ATE253061T1 - Zur behandlung von krebs nützliche thiophen- und furan-2,5-dicarboxamide - Google Patents
Zur behandlung von krebs nützliche thiophen- und furan-2,5-dicarboxamideInfo
- Publication number
- ATE253061T1 ATE253061T1 AT99926680T AT99926680T ATE253061T1 AT E253061 T1 ATE253061 T1 AT E253061T1 AT 99926680 T AT99926680 T AT 99926680T AT 99926680 T AT99926680 T AT 99926680T AT E253061 T1 ATE253061 T1 AT E253061T1
- Authority
- AT
- Austria
- Prior art keywords
- cancer
- dicarboxamide
- furan
- thiophene
- useful
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 201000011510 cancer Diseases 0.000 title abstract 2
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 title 2
- YVORDIMCXSWNQQ-UHFFFAOYSA-N furan-2,5-dicarboxamide Chemical compound NC(=O)C1=CC=C(C(N)=O)O1 YVORDIMCXSWNQQ-UHFFFAOYSA-N 0.000 title 1
- 229930192474 thiophene Natural products 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 102000006495 integrins Human genes 0.000 abstract 2
- 108010044426 integrins Proteins 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9106398P | 1998-06-29 | 1998-06-29 | |
| PCT/IB1999/001221 WO2000000486A1 (en) | 1998-06-29 | 1999-06-29 | Thiophene and furan 2,5-dicarboxamides useful in the treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE253061T1 true ATE253061T1 (de) | 2003-11-15 |
Family
ID=22225790
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99926680T ATE253061T1 (de) | 1998-06-29 | 1999-06-29 | Zur behandlung von krebs nützliche thiophen- und furan-2,5-dicarboxamide |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6960594B2 (de) |
| EP (1) | EP1091952B1 (de) |
| AT (1) | ATE253061T1 (de) |
| AU (1) | AU4385399A (de) |
| DE (1) | DE69912432D1 (de) |
| WO (1) | WO2000000486A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9805655D0 (en) | 1998-03-16 | 1998-05-13 | Celltech Therapeutics Ltd | Chemical compounds |
| US6521626B1 (en) | 1998-03-24 | 2003-02-18 | Celltech R&D Limited | Thiocarboxamide derivatives |
| GB9814414D0 (en) | 1998-07-03 | 1998-09-02 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9826174D0 (en) | 1998-11-30 | 1999-01-20 | Celltech Therapeutics Ltd | Chemical compounds |
| EP1187825A1 (de) | 1999-06-07 | 2002-03-20 | Shire Biochem Inc. | Thiophen integrin inhibitoren |
| AU2001248553A1 (en) | 2000-04-17 | 2001-10-30 | Celltech R And D Limited | Enamine derivatives as cell adhesion molecules |
| FR2808798A1 (fr) * | 2000-05-09 | 2001-11-16 | Hoechst Marion Roussel Inc | Nouveaux derives antagonistes du recepteur de la vitronectine |
| BR0210357A (pt) * | 2001-06-11 | 2004-06-29 | Shire Biochem Inc | Composto e métodos para o tratamento ou a prevenção de infecções pelo flavivìrus |
| US6924276B2 (en) * | 2001-09-10 | 2005-08-02 | Warner-Lambert Company | Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors |
| CN100413861C (zh) | 2002-12-10 | 2008-08-27 | 维勒凯姆制药股份有限公司 | 用于治疗或预防黄病毒感染的化合物 |
| UA87854C2 (en) | 2004-06-07 | 2009-08-25 | Мерк Энд Ко., Инк. | N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators |
| EA016071B1 (ru) * | 2005-05-13 | 2012-01-30 | Вирокем Фарма Инк. | Соединения и способы лечения или предотвращения флавивирусных инфекций |
| AU2007321677B2 (en) * | 2006-11-15 | 2013-04-11 | Vertex Pharmaceuticals (Canada) Incorporated | Thiophene analogues for the treatment or prevention of flavivirus infections |
| EP2470183B1 (de) | 2009-08-26 | 2015-09-16 | Merck Sharp & Dohme Corp. | Heterocyclische amidverbindungen als proteinkinasehemmer |
| US8337334B2 (en) * | 2009-09-14 | 2012-12-25 | Nike, Inc. | Golf balls with clusters of dimples having non-uniform dimple profiles |
| EP2978422A4 (de) | 2013-03-29 | 2017-04-05 | Avoscience, LLC | Lipidfuran-, pyrrol- und thiophenverbindungen zur behandlung von krebs, neurologischen erkrankungen und fibrotischen erkrankungen |
| US10328082B2 (en) | 2014-05-30 | 2019-06-25 | Pfizer Inc. | Methods of use and combinations |
| US20170312246A1 (en) | 2016-04-27 | 2017-11-02 | Avoscience, Llc | Lipidic furan, pyrrole, and thiophene compounds for use in the treatment of atrophic vaginitis |
| WO2023275715A1 (en) | 2021-06-30 | 2023-01-05 | Pfizer Inc. | Metabolites of selective androgen receptor modulators |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU674553B2 (en) * | 1992-10-14 | 1997-01-02 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| JP2000508319A (ja) * | 1996-04-10 | 2000-07-04 | メルク エンド カンパニー インコーポレーテッド | αｖβ３拮抗薬 |
-
1999
- 1999-06-29 AU AU43853/99A patent/AU4385399A/en not_active Abandoned
- 1999-06-29 AT AT99926680T patent/ATE253061T1/de not_active IP Right Cessation
- 1999-06-29 WO PCT/IB1999/001221 patent/WO2000000486A1/en active IP Right Grant
- 1999-06-29 DE DE69912432T patent/DE69912432D1/de not_active Expired - Lifetime
- 1999-06-29 EP EP99926680A patent/EP1091952B1/de not_active Expired - Lifetime
-
2002
- 2002-01-16 US US10/046,396 patent/US6960594B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1091952A1 (de) | 2001-04-18 |
| US6960594B2 (en) | 2005-11-01 |
| DE69912432D1 (de) | 2003-12-04 |
| EP1091952B1 (de) | 2003-10-29 |
| AU4385399A (en) | 2000-01-17 |
| WO2000000486A1 (en) | 2000-01-06 |
| US20020137947A1 (en) | 2002-09-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |