PE20190120A1 - Moleculas de union a bcma y metodos de uso de las mismas - Google Patents

Moleculas de union a bcma y metodos de uso de las mismas

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Publication number
PE20190120A1
PE20190120A1 PE2018001932A PE2018001932A PE20190120A1 PE 20190120 A1 PE20190120 A1 PE 20190120A1 PE 2018001932 A PE2018001932 A PE 2018001932A PE 2018001932 A PE2018001932 A PE 2018001932A PE 20190120 A1 PE20190120 A1 PE 20190120A1
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Peru
Prior art keywords
amino acid
acid sequence
sequence seq
antigen
receptor
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PE2018001932A
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English (en)
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Jed Wiltzius
Rodriguez Ruben Alvarez
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Kite Pharma Inc
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Publication of PE20190120A1 publication Critical patent/PE20190120A1/es

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    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
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    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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Abstract

Referido a un polinucleotido aislado que codifica un receptor de antigeno quimerico (CAR) o un receptor o un receptor de celulas T (TCR), que comprende una molecula de union a antigeno que se une especificamente a un antigeno de maduracion de celulas B (BCMA), en donde la molecula de union a antigeno comprende: (a) una region determinante de complementariedad (CDR) de una region variable de cadena pesada 1 que comprende la secuencia de aminoacidos SEQ ID NO: 145; y/o (b) un CDR de VH que comprende la secuencia de aminoacidos SEQ ID NO: 146; (c) un CDR3 de VH que comprende la secuencia aminoacidos SEQ ID NO: 147; (d) una region variable de cadena liviana (VL) CDR1 que comprende la secuencia de aminoacidos SEQ ID NO: 148; (e) una CDR2 de VL que comprende en la secuencia de aminoacidos SEQ ID NO: 149 y (f) un CDR3 de VL que comprende en la secuencia de aminoacidos SEQ ID NO: 150. En donde, estos polinucleotidos, polipeptidos y celulas in vitro, se pueden usar en una terapia de celulas T CAR modificadas geneticamente para el tratamiento de cancer como el mieloma multiple.
PE2018001932A 2016-04-01 2017-03-31 Moleculas de union a bcma y metodos de uso de las mismas PE20190120A1 (es)

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US201662317334P 2016-04-01 2016-04-01

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US (3) US10689450B2 (es)
EP (1) EP3436036A4 (es)
JP (2) JP7366543B2 (es)
KR (3) KR102522622B1 (es)
CN (3) CN117903307A (es)
AR (1) AR108067A1 (es)
AU (2) AU2017240150C1 (es)
BR (1) BR112018070159A2 (es)
CA (1) CA3019135A1 (es)
CL (1) CL2018002763A1 (es)
CO (1) CO2018010475A2 (es)
CR (1) CR20180462A (es)
CU (1) CU20180120A7 (es)
DO (1) DOP2018000212A (es)
EA (1) EA201891966A1 (es)
EC (1) ECSP18073836A (es)
IL (1) IL261942A (es)
MX (1) MX2023007400A (es)
NZ (1) NZ746700A (es)
PE (1) PE20190120A1 (es)
PH (1) PH12018550164A1 (es)
SG (2) SG10201912515XA (es)
TW (4) TWI707950B (es)
WO (1) WO2017173349A1 (es)
ZA (1) ZA201806962B (es)

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