US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
US4676980A
(en)
|
1985-09-23 |
1987-06-30 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Target specific cross-linked heteroantibodies
|
US6548640B1
(en)
|
1986-03-27 |
2003-04-15 |
Btg International Limited |
Altered antibodies
|
US5959177A
(en)
|
1989-10-27 |
1999-09-28 |
The Scripps Research Institute |
Transgenic plants expressing assembled secretory antibodies
|
US6150584A
(en)
|
1990-01-12 |
2000-11-21 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
US6075181A
(en)
|
1990-01-12 |
2000-06-13 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
US5770429A
(en)
|
1990-08-29 |
1998-06-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
DK0564531T3
(en)
|
1990-12-03 |
1998-09-28 |
Genentech Inc |
Enrichment procedure for variant proteins with altered binding properties
|
LU91067I2
(en)
|
1991-06-14 |
2004-04-02 |
Genentech Inc |
Trastuzumab and its variants and immunochemical derivatives including immotoxins
|
CA2116774C
(en)
|
1991-09-19 |
2003-11-11 |
Paul J. Carter |
Expression in e. coli antibody fragments having at least a cysteine present as a free thiol. use for the production of bifunctional f(ab') 2 antibodies
|
WO1993008829A1
(en)
|
1991-11-04 |
1993-05-13 |
The Regents Of The University Of California |
Compositions that mediate killing of hiv-infected cells
|
US5789199A
(en)
|
1994-11-03 |
1998-08-04 |
Genentech, Inc. |
Process for bacterial production of polypeptides
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
US5840523A
(en)
|
1995-03-01 |
1998-11-24 |
Genetech, Inc. |
Methods and compositions for secretion of heterologous polypeptides
|
GB9603256D0
(en)
|
1996-02-16 |
1996-04-17 |
Wellcome Found |
Antibodies
|
US5888809A
(en)
|
1997-05-01 |
1999-03-30 |
Icos Corporation |
Hamster EF-1α transcriptional regulatory DNA
|
DK0979281T3
(en)
*
|
1997-05-02 |
2005-11-21 |
Genentech Inc |
Process for the preparation of multispecific antibodies with heteromultimers and common components
|
WO1998058964A1
(en)
|
1997-06-24 |
1998-12-30 |
Genentech, Inc. |
Methods and compositions for galactosylated glycoproteins
|
US6040498A
(en)
|
1998-08-11 |
2000-03-21 |
North Caroline State University |
Genetically engineered duckweed
|
WO1999022764A1
(en)
|
1997-10-31 |
1999-05-14 |
Genentech, Inc. |
Methods and compositions comprising glycoprotein glycoforms
|
US6610833B1
(en)
|
1997-11-24 |
2003-08-26 |
The Institute For Human Genetics And Biochemistry |
Monoclonal human natural antibodies
|
IL136544A0
(en)
|
1997-12-05 |
2001-06-14 |
Scripps Research Inst |
Humanization of murine antibody
|
DK1071700T3
(en)
|
1998-04-20 |
2010-06-07 |
Glycart Biotechnology Ag |
Glycosylation modification of antibodies to enhance antibody-dependent cellular cytotoxicity
|
DK2270150T4
(en)
|
1999-04-09 |
2019-08-26 |
Kyowa Hakko Kirin Co Ltd |
PROCEDURE TO CONTROL THE ACTIVITY OF IMMUNOLOGICAL FUNCTIONAL MOLECULE.
|
MXPA02003456A
(en)
|
1999-10-04 |
2002-10-23 |
Medicago Inc |
Method for regulating transcription of foreign genes in the presence of nitrogen.
|
US7125978B1
(en)
|
1999-10-04 |
2006-10-24 |
Medicago Inc. |
Promoter for regulating expression of foreign genes
|
CA2388245C
(en)
|
1999-10-19 |
2012-01-10 |
Tatsuya Ogawa |
The use of serum-free adapted rat cells for producing heterologous polypeptides
|
EP1240319A1
(en)
|
1999-12-15 |
2002-09-18 |
Genentech, Inc. |
Shotgun scanning, a combinatorial method for mapping functional protein epitopes
|
CN101289511A
(en)
|
2000-04-11 |
2008-10-22 |
杰南技术公司 |
Multivalent antibodies and uses therefore
|
US6627442B1
(en)
*
|
2000-08-31 |
2003-09-30 |
Virxsys Corporation |
Methods for stable transduction of cells with hiv-derived viral vectors
|
US7064191B2
(en)
|
2000-10-06 |
2006-06-20 |
Kyowa Hakko Kogyo Co., Ltd. |
Process for purifying antibody
|
US6946292B2
(en)
|
2000-10-06 |
2005-09-20 |
Kyowa Hakko Kogyo Co., Ltd. |
Cells producing antibody compositions with increased antibody dependent cytotoxic activity
|
PL218428B1
(en)
|
2000-10-06 |
2014-12-31 |
Kyowa Hakko Kogyo Kk |
Cells producing antibody compositions
|
US6596541B2
(en)
|
2000-10-31 |
2003-07-22 |
Regeneron Pharmaceuticals, Inc. |
Methods of modifying eukaryotic cells
|
CA2429544C
(en)
|
2000-11-17 |
2010-10-19 |
University Of Rochester |
In vitro methods of producing and identifying immunoglobulin molecules in eukaryotic cells
|
DE60131456T2
(en)
|
2000-11-30 |
2008-07-10 |
Medarex, Inc., Milpitas |
TRANCHROMOSOMAL TRANSGEN RODENTS FOR THE MANUFACTURE OF HUMAN ANTIBODIES
|
KR20100018071A
(en)
|
2001-08-03 |
2010-02-16 |
글리카트 바이오테크놀로지 아게 |
Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity
|
ATE447967T1
(en)
|
2001-09-14 |
2009-11-15 |
Cytos Biotechnology Ag |
PACKAGING OF IMMUNO-STIMULATIVE CPG IN VIRUS-LIKE PARTICLES: PRODUCTION METHOD AND USE
|
EP1432443B1
(en)
|
2001-10-05 |
2009-01-21 |
Cytos Biotechnology AG |
Angiotensin peptide-carrier conjugates and uses thereof
|
KR100988949B1
(en)
|
2001-10-25 |
2010-10-20 |
제넨테크, 인크. |
Glycoprotein compositions
|
AU2002342891B2
(en)
|
2001-11-07 |
2007-12-13 |
Cytos Biotechnology Ag |
Antigen arrays comprising RANKL for treatment of bone disease
|
WO2003040164A2
(en)
|
2001-11-07 |
2003-05-15 |
Cytos Biotechnology Ag |
Antigen arrays presenting il-5, il-3 or eotaxin for treatment of allergic eosinophilic diseases
|
JP2005535282A
(en)
*
|
2001-11-16 |
2005-11-24 |
アイデック ファーマシューティカルズ コーポレイション |
Polycistronic expression of antibodies
|
US20040093621A1
(en)
|
2001-12-25 |
2004-05-13 |
Kyowa Hakko Kogyo Co., Ltd |
Antibody composition which specifically binds to CD20
|
CN1429916A
(en)
*
|
2001-12-30 |
2003-07-16 |
韩泽广 |
Scaled procaryotic cell and eucaryotic cell internal antibody and antigen library construction and screening
|
US20050031613A1
(en)
|
2002-04-09 |
2005-02-10 |
Kazuyasu Nakamura |
Therapeutic agent for patients having human FcgammaRIIIa
|
US7749753B2
(en)
|
2002-04-09 |
2010-07-06 |
Kyowa Hakko Kirin Co., Ltd |
Cells in which activity of the protein involved in transportation of GDP-fucose is reduced or lost
|
JPWO2003084569A1
(en)
|
2002-04-09 |
2005-08-11 |
協和醗酵工業株式会社 |
Antibody composition-containing medicine
|
CA2481657A1
(en)
|
2002-04-09 |
2003-10-16 |
Kyowa Hakko Kogyo Co., Ltd. |
Cells of which genome is modified
|
JPWO2003085118A1
(en)
|
2002-04-09 |
2005-08-11 |
協和醗酵工業株式会社 |
Method for producing antibody composition
|
AU2003236018A1
(en)
|
2002-04-09 |
2003-10-20 |
Kyowa Hakko Kirin Co., Ltd. |
METHOD OF ENHANCING ACTIVITY OF ANTIBODY COMPOSITION OF BINDING TO FcGamma RECEPTOR IIIa
|
NZ556507A
(en)
|
2002-06-03 |
2010-03-26 |
Genentech Inc |
Synthetic antibody phage libraries
|
US20050112095A1
(en)
*
|
2002-07-09 |
2005-05-26 |
Tsu-An Hsu |
Internal ribosome entry sites for recombinant protein expression
|
CN102061288A
(en)
|
2002-07-17 |
2011-05-18 |
希托斯生物技术股份公司 |
Molecular antigen arrays using a virus like particle derived from the AP205 coat protein
|
KR20120041739A
(en)
|
2002-07-18 |
2012-05-02 |
사이토스 바이오테크놀로지 아게 |
Hapten-carrier conjugates and uses thereof
|
PT1524994E
(en)
|
2002-07-19 |
2011-08-01 |
Cytos Biotechnology Ag |
Vaccine compositions containing amyloid beta1-6 antigen arrays
|
BR0311800A
(en)
|
2002-07-19 |
2005-03-22 |
Cytos Biotechnology Ag |
Ghrelin-vehicle conjugates
|
ES2347241T3
(en)
|
2002-12-16 |
2010-10-27 |
Genentech, Inc. |
VARIATIONS OF IMMUNOGLOBULIN AND ITS USES.
|
AU2004205631A1
(en)
|
2003-01-16 |
2004-08-05 |
Genentech, Inc. |
Synthetic antibody phage libraries
|
AU2004223477B2
(en)
*
|
2003-03-20 |
2009-03-26 |
Alphavax, Inc. |
Improved alphavirus replicons and helper constructs
|
NZ542323A
(en)
|
2003-03-26 |
2008-07-31 |
Cytos Biotechnology Ag |
Melan-A peptide analogue-virus-like-particle conjugates
|
WO2004096272A2
(en)
|
2003-04-29 |
2004-11-11 |
Cytos Biotechnology Ag |
Methods and compositions for modulating the interaction between adiponectin and its receptor
|
WO2004102198A2
(en)
|
2003-05-15 |
2004-11-25 |
Cytos Biotechnology Ag |
Selection of b cells with specificity of interest: method of preparation and use
|
EP2395016A3
(en)
*
|
2003-05-30 |
2012-12-19 |
Merus B.V. |
Design and use of paired variable regions of specific binding molecules
|
CN1289668C
(en)
*
|
2003-06-12 |
2006-12-13 |
北京安波特基因工程技术有限公司 |
In vitro molecular directed evolution method for reshaping antibody
|
WO2005004907A1
(en)
|
2003-07-10 |
2005-01-20 |
Cytos Biotechnology Ag |
Packaged virus-like particles
|
MXPA06000562A
(en)
|
2003-07-15 |
2006-03-30 |
Therapeutic Human Polyclonals |
Humanized immunoglobulin loci.
|
EP1688439A4
(en)
|
2003-10-08 |
2007-12-19 |
Kyowa Hakko Kogyo Kk |
Fused protein composition
|
AU2004280065A1
(en)
|
2003-10-09 |
2005-04-21 |
Kyowa Hakko Kirin Co., Ltd. |
Process for producing antibody composition by using RNA inhibiting the function of alpha1,6-fucosyltransferase
|
US9296820B2
(en)
|
2003-11-05 |
2016-03-29 |
Roche Glycart Ag |
Polynucleotides encoding anti-CD20 antigen binding molecules with increased Fc receptor binding affinity and effector function
|
WO2005053742A1
(en)
|
2003-12-04 |
2005-06-16 |
Kyowa Hakko Kogyo Co., Ltd. |
Medicine containing antibody composition
|
KR20060128924A
(en)
|
2004-01-20 |
2006-12-14 |
사이토스 바이오테크놀로지 아게 |
Ghrelin-carrier conjugates
|
CN1961003B
(en)
|
2004-03-31 |
2013-03-27 |
健泰科生物技术公司 |
Humanized anti-TGF-beta antibodies
|
US7785903B2
(en)
|
2004-04-09 |
2010-08-31 |
Genentech, Inc. |
Variable domain library and uses
|
WO2005108425A1
(en)
|
2004-05-10 |
2005-11-17 |
Cytos Biotechnology Ag |
Il-23 p19 antigen array and uses thereof
|
RU2006146605A
(en)
|
2004-06-02 |
2008-07-20 |
Цитос Биотехнологи Аг (Ch) |
MEDICAL APPLICATIONS OF TNF-PEPTIDE-BEARING CONJUGATES FROM EXCEPT HUMAN
|
WO2005117983A2
(en)
|
2004-06-02 |
2005-12-15 |
Cytos Biotechnology Ag |
Carrier conjugates of tnf-peptides
|
CA2575997A1
(en)
|
2004-08-04 |
2006-03-16 |
Cytos Biotechnology Ag |
Carrier conjugates of gnrh-peptides
|
MX2007003171A
(en)
|
2004-09-21 |
2007-05-23 |
Cytos Biotechnology Ag |
Virus-like particles comprising a fusion protein of the coat protein of ap205 and an antigenic polypeptide.
|
EP1809335A2
(en)
|
2004-10-25 |
2007-07-25 |
Cytos Biotechnology AG |
Gastric inhibitory polypeptide (gip) antigen arrays and uses thereof
|
CA2590778A1
(en)
|
2004-12-13 |
2006-06-22 |
Cytos Biotechnology Ag |
Il-15 antigen arrays and uses thereof
|
AU2006224529B2
(en)
|
2005-03-18 |
2012-05-24 |
Cytos Biotechnology Ag |
Cat allergen fusion proteins and uses thereof
|
WO2007047578A2
(en)
*
|
2005-10-14 |
2007-04-26 |
Medimmune, Inc. |
Cell display of antibody libraries
|
EP2465870A1
(en)
|
2005-11-07 |
2012-06-20 |
Genentech, Inc. |
Binding polypeptides with diversified and consensus VH/VL hypervariable sequences
|
EP1973951A2
(en)
|
2005-12-02 |
2008-10-01 |
Genentech, Inc. |
Binding polypeptides with restricted diversity sequences
|
US7846724B2
(en)
*
|
2006-04-11 |
2010-12-07 |
Hoffmann-La Roche Inc. |
Method for selecting CHO cell for production of glycosylated antibodies
|
EP2016101A2
(en)
|
2006-05-09 |
2009-01-21 |
Genentech, Inc. |
Binding polypeptides with optimized scaffolds
|
EP1975239A1
(en)
*
|
2006-09-27 |
2008-10-01 |
Bundesrepublik Deutschland, letztvertreten durch den Präsidenten des Paul-Ehrlich-Instituts Prof. Dr. Johannes Löwer |
Pseudotyping of retroviral vectors, methods for production and use thereof for targeted gene transfer and high-throughput screening
|
US20080226635A1
(en)
|
2006-12-22 |
2008-09-18 |
Hans Koll |
Antibodies against insulin-like growth factor I receptor and uses thereof
|
CN100592373C
(en)
|
2007-05-25 |
2010-02-24 |
群康科技(深圳)有限公司 |
Liquid crystal panel drive device and its drive method
|
US9266967B2
(en)
|
2007-12-21 |
2016-02-23 |
Hoffmann-La Roche, Inc. |
Bivalent, bispecific antibodies
|
US8242247B2
(en)
|
2007-12-21 |
2012-08-14 |
Hoffmann-La Roche Inc. |
Bivalent, bispecific antibodies
|
US8227577B2
(en)
|
2007-12-21 |
2012-07-24 |
Hoffman-La Roche Inc. |
Bivalent, bispecific antibodies
|
US20090162359A1
(en)
|
2007-12-21 |
2009-06-25 |
Christian Klein |
Bivalent, bispecific antibodies
|
DK2235064T3
(en)
|
2008-01-07 |
2016-01-11 |
Amgen Inc |
A process for the preparation of heterodimeric Fc molecules using electrostatic control effects
|
EP2098536A1
(en)
*
|
2008-03-05 |
2009-09-09 |
4-Antibody AG |
Isolation and identification of antigen- or ligand-specific binding proteins
|
CN102369215B
(en)
|
2009-04-02 |
2015-01-21 |
罗切格利卡特公司 |
Multispecific antibodies comprising full length antibodies and single chain fab fragments
|
PT2417156E
(en)
|
2009-04-07 |
2015-04-29 |
Roche Glycart Ag |
Trivalent, bispecific antibodies
|
SG176219A1
(en)
|
2009-05-27 |
2011-12-29 |
Hoffmann La Roche |
Tri- or tetraspecific antibodies
|
US9676845B2
(en)
|
2009-06-16 |
2017-06-13 |
Hoffmann-La Roche, Inc. |
Bispecific antigen binding proteins
|
US8703132B2
(en)
|
2009-06-18 |
2014-04-22 |
Hoffmann-La Roche, Inc. |
Bispecific, tetravalent antigen binding proteins
|
US9834615B2
(en)
*
|
2010-08-16 |
2017-12-05 |
Novimmune Sa |
Methods for the generation of multispecific and multivalent antibodies
|
CA2791109C
(en)
*
|
2011-09-26 |
2021-02-16 |
Merus B.V. |
Generation of binding molecules
|