US20100256340A1 - Trivalent, bispecific antibodies - Google Patents

Trivalent, bispecific antibodies Download PDF

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Publication number
US20100256340A1
US20100256340A1 US12/752,216 US75221610A US2010256340A1 US 20100256340 A1 US20100256340 A1 US 20100256340A1 US 75221610 A US75221610 A US 75221610A US 2010256340 A1 US2010256340 A1 US 2010256340A1
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US
United States
Prior art keywords
antibody
trivalent
chain variable
variable domain
heavy chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US12/752,216
Inventor
Ulrich Brinkmann
Rebecca Croasdale
Eike Hoffmann
Christian Klein
Ekkehard Moessner
Juergen Michael Schanzer
Claudio Sustmann
Pablo Umana
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Roche Glycart AG
Original Assignee
F Hoffmann La Roche AG
Roche Glycart AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP09005108 priority Critical
Priority to EP09005108.7 priority
Application filed by F Hoffmann La Roche AG, Roche Glycart AG filed Critical F Hoffmann La Roche AG
Assigned to ROCHE GLYCART AG reassignment ROCHE GLYCART AG ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: MOESSNER, EKKEHARD, UMANA, PABLO
Assigned to ROCHE GLYCART AG reassignment ROCHE GLYCART AG ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: F. HOFFMANN-LA ROCHE AG
Assigned to F. HOFFMANN-LA ROCHE AG reassignment F. HOFFMANN-LA ROCHE AG ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BRINKMANN, ULRICH, CROASDALE, REBECCA, HOFFMANN, EIKE, SCHANZER, JUERGEN MICHAEL, SUSTMANN, CLAUDIO
Assigned to F. HOFFMANN-LA ROCHE AG reassignment F. HOFFMANN-LA ROCHE AG ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: KLEIN, CHRISTIAN
Publication of US20100256340A1 publication Critical patent/US20100256340A1/en
Application status is Abandoned legal-status Critical

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