MX354663B - Eliminación de células diana por parte de células t citotóxicas específicas de virus utilizando complejos que comprenden mhc de clase i. - Google Patents
Eliminación de células diana por parte de células t citotóxicas específicas de virus utilizando complejos que comprenden mhc de clase i.Info
- Publication number
- MX354663B MX354663B MX2013014869A MX2013014869A MX354663B MX 354663 B MX354663 B MX 354663B MX 2013014869 A MX2013014869 A MX 2013014869A MX 2013014869 A MX2013014869 A MX 2013014869A MX 354663 B MX354663 B MX 354663B
- Authority
- MX
- Mexico
- Prior art keywords
- cells
- polypeptide
- linked
- disulfide
- complex
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title abstract 3
- 210000004027 cell Anatomy 0.000 title abstract 3
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 11
- 229920001184 polypeptide Polymers 0.000 abstract 9
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 9
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 abstract 4
- 102000008949 Histocompatibility Antigens Class I Human genes 0.000 abstract 2
- 108010088652 Histocompatibility Antigens Class I Proteins 0.000 abstract 2
- 108060003951 Immunoglobulin Proteins 0.000 abstract 2
- 102000043129 MHC class I family Human genes 0.000 abstract 2
- 108091054437 MHC class I family Proteins 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 102000015736 beta 2-Microglobulin Human genes 0.000 abstract 2
- 108010081355 beta 2-Microglobulin Proteins 0.000 abstract 2
- 210000004899 c-terminal region Anatomy 0.000 abstract 2
- 230000004927 fusion Effects 0.000 abstract 2
- 102000018358 immunoglobulin Human genes 0.000 abstract 2
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3023—Lung
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
Abstract
La presente invención se refiere a un método para la producción recombinante de un complejo que comprende: i) un polipéptido de fusión que comprende, en dirección N-terminal a C-terminal, un péptido inductor de respuesta de células T, ß2-microglobulina y los dominios extracelulares a1, a2 y a3 de una molécula de MHC de clase I con una frecuencia relativa de 1% o más, ii) un par de cadenas polipeptídicas unidas mediante disulfuro derivadas de una región bisagra de anticuerpo, y en donde cada cadena polipeptídica unida mediante disulfuro comprende un dominio CH2 y un dominio CH3 de origen humano, en donde un dominio CH3 comprende la mutación T366W y el otro dominio CH3 comprende las mutaciones T366S, L368A e Y407V en el domino (numeración según el índice EU de Kabat); y iii) por lo menos un par de un dominio variable de cadena ligera de anticuerpo y un dominio variable de cadena pesada de anticuerpo, en una célula eucariótica, el método comprendiendo las etapas siguientes; cultivar una célula eucariótica que comprende uno o más ácidos nucleicos codificantes del complejo, y recuperar el complejo a partir de la célula o del medio de cultivo, en donde el complejo comprende exactamente un polipéptido de fusión de un péptido inductor de respuesta de células T, ß2-microglobulina y los dominios extracelulares a1, a2 y a3 de una molécula de MHC de clase I, y en donde el polipéptido de fusión se encuentra unido covalentemente ya sea al extremo C-terminal o al extremo N-terminal de una de las cadenas polipeptídicas unidas mediante disulfuro, o unido covalentemente al extremo N-terminal de un dominio variable de anticuerpo que es el dominio variable de cadena pesada o ligera complementario al comprendido en la primera cadena polipeptídica unida mediante disulfuro, o unido covalentemente al extremo C-terminal de un dominio constante de anticuerpo que es el dominio constante de cadena pesas o ligera complementario al comprendido en la primera cadena polipeptídica unida mediante disulfuro.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11171027 | 2011-06-22 | ||
| PCT/EP2012/061734 WO2012175508A1 (en) | 2011-06-22 | 2012-06-19 | Removal of target cells by circulating virus-specific cytotoxic t-cells using mhc class i comprising complexes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2013014869A MX2013014869A (es) | 2014-03-31 |
| MX354663B true MX354663B (es) | 2018-03-14 |
Family
ID=46319142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013014869A MX354663B (es) | 2011-06-22 | 2012-06-19 | Eliminación de células diana por parte de células t citotóxicas específicas de virus utilizando complejos que comprenden mhc de clase i. |
Country Status (23)
| Country | Link |
|---|---|
| US (4) | US20130011394A1 (es) |
| EP (1) | EP2723773B1 (es) |
| JP (2) | JP6246711B2 (es) |
| KR (1) | KR102038155B1 (es) |
| CN (2) | CN103649125A (es) |
| AR (1) | AR086982A1 (es) |
| AU (1) | AU2012274127B2 (es) |
| BR (1) | BR112013029746B1 (es) |
| CA (1) | CA2835772C (es) |
| CL (1) | CL2013003634A1 (es) |
| CO (1) | CO6801646A2 (es) |
| CR (1) | CR20130609A (es) |
| EA (1) | EA201400046A1 (es) |
| EC (1) | ECSP13013098A (es) |
| ES (1) | ES2667864T3 (es) |
| IL (1) | IL229486B (es) |
| MA (1) | MA35604B1 (es) |
| MX (1) | MX354663B (es) |
| PE (1) | PE20141212A1 (es) |
| PL (1) | PL2723773T3 (es) |
| SG (1) | SG195077A1 (es) |
| TW (1) | TWI563087B (es) |
| WO (1) | WO2012175508A1 (es) |
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| MX354660B (es) * | 2012-11-30 | 2018-03-14 | Roche Glycart Ag | Remocion de las celulas de cancer por celulas t citotoxicas, especificas de virus, en circulacion, usando proteinas multifuncionales que comprenden complejo de histocompatilibidad principal (mhc) clase i, dirigidas a celulas de cancer. |
| WO2014093118A1 (en) | 2012-12-11 | 2014-06-19 | Albert Einstein College Of Medicine Of Yeshiva University | Methods for high throughput receptor:ligand identification |
| SG11201504414UA (en) | 2012-12-21 | 2015-07-30 | Hoffmann La Roche | Disulfide-linked multivalent mhc class i comprising multi-function proteins |
| CN105377297B (zh) * | 2013-05-28 | 2019-09-17 | Dcb-美国有限责任公司 | 用于蛋白质药物失活的抗体锁扣 |
| AU2014302784B2 (en) * | 2013-06-24 | 2020-01-23 | Neximmune | Compositions and methods for immunotherapy |
| WO2015095972A1 (en) * | 2013-12-23 | 2015-07-02 | The Centre For Drug Research And Development | Antibodies comprising c-terminal light chain polypeptide extensions and conjugates and methods of use thereof |
| SG10201808825XA (en) | 2014-04-10 | 2018-11-29 | Seattle Childrens Hospital Dba Seattle Childrens Res Inst | Defined composition gene modified t-cell products |
| US11566082B2 (en) | 2014-11-17 | 2023-01-31 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
| WO2016141284A1 (en) * | 2015-03-04 | 2016-09-09 | The Johns Hopkins University | Compositions and methods for enhancing an immune response |
| CN108174604B (zh) | 2015-08-07 | 2023-06-23 | 西雅图儿童医院（Dba西雅图儿童研究所） | 用于实体瘤靶向的双特异性car t细胞 |
| US10654887B2 (en) | 2016-05-11 | 2020-05-19 | Ge Healthcare Bio-Process R&D Ab | Separation matrix |
| US10730908B2 (en) | 2016-05-11 | 2020-08-04 | Ge Healthcare Bioprocess R&D Ab | Separation method |
| US10703774B2 (en) | 2016-09-30 | 2020-07-07 | Ge Healthcare Bioprocess R&D Ab | Separation method |
| CN109071613A (zh) | 2016-05-11 | 2018-12-21 | 通用电气医疗集团生物工艺研发股份公司 | 分离基质 |
| JP6987424B2 (ja) | 2016-05-11 | 2022-01-05 | サイティバ・バイオプロセス・アールアンドディ・アクチボラグ | 分離マトリックスを洗浄および／または消毒する方法 |
| JP7106187B2 (ja) | 2016-05-11 | 2022-07-26 | サイティバ・バイオプロセス・アールアンドディ・アクチボラグ | 分離マトリックスを保存する方法 |
| US10889615B2 (en) | 2016-05-11 | 2021-01-12 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
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| EP3532497A4 (en) | 2016-10-26 | 2020-05-13 | The Board of Trustees of the Leland Stanford Junior University | MODIFIED IMMUNOGLOBULIN BAND REGIONS TO REDUCE HEMAGGLUTINATION |
| JP7091357B2 (ja) | 2016-12-12 | 2022-06-27 | シアトル チルドレンズ ホスピタル （ディービーエイ シアトル チルドレンズ リサーチ インスティテュート） | 哺乳動物細胞における薬物リガンドの誘導による導入遺伝子の発現に対する感受性が増強されたキメラ転写因子バリアント |
| KR20190111022A (ko) | 2016-12-22 | 2019-10-01 | 큐 바이오파마, 인크. | T-세포 조절 다량체 폴리펩타이드 및 이의 사용 방법 |
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