AU2003212796A1 - Crystal structures of jnk-inhibitor complexes and binding pockets thereof - Google Patents

Crystal structures of jnk-inhibitor complexes and binding pockets thereof

Info

Publication number
AU2003212796A1
AU2003212796A1 AU2003212796A AU2003212796A AU2003212796A1 AU 2003212796 A1 AU2003212796 A1 AU 2003212796A1 AU 2003212796 A AU2003212796 A AU 2003212796A AU 2003212796 A AU2003212796 A AU 2003212796A AU 2003212796 A1 AU2003212796 A1 AU 2003212796A1
Authority
AU
Australia
Prior art keywords
jnk
crystal structures
binding pockets
inhibitor complexes
complexes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003212796A
Other versions
AU2003212796A8 (en
Inventor
Xiaoling Xie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vertex Pharmaceuticals Inc
Original Assignee
Vertex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Publication of AU2003212796A8 publication Critical patent/AU2003212796A8/en
Publication of AU2003212796A1 publication Critical patent/AU2003212796A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2003212796A 2002-01-11 2003-01-10 Crystal structures of jnk-inhibitor complexes and binding pockets thereof Abandoned AU2003212796A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34800202P 2002-01-11 2002-01-11
US60/348,002 2002-01-11
PCT/US2003/000899 WO2003060102A2 (en) 2002-01-11 2003-01-10 Crystal structures of jnk-inhibitor complexes and binding pockets thereof

Publications (2)

Publication Number Publication Date
AU2003212796A8 AU2003212796A8 (en) 2003-07-30
AU2003212796A1 true AU2003212796A1 (en) 2003-07-30

Family

ID=23366242

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003212796A Abandoned AU2003212796A1 (en) 2002-01-11 2003-01-10 Crystal structures of jnk-inhibitor complexes and binding pockets thereof

Country Status (3)

Country Link
EP (1) EP1476840A4 (en)
AU (1) AU2003212796A1 (en)
WO (1) WO2003060102A2 (en)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6274738B1 (en) * 1996-03-22 2001-08-14 Geron Corporation Carboxamide derivatives having aryl and thiazole rings
US6147080A (en) * 1996-12-18 2000-11-14 Vertex Pharmaceuticals Incorporated Inhibitors of p38
US6162613A (en) * 1998-02-18 2000-12-19 Vertex Pharmaceuticals, Inc. Methods for designing inhibitors of serine/threonine-kinases and tyrosine kinases
WO1999057253A2 (en) * 1998-05-04 1999-11-11 Vertex Pharmaceuticals Incorporated Crystallizable jnk complexes
AU5147700A (en) * 1999-05-19 2000-12-05 Amgen, Inc. Crystal of a lymphocyte kinase-ligand complex and methods of use
AU5316900A (en) * 1999-06-03 2000-12-28 Vertex Pharmaceuticals Incorporated Inhibitors of c-jun n-terminal kinases (jnk)
PL366110A1 (en) * 1999-08-13 2005-01-24 Vertex Pharmaceuticals Incorporated Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases

Also Published As

Publication number Publication date
WO2003060102A2 (en) 2003-07-24
AU2003212796A8 (en) 2003-07-30
EP1476840A4 (en) 2007-05-09
WO2003060102A3 (en) 2003-11-27
EP1476840A2 (en) 2004-11-17

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase