BRPI0506629A - inibição do fator b, a via alternativa do sistema complemento e métodos relacionados - Google Patents
inibição do fator b, a via alternativa do sistema complemento e métodos relacionadosInfo
- Publication number
- BRPI0506629A BRPI0506629A BRPI0506629-8A BRPI0506629A BRPI0506629A BR PI0506629 A BRPI0506629 A BR PI0506629A BR PI0506629 A BRPI0506629 A BR PI0506629A BR PI0506629 A BRPI0506629 A BR PI0506629A
- Authority
- BR
- Brazil
- Prior art keywords
- alternative
- factor
- inhibition
- complement system
- related methods
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/544—Mucosal route to the airways
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Abstract
INIBIçãO DO FATOR B, A VIA ALTERNATIVA DO SISTEMA COMPLEMENTO E MéTODOS RELACIONADOS, são divulgados novos inibidores da vai alternativa do sistema complemento e, particularmente, novos anticorpos anti-fator B. Também é divulgado o uso de tais inibidores para reduzir ou evitar a hiperreatividade das vias aéreas e/ou inflamação das vias aéreas ao seletivamente inibir a via alternativa do sistema complemento, deste modo tratando doenças em que tais condições desempenham um papel importante. é divulgado ainda o uso de tais inibidores na redução ou prevenção de outras doenças e condições, incluindo lesão de isquemia/reperfusão, ao inibir a via alternativa do sistema complemento.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US54359404P | 2004-02-10 | 2004-02-10 | |
PCT/US2004/015040 WO2004103288A2 (en) | 2003-05-13 | 2004-05-13 | Method of preventing recurrent miscarriages |
US63623904P | 2004-12-14 | 2004-12-14 | |
PCT/US2005/004346 WO2005077417A1 (en) | 2004-02-10 | 2005-02-10 | Inhibition of factor b, the alternative complement pathway and methods related thereto |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0506629A true BRPI0506629A (pt) | 2007-05-02 |
Family
ID=38007673
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0506629-8A BRPI0506629A (pt) | 2004-02-10 | 2005-02-10 | inibição do fator b, a via alternativa do sistema complemento e métodos relacionados |
Country Status (7)
Country | Link |
---|---|
US (4) | US7999082B2 (pt) |
JP (1) | JP5137053B2 (pt) |
BR (1) | BRPI0506629A (pt) |
CY (1) | CY1114558T1 (pt) |
DK (1) | DK1713503T3 (pt) |
ES (1) | ES2432112T3 (pt) |
PT (1) | PT1713503E (pt) |
Families Citing this family (59)
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WO2006128006A1 (en) | 2005-05-26 | 2006-11-30 | The Regents Of The University Of Colorado | Inhibition of the alternative complement pathway for treatment of traumatic brain injury, spinal cord injury and related conditions |
US8168584B2 (en) | 2005-10-08 | 2012-05-01 | Potentia Pharmaceuticals, Inc. | Methods of treating age-related macular degeneration by compstatin and analogs thereof |
EP2826788B1 (en) * | 2006-06-21 | 2017-12-13 | MUSC Foundation for Research Development | Targeting complement factor h for treatment of diseases by the use of cr2-fh molecules |
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WO2007032876A2 (en) | 2005-09-09 | 2007-03-22 | University Of Iowa Research Foundation | Biomarkers associated with age-related macular degeneration |
UA99591C2 (ru) | 2005-11-04 | 2012-09-10 | Дженентек, Инк. | Применение ингибиторов пути комплемента для лечения глазных болезней |
EP2826788B1 (en) * | 2006-06-21 | 2017-12-13 | MUSC Foundation for Research Development | Targeting complement factor h for treatment of diseases by the use of cr2-fh molecules |
CA2680344A1 (en) | 2007-03-14 | 2008-11-20 | Woodruff Emlen | Humaneered anti-factor b antibody |
US20090175847A1 (en) | 2007-05-30 | 2009-07-09 | Abbott Laboratories | Humanized antibodies to ab (20-42) globulomer and uses thereof |
WO2011003098A1 (en) * | 2009-07-02 | 2011-01-06 | Musc Foundation For Research Development | Methods of stimulating liver regeneration |
CN102958535A (zh) | 2009-11-05 | 2013-03-06 | 亚力史剑桥公司 | 阵发性夜间血红蛋白尿、溶血性贫血和涉及血管内和血管外溶血的疾病状态的治疗 |
MX2012013233A (es) | 2010-05-14 | 2013-05-20 | Univ Colorado Regents | Grupos que apuntan a receptor 2 de complemento (cr2) mejorados. |
USRE49339E1 (en) | 2010-06-22 | 2022-12-20 | The Regents Of The University Of Colorado, A Body Corporate | Antibodies to the C3D fragment of complement component 3 |
-
2005
- 2005-02-10 BR BRPI0506629-8A patent/BRPI0506629A/pt not_active IP Right Cessation
- 2005-02-10 ES ES05722948T patent/ES2432112T3/es active Active
- 2005-02-10 US US11/057,047 patent/US7999082B2/en not_active Expired - Fee Related
- 2005-02-10 PT PT57229486T patent/PT1713503E/pt unknown
- 2005-02-10 JP JP2006553251A patent/JP5137053B2/ja not_active Expired - Fee Related
- 2005-02-10 DK DK05722948.6T patent/DK1713503T3/da active
-
2007
- 2007-08-03 US US11/888,997 patent/US8652475B2/en not_active Expired - Fee Related
- 2007-08-22 US US11/843,617 patent/US8703140B2/en not_active Expired - Fee Related
-
2013
- 2013-10-30 CY CY20131100959T patent/CY1114558T1/el unknown
-
2014
- 2014-02-18 US US14/183,213 patent/US20140154307A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP5137053B2 (ja) | 2013-02-06 |
PT1713503E (pt) | 2013-11-14 |
US8652475B2 (en) | 2014-02-18 |
US7999082B2 (en) | 2011-08-16 |
US20080075720A1 (en) | 2008-03-27 |
US8703140B2 (en) | 2014-04-22 |
US20050260198A1 (en) | 2005-11-24 |
ES2432112T3 (es) | 2013-11-29 |
US20140154307A1 (en) | 2014-06-05 |
DK1713503T3 (da) | 2013-11-04 |
JP2007522229A (ja) | 2007-08-09 |
US20080102040A1 (en) | 2008-05-01 |
CY1114558T1 (el) | 2016-10-05 |
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