MA40921A - Récepteurs antigéniques chimériques anti-cldn et procédés d'utilisation - Google Patents

Récepteurs antigéniques chimériques anti-cldn et procédés d'utilisation

Info

Publication number
MA40921A
MA40921A MA040921A MA40921A MA40921A MA 40921 A MA40921 A MA 40921A MA 040921 A MA040921 A MA 040921A MA 40921 A MA40921 A MA 40921A MA 40921 A MA40921 A MA 40921A
Authority
MA
Morocco
Prior art keywords
chemerical
cldn
receptors
genetic
methods
Prior art date
Application number
MA040921A
Other languages
English (en)
Inventor
Scott J Dylla
Paul Anthony Escarpe
David Liu
Robert A Stull
Original Assignee
Abbvie Stemcentrx Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2014/064165 external-priority patent/WO2015069794A2/fr
Application filed by Abbvie Stemcentrx Llc filed Critical Abbvie Stemcentrx Llc
Publication of MA40921A publication Critical patent/MA40921A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
MA040921A 2014-11-05 2015-11-03 Récepteurs antigéniques chimériques anti-cldn et procédés d'utilisation MA40921A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/US2014/064165 WO2015069794A2 (fr) 2013-11-06 2014-11-05 Nouveaux anticorps anti-claudine et leurs méthodes d'utilisation
US201562157928P 2015-05-06 2015-05-06
US201562247108P 2015-10-27 2015-10-27

Publications (1)

Publication Number Publication Date
MA40921A true MA40921A (fr) 2017-09-12

Family

ID=55909771

Family Applications (1)

Application Number Title Priority Date Filing Date
MA040921A MA40921A (fr) 2014-11-05 2015-11-03 Récepteurs antigéniques chimériques anti-cldn et procédés d'utilisation

Country Status (23)

Country Link
US (1) US20170334991A1 (fr)
EP (1) EP3215523A4 (fr)
JP (1) JP2017535283A (fr)
KR (1) KR20170085531A (fr)
CN (1) CN107207580A (fr)
AU (1) AU2015343079A1 (fr)
BR (1) BR112017009517A2 (fr)
CA (1) CA2966618A1 (fr)
CL (1) CL2017001118A1 (fr)
CO (1) CO2017005538A2 (fr)
CR (1) CR20170235A (fr)
DO (1) DOP2017000110A (fr)
EA (1) EA201790967A1 (fr)
EC (1) ECSP17031725A (fr)
IL (1) IL252090A0 (fr)
MA (1) MA40921A (fr)
MX (1) MX2017005797A (fr)
PE (1) PE20171060A1 (fr)
PH (1) PH12017500825A1 (fr)
SG (1) SG11201703669YA (fr)
TW (1) TW201625677A (fr)
WO (1) WO2016073649A1 (fr)
ZA (1) ZA201703471B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201603397QA (en) * 2013-11-06 2016-05-30 Stemcentrx Inc Novel anti-claudin antibodies and methods of use
KR20190082782A (ko) * 2016-10-14 2019-07-10 머크 샤프 앤드 돔 코포레이션 요로상피암을 치료하기 위한 pd-1 길항제 및 에리불린의 조합
CA3125713A1 (en) 2017-09-29 2019-04-04 Daiichi Sankyo Company, Limited Antibody-pyrrolobenzodiazepine derivative conjugate
CN113164408A (zh) * 2018-12-07 2021-07-23 科济生物医药（上海）有限公司 肿瘤联合免疫治疗
EP3909590A4 (fr) * 2019-01-07 2022-11-16 CRAGE medical Co., Limited Association pour immunothérapie cellulaire
US20210347847A1 (en) * 2020-05-11 2021-11-11 The Broad Institute, Inc. Therapeutic targeting of malignant cells using tumor markers
TW202241935A (zh) 2020-12-18 2022-11-01 美商世紀治療股份有限公司 具有可調適受體專一性之嵌合抗原受體系統
KR20230154317A (ko) * 2021-03-05 2023-11-07 상하이 젠베이스 바이오테크놀로지 씨오., 엘티디. 항-cldn6 항체 및 이의 용도
CN114478802B (zh) * 2022-01-28 2023-05-26 郑州大学 一种嵌合抗原受体及其应用
CN117169518B (zh) * 2023-11-03 2024-01-19 赛德特(北京)生物工程有限公司 T淋巴细胞制剂中的cd3抗体残留物的检测方法和试剂盒

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101074261A (zh) * 2006-04-30 2007-11-21 北京同为时代生物技术有限公司 Trail受体1和/或trail受体2特异性抗体及其应用
US8192740B2 (en) * 2007-02-27 2012-06-05 Forerunner Pharma Research Co., Ltd. Pharmaceutical composition comprising anti-GRP78 antibody as active ingredient
SG187457A1 (en) * 2008-01-11 2013-02-28 Univ Tokyo Anti-cldn6 antibody
EP3689911A1 (fr) * 2009-11-11 2020-08-05 Ganymed Pharmaceuticals GmbH Anticorps spécifiques de la claudine 6 (cldn6)
EP2404936A1 (fr) * 2010-07-06 2012-01-11 Ganymed Pharmaceuticals AG Thérapie du cancer utilisant des anticorps in vivo dirigés sur la cible CLDN6
WO2014145252A2 (fr) * 2013-03-15 2014-09-18 Milone Michael C Ciblage de cellules cytotoxiques par des récepteurs chimériques pour une immunothérapie adoptive
SG11201603397QA (en) * 2013-11-06 2016-05-30 Stemcentrx Inc Novel anti-claudin antibodies and methods of use
RS58627B2 (sr) * 2014-04-01 2022-06-30 Biontech Cell&Gene Therapies Gmbh Klaudin-6-specifični imuno receptori i t-ćelijski epitopi
WO2016180467A1 (fr) * 2015-05-11 2016-11-17 Biontech Cell & Gene Therapies Gmbh Renforcement de l'effet de lymphocytes t génétiquement modifiés par car, par vaccination par acide nucléique
RU2018124319A (ru) * 2015-12-04 2020-01-09 ЭББВИ СТЕМСЕНТРКС ЭлЭлСи Новые антитела к клаудину и способы их применения

Also Published As

Publication number Publication date
JP2017535283A (ja) 2017-11-30
ZA201703471B (en) 2019-06-26
EP3215523A1 (fr) 2017-09-13
WO2016073649A1 (fr) 2016-05-12
AU2015343079A1 (en) 2017-05-25
CR20170235A (es) 2017-07-21
ECSP17031725A (es) 2017-06-30
CL2017001118A1 (es) 2018-01-05
CN107207580A (zh) 2017-09-26
PH12017500825A1 (en) 2017-10-18
US20170334991A1 (en) 2017-11-23
IL252090A0 (en) 2017-07-31
EP3215523A4 (fr) 2018-06-20
DOP2017000110A (es) 2017-05-31
BR112017009517A2 (pt) 2017-12-19
SG11201703669YA (en) 2017-06-29
KR20170085531A (ko) 2017-07-24
PE20171060A1 (es) 2017-07-21
EA201790967A1 (ru) 2017-10-31
CA2966618A1 (fr) 2016-05-12
TW201625677A (zh) 2016-07-16
MX2017005797A (es) 2017-10-23
CO2017005538A2 (es) 2017-10-10

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