PA8782201A1 - Anticuerpo humanizados contra el globulómero ab(20-42) y sus usos - Google Patents
Anticuerpo humanizados contra el globulómero ab(20-42) y sus usosInfo
- Publication number
- PA8782201A1 PA8782201A1 PA20088782201A PA8782201A PA8782201A1 PA 8782201 A1 PA8782201 A1 PA 8782201A1 PA 20088782201 A PA20088782201 A PA 20088782201A PA 8782201 A PA8782201 A PA 8782201A PA 8782201 A1 PA8782201 A1 PA 8782201A1
- Authority
- PA
- Panama
- Prior art keywords
- globulomer
- humanized antibody
- antibody against
- alzheimer
- diagnosis
- Prior art date
Links
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
Abstract
PROTEÍNAS DE UNIÓN, Y EN PARTICULAR, ANTICUERPOS HUMANIZADOS QUE PUEDEN USARSE, POR EJEMPLO, EN EL DIAGNÓSTICO, EL TRATAMIENTO Y LA PREVENCIÓN DE LA ENFERMEDAD DE ALZHEIMER Y CONDICIONES RELACIONADAS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US94093207P | 2007-05-30 | 2007-05-30 | |
US99035907P | 2007-11-27 | 2007-11-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
PA8782201A1 true PA8782201A1 (es) | 2009-02-09 |
Family
ID=39791050
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PA20088782201A PA8782201A1 (es) | 2007-05-30 | 2008-05-30 | Anticuerpo humanizados contra el globulómero ab(20-42) y sus usos |
Country Status (22)
Country | Link |
---|---|
US (1) | US20090175847A1 (es) |
EP (1) | EP2150563A1 (es) |
JP (1) | JP2010530740A (es) |
KR (1) | KR20100032398A (es) |
CN (1) | CN101827862A (es) |
AR (1) | AR066794A1 (es) |
AU (1) | AU2008260062A1 (es) |
BR (1) | BRPI0812005A2 (es) |
CA (1) | CA2687414A1 (es) |
CL (1) | CL2008001580A1 (es) |
CO (1) | CO6251291A2 (es) |
CR (1) | CR11179A (es) |
DO (1) | DOP2009000269A (es) |
EC (1) | ECSP099833A (es) |
IL (1) | IL202243A0 (es) |
MX (1) | MX2009012950A (es) |
PA (1) | PA8782201A1 (es) |
PE (1) | PE20090329A1 (es) |
RU (1) | RU2009149370A (es) |
TW (1) | TW200914465A (es) |
UY (1) | UY31114A1 (es) |
WO (1) | WO2008150949A1 (es) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
US7920906B2 (en) | 2005-03-10 | 2011-04-05 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
US9247900B2 (en) | 2004-07-13 | 2016-02-02 | Dexcom, Inc. | Analyte sensor |
PT1713503E (pt) * | 2004-02-10 | 2013-11-14 | Nat Jewish Health | Inibição do factor b, a via alternativa do complemento e métodos relacionados |
US20060270922A1 (en) | 2004-07-13 | 2006-11-30 | Brauker James H | Analyte sensor |
US7713574B2 (en) | 2004-07-13 | 2010-05-11 | Dexcom, Inc. | Transcutaneous analyte sensor |
ES2429541T3 (es) | 2004-11-16 | 2013-11-15 | Kalobios Pharmaceuticals, Inc. | Intercambio de casete de región variable de inmunoglobulina |
CN101227924A (zh) * | 2005-05-26 | 2008-07-23 | 科罗拉多大学评议会 | 用于治疗外伤性脑损伤、脊髓损伤及相关病症的补体旁路抑制 |
EP1976877B2 (en) | 2005-11-30 | 2016-10-05 | AbbVie Inc. | Monoclonal antibodies against amyloid beta protein and uses thereof |
DK1954718T3 (en) | 2005-11-30 | 2014-12-15 | Abbvie Inc | Anti-A-globulomer antibodies antigenbindingsgrupper thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods for producing said antibodies, |
MX358175B (es) * | 2005-12-12 | 2018-08-08 | Ac Immune Sa | Anticuerpos monoclonales especificos 1-42 beta con propiedades terapeuticas. |
WO2008011348A2 (en) | 2006-07-14 | 2008-01-24 | Ac Immune S.A. | Humanized antibody against amyloid beta |
US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
EP2486928A1 (en) | 2007-02-27 | 2012-08-15 | Abbott GmbH & Co. KG | Method for the treatment of amyloidoses |
CA2680344A1 (en) * | 2007-03-14 | 2008-11-20 | Woodruff Emlen | Humaneered anti-factor b antibody |
US8613923B2 (en) | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
US8048420B2 (en) | 2007-06-12 | 2011-11-01 | Ac Immune S.A. | Monoclonal antibody |
SG178809A1 (en) * | 2007-10-05 | 2012-03-29 | Genentech Inc | Use of anti-amyloid beta antibody in ocular diseases |
CA2701793C (en) | 2007-10-05 | 2017-04-25 | Genentech, Inc. | Use of anti-amyloid beta antibody in ocular diseases |
KR101649168B1 (ko) | 2008-05-09 | 2016-08-18 | 애브비 인코포레이티드 | 최종 당화 산물의 수용체(rage)에 대한 항체 및 이의 용도 |
ME01699B (me) | 2009-07-02 | 2014-09-20 | Musc Found For Res Dev | Metode za stimulaciju regeneracije jetre |
AU2013202020B2 (en) * | 2009-07-31 | 2014-11-27 | F. Hoffmann-La Roche Ag | Subcutaneous anti-HER2 antibody formulation |
US9345661B2 (en) * | 2009-07-31 | 2016-05-24 | Genentech, Inc. | Subcutaneous anti-HER2 antibody formulations and uses thereof |
AR078161A1 (es) | 2009-09-11 | 2011-10-19 | Hoffmann La Roche | Formulaciones farmaceuticas muy concentradas de un anticuerpo anti cd20. uso de la formulacion. metodo de tratamiento. |
US8420083B2 (en) | 2009-10-31 | 2013-04-16 | Abbvie Inc. | Antibodies to receptor for advanced glycation end products (RAGE) and uses thereof |
PE20130527A1 (es) | 2010-03-03 | 2013-05-09 | Boehringer Ingelheim Int | Polipeptidos de union a a-beta biparatopicos |
KR20130010123A (ko) | 2010-04-07 | 2013-01-25 | 아비에 인코포레이티드 | TNF-α 결합 단백질 |
CA2796339C (en) * | 2010-04-15 | 2020-03-31 | Abbott Laboratories | Amyloid-beta binding proteins |
US9320793B2 (en) * | 2010-07-14 | 2016-04-26 | Acumen Pharmaceuticals, Inc. | Method for treating a disease associated with soluble, oligomeric species of amyloid beta 1-42 |
CN103179981B (zh) | 2010-07-30 | 2017-02-08 | Ac免疫有限公司 | 安全和功能性的人源化抗β‑淀粉样蛋白抗体 |
US9062101B2 (en) | 2010-08-14 | 2015-06-23 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
US9884909B2 (en) | 2010-12-01 | 2018-02-06 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
US9539324B2 (en) | 2010-12-01 | 2017-01-10 | Alderbio Holdings, Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
US11214610B2 (en) | 2010-12-01 | 2022-01-04 | H. Lundbeck A/S | High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris |
US9078878B2 (en) | 2010-12-01 | 2015-07-14 | Alderbio Holdings Llc | Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75 |
KR20190112175A (ko) | 2010-12-01 | 2019-10-02 | 앨더바이오 홀딩스 엘엘씨 | 항―ngf 조성물 및 그의 용도 |
US9067988B2 (en) | 2010-12-01 | 2015-06-30 | Alderbio Holdings Llc | Methods of preventing or treating pain using anti-NGF antibodies |
CN102516360B (zh) * | 2011-12-08 | 2013-11-06 | 清华大学 | 一种抑制β分泌酶酶切作用的多肽及其应用 |
WO2013177035A2 (en) | 2012-05-24 | 2013-11-28 | Alexion Pharmaceuticals, Inc. | Humaneered anti-factor b antibody |
CA2882034C (en) | 2012-08-16 | 2019-10-29 | Ipierian, Inc. | Methods of treating a tauopathy |
CA2888322A1 (en) * | 2012-10-15 | 2014-04-24 | Medimmune Limited | Antibodies to amyloid beta |
EP3104870A4 (en) * | 2014-02-14 | 2017-09-13 | Ipierian, Inc. | Tau peptides, anti-tau antibodies, and methods of use thereof |
PT3370770T (pt) | 2015-11-03 | 2021-02-22 | Janssen Biotech Inc | Formulações subcutâneas de anticorpos anti-cd38 e suas utilizações |
KR20220034857A (ko) * | 2019-07-16 | 2022-03-18 | 사노피 | 알츠하이머병의 치료를 위한 중화 항-아밀로이드 베타 항체 |
CN117589996A (zh) * | 2022-08-09 | 2024-02-23 | 深圳智源生物医药有限公司 | 强毒性淀粉样蛋白寡聚体的诊断用途 |
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-
2008
- 2008-05-29 PE PE2008000921A patent/PE20090329A1/es not_active Application Discontinuation
- 2008-05-29 US US12/129,469 patent/US20090175847A1/en not_active Abandoned
- 2008-05-30 WO PCT/US2008/065205 patent/WO2008150949A1/en active Application Filing
- 2008-05-30 EP EP08769847A patent/EP2150563A1/en not_active Withdrawn
- 2008-05-30 MX MX2009012950A patent/MX2009012950A/es not_active Application Discontinuation
- 2008-05-30 PA PA20088782201A patent/PA8782201A1/es unknown
- 2008-05-30 CL CL2008001580A patent/CL2008001580A1/es unknown
- 2008-05-30 AU AU2008260062A patent/AU2008260062A1/en not_active Abandoned
- 2008-05-30 AR ARP080102298A patent/AR066794A1/es unknown
- 2008-05-30 TW TW097120376A patent/TW200914465A/zh unknown
- 2008-05-30 BR BRPI0812005A patent/BRPI0812005A2/pt not_active IP Right Cessation
- 2008-05-30 RU RU2009149370/10A patent/RU2009149370A/ru unknown
- 2008-05-30 CN CN200880101484A patent/CN101827862A/zh active Pending
- 2008-05-30 KR KR1020097027470A patent/KR20100032398A/ko not_active Application Discontinuation
- 2008-05-30 CA CA002687414A patent/CA2687414A1/en not_active Abandoned
- 2008-05-30 JP JP2010510504A patent/JP2010530740A/ja not_active Withdrawn
- 2008-05-30 UY UY31114A patent/UY31114A1/es not_active Application Discontinuation
-
2009
- 2009-11-19 IL IL202243A patent/IL202243A0/en unknown
- 2009-11-27 DO DO2009000269A patent/DOP2009000269A/es unknown
- 2009-12-18 CR CR11179A patent/CR11179A/es not_active Application Discontinuation
- 2009-12-21 CO CO09145798A patent/CO6251291A2/es not_active Application Discontinuation
- 2009-12-29 EC EC2009009833A patent/ECSP099833A/es unknown
Also Published As
Publication number | Publication date |
---|---|
CO6251291A2 (es) | 2011-02-21 |
TW200914465A (en) | 2009-04-01 |
AU2008260062A1 (en) | 2008-12-11 |
ECSP099833A (es) | 2010-01-29 |
CR11179A (es) | 2010-05-27 |
MX2009012950A (es) | 2010-03-26 |
CA2687414A1 (en) | 2008-12-11 |
CN101827862A (zh) | 2010-09-08 |
BRPI0812005A2 (pt) | 2019-09-24 |
AR066794A1 (es) | 2009-09-09 |
UY31114A1 (es) | 2009-01-05 |
CL2008001580A1 (es) | 2008-12-05 |
IL202243A0 (en) | 2010-06-16 |
RU2009149370A (ru) | 2011-07-10 |
EP2150563A1 (en) | 2010-02-10 |
US20090175847A1 (en) | 2009-07-09 |
KR20100032398A (ko) | 2010-03-25 |
PE20090329A1 (es) | 2009-03-27 |
WO2008150949A1 (en) | 2008-12-11 |
JP2010530740A (ja) | 2010-09-16 |
DOP2009000269A (es) | 2009-12-15 |
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