BR112019010485A2 - método para a produção de um anticorpo, anticorpo e formulação farmacêutica - Google Patents
método para a produção de um anticorpo, anticorpo e formulação farmacêuticaInfo
- Publication number
- BR112019010485A2 BR112019010485A2 BR112019010485A BR112019010485A BR112019010485A2 BR 112019010485 A2 BR112019010485 A2 BR 112019010485A2 BR 112019010485 A BR112019010485 A BR 112019010485A BR 112019010485 A BR112019010485 A BR 112019010485A BR 112019010485 A2 BR112019010485 A2 BR 112019010485A2
- Authority
- BR
- Brazil
- Prior art keywords
- antibody
- producing
- pharmaceutical formulation
- affinity ligand
- chain affinity
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000003446 ligand Substances 0.000 abstract 3
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 230000013595 glycosylation Effects 0.000 abstract 1
- 238000006206 glycosylation reaction Methods 0.000 abstract 1
- 239000007790 solid phase Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
Abstract
a presente invenção se refere a um método para a produção de um anticorpo que compreende as etapas para formar um complexo de ligante de afinidade de cadeia leve anticorpo-anticorpo, em que o ligante de afinidade de cadeia leve de anticorpo é imobilizado em uma fase sólida, através da aplicação de uma solução que compreende o anticorpo para o ligante de afinidade de cadeia de anticorpo imobilizado, e incubação do complexo formado na etapa anterior com uma ou mais enzimas para modificar a glicosilação do anticorpo, por conseguinte, produzindo o anticorpo.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16205587 | 2016-12-21 | ||
EP17157002 | 2017-02-20 | ||
PCT/EP2017/083429 WO2018114877A1 (en) | 2016-12-21 | 2017-12-19 | In vitro glycoengineering of antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112019010485A2 true BR112019010485A2 (pt) | 2019-09-10 |
Family
ID=60997429
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112019010485A BR112019010485A2 (pt) | 2016-12-21 | 2017-12-19 | método para a produção de um anticorpo, anticorpo e formulação farmacêutica |
Country Status (12)
Country | Link |
---|---|
US (2) | US20200165320A1 (pt) |
EP (1) | EP3559248B1 (pt) |
JP (1) | JP6850351B2 (pt) |
KR (1) | KR102317884B1 (pt) |
CN (1) | CN110088291A (pt) |
AU (1) | AU2017384276B9 (pt) |
BR (1) | BR112019010485A2 (pt) |
CA (1) | CA3044920C (pt) |
IL (1) | IL267351A (pt) |
MX (1) | MX2019006266A (pt) |
TW (1) | TWI780097B (pt) |
WO (1) | WO2018114877A1 (pt) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2019006266A (es) | 2016-12-21 | 2019-08-21 | Hoffmann La Roche | Glucomanipulacion in vitro de anticuerpos. |
IL267352B2 (en) * | 2016-12-21 | 2023-10-01 | Hoffmann La Roche | A method for in vitro glycoengineering of antibodies |
JP2021526845A (ja) | 2018-07-13 | 2021-10-11 | ゲンマブ エー/エス | Cd38抗体を使用したトロゴサイトーシスを介した治療 |
SG11202012993SA (en) | 2018-07-13 | 2021-02-25 | Genmab As | Variants of cd38 antibody and uses thereof |
WO2021144457A1 (en) | 2020-01-16 | 2021-07-22 | Genmab A/S | Formulations of cd38 antibodies and uses thereof |
US20230109496A1 (en) | 2021-09-06 | 2023-04-06 | Genmab B.V. | Antibodies capable of binding to cd27, variants thereof and uses thereof |
Family Cites Families (67)
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ATE531812T1 (de) | 1997-12-05 | 2011-11-15 | Scripps Research Inst | Humanisierung von nager-antikörpern |
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-
2017
- 2017-12-19 MX MX2019006266A patent/MX2019006266A/es unknown
- 2017-12-19 AU AU2017384276A patent/AU2017384276B9/en active Active
- 2017-12-19 KR KR1020197017701A patent/KR102317884B1/ko active IP Right Grant
- 2017-12-19 WO PCT/EP2017/083429 patent/WO2018114877A1/en unknown
- 2017-12-19 BR BR112019010485A patent/BR112019010485A2/pt unknown
- 2017-12-19 EP EP17829955.8A patent/EP3559248B1/en active Active
- 2017-12-19 JP JP2019533340A patent/JP6850351B2/ja active Active
- 2017-12-19 CA CA3044920A patent/CA3044920C/en active Active
- 2017-12-19 CN CN201780079057.7A patent/CN110088291A/zh active Pending
- 2017-12-20 TW TW106144931A patent/TWI780097B/zh active
-
2019
- 2019-06-13 IL IL267351A patent/IL267351A/en unknown
- 2019-06-20 US US16/447,093 patent/US20200165320A1/en not_active Abandoned
-
2023
- 2023-05-16 US US18/318,487 patent/US20240101643A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
KR20190082942A (ko) | 2019-07-10 |
CA3044920C (en) | 2022-06-28 |
US20200165320A1 (en) | 2020-05-28 |
JP6850351B2 (ja) | 2021-03-31 |
AU2017384276A1 (en) | 2019-05-30 |
IL267351A (en) | 2019-08-29 |
AU2017384276B2 (en) | 2020-07-02 |
EP3559248B1 (en) | 2021-11-17 |
KR102317884B1 (ko) | 2021-10-26 |
EP3559248A1 (en) | 2019-10-30 |
CN110088291A (zh) | 2019-08-02 |
CA3044920A1 (en) | 2018-06-28 |
US20240101643A1 (en) | 2024-03-28 |
MX2019006266A (es) | 2019-08-21 |
AU2017384276B9 (en) | 2020-11-26 |
TW201835333A (zh) | 2018-10-01 |
TWI780097B (zh) | 2022-10-11 |
WO2018114877A1 (en) | 2018-06-28 |
JP2020501577A (ja) | 2020-01-23 |
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B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] |