WO2010035284A3 - An improved process for the preparation of rosuvastatin calcium - Google Patents

An improved process for the preparation of rosuvastatin calcium Download PDF

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Publication number
WO2010035284A3
WO2010035284A3 PCT/IN2009/000527 IN2009000527W WO2010035284A3 WO 2010035284 A3 WO2010035284 A3 WO 2010035284A3 IN 2009000527 W IN2009000527 W IN 2009000527W WO 2010035284 A3 WO2010035284 A3 WO 2010035284A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
improved process
rosuvastatin calcium
rosuvastatin
calcium
Prior art date
Application number
PCT/IN2009/000527
Other languages
French (fr)
Other versions
WO2010035284A2 (en
Inventor
Madhuresh Kumar Sethi
Sanjay Mahajan
Bhairaiah Mara
Laxmi Karthikeyan Ayyaran
Debashish Datta
Original Assignee
Matrix Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Matrix Laboratories Ltd filed Critical Matrix Laboratories Ltd
Publication of WO2010035284A2 publication Critical patent/WO2010035284A2/en
Publication of WO2010035284A3 publication Critical patent/WO2010035284A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides an improved process for the preparation of amorphous Rosuvastatin Calcium through novel amine salts of Rosuvastatin.
PCT/IN2009/000527 2008-09-26 2009-09-29 An improved process for the preparation of rosuvastatin calcium WO2010035284A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2367CH2008 2008-09-26
IN2367/CHE/2008 2008-09-26

Publications (2)

Publication Number Publication Date
WO2010035284A2 WO2010035284A2 (en) 2010-04-01
WO2010035284A3 true WO2010035284A3 (en) 2011-03-10

Family

ID=42060199

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2009/000527 WO2010035284A2 (en) 2008-09-26 2009-09-29 An improved process for the preparation of rosuvastatin calcium

Country Status (1)

Country Link
WO (1) WO2010035284A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101304640B1 (en) 2010-09-02 2013-09-05 일동제약주식회사 Novel n-methylbenzylamine salt of rosuvastatin and process for the preparation thereof
WO2012063115A2 (en) 2010-11-11 2012-05-18 Jubilant Life Sciences Ltd. Process for the preparation of rosuvastatin calcium via novel amine intermediate
CN102358747B (en) * 2011-08-30 2012-09-19 浙江宏元药业有限公司 Rosuvastatin calcium intermediate and method for preparing rosuvastatin calcium intermediate and rosuvastatin calcium
CN103232398B (en) * 2012-04-28 2016-04-06 上海科州药物研发有限公司 A kind of Rosuvastatin amino acid salts and its preparation method and application
EP2978743B1 (en) 2013-03-29 2019-11-27 Centrient Pharmaceuticals Netherlands B.V. Amine salts of pravastatin and rosuvastatin
KR101660249B1 (en) * 2014-07-11 2016-09-28 주식회사 경보제약 Method for the preparation of high purity Rosuvastatin Calcium salt
CN108586358A (en) * 2018-07-06 2018-09-28 苏州中联化学制药有限公司 The preparation process of Rosuvastatin calcium preparation

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001060804A1 (en) * 2000-02-15 2001-08-23 Astrazeneca Ab Crystalline salts of 7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-(3r,5s)-3,5-dihydroxyhept-6-enoic acid
WO2004014872A1 (en) * 2002-08-13 2004-02-19 Astrazeneca Uk Limited Process for preparing the calcium salt of rosuvastatin
WO2005051921A1 (en) * 2003-11-24 2005-06-09 Teva Pharmaceutical Industries Ltd. Crystalline ammonium salts of rosuvastatin
WO2005077916A1 (en) * 2004-01-19 2005-08-25 Ranbaxy Laboratories Limited Salts of hmg-coa reductase inhibitors and use thereof
WO2006136408A2 (en) * 2005-06-24 2006-12-28 Lek Pharmaceuticals D.D. Process for preparing pure amorphous rosuvastatin calcium
WO2007040940A1 (en) * 2005-10-03 2007-04-12 Teva Pharmaceutical Industries Ltd. Diastereomeric purification of rosuvastatin

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001060804A1 (en) * 2000-02-15 2001-08-23 Astrazeneca Ab Crystalline salts of 7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-(3r,5s)-3,5-dihydroxyhept-6-enoic acid
WO2004014872A1 (en) * 2002-08-13 2004-02-19 Astrazeneca Uk Limited Process for preparing the calcium salt of rosuvastatin
WO2005051921A1 (en) * 2003-11-24 2005-06-09 Teva Pharmaceutical Industries Ltd. Crystalline ammonium salts of rosuvastatin
WO2005077916A1 (en) * 2004-01-19 2005-08-25 Ranbaxy Laboratories Limited Salts of hmg-coa reductase inhibitors and use thereof
WO2006136408A2 (en) * 2005-06-24 2006-12-28 Lek Pharmaceuticals D.D. Process for preparing pure amorphous rosuvastatin calcium
WO2007040940A1 (en) * 2005-10-03 2007-04-12 Teva Pharmaceutical Industries Ltd. Diastereomeric purification of rosuvastatin

Also Published As

Publication number Publication date
WO2010035284A2 (en) 2010-04-01

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