DE60130910D1 - Enamin-derivate als zell-adhäsionsmoleküle - Google Patents
Enamin-derivate als zell-adhäsionsmoleküleInfo
- Publication number
- DE60130910D1 DE60130910D1 DE60130910T DE60130910T DE60130910D1 DE 60130910 D1 DE60130910 D1 DE 60130910D1 DE 60130910 T DE60130910 T DE 60130910T DE 60130910 T DE60130910 T DE 60130910T DE 60130910 D1 DE60130910 D1 DE 60130910D1
- Authority
- DE
- Germany
- Prior art keywords
- group
- atom
- enamine derivatives
- alk
- cell adhesion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fuel Cell (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0009493 | 2000-04-17 | ||
GB0009493A GB0009493D0 (en) | 2000-04-17 | 2000-04-17 | Chemical compounds |
GB0018353 | 2000-07-26 | ||
GB0018353A GB0018353D0 (en) | 2000-07-26 | 2000-07-26 | Chemical compounds |
GB0018966A GB0018966D0 (en) | 2000-08-02 | 2000-08-02 | Chemical compounds |
GB0018966 | 2000-08-02 | ||
PCT/GB2001/001682 WO2001079173A2 (en) | 2000-04-17 | 2001-04-12 | Enamine derivatives as cell adhesion molecules |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60130910D1 true DE60130910D1 (de) | 2007-11-22 |
DE60130910T2 DE60130910T2 (de) | 2008-07-10 |
Family
ID=27255675
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60130910T Expired - Lifetime DE60130910T2 (de) | 2000-04-17 | 2001-04-12 | Enamin-derivate als zell-adhäsionsmoleküle |
Country Status (8)
Country | Link |
---|---|
US (2) | US6610700B2 (de) |
EP (1) | EP1332132B1 (de) |
JP (1) | JP2003531141A (de) |
AT (1) | ATE375330T1 (de) |
AU (1) | AU2001248553A1 (de) |
DE (1) | DE60130910T2 (de) |
ES (1) | ES2295150T3 (de) |
WO (1) | WO2001079173A2 (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0021898D0 (en) * | 2000-09-06 | 2000-10-25 | Celltech Chiroscience Ltd | Chemical compounds |
SI1370531T1 (sl) | 2001-02-22 | 2007-08-31 | Ucb Pharma Sa | Derivati fenilalanin enamida s ciklobutensko skupino, za uporabo kot integrin inhibitorji |
US7557130B2 (en) | 2001-07-26 | 2009-07-07 | Ucb Pharma, S.A. | Bicyclic heteroaromatic alanines |
GB0216571D0 (en) * | 2002-07-17 | 2002-08-28 | Celltech R&D Ltd | Chemical compounds |
GB0216568D0 (en) * | 2002-07-17 | 2002-08-28 | Celltech R&D Ltd | Chemical compounds |
WO2005091754A2 (en) * | 2004-03-29 | 2005-10-06 | University Of Mississippi | Novel cyclopentenedione antifungal compounds and methods for their use |
MY194883A (en) | 2004-06-04 | 2022-12-21 | Genentech Inc | Method for treating multiple sclerosis |
NZ561681A (en) | 2005-03-21 | 2011-01-28 | Virobay Inc | Alpha ketoamide compounds as cysteine protease inhibitors |
MY149159A (en) | 2005-11-15 | 2013-07-31 | Hoffmann La Roche | Method for treating joint damage |
TW201014605A (en) | 2008-09-16 | 2010-04-16 | Genentech Inc | Methods for treating progressive multiple sclerosis |
WO2010075249A2 (en) | 2008-12-22 | 2010-07-01 | Genentech, Inc. | A method for treating rheumatoid arthritis with b-cell antagonists |
WO2012151319A1 (en) | 2011-05-02 | 2012-11-08 | Virobay, Inc. | Cathepsin inhibitors for the treatment of bone cancer and bone cancer pain |
WO2013101771A2 (en) | 2011-12-30 | 2013-07-04 | Genentech, Inc. | Compositions and method for treating autoimmune diseases |
JP2015506950A (ja) | 2012-01-31 | 2015-03-05 | ジェネンテック, インコーポレイテッド | 抗ig−em1’抗体およびそれを用いる方法 |
JP2018529747A (ja) | 2015-10-06 | 2018-10-11 | ジェネンテック, インコーポレイテッド | 多発性硬化症を治療するための方法 |
CN111349060B (zh) * | 2018-12-21 | 2022-05-03 | 石家庄圣泰化工有限公司 | 四氢噻吩-3-酮-1,1-二氧化物的合成方法 |
Family Cites Families (108)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1437781A (en) | 1972-04-04 | 1976-06-03 | Beecham Group Ltd | Pyridine derivatives having hypoglycaemic activity |
US3938367A (en) | 1975-03-28 | 1976-02-17 | Nasa | Sampler of gas borne particles |
JPS609718B2 (ja) | 1977-08-25 | 1985-03-12 | 塩野義製薬株式会社 | チアジアゾリルチオセフアロスポリン類縁抗生物質 |
JPS5683483A (en) | 1979-12-13 | 1981-07-08 | Santen Pharmaceut Co Ltd | Thiazolidine compound |
JPS5690045A (en) | 1979-12-25 | 1981-07-21 | Tokuyama Soda Co Ltd | Alpha*alpha**di substituted amino phenylenediacetic acid |
JPS56139455A (en) | 1980-04-02 | 1981-10-30 | Santen Pharmaceut Co Ltd | Sulfur-containing acylaminoacid |
US4470973A (en) | 1982-07-19 | 1984-09-11 | E. R. Squibb & Sons, Inc. | Substituted peptide compounds |
FR2540871B1 (fr) | 1983-02-16 | 1986-01-10 | Lipha | Amino-2 phenyl-5 benzodiazepines-1,3; procede de preparation et medicaments les contenant |
GB8332704D0 (en) | 1983-12-07 | 1984-01-11 | Pfizer Ltd | Growth promotants for animals |
IT1176983B (it) | 1984-10-16 | 1987-08-26 | Zambon Spa | Dipeptidi ad attivita' farmacologica |
CN1030415A (zh) | 1987-02-20 | 1989-01-18 | 山之内制药株式会社 | 饱和的杂环碳酰胺衍生物和它的制备方法 |
JPH0784424B2 (ja) | 1987-04-15 | 1995-09-13 | 味の素株式会社 | チロシン誘導体及びその用途 |
US5510346A (en) | 1987-12-07 | 1996-04-23 | Hoechst Marion Roussel, Inc. | 4-heteroaryl-1,3-benzodiazepines and 2-substituted-gamma-(heteroaryl)benzeneethanamines |
IT1223565B (it) | 1987-12-21 | 1990-09-19 | Zambon Spa | Derivati dell'acido tiazolidin 4 carbossilico ad attivita' farmaceutica |
US5256812A (en) | 1989-01-31 | 1993-10-26 | Hoffmann-La Roche Inc. | Carboxamides and sulfonamides |
US5164372A (en) | 1989-04-28 | 1992-11-17 | Fujisawa Pharmaceutical Company, Ltd. | Peptide compounds having substance p antagonism, processes for preparation thereof and pharmaceutical composition comprising the same |
JPH07121917B2 (ja) | 1989-07-31 | 1995-12-25 | 四国化成工業株式会社 | 4(5)―チオカルバモイル―イミダゾール化合物及びその合成方法 |
US5260277A (en) | 1990-09-10 | 1993-11-09 | Tanabe Seiyaku Co., Ltd. | Guanidinyl and related cell adhesion modulation compounds |
IT1244548B (it) | 1991-02-06 | 1994-07-15 | Poli Ind Chimica Spa | Derivati della 5-oxo-l-prolina e loro applicazioni farmaceutiche |
CA2112360A1 (en) | 1991-06-28 | 1993-12-23 | William Edward Bondinell | Bicyclic fibrinogen antagonists |
US5296486A (en) | 1991-09-24 | 1994-03-22 | Boehringer Ingelheim Pharmaceuticals, Inc. | Leukotriene biosynthesis inhibitors |
US5250679A (en) | 1991-10-18 | 1993-10-05 | Genentech, Inc. | Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor |
AU3141693A (en) | 1991-11-22 | 1993-06-15 | Friedman, Mark M. | Non-peptidic surrogates of the arg-gly-asp sequence and pharmaceutical compositions comprising them |
US5227490A (en) | 1992-02-21 | 1993-07-13 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
AU686115B2 (en) | 1992-11-02 | 1998-02-05 | Fujisawa Pharmaceutical Co., Ltd. | Imidazo (I,2-a) pyridine derivatives as bradykinin antagonists, pharmaceuticals and processes for their preparation |
FR2700167B1 (fr) | 1993-01-07 | 1995-02-03 | Rhone Poulenc Rorer Sa | Dérivés de pyrrolidine et thiazolidine, leur préparation et les médicaments les contenant. |
FR2700168B1 (fr) | 1993-01-07 | 1995-02-03 | Rhone Poulenc Rorer Sa | Dérivés de thiazolidine, leur préparation et les médicaments les contenant. |
GB9311661D0 (en) | 1993-06-05 | 1993-07-21 | Smithkline Beecham Plc | Novel compounds |
AU678503B2 (en) | 1993-09-24 | 1997-05-29 | Takeda Chemical Industries Ltd. | Condensed heterocyclic compounds and their use as squalene synthetase inhibitors |
WO1995013811A1 (de) | 1993-11-17 | 1995-05-26 | Byk Nederland Bv | Verwendung substituierter thiazolidinderivate zur behandlung von erhöhtem augeninnendruck |
WO1995015973A1 (en) | 1993-12-06 | 1995-06-15 | Cytel Corporation | Cs-1 peptidomimetics, compositions and methods of using the same |
JP2973271B2 (ja) | 1994-01-18 | 1999-11-08 | 参天製薬株式会社 | エンドペプチダーゼ24.15阻害剤 |
FR2721608B1 (fr) | 1994-06-22 | 1996-07-19 | Rhone Poulenc Rorer Sa | Dérivés de thiazolidine, leur préparation et les médicaments les contenant. |
CA2193508A1 (en) | 1994-07-11 | 1996-01-25 | Eugene D. Thorsett | Inhibitors of leukocyte adhesion |
TW403748B (en) | 1994-11-02 | 2000-09-01 | Takeda Chemical Industries Ltd | An oxazolidinedione derivative, its production and a pharmaceutical composition for lowering blood sugar and lipid in blood comprising the same |
DK0710657T3 (da) | 1994-11-02 | 1999-05-25 | Merck Patent Gmbh | Adhæsionsreceptor-antagonister |
US6306840B1 (en) | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
WO1996026190A1 (en) | 1995-02-22 | 1996-08-29 | Smithkline Beecham Corporation | Integrin receptor antagonists |
US6248713B1 (en) | 1995-07-11 | 2001-06-19 | Biogen, Inc. | Cell adhesion inhibitors |
GB9515073D0 (en) | 1995-07-22 | 1995-09-20 | Blair Neil | Securement device and method |
CA2230209A1 (en) | 1995-08-30 | 1997-03-06 | G.D. Searle & Co. | Meta-guanidine, urea, thiourea or azacyclic amino benzoic acid derivatives as integrin antagonists |
US5714488A (en) | 1995-10-03 | 1998-02-03 | Abbott Laboratories | Bis-heteroarylylmethoxyphenyl ketone derivatives as inhibitors of leukotriene biosynthesis |
JP2000501105A (ja) | 1995-12-22 | 2000-02-02 | デュポン ファーマシューティカルズ カンパニー | 新規なインテグリン受容体アンタゴニスト |
WO1997024124A1 (en) | 1995-12-29 | 1997-07-10 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
GB9604242D0 (en) | 1996-02-28 | 1996-05-01 | Glaxo Wellcome Inc | Chemical compounds |
WO1997036859A1 (en) * | 1996-03-29 | 1997-10-09 | G.D. Searle & Co. | Para-substituted phenylpropanoic acid derivatives as integrin antagonists |
AU2420897A (en) | 1996-03-29 | 1997-10-22 | G.D. Searle & Co. | Meta-substituted phenylene sulphonamide derivatives |
EP0889877B1 (de) | 1996-03-29 | 2001-08-29 | G.D. Searle & Co. | META-SUBSTITUIERTE PHENYLENDERIVATE UND IHRE VERWENDUNG ALS ALPHAvBETA3 INTERGRIN-ANTAGONISTEN ODER INHIBITOREN |
ATE202337T1 (de) | 1996-03-29 | 2001-07-15 | Searle & Co | Cyclopropylalkansäurederivate |
DE19620041A1 (de) | 1996-05-17 | 1998-01-29 | Merck Patent Gmbh | Adhäsionsrezeptor-Antagonisten |
JP3418624B2 (ja) | 1996-06-10 | 2003-06-23 | メルク エンド カンパニー インコーポレーテッド | サイトカイン阻害活性を有する置換イミダゾール類 |
CZ424998A3 (cs) | 1996-06-28 | 1999-03-17 | Merck Patent Gmbh | Deriváty fenylaminu jakožto integrinové inhibitory |
DE19654483A1 (de) | 1996-06-28 | 1998-01-02 | Merck Patent Gmbh | Phenylalanin-Derivate |
KR100637110B1 (ko) | 1996-07-25 | 2006-10-23 | 바이오겐 아이덱 엠에이 인코포레이티드 | 세포 유착 억제제 |
ES2194223T3 (es) | 1996-10-30 | 2003-11-16 | Merck & Co Inc | Antagonistas de la integrina. |
DE19647380A1 (de) | 1996-11-15 | 1998-05-20 | Hoechst Ag | 5-Ring-Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten |
DE19647381A1 (de) | 1996-11-15 | 1998-05-20 | Hoechst Ag | Neue Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten |
JP2001506632A (ja) | 1996-12-09 | 2001-05-22 | イーライ リリー アンド カンパニー | インテグリン拮抗物質 |
WO1998031359A1 (en) | 1997-01-17 | 1998-07-23 | Merck & Co., Inc. | Integrin antagonists |
US6034136A (en) | 1997-03-20 | 2000-03-07 | Novartis Ag | Certain cyclic thio substituted acylaminoacid amide derivatives |
JP2002512625A (ja) | 1997-05-29 | 2002-04-23 | メルク エンド カンパニー インコーポレーテッド | 細胞接着阻害薬としての複素環アミド化合物 |
JP2001517245A (ja) | 1997-05-29 | 2001-10-02 | メルク エンド カンパニー インコーポレーテッド | 細胞接着阻害薬としてのビアリールアルカン酸類 |
WO1998053818A1 (en) | 1997-05-29 | 1998-12-03 | Merck & Co., Inc. | Sulfonamides as cell adhesion inhibitors |
US6093696A (en) | 1997-05-30 | 2000-07-25 | Celltech Therapeutics, Limited | Tyrosine derivatives |
US6482849B1 (en) | 1997-06-23 | 2002-11-19 | Tanabe Seiyaku Co., Ltd. | Inhibitors of α4β1 mediated cell adhesion |
CN1265672A (zh) | 1997-07-31 | 2000-09-06 | 伊兰药品公司 | 能抑制由vla-4介导的白细胞粘连的磺酰化二肽化合物 |
CN1133648C (zh) | 1997-07-31 | 2004-01-07 | 伊兰药品公司 | 抑制vla-4介导的白细胞粘附的取代的苯丙氨酸型化合物 |
CN1265669A (zh) | 1997-07-31 | 2000-09-06 | 伊兰药品公司 | 抑制由vla-4介导的白细胞粘着的化合物 |
EP1001971A1 (de) | 1997-07-31 | 2000-05-24 | Elan Pharmaceuticals, Inc. | Dipeptide und verwandte verbindungen, die die vla-4 vermittelte adhäsion von leukozyten inhibieren |
AR016133A1 (es) | 1997-07-31 | 2001-06-20 | Wyeth Corp | Compuesto de carbamiloxi que inhiben la adhesion de leucocitos mediada por vla-4, compuestos que son prodrogas de dichos compuestos, composicionfarmaceutica, metodo para fijar vla-4 a una muestra biologica, metodo para el tratamiento de una condicion inflamatoria |
JP2001512138A (ja) | 1997-07-31 | 2001-08-21 | エラン・ファーマシューティカルズ・インコーポレーテッド | Vla−4が介在する白血球付着を阻害するベンジル化合物 |
KR20010022414A (ko) | 1997-07-31 | 2001-03-15 | 진 엠. 듀발 | Vla-4에 의해 매개되는 백혈구 부착을 억제시키는4-아미노-페닐알라닌형 화합물 |
EP0994895A1 (de) | 1997-07-31 | 2000-04-26 | Elan Pharmaceuticals, Inc. | Dipeptide, die die vla-4 vermittelte adhäsion von leukozyten inhibieren |
EP1005446B1 (de) * | 1997-08-22 | 2004-02-25 | F. Hoffmann-La Roche Ag | N-aroylphenylalaninderivate |
DK1005445T3 (da) | 1997-08-22 | 2004-10-04 | Hoffmann La Roche | N-alkanoylphenylaninderivater |
WO1999020272A1 (en) | 1997-10-21 | 1999-04-29 | Merck & Co., Inc. | Azapeptide acids as cell adhesion inhibitors |
AU1463499A (en) | 1997-11-21 | 1999-06-15 | Merck & Co., Inc. | Substituted pyrrole derivatives as cell adhesion inhibitors |
ES2221227T3 (es) | 1997-11-24 | 2004-12-16 | MERCK & CO., INC. | Derivados sustituidos de beta-alanina como inhibidores de la adhesion celular. |
IL136267A0 (en) | 1997-11-26 | 2001-05-20 | Du Pont Pharm Co | 1,3,4-THIADIZOLES AND 1,3,4-OXADIAZOLES AS αVβ3 ANTAGONISTS |
NZ504893A (en) | 1997-12-17 | 2002-10-25 | Merck & Co Inc | 5, 6, 7, 8-Tetrahydro-[1,8]-naphthyridin-2-yl derivatives useful as integrin receptor antagonists |
IL136314A0 (en) | 1997-12-17 | 2001-05-20 | Merck & Co Inc | Integrin receptor antagonists |
EP1047425A4 (de) | 1997-12-17 | 2009-04-22 | Merck & Co Inc | Integrinrezeptor antagonisten |
EP0933367A1 (de) | 1997-12-19 | 1999-08-04 | Hoechst Marion Roussel Deutschland GmbH | Acylguanidin Derivate als Inhibitoren von Knochenaufsauge und als Vitronectin Rezeptor Antagonisten |
US6197794B1 (en) | 1998-01-08 | 2001-03-06 | Celltech Therapeutics Limited | Phenylalanine derivatives |
MY153569A (en) | 1998-01-20 | 2015-02-27 | Mitsubishi Tanabe Pharma Corp | Inhibitors of ?4 mediated cell adhesion |
US6329372B1 (en) | 1998-01-27 | 2001-12-11 | Celltech Therapeutics Limited | Phenylalanine derivatives |
ES2226413T3 (es) | 1998-02-26 | 2005-03-16 | Celltech Therapeutics Limited | Derivados de fenilalanina como inhibidores de alfa-4 integrinas. |
ZA994406B (en) | 1998-03-04 | 2000-02-11 | Searle & Co | Meta-azacyclic amino benzoic acid and derivatives thereof. |
US6521626B1 (en) | 1998-03-24 | 2003-02-18 | Celltech R&D Limited | Thiocarboxamide derivatives |
JP2002511462A (ja) | 1998-04-10 | 2002-04-16 | ジー・ディー・サール・アンド・カンパニー | ビトロネクチンアンタゴニストとしてのヘテロ環式グリシルβ−アラニン誘導体 |
WO1999052879A1 (en) | 1998-04-14 | 1999-10-21 | American Home Products Corporation | Acylresorcinol derivatives as selective vitronectin receptor inhibitors |
NZ507534A (en) | 1998-04-16 | 2002-02-01 | Texas Biotechnology Corp | N,N-disubstituted amide substituted propanoic acid derivatives useful for inhibiting the binding of intergrins to their receptors |
DE19821483A1 (de) | 1998-05-14 | 1999-11-18 | Hoechst Marion Roussel De Gmbh | Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
GB9811159D0 (en) | 1998-05-22 | 1998-07-22 | Celltech Therapeutics Ltd | Chemical compounds |
AU8059598A (en) | 1998-06-11 | 1999-12-30 | Merck & Co., Inc. | Heterocyclic amide compounds as cell adhesion inhibitors |
TW591026B (en) | 1998-06-23 | 2004-06-11 | Upjohn Co | Inhibitors of alpha4beta1 mediated cell adhesion |
DE69912432D1 (de) | 1998-06-29 | 2003-12-04 | Iaf Biochem Int | Zur behandlung von krebs nützliche thiophen- und furan-2,5-dicarboxamide |
SK242001A3 (en) | 1998-07-06 | 2001-10-08 | Merck Patent Gmbh | Rdg mimetic compound, method for their producing and method for differentiation inhibiting of cell adhesion |
CA2338275A1 (en) | 1998-07-29 | 2000-02-10 | Merck & Co., Inc. | Integrin receptor antagonists |
CA2339666A1 (en) | 1998-08-07 | 2000-02-17 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
AU5991699A (en) | 1998-09-21 | 2000-04-10 | Biochem Pharma Inc. | Quinolizinones as integrin inhibitors |
GB9821061D0 (en) * | 1998-09-28 | 1998-11-18 | Celltech Therapeutics Ltd | Chemical compounds |
FI982268A (fi) | 1998-10-20 | 2000-04-21 | Tomi Jaervinen | Ei-steroidaalisten anti-inflammatoristen karboksyylihappojen uudet pro drugit, niiden valmistus ja käyttö |
WO2000031607A2 (en) | 1998-11-19 | 2000-06-02 | Timebe, Ltd. | Method and system for conducting commerce over a computer network |
GB9826174D0 (en) | 1998-11-30 | 1999-01-20 | Celltech Therapeutics Ltd | Chemical compounds |
WO2000035855A1 (en) | 1998-12-14 | 2000-06-22 | American Home Products Corporation | 3,4-diamino-3-cyclobutene-1,2-dione derivatives which inhibit leukocyte adhesion mediated by vla-4 |
US6518283B1 (en) | 1999-05-28 | 2003-02-11 | Celltech R&D Limited | Squaric acid derivatives |
GB0021898D0 (en) * | 2000-09-06 | 2000-10-25 | Celltech Chiroscience Ltd | Chemical compounds |
-
2001
- 2001-04-12 WO PCT/GB2001/001682 patent/WO2001079173A2/en active IP Right Grant
- 2001-04-12 EP EP01921580A patent/EP1332132B1/de not_active Expired - Lifetime
- 2001-04-12 AU AU2001248553A patent/AU2001248553A1/en not_active Abandoned
- 2001-04-12 DE DE60130910T patent/DE60130910T2/de not_active Expired - Lifetime
- 2001-04-12 JP JP2001576774A patent/JP2003531141A/ja not_active Abandoned
- 2001-04-12 AT AT01921580T patent/ATE375330T1/de not_active IP Right Cessation
- 2001-04-12 ES ES01921580T patent/ES2295150T3/es not_active Expired - Lifetime
- 2001-04-16 US US09/835,656 patent/US6610700B2/en not_active Expired - Fee Related
-
2003
- 2003-06-10 US US10/458,234 patent/US6780874B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES2295150T3 (es) | 2008-04-16 |
US6610700B2 (en) | 2003-08-26 |
JP2003531141A (ja) | 2003-10-21 |
AU2001248553A1 (en) | 2001-10-30 |
US20030229116A1 (en) | 2003-12-11 |
WO2001079173A2 (en) | 2001-10-25 |
ATE375330T1 (de) | 2007-10-15 |
WO2001079173A3 (en) | 2003-05-15 |
US6780874B2 (en) | 2004-08-24 |
EP1332132A2 (de) | 2003-08-06 |
EP1332132B1 (de) | 2007-10-10 |
US20020037909A1 (en) | 2002-03-28 |
DE60130910T2 (de) | 2008-07-10 |
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Legal Events
Date | Code | Title | Description |
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8381 | Inventor (new situation) |
Inventor name: NORMAN, TIMOTHY JOHN, SLOUGH, BERKSHIRE SL1 3W, GB Inventor name: PORTER, JOHN ROBERT, SLOUGH, BERKSHIRE SL1 3WE, GB Inventor name: HUTCHINSON, BRIAN,WOODSIDE, SLOUGH, BERKSHIRE , GB Inventor name: RATCLIFFE, ANDREW,JAMES, SLOUGH, BERKSHIRE SL1, GB Inventor name: HEAD, JOHN CLIFFORD, SLOUGH, BERKSHIRE SL1 3WE, GB Inventor name: ALEXANDER, RIKKI,PETER, SLOUGH, BERKSHIRE SL1 , GB Inventor name: LANGHAM, BARRY JOHN, SLOUGH, BERKSHIRE SL1 3WE, GB Inventor name: WARRELLOW, GRAHAM JOHN, NORTHWOOD, MIDDLESEX H, GB Inventor name: ARCHIBALD, SARAH,CATHERINE, SLOUGH, BERKSHIRE , GB Inventor name: LINSLEY, JANEEN MARSHA, HIGH WYCOMBE, BUCKINGH, GB |
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8364 | No opposition during term of opposition |