MX2014003357A - Terapia basada en proteina y diagnostico de patalogia mediada por tau en la enfermedad de alzheimer. - Google Patents

Terapia basada en proteina y diagnostico de patalogia mediada por tau en la enfermedad de alzheimer.

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Publication number
MX2014003357A
MX2014003357A MX2014003357A MX2014003357A MX2014003357A MX 2014003357 A MX2014003357 A MX 2014003357A MX 2014003357 A MX2014003357 A MX 2014003357A MX 2014003357 A MX2014003357 A MX 2014003357A MX 2014003357 A MX2014003357 A MX 2014003357A
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MX
Mexico
Prior art keywords
tau
alzheimer
disease
protein
antibodies
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MX2014003357A
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English (en)
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MX347505B (es
Inventor
Michal Noväk
Evan Kontsekovä
Branislav Kovácech
Norbert Zilka
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Axon Neuroscience Se
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Application filed by Axon Neuroscience Se filed Critical Axon Neuroscience Se
Publication of MX2014003357A publication Critical patent/MX2014003357A/es
Publication of MX347505B publication Critical patent/MX347505B/es

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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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Abstract

La invención proporciona anticuerpos terapéuticos y de diagnóstico únicos, así como sus fragmentos, partes, derivados y variantes de los mismos, que unen regiones de la proteína tau que contribuyen a la iniciación y propagación de- interacciones tau-tau patológicas, así como métodos para elaborarlos. La invención también se refiere a métodos para utilizar estos anticuerpos para el diagnóstico, prevención, y tratamiento de enfermedad de Alzheimer y tauopatías relacionadas. La presente invención también proporciona un método para un tratamiento profiláctico y terapéutico de la enfermedad de Alzheimer y otras tauopatías neurodegenerativas. El método implica la inyección de vacunas de anticuerpos y/o péptido que produce una respuesta inmune dirigida a proteínas tau y depósitos tau patológicos en los cerebros de pacientes. Las vacunas adecuadas representan un péptido tau que lleva uno o más de los epítopos terapéuticos tau aquí provistos.
MX2014003357A 2011-09-19 2012-09-14 Terapia basada en proteína y diagnóstico de patalogía mediada por tau en la enfermedad de alzheimer. MX347505B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161536339P 2011-09-19 2011-09-19
US201261653115P 2012-05-30 2012-05-30
PCT/IB2012/002246 WO2013041962A1 (en) 2011-09-19 2012-09-14 Protein-based therapy and diagnosis of tau-mediated pathology in alzheimer's disease

Publications (2)

Publication Number Publication Date
MX2014003357A true MX2014003357A (es) 2015-03-20
MX347505B MX347505B (es) 2017-04-28

Family

ID=47216372

Family Applications (1)

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MX2014003357A MX347505B (es) 2011-09-19 2012-09-14 Terapia basada en proteína y diagnóstico de patalogía mediada por tau en la enfermedad de alzheimer.

Country Status (30)

Country Link
US (5) US9518101B2 (es)
EP (2) EP3275461A1 (es)
JP (7) JP6253583B2 (es)
KR (3) KR102285743B1 (es)
CN (3) CN104185640B (es)
AU (3) AU2012311234B2 (es)
BR (1) BR112014006376B1 (es)
CA (1) CA2848346A1 (es)
CL (3) CL2014000679A1 (es)
CY (1) CY1119792T1 (es)
DK (1) DK2758433T3 (es)
ES (1) ES2656442T3 (es)
HK (1) HK1199459A1 (es)
HR (1) HRP20180083T8 (es)
HU (1) HUE036177T2 (es)
IL (4) IL231201B (es)
LT (1) LT2758433T (es)
ME (1) ME03008B (es)
MX (1) MX347505B (es)
MY (1) MY183989A (es)
PL (1) PL2758433T3 (es)
PT (1) PT2758433T (es)
RS (1) RS56852B1 (es)
RU (2) RU2018102103A (es)
SG (4) SG10201912964PA (es)
SI (1) SI2758433T1 (es)
TR (1) TR201800669T4 (es)
UA (2) UA123390C2 (es)
WO (1) WO2013041962A1 (es)
ZA (1) ZA201401333B (es)

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