MA46893A - Anticorps bispécifiques se liant au facteur ix de coagulation et au facteur x de coagulation - Google Patents

Anticorps bispécifiques se liant au facteur ix de coagulation et au facteur x de coagulation

Info

Publication number
MA46893A
MA46893A MA046893A MA46893A MA46893A MA 46893 A MA46893 A MA 46893A MA 046893 A MA046893 A MA 046893A MA 46893 A MA46893 A MA 46893A MA 46893 A MA46893 A MA 46893A
Authority
MA
Morocco
Prior art keywords
coagulation factor
bispecific antibodies
antibodies binding
coagulation
factor
Prior art date
Application number
MA046893A
Other languages
English (en)
Inventor
Maria Aleman
Allison Goodman
John Kulman
Nina Leksa
Bradley R Pearse
Robert T Peters
Original Assignee
Bioverativ Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioverativ Therapeutics Inc filed Critical Bioverativ Therapeutics Inc
Publication of MA46893A publication Critical patent/MA46893A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
MA046893A 2016-11-23 2017-11-22 Anticorps bispécifiques se liant au facteur ix de coagulation et au facteur x de coagulation MA46893A (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662425921P 2016-11-23 2016-11-23
US201762452809P 2017-01-31 2017-01-31
US201762529805P 2017-07-07 2017-07-07
US201762587284P 2017-11-16 2017-11-16

Publications (1)

Publication Number Publication Date
MA46893A true MA46893A (fr) 2019-10-02

Family

ID=60766147

Family Applications (1)

Application Number Title Priority Date Filing Date
MA046893A MA46893A (fr) 2016-11-23 2017-11-22 Anticorps bispécifiques se liant au facteur ix de coagulation et au facteur x de coagulation

Country Status (21)

Country Link
US (1) US20230192896A1 (fr)
EP (1) EP3545002A2 (fr)
JP (2) JP7227146B2 (fr)
KR (1) KR20190080949A (fr)
CN (1) CN110662770A (fr)
AU (1) AU2017363309A1 (fr)
BR (1) BR112019010349A2 (fr)
CA (1) CA3044574A1 (fr)
CL (1) CL2019001372A1 (fr)
CO (1) CO2019006500A2 (fr)
CR (1) CR20190297A (fr)
DO (1) DOP2019000127A (fr)
EC (1) ECSP19044484A (fr)
IL (1) IL266749A (fr)
MA (1) MA46893A (fr)
MX (1) MX2019005772A (fr)
PE (1) PE20200012A1 (fr)
PH (1) PH12019501126A1 (fr)
TN (1) TN2019000164A1 (fr)
TW (1) TW201819417A (fr)
WO (1) WO2018098363A2 (fr)

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EP3710486A1 (fr) 2017-11-15 2020-09-23 Novo Nordisk A/S Liants de facteur x renforçant l'activation fx
MA52416A (fr) 2018-03-02 2021-04-21 Five Prime Therapeutics Inc Anticorps b7-h4 et leurs procédés d'utilisation
FR3082427B1 (fr) * 2018-06-14 2020-09-25 Lab Francais Du Fractionnement Combinaison de facteur vii et d'un anticorps bispecifique anti-facteurs ix et x
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CN117384296A (zh) * 2018-08-01 2024-01-12 诺和诺德股份有限公司 改进的促凝血抗体
US11220554B2 (en) 2018-09-07 2022-01-11 Novo Nordisk A/S Procoagulant antibodies
CN113423732A (zh) * 2018-09-05 2021-09-21 德克萨斯大学系统董事会 针对endotrophin的单克隆抗体及其用途
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WO2020115281A1 (fr) * 2018-12-07 2020-06-11 Baxalta GmbH Molécules protéiques se liant au facteur ixa et au facteur x
WO2020115283A1 (fr) * 2018-12-07 2020-06-11 Baxalta GmbH Anticorps bispécifiques fixant le facteur ixa et le facteur x
WO2020114614A1 (fr) * 2018-12-07 2020-06-11 Baxalta GmbH Molécules protéiques se liant au facteur ixa et au facteur x
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JP2023106635A (ja) 2020-04-17 2023-08-02 中外製薬株式会社 二重特異性抗原結合分子ならびに、それに関連する組成物、組成物の製造のための使用、キット、および方法
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WO2023111018A1 (fr) * 2021-12-17 2023-06-22 F. Hoffmann-La Roche Ag Anticorps contre le facteur de coagulation x et leurs utilisations
WO2023219922A1 (fr) * 2022-05-12 2023-11-16 Merck Sharp & Dohme Llc Anticorps anti-intégrine et leurs utilisations
JP7459354B2 (ja) 2022-07-08 2024-04-01 ノヴォ ノルディスク アー／エス ＦＶＩＩＩ（ａ）の代わりとなることができる非常に効力があるＩＳＶＤ化合物
WO2024050356A2 (fr) * 2022-08-29 2024-03-07 Invivyd, Inc. Anticorps anti-sars-cov2 et leurs utilisations
US20240158534A1 (en) * 2022-11-15 2024-05-16 Calico Life Sciences Llc Anti-papp-a antibodies and methods of use thereof
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JP2019535325A (ja) 2019-12-12
KR20190080949A (ko) 2019-07-08
PE20200012A1 (es) 2020-01-06
WO2018098363A3 (fr) 2018-09-20
DOP2019000127A (es) 2019-10-15
ECSP19044484A (es) 2019-08-30
CR20190297A (es) 2019-11-01
US20230192896A1 (en) 2023-06-22
CO2019006500A2 (es) 2019-06-28
BR112019010349A2 (pt) 2019-10-08
TW201819417A (zh) 2018-06-01
IL266749A (en) 2019-07-31
TN2019000164A1 (en) 2020-10-05
CA3044574A1 (fr) 2018-05-31
WO2018098363A2 (fr) 2018-05-31
CN110662770A (zh) 2020-01-07
JP2023058589A (ja) 2023-04-25
AU2017363309A1 (en) 2019-07-11
PH12019501126A1 (en) 2019-08-19
CL2019001372A1 (es) 2019-11-04
JP7227146B2 (ja) 2023-02-21
EP3545002A2 (fr) 2019-10-02

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