DK0859959T3 - Peptider, som øger transporten over væv, og fremgangsmåder til identificering og anvendelse af disse - Google Patents
Peptider, som øger transporten over væv, og fremgangsmåder til identificering og anvendelse af disseInfo
- Publication number
- DK0859959T3 DK0859959T3 DK96938439T DK96938439T DK0859959T3 DK 0859959 T3 DK0859959 T3 DK 0859959T3 DK 96938439 T DK96938439 T DK 96938439T DK 96938439 T DK96938439 T DK 96938439T DK 0859959 T3 DK0859959 T3 DK 0859959T3
- Authority
- DK
- Denmark
- Prior art keywords
- phage
- transported
- site
- peptide
- transport
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IE950864A IE80466B1 (en) | 1995-11-10 | 1995-11-10 | Peptides which enhance transport across tissues and methods of identifying and using the same |
US646195P | 1995-11-13 | 1995-11-13 | |
PCT/IE1996/000072 WO1997017613A1 (en) | 1995-11-10 | 1996-11-11 | Peptides which enhance transport across tissues and methods of identifying and using the same |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0859959T3 true DK0859959T3 (da) | 2003-11-24 |
Family
ID=26319862
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK96938439T DK0859959T3 (da) | 1995-11-10 | 1996-11-11 | Peptider, som øger transporten over væv, og fremgangsmåder til identificering og anvendelse af disse |
Country Status (11)
Country | Link |
---|---|
EP (3) | EP1281718A3 (da) |
JP (3) | JP3830525B2 (da) |
AT (1) | ATE246808T1 (da) |
AU (2) | AU705816B2 (da) |
CA (2) | CA2235226A1 (da) |
DE (1) | DE69629385T2 (da) |
DK (1) | DK0859959T3 (da) |
ES (1) | ES2203722T3 (da) |
NZ (2) | NZ322174A (da) |
PT (1) | PT859959E (da) |
WO (2) | WO1997017613A1 (da) |
Families Citing this family (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9700291D0 (sv) | 1997-01-31 | 1997-01-31 | Pharmacia & Upjohn Ab | Selection method and prodcts resulting therefrom |
JP4129298B2 (ja) * | 1997-05-15 | 2008-08-06 | サイトジェン コーポレーション | 胃腸管(git)輸送受容体に結合するランダムペプチド、及び関連した方法 |
US6787523B1 (en) | 1997-12-02 | 2004-09-07 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
US6750324B1 (en) | 1997-12-02 | 2004-06-15 | Neuralab Limited | Humanized and chimeric N-terminal amyloid beta-antibodies |
US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
US7790856B2 (en) | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
US6743427B1 (en) | 1997-12-02 | 2004-06-01 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
US20030147882A1 (en) | 1998-05-21 | 2003-08-07 | Alan Solomon | Methods for amyloid removal using anti-amyloid antibodies |
US7087236B1 (en) | 1998-09-01 | 2006-08-08 | Merrion Research I Limited | Method for inducing a cell-mediated immune response and improved parenteral vaccine formulations thereof |
EP1109897A1 (de) * | 1998-09-07 | 2001-06-27 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Verfahren zur selektion von peptiden für zielgerichteten pharma- und markertransport und peptide damit entdeckt |
US7491796B1 (en) * | 1998-11-19 | 2009-02-17 | Merrion Research Iii Limited | Retro-inversion peptides that target GIT receptors and related methods |
WO2000031546A1 (en) * | 1998-11-19 | 2000-06-02 | Elan Corporation, Plc | Antibodies to peptides that target git receptors and related methods |
US6787637B1 (en) | 1999-05-28 | 2004-09-07 | Neuralab Limited | N-Terminal amyloid-β antibodies |
UA81216C2 (en) | 1999-06-01 | 2007-12-25 | Prevention and treatment of amyloid disease | |
ATE363074T1 (de) | 1999-09-14 | 2007-06-15 | Xenoport Inc | Substrate und screeningverfahren für transportproteine |
WO2001039722A2 (en) | 1999-11-30 | 2001-06-07 | Mayo Foundation For Medical Education And Research | B7-h1, a novel immunoregulatory molecule |
WO2001044300A2 (en) * | 1999-12-13 | 2001-06-21 | Cambridge Antibody Technology Limited | Brain specific binding members |
US7030219B2 (en) | 2000-04-28 | 2006-04-18 | Johns Hopkins University | B7-DC, Dendritic cell co-stimulatory molecules |
US7700751B2 (en) | 2000-12-06 | 2010-04-20 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize β-amyloid peptide |
EP1432729B1 (en) * | 2001-07-02 | 2008-11-12 | Merrion Research III Limited | Peyers's patch and/or m-cell targeting ligands |
SI2336184T1 (sl) | 2002-02-25 | 2015-04-30 | Biogen Idec Ma Inc. | Dajanje sredstev za zdravljenje vnetij |
MY139983A (en) | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
US9535076B2 (en) | 2002-09-12 | 2017-01-03 | The Regents Of The University Of California | Methods and compositions for eliciting an amyloid-selective immune response |
US7432351B1 (en) | 2002-10-04 | 2008-10-07 | Mayo Foundation For Medical Education And Research | B7-H1 variants |
TW200509968A (en) | 2002-11-01 | 2005-03-16 | Elan Pharm Inc | Prevention and treatment of synucleinopathic disease |
US8506959B2 (en) | 2002-11-01 | 2013-08-13 | Neotope Biosciences Limited | Prevention and treatment of synucleinopathic and amyloidogenic disease |
TWI306458B (en) | 2003-05-30 | 2009-02-21 | Elan Pharma Int Ltd | Humanized antibodies that recognize beta amyloid peptide |
PT2336147E (pt) | 2003-12-17 | 2014-07-16 | Janssen Alzheimer Immunotherap | Conjugados transportadores de péptidos beta imunogénicos e seus processos de produção |
SG182163A1 (en) | 2003-12-17 | 2012-07-30 | Wyeth Corp | Immunogenic peptide carrier conjugates and methods of producing same |
MX2007001679A (es) | 2004-08-09 | 2007-05-23 | Elan Pharm Inc | Prevencion y tratamiento de la enfermedad sinucleinopatica y amiloidogenica. |
PT1810026T (pt) | 2004-10-06 | 2018-06-11 | Mayo Found Medical Education & Res | B7-h1 e pd-1 no tratamento do carcinona de células renais |
AR052051A1 (es) | 2004-12-15 | 2007-02-28 | Neuralab Ltd | Anticuerpos ab humanizados usados en mejorar la cognicion |
US8784810B2 (en) | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
WO2009017467A1 (en) | 2007-07-27 | 2009-02-05 | Elan Pharma International Limited | Treatment of amyloidogenic diseases |
EP2035448A4 (en) | 2006-06-01 | 2010-11-03 | Elan Pharm Inc | NEUROACTIVE FRAGMENTS OF APP |
KR100866925B1 (ko) | 2006-08-28 | 2008-11-04 | 주식회사 인실리코텍 | 경구 파지 디스플레이 방법으로 동정된 소장 상피세포흡수촉진 유도 펩타이드 및 이를 이용한 경구투약 시스템 |
WO2008083169A2 (en) | 2006-12-26 | 2008-07-10 | The Johns Hopkins University | Compositions and methods for the treatment of immunologic disorders |
CA2673752A1 (en) | 2006-12-27 | 2008-07-10 | The Johns Hopkins University | Compositions and methods for stimulating an immune response |
US7989173B2 (en) | 2006-12-27 | 2011-08-02 | The Johns Hopkins University | Detection and diagnosis of inflammatory disorders |
WO2008084899A1 (en) * | 2007-01-10 | 2008-07-17 | Insilicotech Co., Ltd. | The enterocyte-transcytotic, tissue target and m cell target peptide identified by the phage display process and drug delivery systems using the same |
ES2570182T3 (es) | 2007-02-23 | 2016-05-17 | Prothena Biosciences Ltd | Prevención y tratamiento de la enfermedad sinucleinopática y amiloidogénica |
EP2583978B1 (en) | 2007-02-23 | 2016-04-06 | Prothena Biosciences Limited | Prevention and treatment of synucleinopathic and amyloidogenic disease |
US8003097B2 (en) | 2007-04-18 | 2011-08-23 | Janssen Alzheimer Immunotherapy | Treatment of cerebral amyloid angiopathy |
JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
US8619257B2 (en) * | 2007-12-13 | 2013-12-31 | Kimberley-Clark Worldwide, Inc. | Recombinant bacteriophage for detection of nosocomial infection |
EP2231181B1 (en) | 2007-12-17 | 2016-02-17 | Marfl AB | New vaccine for the treatment of mycobacterium related disorders |
PT2237803E (pt) | 2007-12-28 | 2015-10-16 | Prothena Biosciences Ltd | Tratamento e profilaxia da amiloidose |
US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
AU2010286361A1 (en) | 2009-08-31 | 2012-03-15 | Amplimmune, Inc. | Methods and compositions for the inhibition of transplant rejection |
EP3252068A3 (en) | 2009-10-12 | 2018-03-14 | Larry J. Smith | Methods and compositions for modulating gene expression using oligonucleotide based drugs administered in vivo or in vitro |
SG11201400125RA (en) | 2011-09-19 | 2014-03-28 | Axon Neuroscience Se | Protein-based therapy and diagnosis of tau-mediated pathology in alzheimer's disease |
US9302005B2 (en) | 2013-03-14 | 2016-04-05 | Mayo Foundation For Medical Education And Research | Methods and materials for treating cancer |
WO2015050663A1 (en) | 2013-10-01 | 2015-04-09 | Mayo Foundation For Medical Education And Research | Methods for treating cancer in patients with elevated levels of bim |
WO2015075635A2 (en) | 2013-11-19 | 2015-05-28 | Prothena Biosciences Limited | Monitoring immunotherapy of lewy body disease from constipation symptoms |
US10302653B2 (en) | 2014-05-22 | 2019-05-28 | Mayo Foundation For Medical Education And Research | Distinguishing antagonistic and agonistic anti B7-H1 antibodies |
US10517875B2 (en) | 2014-07-23 | 2019-12-31 | Mayo Foundation for Medical Engineering and Research | Targeting DNA-PKcs and B7-H1 to treat cancer |
US10875923B2 (en) | 2015-10-30 | 2020-12-29 | Mayo Foundation For Medical Education And Research | Antibodies to B7-H1 |
CN109715823A (zh) * | 2016-04-08 | 2019-05-03 | 美国冷泉港实验室 | 通过测序进行的神经元投射的多重分析 |
CA3096400A1 (en) | 2018-04-09 | 2019-10-17 | Eisai R&D Management Co., Ltd. | Certain pladienolide compounds and methods of use |
JP7334181B2 (ja) | 2018-04-12 | 2023-08-28 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 癌治療用のスプライセオソームターゲティング薬剤としてのプラジエノライド誘導体 |
CN112367996A (zh) | 2018-06-01 | 2021-02-12 | 卫材R&D管理有限公司 | 使用剪接调节剂的方法 |
AU2019277700A1 (en) | 2018-06-01 | 2020-11-19 | Eisai R&D Management Co., Ltd. | Splicing modulator antibody-drug conjugates and methods of use |
JP7365766B2 (ja) | 2018-11-16 | 2023-10-20 | 住友重機械工業株式会社 | 偏心揺動型減速装置 |
KR20210102274A (ko) | 2018-12-13 | 2021-08-19 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 헤르복시디엔 항체-약물 접합체 및 사용 방법 |
WO2021048619A2 (en) | 2019-09-09 | 2021-03-18 | Axon Neuroscience Se | Biomarkers and treatments of alzheimer's disease and mild cognitive impairment |
CN113136372B (zh) * | 2021-05-28 | 2023-08-01 | 广西大学 | 一种重组噬菌体的构建方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69129154T2 (de) * | 1990-12-03 | 1998-08-20 | Genentech Inc | Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften |
IT1270939B (it) * | 1993-05-11 | 1997-05-26 | Angeletti P Ist Richerche Bio | Procedimento per la preparazione di immunogeni e reagenti diagnostici,e immunogeni e reagenti diagnostici cosi' ottenibili. |
AU684510B2 (en) * | 1993-05-28 | 1997-12-18 | Chiron Corporation | Method for selection of biologically active peptide sequences |
-
1996
- 1996-11-11 ES ES96938439T patent/ES2203722T3/es not_active Expired - Lifetime
- 1996-11-11 CA CA002235226A patent/CA2235226A1/en not_active Abandoned
- 1996-11-11 CA CA002234685A patent/CA2234685A1/en not_active Abandoned
- 1996-11-11 PT PT96938439T patent/PT859959E/pt unknown
- 1996-11-11 AT AT96938439T patent/ATE246808T1/de active
- 1996-11-11 NZ NZ322174A patent/NZ322174A/xx unknown
- 1996-11-11 AU AU75852/96A patent/AU705816B2/en not_active Ceased
- 1996-11-11 EP EP02021532A patent/EP1281718A3/en not_active Withdrawn
- 1996-11-11 JP JP51802697A patent/JP3830525B2/ja not_active Expired - Fee Related
- 1996-11-11 WO PCT/IE1996/000072 patent/WO1997017613A1/en active IP Right Grant
- 1996-11-11 AU AU75853/96A patent/AU705688B2/en not_active Ceased
- 1996-11-11 DE DE69629385T patent/DE69629385T2/de not_active Expired - Lifetime
- 1996-11-11 DK DK96938439T patent/DK0859959T3/da active
- 1996-11-11 WO PCT/IE1996/000073 patent/WO1997017614A1/en not_active Application Discontinuation
- 1996-11-11 NZ NZ322175A patent/NZ322175A/xx not_active IP Right Cessation
- 1996-11-11 JP JP51802597A patent/JP4135978B2/ja not_active Expired - Fee Related
- 1996-11-11 EP EP96938439A patent/EP0859959B1/en not_active Expired - Lifetime
- 1996-11-11 EP EP96938440A patent/EP0876615A1/en not_active Withdrawn
-
2005
- 2005-11-30 JP JP2005345975A patent/JP4126055B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ATE246808T1 (de) | 2003-08-15 |
JP2002504072A (ja) | 2002-02-05 |
AU7585296A (en) | 1997-05-29 |
DE69629385T2 (de) | 2004-06-09 |
JP4126055B2 (ja) | 2008-07-30 |
JP3830525B2 (ja) | 2006-10-04 |
EP1281718A3 (en) | 2005-01-19 |
NZ322174A (en) | 1999-02-25 |
JP2002515967A (ja) | 2002-05-28 |
EP0859959B1 (en) | 2003-08-06 |
NZ322175A (en) | 1999-02-25 |
DE69629385D1 (de) | 2003-09-11 |
CA2234685A1 (en) | 1997-05-15 |
PT859959E (pt) | 2003-12-31 |
ES2203722T3 (es) | 2004-04-16 |
WO1997017614A1 (en) | 1997-05-15 |
CA2235226A1 (en) | 1997-05-15 |
AU705688B2 (en) | 1999-05-27 |
JP4135978B2 (ja) | 2008-08-20 |
JP2006117686A (ja) | 2006-05-11 |
AU705816B2 (en) | 1999-06-03 |
EP0859959A1 (en) | 1998-08-26 |
EP0876615A1 (en) | 1998-11-11 |
EP1281718A2 (en) | 2003-02-05 |
WO1997017613A1 (en) | 1997-05-15 |
AU7585396A (en) | 1997-05-29 |
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