CL2016000215A1 - Terapia y diagnóstico basado en proteínas de patología mediada por tau en enfermedad de alzheimer (divisional de sol. n° 679-14). - Google Patents
Terapia y diagnóstico basado en proteínas de patología mediada por tau en enfermedad de alzheimer (divisional de sol. n° 679-14).Info
- Publication number
- CL2016000215A1 CL2016000215A1 CL2016000215A CL2016000215A CL2016000215A1 CL 2016000215 A1 CL2016000215 A1 CL 2016000215A1 CL 2016000215 A CL2016000215 A CL 2016000215A CL 2016000215 A CL2016000215 A CL 2016000215A CL 2016000215 A1 CL2016000215 A1 CL 2016000215A1
- Authority
- CL
- Chile
- Prior art keywords
- tau
- alzheimer
- therapy
- protein
- disease
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0007—Nervous system antigens; Prions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6843—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6081—Albumin; Keyhole limpet haemocyanin [KLH]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Abstract
<p>ANTICUERPO QUE SE UNE A UNO O MÁS EPÍTOPOS DE TAU; ÁCIDO NUCLEICO QUE CODIFICA EL DOMINIO DE UNIÓN O REGIÓN VARIABLE DE DICHO ANTICUERPO; VECTOR; CÉLULA HOSPEDADORA; LÍNEA CELULAR AISLADA O HIBRIDOMA; COMPOSICIÓN FARMACÉUTICA; DISPOSITIVO MÉDICO QUE COMPRENDE AL ANTICUERPO; Y USO PARA TRATAR ALZHEIMER O TAUOPATÍAS RELACIONADAS (DIVISIONAL DE SOL. N° 679-14).</p>
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161536339P | 2011-09-19 | 2011-09-19 | |
US201261653115P | 2012-05-30 | 2012-05-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2016000215A1 true CL2016000215A1 (es) | 2017-08-18 |
Family
ID=47216372
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2014000679A CL2014000679A1 (es) | 2011-09-19 | 2014-03-19 | Anticuerpo de unión a tau; vector; célula hospedadora; hibridoma; péptido que comprende epítope de tau; composición farmacéutica que comprende al anticuerpo o al péptido de tau; dispositivo médico para administrarlos; uso para tratar, prevenir o diagnosticar enfermedad de alzheimer o tautología relacionada; y método para producir anticuerpo |
CL2015001314A CL2015001314A1 (es) | 2011-09-19 | 2015-05-14 | Anticuerpo de unión a tau; vector; célula hospedadora; hibridoma; péptido que comprende epítope de tau; composición farmacéutica que comprende al anticuerpo o al péptido de tau; dispositivo médico para administrarlos; y uso para tratar, prevenir o diagnosticar enfermedad de alzheimer o tautología relacionada (div. sol. n° 679-14). |
CL2016000215A CL2016000215A1 (es) | 2011-09-19 | 2016-01-27 | Terapia y diagnóstico basado en proteínas de patología mediada por tau en enfermedad de alzheimer (divisional de sol. n° 679-14). |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2014000679A CL2014000679A1 (es) | 2011-09-19 | 2014-03-19 | Anticuerpo de unión a tau; vector; célula hospedadora; hibridoma; péptido que comprende epítope de tau; composición farmacéutica que comprende al anticuerpo o al péptido de tau; dispositivo médico para administrarlos; uso para tratar, prevenir o diagnosticar enfermedad de alzheimer o tautología relacionada; y método para producir anticuerpo |
CL2015001314A CL2015001314A1 (es) | 2011-09-19 | 2015-05-14 | Anticuerpo de unión a tau; vector; célula hospedadora; hibridoma; péptido que comprende epítope de tau; composición farmacéutica que comprende al anticuerpo o al péptido de tau; dispositivo médico para administrarlos; y uso para tratar, prevenir o diagnosticar enfermedad de alzheimer o tautología relacionada (div. sol. n° 679-14). |
Country Status (30)
Country | Link |
---|---|
US (5) | US9518101B2 (es) |
EP (2) | EP3275461A1 (es) |
JP (7) | JP6253583B2 (es) |
KR (3) | KR20210099167A (es) |
CN (3) | CN115417916A (es) |
AU (3) | AU2012311234B2 (es) |
BR (1) | BR112014006376B1 (es) |
CA (1) | CA2848346A1 (es) |
CL (3) | CL2014000679A1 (es) |
CY (1) | CY1119792T1 (es) |
DK (1) | DK2758433T3 (es) |
ES (1) | ES2656442T3 (es) |
HK (1) | HK1199459A1 (es) |
HR (1) | HRP20180083T8 (es) |
HU (1) | HUE036177T2 (es) |
IL (4) | IL231201B (es) |
LT (1) | LT2758433T (es) |
ME (1) | ME03008B (es) |
MX (1) | MX347505B (es) |
MY (1) | MY183989A (es) |
PL (1) | PL2758433T3 (es) |
PT (1) | PT2758433T (es) |
RS (1) | RS56852B1 (es) |
RU (2) | RU2018102103A (es) |
SG (4) | SG10201912964PA (es) |
SI (1) | SI2758433T1 (es) |
TR (1) | TR201800669T4 (es) |
UA (2) | UA123390C2 (es) |
WO (1) | WO2013041962A1 (es) |
ZA (1) | ZA201401333B (es) |
Families Citing this family (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2826286C (en) * | 2011-01-31 | 2021-09-21 | Intellect Neurosciences Inc. | Treatment of tauopathies |
EP2870176A4 (en) | 2012-07-03 | 2016-09-28 | Univ Washington | ANTIBODIES DIRECTED AGAINST TAU |
US9567395B2 (en) | 2012-08-16 | 2017-02-14 | Ipierian, Inc. | Methods of treating a tauopathy |
US8980270B2 (en) | 2013-01-18 | 2015-03-17 | Ipierian, Inc. | Methods of treating a tauopathy |
AU2014248515B2 (en) | 2013-03-13 | 2019-03-07 | Prothena Biosciences Limited | Tau immunotherapy |
CN111569063A (zh) * | 2013-11-27 | 2020-08-25 | 伊皮埃里安股份有限公司 | 治疗tau病变的方法 |
US10981953B2 (en) * | 2013-12-26 | 2021-04-20 | Toagosei Co, Ltd. | Method for promoting expression of calreticulin, and synthetic peptide for use in method for promoting expression of calreticulin |
JP2017512751A (ja) | 2014-02-14 | 2017-05-25 | アイピエリアン,インコーポレイティド | タウペプチド、抗タウ抗体、およびそれらの使用方法 |
EA036307B1 (ru) | 2014-06-26 | 2020-10-23 | Янссен Вэксинс Энд Превеншн Б.В. | Антитела и антигенсвязывающие фрагменты, которые специфично связываются с белком тау, ассоциированным с микротрубочками |
ZA201608812B (en) | 2014-06-26 | 2019-08-28 | Janssen Vaccines & Prevention Bv | Antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau |
TWI734975B (zh) | 2014-06-27 | 2021-08-01 | 美商C2N醫療診斷有限責任公司 | 人類化抗-tau抗體 |
US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
KR102502356B1 (ko) | 2014-09-30 | 2023-02-21 | 워싱턴 유니버시티 | 타우 (tau) 활동 계측 |
EP3221349B1 (en) | 2014-11-19 | 2020-11-04 | Axon Neuroscience SE | Humanized tau antibodies in alzheimer's disease |
JO3576B1 (ar) * | 2015-02-26 | 2020-07-05 | Lilly Co Eli | أجسام مضادة لـ tau واستخداماتها |
CN107849124B (zh) | 2015-06-05 | 2021-09-24 | 基因泰克公司 | 抗tau抗体及使用方法 |
MX2017015817A (es) | 2015-07-06 | 2018-04-10 | Ucb Biopharma Sprl | Anticuerpos de union a tau. |
AU2016289753C1 (en) | 2015-07-06 | 2021-08-05 | UCB Biopharma SRL | Tau-binding antibodies |
JO3711B1 (ar) * | 2015-07-13 | 2021-01-31 | H Lundbeck As | أجسام مضادة محددة لبروتين تاو وطرق استعمالها |
GB201518675D0 (en) * | 2015-10-21 | 2015-12-02 | Cellcap Technologies Ltd | Detection of structural forms of proteins |
WO2017189959A1 (en) | 2016-04-29 | 2017-11-02 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
WO2017189964A2 (en) | 2016-04-29 | 2017-11-02 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
KR20230070336A (ko) | 2016-05-02 | 2023-05-22 | 프로테나 바이오사이언시즈 리미티드 | 타우 인식 항체 |
EP3452507B1 (en) | 2016-05-02 | 2022-10-19 | Prothena Biosciences Limited | Tau immunotherapy |
EA201892417A1 (ru) * | 2016-05-02 | 2019-05-31 | Протена Биосайенсис Лимитед | Антитела, распознающие тау |
SG11201809699XA (en) | 2016-05-18 | 2018-12-28 | Voyager Therapeutics Inc | Modulatory polynucleotides |
KR101997319B1 (ko) | 2016-06-21 | 2019-07-08 | 전남대학교산학협력단 | 이형태체 항원인식 항체 생산을 유도하는 플라젤린 백신보조제 기반의 백신의 제조 및 그 응용 |
WO2018031361A2 (en) | 2016-08-09 | 2018-02-15 | Eli Lilly And Company | Combination therapy |
FR3058143B1 (fr) * | 2016-10-27 | 2021-03-12 | Univ Grenoble Alpes | Nanocorps anti-tau |
CN117820467A (zh) | 2016-12-07 | 2024-04-05 | 基因泰克公司 | 抗tau抗体和使用方法 |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
CA3044679A1 (en) | 2016-12-07 | 2018-06-14 | Genentech, Inc. | Anti-tau antibodies and methods of use |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
KR102032314B1 (ko) * | 2016-12-21 | 2019-10-16 | 주식회사 아델 | 변이된 타우 단백질 단편 및 이의 용도 |
WO2018152359A1 (en) | 2017-02-17 | 2018-08-23 | Denali Therapeutics Inc. | Anti-tau antibodies and methods of use thereof |
JP7109467B2 (ja) * | 2017-03-28 | 2022-07-29 | ヤンセン ファッシンズ アンド プリベンション ベーフェー | タウに特異的に結合する結合分子 |
WO2018195376A1 (en) * | 2017-04-21 | 2018-10-25 | Ohio University | Peptide-based inhibitors of mark family proteins |
AU2018263935A1 (en) | 2017-05-02 | 2019-12-19 | Prothena Biosciences Limited | Antibodies recognizing tau |
JP7029718B2 (ja) * | 2017-07-31 | 2022-03-04 | 国立研究開発法人量子科学技術研究開発機構 | リン酸化タウタンパク質の測定方法 |
CA3076242A1 (en) | 2017-10-02 | 2019-04-11 | Blackthorn Therapeutics, Inc. | Methods and systems for computer-generated predictive application of neuroimaging and gene expression mapping data |
KR20200058480A (ko) | 2017-10-16 | 2020-05-27 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 항-타우 항체 및 그의 용도 |
TW202333768A (zh) | 2017-10-25 | 2023-09-01 | 美商健生醫藥公司 | Tau胜肽之組成物及其用途 |
WO2019120527A1 (en) * | 2017-12-20 | 2019-06-27 | Michael Heneka | Novel means and methods for treating neurodegenerative diseases |
WO2019175735A1 (en) | 2018-03-11 | 2019-09-19 | Koorosh Shahpasand | Conformation-independent antibodies against neurotoxic tau proteins |
CA3095443A1 (en) * | 2018-03-28 | 2019-10-03 | Axon Neuroscience Se | Antibody-based methods of detecting and treating alzheimer's disease |
RU2679059C1 (ru) * | 2018-04-17 | 2019-02-05 | Александр Олегович Морозов | Пептид и способ лечения болезни альцгеймера |
RU2679080C1 (ru) * | 2018-04-17 | 2019-02-05 | Александр Олегович Морозов | Пептид и способ лечения болезни альцгеймера |
US11085935B2 (en) | 2018-05-03 | 2021-08-10 | Washington University | Methods of treating based on site-specific tau phosphorylation |
AU2019262220A1 (en) * | 2018-05-03 | 2020-11-12 | Washington University | Methods of diagnosing and treating based on site-specific tau phosphorylation |
JP7102557B2 (ja) | 2018-07-03 | 2022-07-19 | エフ.ホフマン-ラ ロシュ アーゲー | Tau発現調節用オリゴヌクレオチド |
JP2021530552A (ja) | 2018-07-31 | 2021-11-11 | イーライ リリー アンド カンパニー | 併用療法 |
EP3877410A4 (en) * | 2018-11-08 | 2022-08-10 | Prothena Biosciences Limited | ANTIBODIES FOR DETECTING TAU |
WO2020106598A1 (en) * | 2018-11-19 | 2020-05-28 | The Board Of Regents Of The University Of Texas System | Tau peptide antigens and antibodies binding thereto for the treatment of tauopathies |
SG11202106717PA (en) * | 2019-02-08 | 2021-07-29 | Prothena Biosciences Ltd | Antibodies recognizing tau |
JP2022524588A (ja) | 2019-03-03 | 2022-05-09 | プロセナ バイオサイエンシーズ リミテッド | タウ認識抗体 |
US20220177558A1 (en) * | 2019-03-25 | 2022-06-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Treatment of taupathy disorders by targeting new tau species |
KR102633666B1 (ko) * | 2019-05-31 | 2024-02-06 | 일라이 릴리 앤드 캄파니 | 인간 타우를 표적화하는 화합물 및 방법 |
GB201909393D0 (en) | 2019-06-28 | 2019-08-14 | Gen2 Neuroscience Ltd | Tau epitope and binding molecules |
WO2021024209A1 (en) * | 2019-08-06 | 2021-02-11 | Aprinoia Therapeutics Inc. | Antibodies that bind to pathological tau species and uses thereof |
AU2020331020A1 (en) * | 2019-08-13 | 2022-03-03 | Washington University | Methods to detect MTBR tau isoforms and use thereof |
US20220275038A1 (en) * | 2019-08-15 | 2022-09-01 | Tokyo Medical University | Clsp derivative incapable of being affected by clsp inhibiting substance, and clsp activity enhancing/protecting agent |
MX2022002852A (es) | 2019-09-09 | 2022-03-25 | Axon Neuroscience Se | Biomarcadores y tratamientos de la enfermedad de alzheimer y deterioro cognitivo leve. |
IL270800A (en) * | 2019-11-20 | 2021-05-31 | Yeda Res & Dev | A method for treating Alzheimer's disease |
CN110841059A (zh) * | 2019-12-03 | 2020-02-28 | 南通大学 | 老年性痴呆小鼠模型的制备方法 |
KR20220137674A (ko) * | 2020-02-05 | 2022-10-12 | 스미토모 파마 가부시키가이샤 | 타우병증 및 인지증 관련 질환의 판정약 및 판정 방법 |
EP4252243A2 (en) | 2020-11-30 | 2023-10-04 | Enigma Biointelligence, Inc. | Non-invasive assessment of alzheimer's disease |
EP4291234A1 (en) * | 2021-02-14 | 2023-12-20 | Prothena Biosciences Limited | Methods of using antibodies recognizing tau |
JP2024509683A (ja) * | 2021-02-19 | 2024-03-05 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 抗pt217 tau抗体 |
CN113430230A (zh) * | 2021-06-24 | 2021-09-24 | 南通大学 | tau截断体蛋白在诱导tau病理聚集中的应用 |
WO2023060276A1 (en) * | 2021-10-08 | 2023-04-13 | Arbele Limited | Compositions and methods for detecting cadherin-17 protein |
CN113861441A (zh) * | 2021-10-28 | 2021-12-31 | 南开大学 | 一种tau蛋白特异的纳米分子伴侣的制备方法及其在抑制tau聚集中的应用 |
WO2023092004A1 (en) | 2021-11-17 | 2023-05-25 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of tau-related disorders |
CN116554342A (zh) * | 2022-01-29 | 2023-08-08 | 元本(珠海横琴)生物科技有限公司 | 一种融合表达Tau-4R蛋白的大肠杆菌工程菌株 |
WO2023161526A1 (en) | 2022-02-28 | 2023-08-31 | Tridem Bioscience Gmbh & Co Kg | A CONJUGATE CONSISTING OF OR COMPRISING AT LEAST A ß-GLUCAN OR A MANNAN |
Family Cites Families (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4360019A (en) | 1979-02-28 | 1982-11-23 | Andros Incorporated | Implantable infusion device |
US4424200A (en) | 1979-05-14 | 1984-01-03 | Nuc Med Inc. | Method for radiolabeling proteins with technetium-99m |
US4692147A (en) | 1980-04-02 | 1987-09-08 | Medtronic, Inc. | Drug administration device |
US4479930A (en) | 1982-07-26 | 1984-10-30 | Trustees Of The University Of Massachusetts | Amines coupled wth dicyclic dianhydrides capable of being radiolabeled product |
US4487603A (en) | 1982-11-26 | 1984-12-11 | Cordis Corporation | Implantable microinfusion pump system |
US5208036A (en) | 1985-01-07 | 1993-05-04 | Syntex (U.S.A.) Inc. | N-(ω, (ω-1)-dialkyloxy)- and N-(ω, (ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
US4725852A (en) | 1985-05-09 | 1988-02-16 | Burlington Industries, Inc. | Random artificially perturbed liquid apparatus and method |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
US5811310A (en) * | 1986-09-30 | 1998-09-22 | Albert Einstein College Of Medicine Of Yeshiva Univ. | The Alz-50 monoclonal antibody and diagnostic assay for alzheimer's disease |
EP0623679B1 (en) | 1987-05-21 | 2003-06-25 | Micromet AG | Targeted multifunctional proteins |
US5202238A (en) | 1987-10-27 | 1993-04-13 | Oncogen | Production of chimeric antibodies by homologous recombination |
US5204244A (en) | 1987-10-27 | 1993-04-20 | Oncogen | Production of chimeric antibodies by homologous recombination |
JPH02503867A (ja) | 1988-04-15 | 1990-11-15 | プロテイン デザイン ラブズ インコーポレーテッド | Il‐2レセプター特異的キメラ抗体 |
JP2919890B2 (ja) | 1988-11-11 | 1999-07-19 | メディカル リサーチ カウンスル | 単一ドメインリガンド、そのリガンドからなる受容体、その製造方法、ならびにそのリガンドおよび受容体の使用 |
IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
JPH0832638B2 (ja) | 1989-05-25 | 1996-03-29 | カイロン コーポレイション | サブミクロン油滴乳剤を含んで成るアジュバント製剤 |
US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
AU638762B2 (en) | 1989-10-05 | 1993-07-08 | Optein Inc | Cell-free synthesis and isolation of novel genes and polypeptides |
US5279833A (en) | 1990-04-04 | 1994-01-18 | Yale University | Liposomal transfection of nucleic acids into animal cells |
US5264618A (en) | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
GB9020282D0 (en) | 1990-09-17 | 1990-10-31 | Gorman Scott D | Altered antibodies and their preparation |
US6277969B1 (en) | 1991-03-18 | 2001-08-21 | New York University | Anti-TNF antibodies and peptides of human tumor necrosis factor |
DE4122599C2 (de) | 1991-07-08 | 1993-11-11 | Deutsches Krebsforsch | Phagemid zum Screenen von Antikörpern |
US5283185A (en) | 1991-08-28 | 1994-02-01 | University Of Tennessee Research Corporation | Method for delivering nucleic acids into cells |
ATE386115T1 (de) * | 1991-12-06 | 2008-03-15 | Max Planck Gesellschaft | Verwendung von proteinkinasen zur diagnose und behandlung der alzheimer krankheit |
AU6014094A (en) | 1992-12-02 | 1994-06-22 | Baylor College Of Medicine | Episomal vectors for gene therapy |
JPH09501936A (ja) | 1993-08-26 | 1997-02-25 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 生物活性ペプチドをコードする裸のポリヌクレオチドを投与するための方法、組成物および装置 |
US5505947A (en) | 1994-05-27 | 1996-04-09 | The University Of North Carolina At Chapel Hill | Attenuating mutations in Venezuelan Equine Encephalitis virus |
EP0791067B1 (en) * | 1994-10-28 | 2008-12-17 | Max-Planck-Gesellschaft Zur Förderung Der Wissenschaften E.V. | Protein kinase npk-110 |
GB9506197D0 (en) | 1995-03-27 | 1995-05-17 | Hoffmann La Roche | Inhibition of tau-tau association. |
US5643207A (en) | 1995-04-28 | 1997-07-01 | Medtronic, Inc. | Implantable techniques for infusing a therapeutic agent with endogenous bodily fluid |
US7153510B1 (en) | 1995-05-04 | 2006-12-26 | Yale University | Recombinant vesiculoviruses and their uses |
DK0859959T3 (da) | 1995-11-10 | 2003-11-24 | Elan Corp Plc | Peptider, som øger transporten over væv, og fremgangsmåder til identificering og anvendelse af disse |
US5820589A (en) | 1996-04-30 | 1998-10-13 | Medtronic, Inc. | Implantable non-invasive rate-adjustable pump |
AUPP221098A0 (en) | 1998-03-06 | 1998-04-02 | Diatech Pty Ltd | V-like domain binding molecules |
AU1631700A (en) | 1998-11-23 | 2000-06-13 | Idec Pharmaceuticals Corporation | Tumor antigen-specific antibody-gp39 chimeric protein constructs |
US6198966B1 (en) | 1999-02-26 | 2001-03-06 | Medtronic, Inc. | Recirculating implantable drug delivery system |
JP3383618B2 (ja) | 1999-08-18 | 2003-03-04 | 松下電器産業株式会社 | 移動体通信端末装置及び受信強度検出方法 |
WO2001018544A1 (en) * | 1999-09-09 | 2001-03-15 | Mcgill University | Diagnosis, prognosis and treatment of trinucleotide repeat-associated diseases and intranuclear inclusions-associated diseases |
JP2003508788A (ja) * | 1999-09-09 | 2003-03-04 | マックス−プランク−ゲゼルシャフト ツール フォルデルング デル ヴィッセンシャフテン エー.ファウ. | ペアードヘリカルフィラメントの核形成のための最小タウペプチド |
US6589746B1 (en) | 1999-10-21 | 2003-07-08 | University Of Cincinnati | Method of detecting axonally-derived protein tau in patients with traumatic CNS injury |
AT500379B8 (de) * | 2001-02-02 | 2009-08-15 | Axon Neuroscience | Tau-proteine |
DE50111493D1 (de) | 2001-09-03 | 2007-01-04 | Bio Life Science Forschungs & Entwicklungsgesellschaft Mbh | Antigen-Mimotope und Vakzine gegen Krebserkrankungen |
TWI226905B (en) | 2001-10-19 | 2005-01-21 | Bioware Technology Co Ltd | Low pressure-accelerated particle gene gun |
CN100572392C (zh) | 2002-07-12 | 2009-12-23 | 阿克松神经科学研究和发展股份有限公司 | 截短tau蛋白 |
WO2004013172A2 (en) * | 2002-07-24 | 2004-02-12 | Innogenetics N.V. | Fragments of beta-amyloid as targets for vaccination against alzheimer disease |
EP1516930A1 (en) | 2003-09-16 | 2005-03-23 | Georg-August Universität Göttingen | Cellular model of tauopathies for lead identification and drug discovery |
US20050142609A1 (en) | 2003-10-08 | 2005-06-30 | Ebioscience | Native immunoglobulin binding reagents and methods for making and using same |
CN1721437A (zh) * | 2004-07-13 | 2006-01-18 | 中南大学 | 一种与Tau蛋白相关的多肽抗原及抗体 |
US8012936B2 (en) * | 2006-03-29 | 2011-09-06 | New York University | Tau fragments for immunotherapy |
US20070280935A1 (en) | 2006-04-07 | 2007-12-06 | Bernd Bohrmann | Antibody that recognizes phosphorylated peptides |
US8377875B2 (en) | 2007-01-11 | 2013-02-19 | Ramot At Tel-Aviv University Ltd. | Therapeutics based on tau/microtubule dynamics |
TR201802286T4 (tr) * | 2007-04-20 | 2018-03-21 | The Chemo Sero Therapeutic Res Institute | Peptidle bağışıklık yanıtının arttırılması için yöntem. |
WO2009000520A1 (en) | 2007-06-25 | 2008-12-31 | Universität Duisburg-Essen | Screening-method for polymorphic markers in htra1 gene in neurodegenerative disorders |
UA107571C2 (xx) * | 2009-04-03 | 2015-01-26 | Фармацевтична композиція | |
CN102596221B (zh) | 2009-06-10 | 2019-06-04 | 纽约大学 | 病理tau蛋白的免疫靶向 |
US8609097B2 (en) | 2009-06-10 | 2013-12-17 | Hoffmann-La Roche Inc. | Use of an anti-Tau pS422 antibody for the treatment of brain diseases |
JP6124591B2 (ja) * | 2009-08-28 | 2017-05-10 | ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム | タウオリゴマーに結合する抗体 |
WO2011053565A2 (en) | 2009-10-29 | 2011-05-05 | Biomedical Sciences Research Centre "Alexander Fleming" | Compositions and methods for detecting a tauopathy |
CN102791725A (zh) * | 2009-11-06 | 2012-11-21 | J.大卫格莱斯顿学会 | 调节tau水平的方法和组合物 |
EP2905332B1 (en) * | 2009-11-19 | 2018-09-12 | Solis BioDyne OÜ | Compositions for increasing polypeptide stability and activity, and related methods |
CL2010000019A1 (es) | 2010-01-11 | 2010-06-11 | Univ Chile | Anticuerpo monoclonal contra el tnf humano y sus fragmentos, secuencias nucleotidicas que lo codifican, vector de expresion y celulas que las contienen, composiciones y kit que comprenden el anticuerpo, uso de los mismos y metodo para su obtencion. |
-
2012
- 2012-09-14 ES ES12788639.8T patent/ES2656442T3/es active Active
- 2012-09-14 MX MX2014003357A patent/MX347505B/es active IP Right Grant
- 2012-09-14 SG SG10201912964PA patent/SG10201912964PA/en unknown
- 2012-09-14 CN CN202210373330.XA patent/CN115417916A/zh active Pending
- 2012-09-14 SG SG10201703771WA patent/SG10201703771WA/en unknown
- 2012-09-14 DK DK12788639.8T patent/DK2758433T3/en active
- 2012-09-14 RU RU2018102103A patent/RU2018102103A/ru unknown
- 2012-09-14 UA UAA201706478A patent/UA123390C2/uk unknown
- 2012-09-14 JP JP2014530333A patent/JP6253583B2/ja active Active
- 2012-09-14 RS RS20180054A patent/RS56852B1/sr unknown
- 2012-09-14 TR TR2018/00669T patent/TR201800669T4/tr unknown
- 2012-09-14 AU AU2012311234A patent/AU2012311234B2/en active Active
- 2012-09-14 US US14/345,561 patent/US9518101B2/en active Active
- 2012-09-14 KR KR1020217024024A patent/KR20210099167A/ko not_active Application Discontinuation
- 2012-09-14 HU HUE12788639A patent/HUE036177T2/hu unknown
- 2012-09-14 SI SI201231187T patent/SI2758433T1/en unknown
- 2012-09-14 EP EP17190247.1A patent/EP3275461A1/en active Pending
- 2012-09-14 SG SG11201400125RA patent/SG11201400125RA/en unknown
- 2012-09-14 LT LTEP12788639.8T patent/LT2758433T/lt unknown
- 2012-09-14 MY MYPI2014000803A patent/MY183989A/en unknown
- 2012-09-14 PL PL12788639T patent/PL2758433T3/pl unknown
- 2012-09-14 ME MEP-2018-18A patent/ME03008B/me unknown
- 2012-09-14 EP EP12788639.8A patent/EP2758433B1/en active Active
- 2012-09-14 CN CN201280056856.XA patent/CN104185640B/zh active Active
- 2012-09-14 PT PT127886398T patent/PT2758433T/pt unknown
- 2012-09-14 CN CN201810662577.7A patent/CN109265543B/zh active Active
- 2012-09-14 UA UAA201404170A patent/UA115657C2/uk unknown
- 2012-09-14 CA CA2848346A patent/CA2848346A1/en not_active Abandoned
- 2012-09-14 KR KR1020147010525A patent/KR102130439B1/ko active IP Right Grant
- 2012-09-14 WO PCT/IB2012/002246 patent/WO2013041962A1/en active Application Filing
- 2012-09-14 RU RU2014115481A patent/RU2645259C2/ru active
- 2012-09-14 KR KR1020207018712A patent/KR102285743B1/ko active IP Right Grant
- 2012-09-14 BR BR112014006376-1A patent/BR112014006376B1/pt active IP Right Grant
- 2012-09-14 SG SG10201912955PA patent/SG10201912955PA/en unknown
-
2014
- 2014-02-21 ZA ZA2014/01333A patent/ZA201401333B/en unknown
- 2014-02-27 IL IL231201A patent/IL231201B/en active IP Right Grant
- 2014-03-19 CL CL2014000679A patent/CL2014000679A1/es unknown
- 2014-12-24 HK HK14112922.2A patent/HK1199459A1/xx unknown
-
2015
- 2015-05-14 CL CL2015001314A patent/CL2015001314A1/es unknown
-
2016
- 2016-01-27 CL CL2016000215A patent/CL2016000215A1/es unknown
- 2016-11-03 US US15/342,629 patent/US9828421B2/en active Active
- 2016-11-28 JP JP2016230258A patent/JP6360869B2/ja active Active
-
2017
- 2017-02-24 JP JP2017033138A patent/JP6286590B2/ja active Active
- 2017-05-19 US US15/599,685 patent/US9845352B2/en active Active
- 2017-11-02 US US15/801,341 patent/US11098106B2/en active Active
- 2017-12-07 AU AU2017272259A patent/AU2017272259B2/en active Active
-
2018
- 2018-01-17 CY CY20181100058T patent/CY1119792T1/el unknown
- 2018-01-17 HR HRP20180083TT patent/HRP20180083T8/hr unknown
- 2018-03-27 JP JP2018059946A patent/JP6499345B2/ja active Active
- 2018-06-03 IL IL259775A patent/IL259775B/en active IP Right Grant
- 2018-07-12 JP JP2018132100A patent/JP6637124B2/ja active Active
-
2019
- 2019-12-19 JP JP2019228943A patent/JP6950981B2/ja active Active
-
2020
- 2020-01-29 AU AU2020200624A patent/AU2020200624B2/en active Active
- 2020-05-04 IL IL274440A patent/IL274440B/en unknown
-
2021
- 2021-07-27 US US17/443,779 patent/US20220010004A1/en active Pending
- 2021-09-15 JP JP2021150176A patent/JP7182316B2/ja active Active
- 2021-11-02 IL IL287794A patent/IL287794A/en unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CL2016000215A1 (es) | Terapia y diagnóstico basado en proteínas de patología mediada por tau en enfermedad de alzheimer (divisional de sol. n° 679-14). | |
AR085198A1 (es) | Composicion farmaceutica | |
UA118441C2 (uk) | Антитіло, що розпізнає альфа-синуклеїн | |
PA8782201A1 (es) | Anticuerpo humanizados contra el globulómero ab(20-42) y sus usos | |
CL2017002345A1 (es) | Un nuevo complejo que comprende un péptido de penetración celular, una molécula cargo y un agonista peptídico de tlr | |
AR092779A1 (es) | Composicon farmaceutica que comprende anticuerpos que se unen a conformeros de proteinas tau | |
PE20170782A1 (es) | Anticuerpos frente a cd73 y usos de los mismos | |
WO2014031694A3 (en) | Anti-tau antibodies and methods of making and using in treatment of tauopathies | |
BR112017008165B8 (pt) | anticorpo de domínio único direcionado contra um componente intracelular e seu uso, métodos in vitro para medir os níveis do referido anticorpo e para diagnosticar um distúrbio mediado por um componente intracelular, polipeptídeo isolado e composição compreendendo o referido anticorpo ou polipeptídeo isolado | |
AR085591A1 (es) | Anticuerpos del antigeno carcinoembrionario humano (cea) | |
AR092818A1 (es) | Anticuerpo tau humanizado | |
MX2019007480A (es) | Anticuerpos monoclonales anti-alfa-sinucleina para prevenir la agregacion de tau. | |
MA34926B1 (fr) | Composition effervescente sous forme solide utilisable dans des applications vaginales pour le traitement d'infections vaginales | |
UA115540C2 (uk) | Антитіло до il-36r | |
UA113609C2 (xx) | Антигензв'язуючий білок, який зв'язує людський il-23 | |
CL2012002415A1 (es) | Anticuerpo monoclonal aislado que se une al inhibidor de la via del factor tisular humano (tfpi); composicion farmacéutica que comprende dicho anticuerpo; procedimientos para tratar deficiencias o defectos genéticos o adquiridos en la coagulación; molecula de acido nucleico que codifica el anticuerpo; vector y célula huesped. | |
ECSP11011297A (es) | Proteinas ligadoras il-17 | |
PE20161032A1 (es) | Anticuerpos anti-tau(ps422) humanizados y metodos de utilizacion | |
CL2013002811A1 (es) | Anticuerpo monoclonal aislado que se une a un epitopo del inhibidor de la ruta del factor tisular humano; molecula de acido nucleico que lo codifica; composicion farmaceutica que lo comprende; y su uso para tratar deficiencias o defectos geneticos o adquiridos en la coagulacion. | |
EA201690159A1 (ru) | Способы и композиции для лечения рака | |
EA201390813A1 (ru) | Антитела и их применение | |
UA111340C2 (uk) | Антитіло, яке специфічно зв'язується з tnf-альфа людини | |
EA201400964A1 (ru) | Cx3cr1-связывающие полипептиды | |
AR084627A1 (es) | Formulacion farmaceutica que comprende una droga biofarmaceutica | |
BR112016013185A2 (pt) | Inibidores de cinase relacionada à tropomiosina (trk) |