MA44659A - Anticorps anti-tim-3 et compositions - Google Patents

Anticorps anti-tim-3 et compositions

Info

Publication number
MA44659A
MA44659A MA044659A MA44659A MA44659A MA 44659 A MA44659 A MA 44659A MA 044659 A MA044659 A MA 044659A MA 44659 A MA44659 A MA 44659A MA 44659 A MA44659 A MA 44659A
Authority
MA
Morocco
Prior art keywords
tim
antibodies
compositions
Prior art date
Application number
MA044659A
Other languages
English (en)
Other versions
MA44659B1 (fr
Inventor
Thomas Bouquin
Monika Gad
Gunther Roland Galler
Torben Gjetting
Michael Monrad Grandal
Ivan David Horak
Klaus Koefoed
Michael Kragh
Trine Lindsted
Mikkel Wandahl Pedersen
Original Assignee
Symphogen As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Symphogen As filed Critical Symphogen As
Publication of MA44659A publication Critical patent/MA44659A/fr
Publication of MA44659B1 publication Critical patent/MA44659B1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39566Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against immunoglobulins, e.g. anti-idiotypic antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46Hybrid immunoglobulins
    • C07K16/468Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51Complete heavy chain or Fd fragment, i.e. VH + CH1
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515Complete light chain, i.e. VL + CL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75Agonist effect on antigen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
MA44659A 2016-04-12 2017-04-11 Anticorps anti-tim-3 et compositions MA44659B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662321476P 2016-04-12 2016-04-12
PCT/EP2017/058696 WO2017178493A1 (fr) 2016-04-12 2017-04-11 Anticorps anti-tim-3 et compositions

Publications (2)

Publication Number Publication Date
MA44659A true MA44659A (fr) 2021-04-14
MA44659B1 MA44659B1 (fr) 2021-12-31

Family

ID=58547516

Family Applications (1)

Application Number Title Priority Date Filing Date
MA44659A MA44659B1 (fr) 2016-04-12 2017-04-11 Anticorps anti-tim-3 et compositions

Country Status (34)

Country Link
US (2) US11390674B2 (fr)
EP (2) EP3978531A1 (fr)
JP (2) JP7123804B2 (fr)
KR (1) KR102473028B1 (fr)
CN (2) CN116693685A (fr)
AU (1) AU2017251250B2 (fr)
BR (1) BR112018070919A2 (fr)
CA (1) CA3020647A1 (fr)
CL (1) CL2018002878A1 (fr)
CO (1) CO2018010458A2 (fr)
CY (1) CY1125440T1 (fr)
DK (1) DK3443009T3 (fr)
EA (1) EA039020B1 (fr)
ES (1) ES2900381T3 (fr)
HR (1) HRP20211820T1 (fr)
HU (1) HUE056677T2 (fr)
IL (1) IL262176B2 (fr)
LT (1) LT3443009T (fr)
MA (1) MA44659B1 (fr)
MD (1) MD3443009T2 (fr)
MX (1) MX2018012076A (fr)
PE (1) PE20181805A1 (fr)
PH (1) PH12018502112A1 (fr)
PL (1) PL3443009T3 (fr)
PT (1) PT3443009T (fr)
RS (1) RS62736B1 (fr)
SA (1) SA518400222B1 (fr)
SG (2) SG10201912937SA (fr)
SI (1) SI3443009T1 (fr)
TN (1) TN2018000333A1 (fr)
TW (1) TWI752950B (fr)
UA (1) UA126854C2 (fr)
WO (1) WO2017178493A1 (fr)
ZA (1) ZA201806429B (fr)

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JP2020513009A (ja) 2017-04-05 2020-04-30 シムフォゲン・アクティーゼルスカブSymphogen A/S Pd−1、tim−3、およびlag−3を標的とする併用治療
IL310079A (en) 2017-08-28 2024-03-01 Bristol Myers Squibb Co TIM-3 antagonists for the treatment and diagnosis of cancer
JP7358361B2 (ja) * 2018-01-12 2023-10-10 ブリストル-マイヤーズ スクイブ カンパニー Tim3に対する抗体およびその使用
WO2019179420A1 (fr) * 2018-03-20 2019-09-26 Wuxi Biologics (Shanghai) Co., Ltd. Nouveaux anticorps anti-tim-3
TW202003565A (zh) 2018-03-23 2020-01-16 美商必治妥美雅史谷比公司 抗mica及/或micb抗體及其用途
WO2019196911A1 (fr) * 2018-04-12 2019-10-17 Nanjing Leads Biolabs Co., Ltd. Anticorps de liaison à tim-3 et son utilisation
EP3785732A4 (fr) 2018-04-24 2022-02-23 Ampsource Biopharma Shanghai Inc. Anticorps dirigé contre tim-3 et application associée
CN112566936A (zh) * 2018-08-21 2021-03-26 阿尔伯特爱因斯坦医学院 针对人tim-3的单克隆抗体
CN111253485A (zh) * 2018-11-30 2020-06-09 上海开拓者生物医药有限公司 抗人tim-3单克隆抗体及其应用
KR20210104704A (ko) 2018-12-19 2021-08-25 바이엘 악티엔게젤샤프트 항 ceacam6 및 tim3 항체의 제약 조합물
KR20220016157A (ko) 2019-05-30 2022-02-08 브리스톨-마이어스 스큅 컴퍼니 세포 국재화 시그너쳐 및 조합 요법
WO2020243568A1 (fr) 2019-05-30 2020-12-03 Bristol-Myers Squibb Company Procédés d'identification d'un sujet approprié pour une thérapie d'immuno-oncologie (i-o)
US20220363760A1 (en) 2019-05-30 2022-11-17 Bristol-Myers Squibb Company Multi-tumor gene signature for suitability to immuno-oncology therapy
KR102572804B1 (ko) * 2020-02-25 2023-08-31 국립암센터 CD11b+ 세포에서 TIM-3의 발현 수준을 측정하는 암 진단 또는 예후 예측을 위한 정보제공 방법
CN113214396B (zh) * 2020-07-31 2022-04-19 北京市神经外科研究所 抗tim3的单链抗体及其在制备治疗肿瘤的药物中的用途
AU2021334361A1 (en) 2020-08-31 2023-05-11 Bristol-Myers Squibb Company Cell localization signature and immunotherapy
WO2022120179A1 (fr) 2020-12-03 2022-06-09 Bristol-Myers Squibb Company Signatures géniques multi-tumorales et leurs utilisations
AU2021411486A1 (en) 2020-12-28 2023-06-29 Bristol-Myers Squibb Company Antibody compositions and methods of use thereof
JP2024501029A (ja) 2020-12-28 2024-01-10 ブリストル-マイヤーズ スクイブ カンパニー Pd1/pd-l1抗体の皮下投与
EP4314068A1 (fr) 2021-04-02 2024-02-07 The Regents Of The University Of California Anticorps dirigés contre un cdcp1 clivé et leurs utilisations
AR126001A1 (es) * 2021-06-01 2023-08-30 Symphogen As Anticuerpos y composiciones anti-nkg2a
AU2022340907A1 (en) 2021-09-02 2024-03-07 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Anti-cecam6 antibodies with reduced side-effects
AU2022336665A1 (en) 2021-09-03 2024-03-21 Oncoone Research & Development Gmbh IMPROVED Fc SILENCED ANTI-oxMIF ANTIBODIES WITH REDUCED AGGREGATION POTENTIAL AND REDUCED HYDROPHOBICITY
WO2023178329A1 (fr) 2022-03-18 2023-09-21 Bristol-Myers Squibb Company Procédés d'isolement de polypeptides
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Also Published As

Publication number Publication date
MX2018012076A (es) 2019-02-20
IL262176A (en) 2018-11-29
PT3443009T (pt) 2021-12-10
JP2019519199A (ja) 2019-07-11
CA3020647A1 (fr) 2017-10-19
PH12018502112A1 (en) 2019-09-23
PL3443009T3 (pl) 2022-01-31
HUE056677T2 (hu) 2022-02-28
EP3443009A1 (fr) 2019-02-20
PE20181805A1 (es) 2018-11-19
SG10201912937SA (en) 2020-02-27
CL2018002878A1 (es) 2019-04-26
RS62736B1 (sr) 2022-01-31
WO2017178493A1 (fr) 2017-10-19
LT3443009T (lt) 2021-12-27
HRP20211820T1 (hr) 2022-03-04
EA201892294A1 (ru) 2019-04-30
JP7123804B2 (ja) 2022-08-23
CO2018010458A2 (es) 2018-10-10
KR20180133482A (ko) 2018-12-14
MA44659B1 (fr) 2021-12-31
SG11201808724SA (en) 2018-11-29
US11390674B2 (en) 2022-07-19
MD3443009T2 (ro) 2022-02-28
CY1125440T1 (el) 2023-03-24
SI3443009T1 (sl) 2022-04-29
AU2017251250A1 (en) 2018-10-18
DK3443009T3 (da) 2021-12-13
AU2017251250B2 (en) 2024-03-21
TN2018000333A1 (en) 2020-01-16
KR102473028B1 (ko) 2022-11-30
ZA201806429B (en) 2023-02-22
TW201736397A (zh) 2017-10-16
US20230105714A1 (en) 2023-04-06
CN109451741B (zh) 2023-07-28
US20190276531A1 (en) 2019-09-12
JP2022172142A (ja) 2022-11-15
CN109451741A (zh) 2019-03-08
TWI752950B (zh) 2022-01-21
ES2900381T3 (es) 2022-03-16
UA126854C2 (uk) 2023-02-15
CN116693685A (zh) 2023-09-05
SA518400222B1 (ar) 2022-03-14
IL262176B2 (en) 2023-03-01
EP3443009B1 (fr) 2021-09-08
EP3978531A1 (fr) 2022-04-06
IL262176B (en) 2022-11-01
BR112018070919A2 (pt) 2019-01-29
EA039020B1 (ru) 2021-11-23

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