090393A (en) 1994-03-29
EP0659193B1 (de) 1997-12-10
ES2110115T3 (es) 1998-02-01
DE69315699T2 (de) 1998-04-09
US5354738A (en) 1994-10-11
JP3489628B2 (ja) 2004-01-26
JPH08501099A (ja) 1996-02-06

Similar Documents

Publication Publication Date Title
DE69413237T2 (de) Plättchenaggregationsinhibitoren
FI954609A (fi) 1-amidinofenyyli-pyrrolidoneja, -piperidinoneja ja -atsetinoneja verihiutaleiden kasaantumisen inhibiittoreina
DE69315699D1 (de) Inhibitoren gegen die aggregation von blutplättchen
LV12209A (lv) Ar fenilgrupu aizvietoti heterocikli ka ciklooksigenazes-2 inhibitori
WO1992015607A3 (en) Phenyl amidines derivatives useful as platelet aggregation inhibitors
RU95101048A (ru) Производные пролинамида, фармкомпозиция на их основе
LU91145I2 (fr) FIROCOXIB facultativement sous forme d'un sel pharmaceutiquement acceptable (PREVICOX).
DE69705300T2 (de) Cyclopropylalkansäurederivate
RU94036772A (ru) Применение 2-фенил-3-ароилбензотиофенов для ингибирования эндометриоза
DK0804418T3 (da) Platelataggregationshæmmere
FI935800A0 (fi) Antidepressiva och mot Parkisons sjukdom verksamma foereningar
EE03488B1 (et) Meetod anhüdroekgoniini estrite valmistamiseks
DE69622868T2 (de) Inhibitoren der blutplättchen-aggregation, die c-terminale aminosäurereste mit aminergen seitenketten enthalten

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee