AR076193A1 - Anticuerpos biespecificos trivalentes - Google Patents

Anticuerpos biespecificos trivalentes

Info

Publication number
AR076193A1
AR076193A1 ARP100101122A ARP100101122A AR076193A1 AR 076193 A1 AR076193 A1 AR 076193A1 AR P100101122 A ARP100101122 A AR P100101122A AR P100101122 A ARP100101122 A AR P100101122A AR 076193 A1 AR076193 A1 AR 076193A1
Authority
AR
Argentina
Prior art keywords
antibody
domain
polypeptide
terminus
variable domain
Prior art date
Application number
ARP100101122A
Other languages
English (en)
Original Assignee
Roche Glycart Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Glycart Ag filed Critical Roche Glycart Ag
Publication of AR076193A1 publication Critical patent/AR076193A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

Métodos para su produccion, composiciones farmacéuticas que contienen dichos anticuerpos y usos de los mismos, para la preparacion de un medicamento destinado al tratamiento del cáncer. Reivindicacion 1: Un anticuerpo biespecífico trivalente, que comprende a) un anticuerpo de longitud completa que se une específicamente a un primer antígeno y que consiste de dos cadenas pesadas de anticuerpo y dos cadenas ligeras de anticuerpo, b) un polipéptido que consiste de: ba) un dominio variable de cadena pesada (VH) de anticuerpo, o bb) un dominio variable de cadena pesada (VH) de anticuerpo y un dominio constante 1 de anticuerpo (CH1), en el que dicho polipéptido se encuentra fusionado con el extremo N del dominio VH mediante un péptido conector al extremo C de una de las dos cadenas pesadas de dicho anticuerpo de longitud completa, c) un polipéptido que consiste de: ca) un dominio variable cadena ligera de anticuerpo (VL), o cb) un dominio variable de cadena ligera (VL) de anticuerpo y un dominio constante de cadena ligera (CL) de anticuerpo, en el que dicho polipéptido se encuentra fusionado con el extremo N del dominio VL mediante un péptido conector al extremo C de la otra de las dos cadenas pesadas de dicho anticuerpo de longitud completa, y en el que el dominio variable de cadena pesada (VH) de anticuerpo del polipéptido de b) y el dominio variable de cadena ligera (VL) de anticuerpo del polipéptido de c) conjuntamente forman un sitio de fijacion al antígeno que se une específicamente a un segundo antígeno.
ARP100101122A 2009-04-07 2010-04-05 Anticuerpos biespecificos trivalentes AR076193A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP09005108 2009-04-07

Publications (1)

Publication Number Publication Date
AR076193A1 true AR076193A1 (es) 2011-05-26

Family

ID=40942481

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100101122A AR076193A1 (es) 2009-04-07 2010-04-05 Anticuerpos biespecificos trivalentes

Country Status (21)

Country Link
US (4) US20100256340A1 (es)
EP (1) EP2417156B1 (es)
JP (2) JP5616428B2 (es)
KR (1) KR101456326B1 (es)
CN (1) CN102369214B (es)
AR (1) AR076193A1 (es)
AU (1) AU2010234031B2 (es)
BR (1) BRPI1010297A2 (es)
CA (1) CA2757931C (es)
CY (1) CY1116376T1 (es)
DK (1) DK2417156T3 (es)
ES (1) ES2537100T3 (es)
HR (1) HRP20150444T1 (es)
IL (1) IL214884A (es)
MX (1) MX2011010168A (es)
PL (1) PL2417156T3 (es)
PT (1) PT2417156E (es)
SG (1) SG175077A1 (es)
SI (1) SI2417156T1 (es)
TW (1) TW201039850A (es)
WO (1) WO2010115589A1 (es)

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