PE20090329A1 - Anticuerpos humanizados contra el globulomero ab(20-42) y sus usos - Google Patents
Anticuerpos humanizados contra el globulomero ab(20-42) y sus usosInfo
- Publication number
- PE20090329A1 PE20090329A1 PE2008000921A PE2008000921A PE20090329A1 PE 20090329 A1 PE20090329 A1 PE 20090329A1 PE 2008000921 A PE2008000921 A PE 2008000921A PE 2008000921 A PE2008000921 A PE 2008000921A PE 20090329 A1 PE20090329 A1 PE 20090329A1
- Authority
- PE
- Peru
- Prior art keywords
- cdr
- containing seq
- globulomer
- antibodies against
- humanized antibodies
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 108060003951 Immunoglobulin Proteins 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 102000018358 immunoglobulin Human genes 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
Abstract
SE REFIERE A UNA PROTEINA DE UNION TAL COMO UNA MOLECULA DE INMUNOGLOBULINA, UN ANTICUERPO MONOCLONAL, UN ANTICUERPO HUMANIZADO, UN Fab, ENTRE OTROS, QUE COMPRENDE UN DOMINIO DE UNION A ANTIGENO QUE SE UNE AL GLOBULOMERO BETA AMILOIDE(20-42) QUE COMPRENDE UNA CDR CUYA SECUENCIA DE AMINOACIDOS CONSISTE EN: A) CDR-VH1 QUE CONTIENE LA SEC ID Nº 5; B) CDR-VH2 QUE CONTIENE LA SEC ID Nº 6; C) CDR-VH3 QUE CONTIENE LA SEC ID Nº 7; D) CDR-VL1 QUE CONTIENE LA SEC ID Nº 8; E) CDR-VL2 QUE CONTIENE LA SEC ID Nº 9; CDR-VL3 QUE CONTIENE LA SEC ID Nº 10. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA QUE CONTIENE DICHA PROTEINA DE UNION O UN ANTICUERPO CONJUGADO EN FORMA DE CRISTAL, SIENDO UTIL EN EL TRATAMIENTO Y DIAGNOSTICO DE LA ENFERMEDAD DE ALZHEIMER
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US94093207P | 2007-05-30 | 2007-05-30 | |
US99035907P | 2007-11-27 | 2007-11-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20090329A1 true PE20090329A1 (es) | 2009-03-27 |
Family
ID=39791050
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2008000921A PE20090329A1 (es) | 2007-05-30 | 2008-05-29 | Anticuerpos humanizados contra el globulomero ab(20-42) y sus usos |
Country Status (22)
Country | Link |
---|---|
US (1) | US20090175847A1 (es) |
EP (1) | EP2150563A1 (es) |
JP (1) | JP2010530740A (es) |
KR (1) | KR20100032398A (es) |
CN (1) | CN101827862A (es) |
AR (1) | AR066794A1 (es) |
AU (1) | AU2008260062A1 (es) |
BR (1) | BRPI0812005A2 (es) |
CA (1) | CA2687414A1 (es) |
CL (1) | CL2008001580A1 (es) |
CO (1) | CO6251291A2 (es) |
CR (1) | CR11179A (es) |
DO (1) | DOP2009000269A (es) |
EC (1) | ECSP099833A (es) |
IL (1) | IL202243A0 (es) |
MX (1) | MX2009012950A (es) |
PA (1) | PA8782201A1 (es) |
PE (1) | PE20090329A1 (es) |
RU (1) | RU2009149370A (es) |
TW (1) | TW200914465A (es) |
UY (1) | UY31114A1 (es) |
WO (1) | WO2008150949A1 (es) |
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DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
US7920906B2 (en) | 2005-03-10 | 2011-04-05 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
US9247900B2 (en) | 2004-07-13 | 2016-02-02 | Dexcom, Inc. | Analyte sensor |
BRPI0506629A (pt) * | 2004-02-10 | 2007-05-02 | Univ Colorado | inibição do fator b, a via alternativa do sistema complemento e métodos relacionados |
WO2006127694A2 (en) | 2004-07-13 | 2006-11-30 | Dexcom, Inc. | Analyte sensor |
US8170803B2 (en) | 2004-07-13 | 2012-05-01 | Dexcom, Inc. | Transcutaneous analyte sensor |
PL3540062T3 (pl) | 2004-11-16 | 2021-12-27 | Humanigen, Inc. | Wymiana kasety dla regionu zmiennego immunoglobuliny |
CA2610340C (en) * | 2005-05-26 | 2016-02-16 | Vernon Michael Holers | Inhibition of the alternative complement pathway for treatment of traumatic brain injury, spinal cord injury and related conditions |
RU2432362C2 (ru) | 2005-11-30 | 2011-10-27 | Эбботт Лэборетриз | Моноклональные антитела и их применения |
DK1954718T3 (en) | 2005-11-30 | 2014-12-15 | Abbvie Inc | Anti-A-globulomer antibodies antigenbindingsgrupper thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods for producing said antibodies, |
EP2808032B1 (en) * | 2005-12-12 | 2018-08-01 | AC Immune S.A. | A beta 1-42 specific monoclonal antibodies with therapeutic properties |
CA2657681C (en) * | 2006-07-14 | 2019-03-19 | Ac Immune S.A. | Humanized antibodies against beta amyloid protein |
US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
US20100311767A1 (en) | 2007-02-27 | 2010-12-09 | Abbott Gmbh & Co. Kg | Method for the treatment of amyloidoses |
EP2565207A3 (en) | 2007-03-14 | 2013-06-12 | Alexion Cambridge Corporation | Humaneered Anti-Factor B Antibody |
US8613923B2 (en) * | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
US8048420B2 (en) | 2007-06-12 | 2011-11-01 | Ac Immune S.A. | Monoclonal antibody |
EP2586795B1 (en) | 2007-10-05 | 2018-05-16 | Genentech, Inc. | Use of anti-amyloid beta antibody in ocular diseases |
ES2609918T3 (es) * | 2007-10-05 | 2017-04-25 | Genentech, Inc. | Uso de anticuerpo anti-amiloide beta en enfermedades oculares |
MY159667A (en) | 2008-05-09 | 2017-01-13 | Abbvie Inc | Antibodies to receptor of advanced glycation end products (rage) and uses thereof |
JP5871798B2 (ja) | 2009-07-02 | 2016-03-01 | エムユーエスシー ファウンデーション フォー リサーチ ディベロップメント | 肝再生を刺激する方法 |
US9345661B2 (en) * | 2009-07-31 | 2016-05-24 | Genentech, Inc. | Subcutaneous anti-HER2 antibody formulations and uses thereof |
AU2013202020B2 (en) * | 2009-07-31 | 2014-11-27 | F. Hoffmann-La Roche Ag | Subcutaneous anti-HER2 antibody formulation |
AR078161A1 (es) | 2009-09-11 | 2011-10-19 | Hoffmann La Roche | Formulaciones farmaceuticas muy concentradas de un anticuerpo anti cd20. uso de la formulacion. metodo de tratamiento. |
WO2011053707A1 (en) | 2009-10-31 | 2011-05-05 | Abbott Laboratories | Antibodies to receptor for advanced glycation end products (rage) and uses thereof |
UY33253A (es) | 2010-03-03 | 2011-09-30 | Boehringer Ingelheim Int | Polipéptidos de unión a a-beta |
CA2795734A1 (en) * | 2010-04-07 | 2011-10-13 | Abbvie Inc. | Tnf-.alpha. binding proteins |
MX336196B (es) | 2010-04-15 | 2016-01-11 | Abbvie Inc | Proteinas de union a amiloide beta. |
US9320793B2 (en) * | 2010-07-14 | 2016-04-26 | Acumen Pharmaceuticals, Inc. | Method for treating a disease associated with soluble, oligomeric species of amyloid beta 1-42 |
EP2598882B1 (en) | 2010-07-30 | 2017-07-26 | AC Immune S.A. | Safe and functional humanized antibodies for use in treating an amyloidosis |
MX358739B (es) | 2010-08-14 | 2018-09-03 | Abbvie Inc Star | Proteinas de union a amiloide beta. |
US9078878B2 (en) | 2010-12-01 | 2015-07-14 | Alderbio Holdings Llc | Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75 |
US9067988B2 (en) | 2010-12-01 | 2015-06-30 | Alderbio Holdings Llc | Methods of preventing or treating pain using anti-NGF antibodies |
US9539324B2 (en) | 2010-12-01 | 2017-01-10 | Alderbio Holdings, Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
US9884909B2 (en) | 2010-12-01 | 2018-02-06 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
US11214610B2 (en) | 2010-12-01 | 2022-01-04 | H. Lundbeck A/S | High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris |
US9783601B2 (en) | 2010-12-01 | 2017-10-10 | Alderbio Holdings Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
CN102516360B (zh) * | 2011-12-08 | 2013-11-06 | 清华大学 | 一种抑制β分泌酶酶切作用的多肽及其应用 |
WO2013177035A2 (en) | 2012-05-24 | 2013-11-28 | Alexion Pharmaceuticals, Inc. | Humaneered anti-factor b antibody |
HUE048780T2 (hu) | 2012-08-16 | 2020-09-28 | Ipierian Inc | Tauopátia kezelésére szolgáló módszerek |
WO2014060444A1 (en) | 2012-10-15 | 2014-04-24 | Medimmune Limited | Antibodies to amyloid beta |
EP3104870A4 (en) * | 2014-02-14 | 2017-09-13 | Ipierian, Inc. | Tau peptides, anti-tau antibodies, and methods of use thereof |
HUE053366T2 (hu) | 2015-11-03 | 2021-06-28 | Janssen Biotech Inc | Szubkután anti-CD38-ellenanyag-készítmények és alkalmazásuk |
CA3147239A1 (en) * | 2019-07-16 | 2021-01-21 | Sanofi | Neutralizing anti-amyloid beta antibodies for the treatment of alzheimer's disease |
CN117589996A (zh) * | 2022-08-09 | 2024-02-23 | 深圳智源生物医药有限公司 | 强毒性淀粉样蛋白寡聚体的诊断用途 |
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-
2008
- 2008-05-29 PE PE2008000921A patent/PE20090329A1/es not_active Application Discontinuation
- 2008-05-29 US US12/129,469 patent/US20090175847A1/en not_active Abandoned
- 2008-05-30 KR KR1020097027470A patent/KR20100032398A/ko not_active Application Discontinuation
- 2008-05-30 TW TW097120376A patent/TW200914465A/zh unknown
- 2008-05-30 JP JP2010510504A patent/JP2010530740A/ja not_active Withdrawn
- 2008-05-30 UY UY31114A patent/UY31114A1/es not_active Application Discontinuation
- 2008-05-30 EP EP08769847A patent/EP2150563A1/en not_active Withdrawn
- 2008-05-30 AR ARP080102298A patent/AR066794A1/es unknown
- 2008-05-30 WO PCT/US2008/065205 patent/WO2008150949A1/en active Application Filing
- 2008-05-30 MX MX2009012950A patent/MX2009012950A/es not_active Application Discontinuation
- 2008-05-30 BR BRPI0812005A patent/BRPI0812005A2/pt not_active IP Right Cessation
- 2008-05-30 CL CL2008001580A patent/CL2008001580A1/es unknown
- 2008-05-30 PA PA20088782201A patent/PA8782201A1/es unknown
- 2008-05-30 CN CN200880101484A patent/CN101827862A/zh active Pending
- 2008-05-30 AU AU2008260062A patent/AU2008260062A1/en not_active Abandoned
- 2008-05-30 RU RU2009149370/10A patent/RU2009149370A/ru unknown
- 2008-05-30 CA CA002687414A patent/CA2687414A1/en not_active Abandoned
-
2009
- 2009-11-19 IL IL202243A patent/IL202243A0/en unknown
- 2009-11-27 DO DO2009000269A patent/DOP2009000269A/es unknown
- 2009-12-18 CR CR11179A patent/CR11179A/es not_active Application Discontinuation
- 2009-12-21 CO CO09145798A patent/CO6251291A2/es not_active Application Discontinuation
- 2009-12-29 EC EC2009009833A patent/ECSP099833A/es unknown
Also Published As
Publication number | Publication date |
---|---|
BRPI0812005A2 (pt) | 2019-09-24 |
KR20100032398A (ko) | 2010-03-25 |
WO2008150949A1 (en) | 2008-12-11 |
CA2687414A1 (en) | 2008-12-11 |
EP2150563A1 (en) | 2010-02-10 |
JP2010530740A (ja) | 2010-09-16 |
US20090175847A1 (en) | 2009-07-09 |
TW200914465A (en) | 2009-04-01 |
AU2008260062A1 (en) | 2008-12-11 |
CR11179A (es) | 2010-05-27 |
UY31114A1 (es) | 2009-01-05 |
RU2009149370A (ru) | 2011-07-10 |
CN101827862A (zh) | 2010-09-08 |
AR066794A1 (es) | 2009-09-09 |
DOP2009000269A (es) | 2009-12-15 |
PA8782201A1 (es) | 2009-02-09 |
CL2008001580A1 (es) | 2008-12-05 |
IL202243A0 (en) | 2010-06-16 |
MX2009012950A (es) | 2010-03-26 |
ECSP099833A (es) | 2010-01-29 |
CO6251291A2 (es) | 2011-02-21 |
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