PL2343380T3 - Wymiana kasety dla regionu zmiennego immunoglobuliny - Google Patents
Wymiana kasety dla regionu zmiennego immunoglobulinyInfo
- Publication number
- PL2343380T3 PL2343380T3 PL10014128T PL10014128T PL2343380T3 PL 2343380 T3 PL2343380 T3 PL 2343380T3 PL 10014128 T PL10014128 T PL 10014128T PL 10014128 T PL10014128 T PL 10014128T PL 2343380 T3 PL2343380 T3 PL 2343380T3
- Authority
- PL
- Poland
- Prior art keywords
- variable region
- immunoglobulin variable
- cassette exchange
- region cassette
- exchange
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/005—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62858104P | 2004-11-16 | 2004-11-16 | |
| EP05851809.3A EP1824987B1 (en) | 2004-11-16 | 2005-11-16 | Immunoglobulin variable region cassette exchange |
| EP10014128.2A EP2343380B1 (en) | 2004-11-16 | 2005-11-16 | Immunoglobulin variable region cassette exchange |
| PCT/US2005/041825 WO2006055778A2 (en) | 2004-11-16 | 2005-11-16 | Immunoglobulin variable region cassette exchange |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2343380T3 true PL2343380T3 (pl) | 2020-03-31 |
Family
ID=36407771
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL10014128T PL2343380T3 (pl) | 2004-11-16 | 2005-11-16 | Wymiana kasety dla regionu zmiennego immunoglobuliny |
| PL19169135T PL3540062T3 (pl) | 2004-11-16 | 2005-11-16 | Wymiana kasety dla regionu zmiennego immunoglobuliny |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL19169135T PL3540062T3 (pl) | 2004-11-16 | 2005-11-16 | Wymiana kasety dla regionu zmiennego immunoglobuliny |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20060134098A1 (pl) |
| EP (3) | EP2343380B1 (pl) |
| JP (1) | JP2008520586A (pl) |
| AU (1) | AU2005306502B2 (pl) |
| CA (1) | CA2587158C (pl) |
| DK (2) | DK2343380T3 (pl) |
| ES (3) | ES2429541T3 (pl) |
| PL (2) | PL2343380T3 (pl) |
| PT (2) | PT2343380T (pl) |
| WO (1) | WO2006055778A2 (pl) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8288322B2 (en) | 2000-04-17 | 2012-10-16 | Dyax Corp. | Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries |
| BRPI0506629A (pt) * | 2004-02-10 | 2007-05-02 | Univ Colorado | inibição do fator b, a via alternativa do sistema complemento e métodos relacionados |
| PL2343380T3 (pl) | 2004-11-16 | 2020-03-31 | Humanigen, Inc. | Wymiana kasety dla regionu zmiennego immunoglobuliny |
| JP5707024B2 (ja) * | 2005-05-26 | 2015-04-22 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド,ア ボディー コーポレイトTHE REGENTS OF THE UNIVERSITY OF COLORADO,a body corporate | 外傷性脳損傷、脊髄損傷および関連状態を治療するために補体副経路を阻害する作用剤 |
| US8357781B2 (en) | 2006-06-01 | 2013-01-22 | Janssen Alzheimer Immunotherapy | Neuroactive fragments of APP |
| US20080171038A1 (en) * | 2006-11-08 | 2008-07-17 | Kalobios Pharmaceuticals, Inc. | Methods of treating idiopathic thrombocytopenia purpura using a gm-csf antagonist |
| CN101605547A (zh) | 2006-11-21 | 2009-12-16 | 卡罗拜奥斯制药公司 | 使用gm-csf拮抗剂治疗慢性炎症疾病的方法 |
| US8398972B2 (en) * | 2006-11-21 | 2013-03-19 | Kalobios Pharmaceuticals, Inc. | Methods of treating dementia using a GM-CSF antagonist |
| BRPI0807952A2 (pt) | 2007-02-20 | 2014-06-10 | Anaptysbio Inc | Sistemas de hipermutação somática |
| US8637016B2 (en) * | 2007-03-08 | 2014-01-28 | Kalobios Pharmaceuticals, Inc. | EphA3 antibodies for the treatment of solid tumors |
| EP2565207A3 (en) * | 2007-03-14 | 2013-06-12 | Alexion Cambridge Corporation | Humaneered Anti-Factor B Antibody |
| US20100330090A1 (en) * | 2007-07-17 | 2010-12-30 | Irm Llc | Antagonist antibodies of protease activated receptor-1 (par1) |
| JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
| CA2706732A1 (en) | 2007-11-30 | 2009-06-11 | Kalobios Pharmaceuticals, Inc. | Antibodies to the pcrv antigen of pseudomonas aeruginosa |
| WO2009114815A1 (en) | 2008-03-13 | 2009-09-17 | Dyax Corp | Libraries of genetic packages comprising novel hc cdr3 designs |
| WO2009132287A2 (en) | 2008-04-24 | 2009-10-29 | Dyax Corp. | Libraries of genetic packages comprising novel hc cdr1, cdr2, and cdr3 and novel lc cdr1, cdr2, and cdr3 designs |
| WO2009134805A2 (en) * | 2008-04-28 | 2009-11-05 | Kalobios Pharmaceuticals, Inc. | Antibodies to granulocyte-macrophage colony-stimulating factor |
| CA2751433A1 (en) | 2009-02-04 | 2010-08-12 | Kalobios Pharmaceuticals, Inc. | Combination antibiotic and antibody therapy for the treatment of pseudomonas aeruginosa infection |
| US9079942B2 (en) | 2009-02-09 | 2015-07-14 | Epitomics, Inc. | CDR-anchored amplification method |
| WO2010093814A1 (en) | 2009-02-11 | 2010-08-19 | Kalobios Pharmaceuticals, Inc. | Methods of treating dementia using a gm-csf antagonist |
| WO2010102244A1 (en) | 2009-03-06 | 2010-09-10 | Kalobios Pharmaceuticals, Inc. | Treatment of leukemias and chronic myeloproliferative diseases with antibodies to epha3 |
| AU2010249470B2 (en) * | 2009-05-20 | 2015-06-25 | Novimmune S.A. | Synthetic Polypeptide Libraries And Methods For Generating Naturally Diversified Polypeptide Variants |
| RS20120461A1 (sr) | 2009-07-02 | 2013-06-28 | Musc Foundation For Research Development | Metode za stimulaciju regeneracije jetre |
| US8293483B2 (en) | 2009-09-11 | 2012-10-23 | Epitomics, Inc. | Method for identifying lineage-related antibodies |
| PT2488554T (pt) | 2009-10-14 | 2019-09-13 | Humanigen Inc | Anticorpos para epha3 |
| AR079336A1 (es) * | 2009-12-11 | 2012-01-18 | Irm Llc | Antagonistas de la pro-proteina convertasa-subtilisina/quexina tipo 9 (pcsk9) |
| US9150641B2 (en) | 2009-12-22 | 2015-10-06 | Hoffmann—La Roche Inc. | Sequence dependent aggregation |
| CN105315370A (zh) | 2010-02-18 | 2016-02-10 | 加利福尼亚大学董事会 | 整合素αVβ8中和抗体 |
| CA2794851A1 (en) * | 2010-04-02 | 2011-10-06 | Kalobios Pharmaceuticals, Inc. | Generation of antibodies to an epitope of interest |
| CN103562227B (zh) | 2011-02-11 | 2016-12-21 | 诺瓦提斯公司 | Pcsk9拮抗剂 |
| US9880160B2 (en) | 2011-03-15 | 2018-01-30 | X-Body, Inc. | Antibody screening methods |
| WO2012168491A1 (en) | 2011-06-10 | 2012-12-13 | Novartis Ag | Pharmaceutical formulations of pcsk9 antagonists |
| WO2012170607A2 (en) | 2011-06-10 | 2012-12-13 | Novartis Ag | Use of pcsk9 antagonists |
| EP2764021A2 (en) * | 2011-10-05 | 2014-08-13 | Kalobios Pharmaceuticals, Inc. | Generation of antibodies to an epitope of interest that contains a phosphomimetic amino acid |
| WO2013063186A2 (en) | 2011-10-26 | 2013-05-02 | Novartis Animal Health Us, Inc. | Monoclonal antibodies and methods of use |
| WO2013177035A2 (en) | 2012-05-24 | 2013-11-28 | Alexion Pharmaceuticals, Inc. | Humaneered anti-factor b antibody |
| WO2014084859A1 (en) | 2012-11-30 | 2014-06-05 | Novartis Ag | Molecules and methods for modulating tmem16a activities |
| AR096601A1 (es) | 2013-06-21 | 2016-01-20 | Novartis Ag | Anticuerpos del receptor 1 de ldl oxidado similar a lectina y métodos de uso |
| SG11201604632PA (en) | 2013-12-09 | 2016-07-28 | Allakos Inc | Anti-siglec-8 antibodies and methods of use thereof |
| JP6825909B2 (ja) | 2014-02-28 | 2021-02-03 | アラコス インコーポレイテッド | シグレック−8関連疾患を処置するための方法および組成物 |
| PT3157951T (pt) * | 2014-06-17 | 2020-08-24 | Academia Sinica | Anticorpos anti-ige humanizados que reticulam cd23 em linfócitos b, mas não sensibilizam mastócitos |
| MA41044A (fr) | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
| WO2016205567A1 (en) | 2015-06-17 | 2016-12-22 | Allakos Inc. | Methods and compositions for treating fibrotic diseases |
| JP6654779B2 (ja) * | 2015-10-13 | 2020-02-26 | 株式会社バイオピーク | ターゲットを認識するタンパク質の発現スクリーニング法 |
| US10604577B2 (en) | 2015-10-22 | 2020-03-31 | Allakos Inc. | Methods and compositions for treating systemic mastocytosis |
| EP3383891A1 (en) | 2015-12-04 | 2018-10-10 | Novartis AG | Antibody cytokine engrafted compositions and methods of use for immunoregulation |
| US11052111B2 (en) | 2015-12-08 | 2021-07-06 | Chimera Bioengineering, Inc. | Smart CAR devices and DE CAR polypeptides for treating disease and methods for enhancing immune responses |
| EP3512883A1 (en) | 2016-09-13 | 2019-07-24 | Humanigen, Inc. | Epha3 antibodies for the treatment of pulmonary fibrosis |
| JP2020500508A (ja) | 2016-10-28 | 2020-01-16 | バンヤン・バイオマーカーズ・インコーポレーテッド | ユビキチンc末端ヒドロラーゼl1(uch−l1)およびグリア線維酸性タンパク質(gfap)に対する抗体および関連する方法 |
| WO2018185618A1 (en) | 2017-04-03 | 2018-10-11 | Novartis Ag | Anti-cdh6 antibody drug conjugates and anti-gitr antibody combinations and methods of treatment |
| EA201992626A1 (ru) | 2017-05-05 | 2020-04-24 | Аллакос Инк. | Способы и композиции для лечения аллергических заболеваний глаз |
| CN111107868A (zh) | 2017-05-24 | 2020-05-05 | 诺华股份有限公司 | 抗体细胞因子移植蛋白及使用方法 |
| JOP20190271A1 (ar) | 2017-05-24 | 2019-11-21 | Novartis Ag | بروتينات مطعّمة بسيتوكين- الجسم المضاد وطرق الاستخدام للاضطرابات المتعلقة بالمناعة |
| IL322309A (en) | 2017-05-24 | 2025-09-01 | Novartis Ag | IL2 antibody grafted proteins and methods of use in cancer treatment |
| WO2018215937A1 (en) | 2017-05-24 | 2018-11-29 | Novartis Ag | Interleukin-7 antibody cytokine engrafted proteins and methods of use in the treatment of cancer |
| US11130805B2 (en) | 2017-10-02 | 2021-09-28 | Humanigen, Inc. | Methods of treating CART-T cell therapy-induced neuroinflammation using a GM-CSF antagonist |
| JP7320498B2 (ja) | 2017-10-02 | 2023-08-03 | ヒューマニジェン,インコーポレイテッド | Gm-csfアンタゴニストを使用した免疫療法関連毒性の治療方法 |
| US10899831B2 (en) | 2017-10-02 | 2021-01-26 | Humanigen, Inc. | Method of reducing the level of non-GM-CSF cytokines/chemokines in immunotherapy-related toxicity |
| US10927168B2 (en) | 2017-10-02 | 2021-02-23 | Humanicen, Inc. | Method of reducing tumor relapse rate in immunotherapy by administration of lenzilumab |
| KR20210141447A (ko) | 2018-12-26 | 2021-11-23 | 실리오 디벨럽먼트, 인크. | 항-ctla4 항체 및 이의 사용 방법 |
| TW202246324A (zh) | 2021-03-01 | 2022-12-01 | 美商艾希利歐發展股份有限公司 | 用於治療癌症的經掩蔽之ctla4及pd1/pdl1抗體之組合 |
| EP4301467A1 (en) | 2021-03-01 | 2024-01-10 | Xilio Development, Inc. | Combination of ctla4 and pd1/pdl1 antibodies for treating cancer |
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-
2005
- 2005-11-16 PL PL10014128T patent/PL2343380T3/pl unknown
- 2005-11-16 CA CA2587158A patent/CA2587158C/en not_active Expired - Lifetime
- 2005-11-16 AU AU2005306502A patent/AU2005306502B2/en not_active Ceased
- 2005-11-16 EP EP10014128.2A patent/EP2343380B1/en not_active Expired - Lifetime
- 2005-11-16 PT PT10014128T patent/PT2343380T/pt unknown
- 2005-11-16 ES ES05851809T patent/ES2429541T3/es not_active Expired - Lifetime
- 2005-11-16 WO PCT/US2005/041825 patent/WO2006055778A2/en not_active Ceased
- 2005-11-16 ES ES10014128T patent/ES2744149T3/es not_active Expired - Lifetime
- 2005-11-16 ES ES19169135T patent/ES2881353T3/es not_active Expired - Lifetime
- 2005-11-16 EP EP19169135.1A patent/EP3540062B1/en not_active Expired - Lifetime
- 2005-11-16 JP JP2007541495A patent/JP2008520586A/ja active Pending
- 2005-11-16 DK DK10014128.2T patent/DK2343380T3/da active
- 2005-11-16 PT PT191691351T patent/PT3540062T/pt unknown
- 2005-11-16 US US11/282,107 patent/US20060134098A1/en not_active Abandoned
- 2005-11-16 DK DK19169135.1T patent/DK3540062T3/da active
- 2005-11-16 PL PL19169135T patent/PL3540062T3/pl unknown
- 2005-11-16 EP EP05851809.3A patent/EP1824987B1/en not_active Revoked
-
2015
- 2015-12-14 US US14/968,709 patent/US10919983B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| PL3540062T3 (pl) | 2021-12-27 |
| US20060134098A1 (en) | 2006-06-22 |
| JP2008520586A (ja) | 2008-06-19 |
| ES2744149T3 (es) | 2020-02-21 |
| EP3540062B1 (en) | 2021-05-12 |
| AU2005306502A1 (en) | 2006-05-26 |
| PT2343380T (pt) | 2019-09-18 |
| EP1824987A2 (en) | 2007-08-29 |
| US10919983B2 (en) | 2021-02-16 |
| CA2587158A1 (en) | 2006-05-26 |
| EP3540062A1 (en) | 2019-09-18 |
| AU2005306502B2 (en) | 2012-11-15 |
| EP1824987A4 (en) | 2008-03-19 |
| ES2429541T3 (es) | 2013-11-15 |
| WO2006055778A2 (en) | 2006-05-26 |
| PT3540062T (pt) | 2021-07-06 |
| US20160102152A1 (en) | 2016-04-14 |
| CA2587158C (en) | 2016-01-12 |
| WO2006055778A3 (en) | 2006-11-23 |
| EP2343380A1 (en) | 2011-07-13 |
| EP1824987B1 (en) | 2013-08-21 |
| EP2343380B1 (en) | 2019-06-12 |
| DK2343380T3 (da) | 2019-09-09 |
| ES2881353T3 (es) | 2021-11-29 |
| DK3540062T3 (da) | 2021-06-28 |
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