PE20161032A1 - Anticuerpos anti-tau(ps422) humanizados y metodos de utilizacion - Google Patents

Anticuerpos anti-tau(ps422) humanizados y metodos de utilizacion

Info

Publication number
PE20161032A1
PE20161032A1 PE2016000824A PE2016000824A PE20161032A1 PE 20161032 A1 PE20161032 A1 PE 20161032A1 PE 2016000824 A PE2016000824 A PE 2016000824A PE 2016000824 A PE2016000824 A PE 2016000824A PE 20161032 A1 PE20161032 A1 PE 20161032A1
Authority
PE
Peru
Prior art keywords
rhv
seq
domain
methods
humanized anti
Prior art date
Application number
PE2016000824A
Other languages
English (en)
Inventor
Joerg Benz
Bernd Bohrmann
Guy Georges
Michael Schraeml
Fiona Grueninger
Hubert Kettenberger
Olaf Mundigl
Ulrich Goepfert
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20161032A1 publication Critical patent/PE20161032A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

Se refiere a un anticuerpo humanizado que comprende: a) un dominio de cadena pesa de RHV de SEQ ID N° 08, 18 y 10 y un dominio de cadena ligera de RHV de SEQ ID N° 13, 14 y 15 o b) un dominio de cadena pesa de RHV de SEQ ID N° 08, 09 y 10 y un dominio de cadena ligera de RHV de SEQ ID N° 12, 05 y 15 o c) un dominio de cadena pesa de RHV de SEQ ID N° 08, 09 y 10 y un dominio de cadena ligera de RHV de SEQ ID N° 13, 14 y 15. Tambien se refiere a una formulacion farmaceutica. Dicho anticuerpo se une especificamente a Tau (pS422) humano, siendo util en el tratamiento de Alzheimer
PE2016000824A 2013-12-20 2014-12-17 Anticuerpos anti-tau(ps422) humanizados y metodos de utilizacion PE20161032A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13199123 2013-12-20
EP14174047 2014-06-26

Publications (1)

Publication Number Publication Date
PE20161032A1 true PE20161032A1 (es) 2016-10-19

Family

ID=52347277

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2016000824A PE20161032A1 (es) 2013-12-20 2014-12-17 Anticuerpos anti-tau(ps422) humanizados y metodos de utilizacion

Country Status (27)

Country Link
US (3) US9562091B2 (es)
EP (1) EP3083680B1 (es)
JP (1) JP6608827B2 (es)
KR (1) KR20160099088A (es)
CN (1) CN105899533B (es)
AU (1) AU2014368696A1 (es)
BR (1) BR112016013562A2 (es)
CA (1) CA2932958A1 (es)
CL (1) CL2016001519A1 (es)
CR (1) CR20160270A (es)
DK (1) DK3083680T3 (es)
EA (1) EA201600473A1 (es)
ES (1) ES2778498T3 (es)
HK (1) HK1223953A1 (es)
HR (1) HRP20200384T1 (es)
IL (1) IL245862A0 (es)
LT (1) LT3083680T (es)
MX (1) MX2016007208A (es)
PE (1) PE20161032A1 (es)
PH (1) PH12016500940A1 (es)
PL (1) PL3083680T3 (es)
PT (1) PT3083680T (es)
RS (1) RS60031B1 (es)
SG (1) SG11201605044RA (es)
SI (1) SI3083680T1 (es)
TW (2) TW201630933A (es)
WO (1) WO2015091656A1 (es)

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