AR074399A1 - Moleculas biespecificas de union a egfr/igfir - Google Patents
Moleculas biespecificas de union a egfr/igfirInfo
- Publication number
- AR074399A1 AR074399A1 ARP090104530A ARP090104530A AR074399A1 AR 074399 A1 AR074399 A1 AR 074399A1 AR P090104530 A ARP090104530 A AR P090104530A AR P090104530 A ARP090104530 A AR P090104530A AR 074399 A1 AR074399 A1 AR 074399A1
- Authority
- AR
- Argentina
- Prior art keywords
- seq
- loop
- acid sequence
- amino acid
- amino acids
- Prior art date
Links
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 title abstract 4
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 title abstract 4
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 title abstract 4
- 101001034652 Homo sapiens Insulin-like growth factor 1 receptor Proteins 0.000 title abstract 2
- 102100039688 Insulin-like growth factor 1 receptor Human genes 0.000 title abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 6
- 150000001413 amino acids Chemical class 0.000 abstract 6
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 102000040430 polynucleotide Human genes 0.000 abstract 2
- 108091033319 polynucleotide Proteins 0.000 abstract 2
- 239000002157 polynucleotide Substances 0.000 abstract 2
- 239000013636 protein dimer Substances 0.000 abstract 2
- 102100037362 Fibronectin Human genes 0.000 abstract 1
- 102000002090 Fibronectin type III Human genes 0.000 abstract 1
- 108050009401 Fibronectin type III Proteins 0.000 abstract 1
- 108010067306 Fibronectins Proteins 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
- C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Moléculas biespecíficas que comprenden un dominio de unión a EGFR y un dominio a IGFIR distinto para el uso en aplicaciones de diagnóstico, investigación y terapéuticas. Células que comprenden tales proteínas, a polinucleótidos que codifican tales proteínas o fragmentos de las mismas y a vectores que comprenden los polinucleótidos que codifican las proteínas innovadoras. Ejemplos de moléculas biespecíficas incluyen dímeros de proteína similar a anticuerpo basados en el décimo dominio de fibronectina de tipo III. Reivindicación 1: Un dímero de proteína similar a anticuerpo, caracterizado porque comprende a) un décimo dominio de fibronectina de tipo III (10Fn3) que se une a IGF-IR con una KD menor de 500 nM unido covalentemente o no covalentemente con b) un 10Fn3 que se une a EGFR con una KD menor de 500 nM; en el que el 10Fn3 de unión de IGF-IR comprende un bucle BC que tiene la secuencia de aminoácidos expuesta en los aminoácidos 21-30 de la SEC ID Ns 3, un bucle DE que tiene la secuencia de aminoácidos expuesta en los aminoácidos 51-56 de la SEC ID Ns 3 y un bucle FG que tiene la secuencia de aminoácidos expuesta en los aminoácidos 76-83 de la SEC ID Ns 3 y en el que el 10Fn3 de unión de EGFR comprende un bucle BC que tiene la secuencia de aminoácidos expuesta en los aminoácidos 21-30 de la SEC ID Ns 112, un bucle DE que tiene la secuencia de aminoácidos expuesta en los aminoácidos 51-56 de la SEC ID Ns 112 y un bucle FG que tiene la secuencia de aminoácidos expuesta en los aminoácidos 76-92 de la SEC ID Ns 112.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20016408P | 2008-11-24 | 2008-11-24 | |
US20028208P | 2008-11-26 | 2008-11-26 | |
US21296609P | 2009-04-17 | 2009-04-17 | |
US17827909P | 2009-05-14 | 2009-05-14 | |
US22733009P | 2009-07-21 | 2009-07-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR074399A1 true AR074399A1 (es) | 2011-01-12 |
Family
ID=41667546
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP090104530A AR074399A1 (es) | 2008-11-24 | 2009-11-24 | Moleculas biespecificas de union a egfr/igfir |
Country Status (21)
Country | Link |
---|---|
US (5) | US8343501B2 (es) |
EP (2) | EP2350126B1 (es) |
JP (2) | JP5823870B2 (es) |
KR (1) | KR20110098922A (es) |
CN (1) | CN102439036B (es) |
AR (1) | AR074399A1 (es) |
AU (1) | AU2009316271A1 (es) |
BR (1) | BRPI0922613A2 (es) |
CA (1) | CA2744405A1 (es) |
CL (1) | CL2011001214A1 (es) |
CO (1) | CO6382161A2 (es) |
EA (1) | EA022415B1 (es) |
ES (1) | ES2555381T3 (es) |
IL (1) | IL212715A0 (es) |
MX (1) | MX2011005257A (es) |
NZ (2) | NZ601693A (es) |
PE (1) | PE20110587A1 (es) |
TN (1) | TN2011000225A1 (es) |
TW (1) | TWI496582B (es) |
WO (1) | WO2010060095A1 (es) |
ZA (1) | ZA201103766B (es) |
Families Citing this family (63)
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SG149004A1 (en) | 2003-12-05 | 2009-01-29 | Bristol Myers Squibb Co | Inhibitors of type 2 vascular endothelial growth factor receptors |
EP2727936B1 (en) | 2006-11-22 | 2016-09-07 | Bristol-Myers Squibb Company | Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including IGF-IR |
AU2008319298B2 (en) | 2007-10-31 | 2014-07-31 | Medimmune, Llc | Protein scaffolds |
WO2009102421A2 (en) | 2008-02-14 | 2009-08-20 | Bristol-Myers Squibb Company | Targeted therapeutics based on engineered proteins that bind egfr |
PT2274331E (pt) | 2008-05-02 | 2014-02-27 | Novartis Ag | Moléculas de ligação baseadas em fibronectina melhoradas e suas utilizações |
PE20091931A1 (es) | 2008-05-22 | 2009-12-31 | Bristol Myers Squibb Co | Proteinas de dominio de armazon basadas en fibronectina multivalentes |
RS55218B1 (sr) | 2008-10-31 | 2017-02-28 | Janssen Biotech Inc | Kompozicije fibronektin tip iii skalno baziranih domena, metode i upotrebe |
TWI496582B (zh) | 2008-11-24 | 2015-08-21 | 必治妥美雅史谷比公司 | 雙重專一性之egfr/igfir結合分子 |
US8067201B2 (en) | 2009-04-17 | 2011-11-29 | Bristol-Myers Squibb Company | Methods for protein refolding |
ES2860453T3 (es) | 2009-10-30 | 2021-10-05 | Novartis Ag | Bibliotecas universales del dominio de unión del lado inferior de la fibronectina de tipo III |
KR20130010461A (ko) | 2010-02-18 | 2013-01-28 | 브리스톨-마이어스 스큅 컴퍼니 | Il―23에 결합하는 피브로넥틴 기반 스캐폴드 도메인 단백질 |
BR112012026003B1 (pt) | 2010-04-13 | 2022-03-15 | Medimmune, Llc | Estrutura multimérica recombinante específica trail r2, seu uso, bem como composição |
AU2011245225B2 (en) | 2010-04-30 | 2015-09-17 | Janssen Biotech, Inc. | Stabilized fibronectin domain compositions, methods and uses |
TW201138808A (en) | 2010-05-03 | 2011-11-16 | Bristol Myers Squibb Co | Serum albumin binding molecules |
CN103180339B (zh) | 2010-05-26 | 2016-04-27 | 百时美施贵宝公司 | 具有改善的稳定性的基于纤连蛋白的支架蛋白质 |
US20130171185A1 (en) | 2010-07-06 | 2013-07-04 | Ethan Settembre | Norovirus derived immunogenic compositions and methods |
CN107903321A (zh) * | 2010-07-30 | 2018-04-13 | 诺华有限公司 | 纤连蛋白摇篮分子和其库 |
BR112013022557A2 (pt) * | 2011-03-04 | 2017-08-01 | Shire Human Genetic Therapies | ligantes de peptídeo composições de polipeptídeo e métodos para uso dos mesmos |
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SI2697257T1 (sl) | 2011-04-13 | 2017-02-28 | Bristol-Myers Squibb Company | FC fuzijski proteini, ki vsebujejo nove linkerje ali razmestitve |
EP2710382B1 (en) | 2011-05-17 | 2017-10-18 | Bristol-Myers Squibb Company | Improved methods for the selection of binding proteins |
US20140187488A1 (en) * | 2011-05-17 | 2014-07-03 | Bristol-Myers Squibb Company | Methods for maintaining pegylation of polypeptides |
EP4151785A1 (en) | 2011-09-27 | 2023-03-22 | Janssen Biotech, Inc. | Fibronectin type iii repeat based protein scaffolds with alternative binding surfaces |
AU2012323316B2 (en) | 2011-10-11 | 2017-08-10 | Viela Bio, Inc. | CD40L-specific Tn3-derived scaffolds and methods of use thereof |
JP2015504038A (ja) | 2011-10-31 | 2015-02-05 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 低減した免疫原性を有するフィブロネクチン結合ドメイン |
WO2013177187A2 (en) | 2012-05-22 | 2013-11-28 | Massachusetts Institute Of Technology | Synergistic tumor treatment with extended-pk il-2 and therapeutic agents |
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KR102478402B1 (ko) | 2013-10-14 | 2022-12-15 | 얀센 바이오테크 인코포레이티드 | 시스테인 조작된 피브로넥틴 iii형 도메인 결합 분자 |
WO2015113494A1 (zh) * | 2014-01-28 | 2015-08-06 | 北京韩美药品有限公司 | 双功能融合蛋白及其制备方法和用途 |
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AU2015301753B2 (en) | 2014-08-12 | 2021-04-08 | Massachusetts Institute Of Technology | Synergistic tumor treatment with IL-2 and integrin-binding-Fc-fusion protein |
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CN114316061A (zh) | 2015-01-02 | 2022-04-12 | 武田药品工业株式会社 | 针对血浆激肽释放酶和因子xii的双特异性抗体 |
JP7068160B2 (ja) | 2015-07-21 | 2022-05-16 | 武田薬品工業株式会社 | 第XIIa因子のモノクローナル抗体阻害剤 |
KR20180056701A (ko) | 2015-09-23 | 2018-05-29 | 브리스톨-마이어스 스큅 컴퍼니 | 패스트-오프 레이트 혈청 알부민 결합 피브로넥틴 유형 iii 도메인 |
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WO2017210335A1 (en) | 2016-06-01 | 2017-12-07 | Bristol-Myers Squibb Company | Imaging methods using 18f-radiolabeled biologics |
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CN112771071A (zh) | 2018-09-28 | 2021-05-07 | 麻省理工学院 | 胶原蛋白定位的免疫调节分子及其方法 |
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