CN110225926A - 抗Tau纳米抗体 - Google Patents
抗Tau纳米抗体 Download PDFInfo
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- CN110225926A CN110225926A CN201780080870.6A CN201780080870A CN110225926A CN 110225926 A CN110225926 A CN 110225926A CN 201780080870 A CN201780080870 A CN 201780080870A CN 110225926 A CN110225926 A CN 110225926A
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- 235000010262 sodium metabisulphite Nutrition 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Peptides Or Proteins (AREA)
- Lubricants (AREA)
- Carbon And Carbon Compounds (AREA)
- Catalysts (AREA)
Abstract
Description
侧链特性 | 氨基酸 |
非极性 | GAPILV |
不带电极性 | CSTMNQ |
带电极性 | DEKR |
芳香 | HFWY |
其他 | NQDE |
原始残基 | 替换实施例 |
A | VLI |
R | KQN |
N | QHKR |
D | E |
C | S |
G | N |
E | D |
H | NQKR |
I | LVMAF |
L | IVMAF |
K | RQN |
M | LFI |
F | LVIA |
P | G |
S | T |
T | S |
W | Y |
Y | WFTS |
V | ILMFA |
Claims (18)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1660450A FR3058143B1 (fr) | 2016-10-27 | 2016-10-27 | Nanocorps anti-tau |
FR1660450 | 2016-10-27 | ||
PCT/EP2017/077691 WO2018078140A1 (fr) | 2016-10-27 | 2017-10-27 | Nanocorps anti-tau |
Publications (2)
Publication Number | Publication Date |
---|---|
CN110225926A true CN110225926A (zh) | 2019-09-10 |
CN110225926B CN110225926B (zh) | 2024-05-03 |
Family
ID=58314353
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201780080870.6A Active CN110225926B (zh) | 2016-10-27 | 2017-10-27 | 抗Tau纳米抗体 |
Country Status (7)
Country | Link |
---|---|
US (1) | US10590191B2 (zh) |
EP (1) | EP3532495A1 (zh) |
JP (1) | JP7197494B2 (zh) |
CN (1) | CN110225926B (zh) |
CA (1) | CA3041066A1 (zh) |
FR (1) | FR3058143B1 (zh) |
WO (1) | WO2018078140A1 (zh) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3583123A1 (en) | 2017-02-17 | 2019-12-25 | Denali Therapeutics Inc. | Anti-tau antibodies and methods of use thereof |
CN112649615A (zh) * | 2020-12-21 | 2021-04-13 | 大连理工大学 | 一种检测不同大小的可溶性Aβ寡聚体的方法及应用 |
FR3134390A1 (fr) | 2022-04-11 | 2023-10-13 | Universite Grenoble Alpes | Peptide utile pour le transport de molecules au travers de barrieres cellulaires |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104185640A (zh) * | 2011-09-19 | 2014-12-03 | 阿克松神经系统科学公司 | 阿尔茨海默病中的tau蛋白介导病变的基于蛋白质的疗法和诊断 |
CN105339002A (zh) * | 2013-06-10 | 2016-02-17 | 伊皮埃里安股份有限公司 | 治疗tau病变的方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4861719A (en) | 1986-04-25 | 1989-08-29 | Fred Hutchinson Cancer Research Center | DNA constructs for retrovirus packaging cell lines |
US5278056A (en) | 1988-02-05 | 1994-01-11 | The Trustees Of Columbia University In The City Of New York | Retroviral packaging cell lines and process of using same |
EP0689601B1 (en) | 1993-02-22 | 2006-10-04 | The Rockefeller University | Production of high titer helper-free retroviruses by transient transfection |
FR2712812B1 (fr) | 1993-11-23 | 1996-02-09 | Centre Nat Rech Scient | Composition pour la production de produits thérapeutiques in vivo. |
AU701643B2 (en) | 1994-09-12 | 1999-02-04 | Schering Aktiengesellschaft | Process for manufacture of a modified collagen-induced platelet aggregation inhibitor pallidipin |
IL116816A (en) | 1995-01-20 | 2003-05-29 | Rhone Poulenc Rorer Sa | Cell for the production of a defective recombinant adenovirus or an adeno-associated virus and the various uses thereof |
US6013516A (en) | 1995-10-06 | 2000-01-11 | The Salk Institute For Biological Studies | Vector and method of use for nucleic acid delivery to non-dividing cells |
US8778343B2 (en) | 2009-08-28 | 2014-07-15 | The Board Of Regents Of The University Of Texas System | Antibodies that bind tau oligomers |
GB201112056D0 (en) | 2011-07-14 | 2011-08-31 | Univ Leuven Kath | Antibodies |
WO2014059442A2 (en) | 2012-10-12 | 2014-04-17 | Arizona Board Agents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University | Antibody based reagents that specifically recognize toxic oligomeric forms of tau |
EP2899208A1 (en) | 2014-01-28 | 2015-07-29 | F.Hoffmann-La Roche Ag | Camelid single-domain antibody directed against phosphorylated tau proteins and methods for producing conjugates thereof |
-
2016
- 2016-10-27 FR FR1660450A patent/FR3058143B1/fr active Active
-
2017
- 2017-10-27 US US16/345,279 patent/US10590191B2/en active Active
- 2017-10-27 CA CA3041066A patent/CA3041066A1/fr active Pending
- 2017-10-27 EP EP17798139.6A patent/EP3532495A1/fr active Pending
- 2017-10-27 WO PCT/EP2017/077691 patent/WO2018078140A1/fr unknown
- 2017-10-27 JP JP2019545850A patent/JP7197494B2/ja active Active
- 2017-10-27 CN CN201780080870.6A patent/CN110225926B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104185640A (zh) * | 2011-09-19 | 2014-12-03 | 阿克松神经系统科学公司 | 阿尔茨海默病中的tau蛋白介导病变的基于蛋白质的疗法和诊断 |
CN105339002A (zh) * | 2013-06-10 | 2016-02-17 | 伊皮埃里安股份有限公司 | 治疗tau病变的方法 |
Non-Patent Citations (1)
Title |
---|
DIANA L. CASTILLO-CARRANZA等: "Specific Targeting of Tau Oligomers in Htau Mice Prevents Cognitive Impairment and Tau Toxicity Following Injection with Brain-Derived Tau Oligomeric Seeds", 《JOURNAL OF ALZHEIMER’S DISEASE》 * |
Also Published As
Publication number | Publication date |
---|---|
JP7197494B2 (ja) | 2022-12-27 |
US10590191B2 (en) | 2020-03-17 |
CN110225926B (zh) | 2024-05-03 |
FR3058143A1 (fr) | 2018-05-04 |
FR3058143B1 (fr) | 2021-03-12 |
EP3532495A1 (fr) | 2019-09-04 |
JP2020505056A (ja) | 2020-02-20 |
CA3041066A1 (fr) | 2018-05-03 |
WO2018078140A1 (fr) | 2018-05-03 |
US20190263898A1 (en) | 2019-08-29 |
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