|
US5981481A
(en)
|
1974-12-06 |
1999-11-09 |
The Johns Hopkins University |
Human C3b/C4b receptor (CR1)
|
|
US5212071A
(en)
|
1988-04-01 |
1993-05-18 |
The Johns Hopkins University |
Nucleic acids encoding a human C3b/C4b receptor (CR1)
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4845083A
(en)
|
1983-10-05 |
1989-07-04 |
Merck Frosst Canada, Inc. |
Method of inhibiting mammalian leukotriene biosynthesis
|
|
JPH0742235B2
(ja)
|
1985-11-08 |
1995-05-10 |
三共株式会社 |
自己免疫性疾病の予防・治療剤
|
|
US5260203A
(en)
|
1986-09-02 |
1993-11-09 |
Enzon, Inc. |
Single polypeptide chain binding molecules
|
|
US5256642A
(en)
|
1988-04-01 |
1993-10-26 |
The Johns Hopkins University |
Compositions of soluble complement receptor 1 (CR1) and a thrombolytic agent, and the methods of use thereof
|
|
DE3830271A1
(de)
|
1988-09-06 |
1990-03-15 |
Goetze Otto |
Mittel mit immunsuppressiver wirkung
|
|
US5328470A
(en)
|
1989-03-31 |
1994-07-12 |
The Regents Of The University Of Michigan |
Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
|
|
EP0402226A1
(en)
|
1989-06-06 |
1990-12-12 |
Institut National De La Recherche Agronomique |
Transformation vectors for yeast yarrowia
|
|
FR2648133B1
(fr)
|
1989-06-08 |
1992-02-21 |
Sanofi Sa |
Lauramides n-substitues, leur preparation et compositions les contenant
|
|
US5331090A
(en)
|
1989-09-08 |
1994-07-19 |
California Institute Of Biological Research |
CR2 ligand compositions and methods for modulating immune cell functions
|
|
US5310729A
(en)
|
1990-04-20 |
1994-05-10 |
California Institute Of Biological Research |
Interferon-related polypeptides as CR2 ligands and their use for modulating immune cell functions
|
|
GB8928874D0
(en)
|
1989-12-21 |
1990-02-28 |
Celltech Ltd |
Humanised antibodies
|
|
US6458360B1
(en)
|
1990-04-25 |
2002-10-01 |
The Johns Hopkins University |
Soluble complement regulatory molecules
|
|
GB9102635D0
(en)
|
1991-02-07 |
1991-03-27 |
British Bio Technology |
Compounds
|
|
EP0512733A2
(en)
|
1991-05-03 |
1992-11-11 |
Washington University |
Modified complement system regulator
|
|
DE4222534A1
(de)
|
1992-07-09 |
1994-01-13 |
Behringwerke Ag |
Verwendung von Komplement-Inhibitoren zur Herstellung eines Arzneimittels zur Prophylaxe und Therapie von entzündlichen Darm- und Hauterkrankungen sowie Purpura
|
|
US5976540A
(en)
|
1993-05-17 |
1999-11-02 |
T Cell Sciences, Inc. |
Compositions comprising complement related proteins and carbohydrates, and methods for producing and using said compositions
|
|
US5679546A
(en)
|
1993-09-24 |
1997-10-21 |
Cytomed, Inc. |
Chimeric proteins which block complement activation
|
|
US5869615A
(en)
|
1994-01-03 |
1999-02-09 |
Washington University |
Modified complement proteases
|
|
US6074642A
(en)
|
1994-05-02 |
2000-06-13 |
Alexion Pharmaceuticals, Inc. |
Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis
|
|
US5679345A
(en)
|
1994-06-02 |
1997-10-21 |
The Johns Hopkins University |
Method for preventing complement-dependent rejection of organ or tissue transplants
|
|
US6309636B1
(en)
|
1995-09-14 |
2001-10-30 |
Cancer Research Institute Of Contra Costa |
Recombinant peptides derived from the Mc3 anti-BA46 antibody, methods of use thereof, and methods of humanizing antibody peptides
|
|
US6627195B1
(en)
|
1994-10-25 |
2003-09-30 |
Smithkline Beecham Corporation |
Binding agents to CD23
|
|
US6165463A
(en)
|
1997-10-16 |
2000-12-26 |
Inhale Therapeutic Systems, Inc. |
Dispersible antibody compositions and methods for their preparation and use
|
|
US5922320A
(en)
|
1996-06-14 |
1999-07-13 |
Georgetown University |
Recombinant proCVF
|
|
WO1997047321A1
(en)
|
1996-06-14 |
1997-12-18 |
The Johns Hopkins University School Of Medicine |
Use of chimeric vaccinia virus complement control proteins to inhibit complement
|
|
WO1998007835A2
(en)
|
1996-08-21 |
1998-02-26 |
Sugen, Inc. |
Crystal structures of a protein tyrosine kinase
|
|
US6214966B1
(en)
|
1996-09-26 |
2001-04-10 |
Shearwater Corporation |
Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution
|
|
GB9624731D0
(en)
|
1996-11-28 |
1997-01-15 |
Univ Leicester |
Complement inhibitor
|
|
US6368596B1
(en)
|
1997-07-08 |
2002-04-09 |
Board Of Regents, The University Of Texas System |
Compositions and methods for homoconjugates of antibodies which induce growth arrest or apoptosis of tumor cells
|
|
DE69835524T2
(de)
|
1997-08-26 |
2007-04-05 |
Amgen Fremont Inc. |
Ein verfahren zur inhibierung der komplementaktivierung über einen alternativen weg
|
|
US8088386B2
(en)
|
1998-03-20 |
2012-01-03 |
Genentech, Inc. |
Treatment of complement-associated disorders
|
|
WO1999037149A1
(en)
|
1998-01-27 |
1999-07-29 |
Brigham & Women's Hospital |
Methods of treating cytotoxic damage
|
|
US6956107B2
(en)
|
1998-02-20 |
2005-10-18 |
Tanox, Inc. |
Inhibitors of complement activation
|
|
CN101298481A
(zh)
|
1998-02-20 |
2008-11-05 |
吉宁特有限公司 |
补体活化的抑制剂
|
|
US7112327B2
(en)
|
1998-02-20 |
2006-09-26 |
Tanox, Inc. |
Inhibition of complement activation
|
|
AU3066699A
(en)
|
1998-03-03 |
1999-09-20 |
Johns Hopkins University, The |
Smallpox inhibitor of complement enzymes (spice) protein and methods of inhibiting complement activation
|
|
CA2331258C
(en)
|
1998-06-12 |
2011-09-20 |
Henry M. Jackson Foundation For The Advancement Of Military Medicine |
Enhancement of b cell activation and immunoglobulin secretion by co-stimulation of receptors for antigen and ebv gp350/220
|
|
US6572856B1
(en)
|
1998-09-10 |
2003-06-03 |
The University Of Virginia Patent Foundation |
Methods for the prevention and treatment of cancer using anti-C3b(i) antibodies
|
|
EP1001021B1
(en)
|
1998-09-25 |
2003-08-27 |
Wolfgang Prodinger |
Monoclonal antibody to human CD21, and its uses
|
|
US6224866B1
(en)
|
1998-10-07 |
2001-05-01 |
Biocrystal Ltd. |
Immunotherapy of B cell involvement in progression of solid, nonlymphoid tumors
|
|
AU1705100A
(en)
|
1998-10-09 |
2000-05-01 |
Musc Foundation For Research Development |
Blocking factor b to treat complement-mediated immune disease
|
|
AU776910B2
(en)
|
1998-12-08 |
2004-09-23 |
Merck Patent Gesellschaft Mit Beschrankter Haftung |
Modifying protein immunogenicity
|
|
WO2000040749A2
(en)
|
1999-01-06 |
2000-07-13 |
Genenews Inc. |
Method for the detection of gene transcripts in blood and uses thereof
|
|
HK1043312B
(en)
|
1999-05-07 |
2006-07-28 |
Genentech, Inc. |
Treatment of autoimmune diseases with antagonists which bind to b cell surface markers
|
|
US7576182B1
(en)
|
1999-08-31 |
2009-08-18 |
Genentech, Inc. |
Compositions and methods for the treatment of immune related diseases
|
|
GB9930659D0
(en)
|
1999-12-24 |
2000-02-16 |
Bio Discovery Ltd |
Inhibitors of complement activation
|
|
GB0008582D0
(en)
|
2000-04-08 |
2000-05-31 |
Adprotech Plc |
DNA immunization vectors
|
|
WO2001084149A2
(en)
|
2000-04-29 |
2001-11-08 |
University Of Iowa Research Foundation |
Diagnostics and therapeutics for macular degeneration-related disorders
|
|
US7439330B2
(en)
*
|
2000-05-08 |
2008-10-21 |
President And Fellows Of Harvard College |
Anti-glycated CD59 antibodies and uses thereof
|
|
US20020058029A1
(en)
|
2000-09-18 |
2002-05-16 |
Nabil Hanna |
Combination therapy for treatment of autoimmune diseases using B cell depleting/immunoregulatory antibody combination
|
|
WO2002068579A2
(en)
|
2001-01-10 |
2002-09-06 |
Pe Corporation (Ny) |
Kits, such as nucleic acid arrays, comprising a majority of human exons or transcripts, for detecting expression and other uses thereof
|
|
US7645739B2
(en)
|
2001-02-21 |
2010-01-12 |
Alavita Pharmaceuticals, Inc. |
Modified annexin compositions and methods of using same
|
|
US7635680B2
(en)
|
2001-02-21 |
2009-12-22 |
Alavita Pharmaceuticals, Inc. |
Attenuation of reperfusion injury
|
|
US7635676B2
(en)
|
2001-02-21 |
2009-12-22 |
Alavita Pharmaccuticals, Inc. |
Modified annexin proteins and methods for their use in organ transplantation
|
|
EP1379266B1
(en)
|
2001-02-21 |
2007-04-18 |
SurroMed, Inc. |
Modified annexin proteins and prevention and treatment of thrombosis
|
|
US6820011B2
(en)
|
2001-04-11 |
2004-11-16 |
The Regents Of The University Of Colorado |
Three-dimensional structure of complement receptor type 2 and uses thereof
|
|
JP2004529945A
(ja)
|
2001-05-17 |
2004-09-30 |
ラ ホヤ ファーマシューティカル カンパニー |
Cd21を阻害する薬剤を使用して抗体媒介性病理を処置する方法
|
|
AU2002336437A1
(en)
|
2001-08-29 |
2003-03-10 |
University Of Virginia Patent Foundation |
Therapeutic uses of complement receptor 2
|
|
EP1336618A1
(en)
*
|
2002-02-15 |
2003-08-20 |
HANS-KNÖLL-INSTITUT FÜR NATURSTOFF-FORSCHUNG e.V. |
Porcine complement regulator factor H and its use
|
|
US20030180292A1
(en)
|
2002-03-14 |
2003-09-25 |
Idec Pharmaceuticals |
Treatment of B cell malignancies using anti-CD40L antibodies in combination with anti-CD20 antibodies and/or chemotherapeutics and radiotherapy
|
|
WO2003084524A1
(en)
|
2002-03-29 |
2003-10-16 |
Neurogen Corporation |
Combination therapy for the treatment of conditions with pathogenic inflammatory components
|
|
US7538195B2
(en)
|
2002-06-14 |
2009-05-26 |
Immunogen Inc. |
Anti-IGF-I receptor antibody
|
|
US20050271660A1
(en)
|
2002-09-06 |
2005-12-08 |
Alexion Pharmaceuticals, Inc. |
Nebulization of monoclonal antibodies for treating pulmonary diseases
|
|
AU2003270330B2
(en)
|
2002-09-06 |
2009-07-30 |
Alexion Pharmaceuticals, Inc. |
Method of treatment of asthma using antibodies to complement component C5
|
|
US7541440B2
(en)
|
2002-09-30 |
2009-06-02 |
Immunomedics, Inc. |
Chimeric, human and humanized anti-granulocyte antibodies and methods of use
|
|
WO2004031240A1
(en)
|
2002-10-04 |
2004-04-15 |
Stichting Sanquin Bloedvoorziening |
Monoclonal antibody anti-c3-2 directed against the third component of complement (c3) and its use in methods to inhibit complement activation
|
|
CA2505601C
(en)
|
2002-11-15 |
2014-10-28 |
Musc Foundation For Research Development |
Complement receptor 2 targeted complement modulators
|
|
US7534427B2
(en)
|
2002-12-31 |
2009-05-19 |
Immunomedics, Inc. |
Immunotherapy of B cell malignancies and autoimmune diseases using unconjugated antibodies and conjugated antibodies and antibody combinations and fusion proteins
|
|
JP2006518750A
(ja)
|
2003-02-21 |
2006-08-17 |
リクスホスピタレット−ラジウムホスピタレット・ホーエフ |
胎便吸引症候群の治療のための方法および組成物
|
|
CN1791422A
(zh)
*
|
2003-03-28 |
2006-06-21 |
应用研究系统Ars股份公司 |
凝聚素在治疗和/或预防周围神经疾病中的用途
|
|
US20070123466A1
(en)
|
2003-05-13 |
2007-05-31 |
New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery |
Method of treating recurrent miscarriages
|
|
JP4029772B2
(ja)
|
2003-05-16 |
2008-01-09 |
株式会社日立製作所 |
磁気ヘッドおよびそれを用いた磁気記録再生装置
|
|
ATE427356T1
(de)
|
2003-06-02 |
2009-04-15 |
Varleigh Ltd |
Komplementinhibitoren aus zecken
|
|
EP1488798A1
(en)
|
2003-06-18 |
2004-12-22 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
HIP/PAP polypeptide composition for use in liver regeneration and for the prevention of liver failure
|
|
WO2005003159A1
(en)
|
2003-07-03 |
2005-01-13 |
Koeln Johanna |
Complement depletion using recombinant human c3-derivatives
|
|
WO2005014618A2
(en)
|
2003-08-08 |
2005-02-17 |
Immunomedics, Inc. |
Bispecific antibodies for inducing apoptosis of tumor and diseased cells
|
|
US7638481B2
(en)
|
2003-09-05 |
2009-12-29 |
University Of Louisville Research Foundation, Inc. |
Treatment of spinal cord injury
|
|
CA2542886A1
(en)
|
2003-11-05 |
2005-05-19 |
Neelima M. Bhat |
Enhanced b cell cytotoxicity of cdim binding antibody
|
|
US8454963B2
(en)
|
2003-11-13 |
2013-06-04 |
Musc Foundation For Research Development |
Tissue targeted complement modulators
|
|
US7959919B2
(en)
|
2003-11-19 |
2011-06-14 |
Novelmed Therapeutics, Inc. |
Method of inhibiting factor B-mediated complement activation
|
|
EP2990053A1
(en)
|
2004-01-20 |
2016-03-02 |
KaloBios Pharmaceuticals, Inc. |
Antibody specificity transfer using minimal essential binding determinants
|
|
US20050214286A1
(en)
|
2004-01-27 |
2005-09-29 |
University Of Southern California |
Polymer-bound antibody cancer therapeutic agent
|
|
BRPI0506629A
(pt)
|
2004-02-10 |
2007-05-02 |
Univ Colorado |
inibição do fator b, a via alternativa do sistema complemento e métodos relacionados
|
|
AU2005212369B2
(en)
|
2004-02-10 |
2011-06-23 |
Musc Foundation For Research Development |
Inhibition of factor B, the alternative complement pathway and methods related thereto
|
|
DK1755674T3
(en)
*
|
2004-05-14 |
2015-02-09 |
Alexion Pharma Inc |
PROLONGED SURVIVAL OF A allograft by inhibiting complement activity
|
|
US7919094B2
(en)
|
2004-06-10 |
2011-04-05 |
Omeros Corporation |
Methods for treating conditions associated with MASP-2 dependent complement activation
|
|
WO2006012621A2
(en)
|
2004-07-23 |
2006-02-02 |
University Of Virginia Patent Foundation |
Compositions and methods for regulating the alternative pathway of complement
|
|
AU2005334481A1
(en)
|
2004-08-11 |
2007-01-25 |
Trubion Pharmaceuticals, Inc. |
Binding domain fusion proteins
|
|
KR101249287B1
(ko)
|
2004-09-03 |
2013-04-01 |
크리어빌리스 쎄라퓨틱스 에스.피.에이. |
인간 및 비인간 hmgb1 boxa의 단백질분해효소내성 돌연변이 및 그들의 치료/진단 용도
|
|
US7563443B2
(en)
|
2004-09-17 |
2009-07-21 |
Domantis Limited |
Monovalent anti-CD40L antibody polypeptides and compositions thereof
|
|
NZ554725A
(en)
|
2004-10-25 |
2009-10-30 |
Merck & Co Inc |
Anti-ADDL antibodies and uses thereof
|
|
US7423128B2
(en)
|
2004-11-03 |
2008-09-09 |
Amgen Fremont Inc. |
Anti-properdin antibodies, and methods for making and using same
|
|
PL2343380T3
(pl)
|
2004-11-16 |
2020-03-31 |
Humanigen, Inc. |
Wymiana kasety dla regionu zmiennego immunoglobuliny
|
|
BRPI0518289A2
(pt)
|
2004-11-18 |
2008-11-11 |
Univ Yale |
mÉtodos e composiÇÕes para o tratamento de desordens oculares
|
|
CA2593846A1
(en)
|
2005-01-14 |
2006-08-10 |
The Regents Of The University Of California |
Compositions and methods for inhibiting drusen formation and for diagnosing or treating drusen-related disorders
|
|
CA2597411C
(en)
|
2005-02-14 |
2014-08-12 |
University Of Iowa Research Foundation |
Use of complement factor h polymorphisms in treatment and diagnosis of age-related macular degeneration
|
|
JP5707024B2
(ja)
|
2005-05-26 |
2015-04-22 |
ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド,ア ボディー コーポレイトTHE REGENTS OF THE UNIVERSITY OF COLORADO,a body corporate |
外傷性脳損傷、脊髄損傷および関連状態を治療するために補体副経路を阻害する作用剤
|
|
CA2616863A1
(en)
*
|
2005-07-29 |
2007-02-01 |
Australian Stem Cell Centre Limited |
Compositions and methods for growth of pluripotent cells
|
|
EP1922062A2
(en)
|
2005-09-08 |
2008-05-21 |
DSMIP Assets B.V. |
Method of treatment or prevention of age-related macular degeneration
|
|
EP1937706A4
(en)
|
2005-09-09 |
2008-10-22 |
Univ Iowa Res Found |
ORGANIC MARKERS RELATED TO AGE DEPENDENT MAKULAR GENERATION
|
|
US20070081989A1
(en)
|
2005-09-19 |
2007-04-12 |
Sanders Martin E |
Treatment of B cell diseases using anti-germline antibody binding agents
|
|
HUE026423T2
(en)
|
2005-11-04 |
2016-05-30 |
Genentech Inc |
Use of complement biosynthetic pathway inhibitors for treating eye diseases
|
|
CA2644020C
(en)
*
|
2006-03-02 |
2016-05-10 |
Alexion Pharmaceuticals, Inc. |
Prolongation of survival of an allograft by inhibiting complement activity
|
|
WO2007112403A2
(en)
|
2006-03-27 |
2007-10-04 |
The Regents Of The University Of Colorado |
Prevention and treatment of ischemia-reperfusion injury
|
|
US8945564B2
(en)
|
2006-04-21 |
2015-02-03 |
Novartis Ag |
Antagonist anti-CD40 antibody pharmaceutical compositions
|
|
EP1854810A1
(en)
|
2006-05-09 |
2007-11-14 |
PanGenetics B.V. |
Deimmunized antagonistic anti-human CD40 monoclonal antibody from the ch5D12 antibody
|
|
EP2044111B1
(en)
|
2006-06-21 |
2014-08-13 |
MUSC Foundation For Research Development |
Targeting complement factor h for treatment of diseases
|
|
US7705475B2
(en)
|
2006-08-03 |
2010-04-27 |
Stats Chippac Ltd. |
Integrated circuit package system
|
|
SI2097455T1
(sl)
|
2006-11-02 |
2015-03-31 |
Genentech, Inc. |
Humanizirana protitelesa proti faktorju tipa d
|
|
EP2565207A3
(en)
|
2007-03-14 |
2013-06-12 |
Alexion Cambridge Corporation |
Humaneered Anti-Factor B Antibody
|
|
PE20090329A1
(es)
|
2007-05-30 |
2009-03-27 |
Abbott Lab |
Anticuerpos humanizados contra el globulomero ab(20-42) y sus usos
|
|
KR20150029002A
(ko)
|
2007-06-07 |
2015-03-17 |
제넨테크, 인크. |
보체-관련 장애의 예방 및 치료를 위한 C3b 항체 및 방법
|
|
CN101970002B
(zh)
|
2007-08-27 |
2016-05-18 |
诺福麦德治疗学股份有限公司 |
用因子Bb特异性抗体抑制补体活化的方法
|
|
CL2008003241A1
(es)
|
2007-11-02 |
2009-07-31 |
Novartis Ag |
Molecula de enlace que comprende una porcion de enlace de antigeno que se enlaza con un neoepitopo de c3b; composicion farmaceutica que la comprende; y su uso para tratar trastornos oculares
|
|
BRPI0820343A2
(pt)
|
2007-11-08 |
2017-08-22 |
Genentech Inc |
Anticorpos de antifator b e seus usos
|
|
KR100951695B1
(ko)
|
2007-12-24 |
2010-04-07 |
(주)페타리 |
아이솔레이터 및 그 제조 방법
|
|
PL2262831T3
(pl)
|
2008-03-03 |
2015-08-31 |
Novelmed Therapeutics Inc |
Przeciwciała przeciwko properdynie
|
|
PY09026846A
(es)
|
2008-08-05 |
2015-09-01 |
Novartis Ag |
Composiciones y métodos para anticuerpos que se dirigen a la proteína de complemento c5
|
|
US7964105B2
(en)
|
2008-08-07 |
2011-06-21 |
William Harris Moss |
Method for improving belt press dewatering
|
|
BRPI0921845A2
(pt)
|
2008-11-12 |
2019-09-17 |
Medimmune Llc |
formulação aquosa estéril estável, forma de dosagem unitária farmacêutica, seringa pré-carregada, e, métodos para tratar uma doença ou distúrbio, para tratar ou prevenir rejeição, para esgotar células t que expressam icos em um paciente humano, e para interromper arquitetura central germinal em um órgão linfóide secundário de um primata
|
|
US8840868B2
(en)
|
2009-02-04 |
2014-09-23 |
The Regents Of The University Of Colorado, A Body Corporate |
Non-invasive detection of complement-mediated inflammation using CR2-targeted nanoparticles
|
|
US20100291106A1
(en)
|
2009-05-06 |
2010-11-18 |
Novartis Ag |
Compositions and methods for antibodies targeting complement protein c3b
|
|
US9291622B2
(en)
|
2009-05-21 |
2016-03-22 |
Apellis Pharmaceuticals, Inc. |
Complement assays and uses thereof
|
|
RS20120461A1
(sr)
|
2009-07-02 |
2013-06-28 |
Musc Foundation For Research Development |
Metode za stimulaciju regeneracije jetre
|
|
NZ600393A
(en)
|
2009-11-05 |
2014-08-29 |
Alexion Cambridge Corp |
Treatment of paroxysmal nocturnal hemoglobinuria, hemolytic anemias and disease states involving intravascular and extravascular hemolysis
|
|
MX2012013233A
(es)
|
2010-05-14 |
2013-05-20 |
Univ Colorado Regents |
Grupos que apuntan a receptor 2 de complemento (cr2) mejorados.
|
|
CN103249432A
(zh)
|
2010-06-22 |
2013-08-14 |
科罗拉多大学董事会,法人团体 |
补体成分3的C3d片段的抗体
|
|
CN103248395A
(zh)
|
2012-02-09 |
2013-08-14 |
中兴通讯股份有限公司 |
一种窄带干扰抑制方法及装置
|
|
WO2013177035A2
(en)
|
2012-05-24 |
2013-11-28 |
Alexion Pharmaceuticals, Inc. |
Humaneered anti-factor b antibody
|