PE20211858A1 - Variantes de anticuerpos anti-cd38 y sus usos - Google Patents
Variantes de anticuerpos anti-cd38 y sus usosInfo
- Publication number
- PE20211858A1 PE20211858A1 PE2021000038A PE2021000038A PE20211858A1 PE 20211858 A1 PE20211858 A1 PE 20211858A1 PE 2021000038 A PE2021000038 A PE 2021000038A PE 2021000038 A PE2021000038 A PE 2021000038A PE 20211858 A1 PE20211858 A1 PE 20211858A1
- Authority
- PE
- Peru
- Prior art keywords
- seq
- variant
- antibody variant
- cdr1
- cdr2
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Dispersion Chemistry (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invencion se refiere a una variante de anticuerpo que se une a la CD38 humana, donde la variante de anticuerpo comprende (a) una CDR1 de VH de SEQ ID N°: 2, una CDR2 de VH de SEQ ID N°: 3, una CDR3 de VH de SEQ ID N°: 4, una CDR1 de VL de SEQ ID N°: 6, una CDR2 de VL que comprende la secuencia AAS y una CDR3 de VL de SEQ ID N°: 7, y (b) una variante de la region Fc que comprende una mutacion en uno o mas residuos de aminoacidos correspondientes a E430, E345 y S440 en una cadena pesada de la IgG1 humana. Tambien se refiere a acidos nucleicos, vectores de expresion, vehiculo de administracion tal como una nanoparticula lipidica (LNP), celulas huesped recombinante, composiciones farmaceuticas y metodos que comprenden la variante de anticuerpo de la invencion. Dicha variante es util en el tratamiento de enfermedades que involucran celulas que expresan CD38, tales como en cancer hematologico, carcinomas bronco-epiteliales de pulmon, cancer de mama, tumores pancreaticos que evolucionan a partir de las celulas beta (insulinomas), tumores que evolucionan a partir del epitelio en el intestino, entre otros.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862697730P | 2018-07-13 | 2018-07-13 | |
US201962848874P | 2019-05-16 | 2019-05-16 | |
PCT/EP2019/069028 WO2020012036A1 (en) | 2018-07-13 | 2019-07-15 | Variants of cd38 antibody and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20211858A1 true PE20211858A1 (es) | 2021-09-21 |
Family
ID=67396922
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2021000038A PE20211858A1 (es) | 2018-07-13 | 2019-07-15 | Variantes de anticuerpos anti-cd38 y sus usos |
Country Status (21)
Country | Link |
---|---|
US (2) | US20200017600A1 (es) |
EP (1) | EP3820900A1 (es) |
JP (1) | JP2021524276A (es) |
KR (1) | KR20210031932A (es) |
CN (1) | CN112513082A (es) |
AU (1) | AU2019300223A1 (es) |
BR (1) | BR112020026432A2 (es) |
CA (1) | CA3106146A1 (es) |
CL (1) | CL2021000066A1 (es) |
CO (1) | CO2021001544A2 (es) |
CR (1) | CR20210081A (es) |
DO (1) | DOP2021000006A (es) |
EC (1) | ECSP21010092A (es) |
IL (1) | IL279937A (es) |
MA (1) | MA53122A (es) |
MX (1) | MX2020013631A (es) |
PE (1) | PE20211858A1 (es) |
PH (1) | PH12021550054A1 (es) |
SG (1) | SG11202012993SA (es) |
TW (1) | TW202019518A (es) |
WO (1) | WO2020012036A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
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EP2869845B1 (en) | 2012-07-06 | 2019-08-28 | Genmab B.V. | Dimeric protein with triple mutations |
US20220275090A1 (en) | 2021-02-22 | 2022-09-01 | Janssen Biotech, Inc. | Combination Therapies with Anti-CD38 Antibodies and PARP or Adenosine Receptor Inhibitors |
WO2023044346A2 (en) | 2021-09-14 | 2023-03-23 | Ausper Biopharma Co., Ltd. | Vaccines for coronavirus prevention and treatment |
AU2022350815A1 (en) * | 2021-09-23 | 2024-05-02 | Sound Biopharmaceuticals Co. Ltd. | Cd38 monoclonal antibody and application thereof |
CA3237175A1 (en) | 2021-11-03 | 2023-05-11 | Janssen Biotech, Inc. | Corticosteriod reduction in treatment with anti-cd38 antibodies |
CN114409788B (zh) * | 2022-03-04 | 2022-10-04 | 四川大学华西医院 | 抗cd38的抗体及其应用 |
WO2024094660A1 (en) | 2022-10-31 | 2024-05-10 | Genmab A/S | Cd38 antibodies and uses thereof |
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MX2019007411A (es) | 2016-12-21 | 2019-08-29 | Hoffmann La Roche | Reuso de enzimas en glucomanipulacion in vitro de anticuerpos. |
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2019
- 2019-07-15 MX MX2020013631A patent/MX2020013631A/es unknown
- 2019-07-15 JP JP2021500814A patent/JP2021524276A/ja active Pending
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- 2019-07-15 PE PE2021000038A patent/PE20211858A1/es unknown
- 2019-07-15 BR BR112020026432-6A patent/BR112020026432A2/pt unknown
- 2019-07-15 KR KR1020217003848A patent/KR20210031932A/ko unknown
- 2019-07-15 TW TW108124908A patent/TW202019518A/zh unknown
- 2019-07-15 SG SG11202012993SA patent/SG11202012993SA/en unknown
- 2019-07-15 CN CN201980047066.7A patent/CN112513082A/zh active Pending
- 2019-07-15 CR CR20210081A patent/CR20210081A/es unknown
- 2019-07-15 CA CA3106146A patent/CA3106146A1/en active Pending
- 2019-07-15 US US16/512,206 patent/US20200017600A1/en active Pending
- 2019-07-15 AU AU2019300223A patent/AU2019300223A1/en active Pending
- 2019-07-15 EP EP19742548.1A patent/EP3820900A1/en active Pending
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2020
- 2020-02-10 US US16/786,563 patent/US20200165352A1/en active Pending
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2021
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SG11202012993SA (en) | 2021-02-25 |
CN112513082A (zh) | 2021-03-16 |
CA3106146A1 (en) | 2020-01-16 |
CO2021001544A2 (es) | 2021-03-08 |
TW202019518A (zh) | 2020-06-01 |
MX2020013631A (es) | 2021-03-25 |
AU2019300223A1 (en) | 2021-01-07 |
JP2021524276A (ja) | 2021-09-13 |
EP3820900A1 (en) | 2021-05-19 |
US20200165352A1 (en) | 2020-05-28 |
KR20210031932A (ko) | 2021-03-23 |
US20200017600A1 (en) | 2020-01-16 |
PH12021550054A1 (en) | 2021-09-27 |
ECSP21010092A (es) | 2021-03-31 |
WO2020012036A1 (en) | 2020-01-16 |
DOP2021000006A (es) | 2021-03-15 |
BR112020026432A2 (pt) | 2021-03-23 |
IL279937A (en) | 2021-03-01 |
MA53122A (fr) | 2021-05-19 |
CR20210081A (es) | 2021-06-24 |
CL2021000066A1 (es) | 2021-05-28 |
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