FR3058143B1 - Nanocorps anti-tau - Google Patents
Nanocorps anti-tau Download PDFInfo
- Publication number
- FR3058143B1 FR3058143B1 FR1660450A FR1660450A FR3058143B1 FR 3058143 B1 FR3058143 B1 FR 3058143B1 FR 1660450 A FR1660450 A FR 1660450A FR 1660450 A FR1660450 A FR 1660450A FR 3058143 B1 FR3058143 B1 FR 3058143B1
- Authority
- FR
- France
- Prior art keywords
- tau
- nanocbodies
- relates
- present
- nanobodies
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 108010003723 Single-Domain Antibodies Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1660450A FR3058143B1 (fr) | 2016-10-27 | 2016-10-27 | Nanocorps anti-tau |
CN201780080870.6A CN110225926B (zh) | 2016-10-27 | 2017-10-27 | 抗Tau纳米抗体 |
JP2019545850A JP7197494B2 (ja) | 2016-10-27 | 2017-10-27 | 抗Tauナノボディ |
US16/345,279 US10590191B2 (en) | 2016-10-27 | 2017-10-27 | Anti-tau nanobodies |
CA3041066A CA3041066A1 (fr) | 2016-10-27 | 2017-10-27 | Nanocorps anti-tau |
PCT/EP2017/077691 WO2018078140A1 (fr) | 2016-10-27 | 2017-10-27 | Nanocorps anti-tau |
EP17798139.6A EP3532495A1 (fr) | 2016-10-27 | 2017-10-27 | Nanocorps anti-tau |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1660450 | 2016-10-27 | ||
FR1660450A FR3058143B1 (fr) | 2016-10-27 | 2016-10-27 | Nanocorps anti-tau |
Publications (2)
Publication Number | Publication Date |
---|---|
FR3058143A1 FR3058143A1 (fr) | 2018-05-04 |
FR3058143B1 true FR3058143B1 (fr) | 2021-03-12 |
Family
ID=58314353
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR1660450A Active FR3058143B1 (fr) | 2016-10-27 | 2016-10-27 | Nanocorps anti-tau |
Country Status (6)
Country | Link |
---|---|
US (1) | US10590191B2 (fr) |
EP (1) | EP3532495A1 (fr) |
JP (1) | JP7197494B2 (fr) |
CA (1) | CA3041066A1 (fr) |
FR (1) | FR3058143B1 (fr) |
WO (1) | WO2018078140A1 (fr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MA47499A (fr) | 2017-02-17 | 2019-12-25 | Denali Therapeutics Inc | Anticorps anti-tau et leurs procédés d'utilisation |
CN112649615A (zh) * | 2020-12-21 | 2021-04-13 | 大连理工大学 | 一种检测不同大小的可溶性Aβ寡聚体的方法及应用 |
FR3134390A1 (fr) | 2022-04-11 | 2023-10-13 | Universite Grenoble Alpes | Peptide utile pour le transport de molecules au travers de barrieres cellulaires |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4861719A (en) | 1986-04-25 | 1989-08-29 | Fred Hutchinson Cancer Research Center | DNA constructs for retrovirus packaging cell lines |
US5278056A (en) | 1988-02-05 | 1994-01-11 | The Trustees Of Columbia University In The City Of New York | Retroviral packaging cell lines and process of using same |
DE69434860T2 (de) | 1993-02-22 | 2007-03-15 | The Rockefeller University | Herstellung von helfer-freien retroviren mit hohem titer mittels transienter transfektion |
FR2712812B1 (fr) | 1993-11-23 | 1996-02-09 | Centre Nat Rech Scient | Composition pour la production de produits thérapeutiques in vivo. |
MX9701720A (es) | 1994-09-12 | 1997-06-28 | Schering Ag | Proceso para la fabricacion de una palidipina modificada, inhibidora de la agregacion plaquetaria inducida por colageno. |
IL116816A (en) | 1995-01-20 | 2003-05-29 | Rhone Poulenc Rorer Sa | Cell for the production of a defective recombinant adenovirus or an adeno-associated virus and the various uses thereof |
US6013516A (en) | 1995-10-06 | 2000-01-11 | The Salk Institute For Biological Studies | Vector and method of use for nucleic acid delivery to non-dividing cells |
EP2470211B1 (fr) * | 2009-08-28 | 2016-01-27 | The Board of Regents of The University of Texas System | Anticorps liant les oligomères de la protéine tau |
GB201112056D0 (en) * | 2011-07-14 | 2011-08-31 | Univ Leuven Kath | Antibodies |
CN104185640B (zh) * | 2011-09-19 | 2018-07-20 | 阿克松神经系统科学公司 | 阿尔茨海默病中的tau蛋白介导病变的基于蛋白质的疗法和诊断 |
EP4356927A2 (fr) * | 2012-10-12 | 2024-04-24 | Arizona Board of Regents on behalf of Arizona State University | Réactifs à base d'anticorps qui reconnaissent spécifiquement des formes oligomériques toxiques de tau |
EP2899208A1 (fr) * | 2014-01-28 | 2015-07-29 | F.Hoffmann-La Roche Ag | Anticorps à domaine unique de camélidés dirigés contre des protéines tau phosphorylées et procédés de production de conjugués de ceux-ci |
-
2016
- 2016-10-27 FR FR1660450A patent/FR3058143B1/fr active Active
-
2017
- 2017-10-27 CA CA3041066A patent/CA3041066A1/fr active Pending
- 2017-10-27 US US16/345,279 patent/US10590191B2/en active Active
- 2017-10-27 EP EP17798139.6A patent/EP3532495A1/fr active Pending
- 2017-10-27 JP JP2019545850A patent/JP7197494B2/ja active Active
- 2017-10-27 WO PCT/EP2017/077691 patent/WO2018078140A1/fr unknown
Also Published As
Publication number | Publication date |
---|---|
FR3058143A1 (fr) | 2018-05-04 |
CA3041066A1 (fr) | 2018-05-03 |
US20190263898A1 (en) | 2019-08-29 |
EP3532495A1 (fr) | 2019-09-04 |
WO2018078140A1 (fr) | 2018-05-03 |
US10590191B2 (en) | 2020-03-17 |
JP2020505056A (ja) | 2020-02-20 |
CN110225926A (zh) | 2019-09-10 |
JP7197494B2 (ja) | 2022-12-27 |
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Legal Events
Date | Code | Title | Description |
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PLFP | Fee payment |
Year of fee payment: 2 |
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PLSC | Publication of the preliminary search report |
Effective date: 20180504 |
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Year of fee payment: 3 |
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PLFP | Fee payment |
Year of fee payment: 4 |
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PLFP | Fee payment |
Year of fee payment: 5 |
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PLFP | Fee payment |
Year of fee payment: 6 |
|
TQ | Partial transmission of property |
Owner name: UNIVERSITE GRENOBLE ALPES, FR Effective date: 20220620 Owner name: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERC, FR Effective date: 20220620 Owner name: CENTRE HOSPITALIER UNIVERSITAIRE GRENOBLE, FR Effective date: 20220620 |
|
PLFP | Fee payment |
Year of fee payment: 7 |
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PLFP | Fee payment |
Year of fee payment: 8 |