BRPI0516751A - pirimidinas bicìclicas que inibem hcv - Google Patents
pirimidinas bicìclicas que inibem hcvInfo
- Publication number
- BRPI0516751A BRPI0516751A BRPI0516751-5A BRPI0516751A BRPI0516751A BR PI0516751 A BRPI0516751 A BR PI0516751A BR PI0516751 A BRPI0516751 A BR PI0516751A BR PI0516751 A BRPI0516751 A BR PI0516751A
- Authority
- BR
- Brazil
- Prior art keywords
- hcv
- present
- bicyclic pyrimidines
- inhibit hcv
- pyrimidines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
- C07D489/04—Salts; Organic complexes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
PIRIMIDINAS BICìCLICAS QUE INIBEM HCV. A presente invenção refere-se ao uso de pirimidinas bicíclicas como inibidores da replicação do HCV assim como ao seu uso nas composições farmacêuticas voltadas para tratar ou combater infecções pelo HCV. Em adição, a presente invenção se refere a processos para a preparação de tais composições farmacêuticas. A presente invenção se refere ainda a combinações das presentes pirimidinas bicíclicas com outros agentes anti-HCV.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04104815 | 2004-09-30 | ||
EP05102810 | 2005-04-08 | ||
PCT/EP2005/054912 WO2006035061A1 (en) | 2004-09-30 | 2005-09-29 | Hcv inhibiting bi-cyclic pyrimidines |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0516751A true BRPI0516751A (pt) | 2008-09-16 |
Family
ID=35448001
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0516751-5A BRPI0516751A (pt) | 2004-09-30 | 2005-09-29 | pirimidinas bicìclicas que inibem hcv |
Country Status (15)
Country | Link |
---|---|
US (1) | US7977342B2 (pt) |
EP (1) | EP1799218A1 (pt) |
JP (1) | JP5046942B2 (pt) |
KR (1) | KR20070058602A (pt) |
CN (1) | CN100594903C (pt) |
AP (1) | AP2007003923A0 (pt) |
AR (1) | AR052771A1 (pt) |
AU (1) | AU2005288858B2 (pt) |
BR (1) | BRPI0516751A (pt) |
CA (1) | CA2577745C (pt) |
IL (1) | IL181226A (pt) |
NO (1) | NO20072235L (pt) |
RU (1) | RU2380101C2 (pt) |
TW (1) | TW200626157A (pt) |
WO (1) | WO2006035061A1 (pt) |
Families Citing this family (59)
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AR056347A1 (es) | 2005-05-12 | 2007-10-03 | Tibotec Pharm Ltd | Uso de compuestos de pteridina para fabricar medicamentos y composiciones farmaceuticas |
WO2007011759A2 (en) * | 2005-07-15 | 2007-01-25 | Kalypsys, Inc. | Inhibitors of mitotic kinesin |
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CN101443334A (zh) * | 2005-12-21 | 2009-05-27 | 艾博特公司 | 抗病毒化合物 |
WO2007076034A2 (en) | 2005-12-21 | 2007-07-05 | Abbott Laboratories | Anti-viral compounds |
WO2007081517A2 (en) * | 2005-12-21 | 2007-07-19 | Abbott Laboratories | Anti-viral compounds |
DE102006029074A1 (de) * | 2006-06-22 | 2007-12-27 | Friedrich-Schiller-Universität Jena | 4-Amino-3-arylamino-6-arylpyrazolo[3,4-d]pyrimidin-Derivate, Verfahren zu ihrer Herstellung und deren Verwendung als antivirale Wirkstoffe |
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BRPI0911688A2 (pt) | 2008-07-31 | 2015-07-28 | Genentech Inc | "compostos de pirimidina, composições e métodos de uso" |
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JPWO2015005491A1 (ja) * | 2013-07-12 | 2017-03-02 | 国立大学法人京都大学 | 疾病の発症又は進行の一因となる異常スプライシングを抑制できる物質のスクリーニング方法 |
ES2900570T3 (es) | 2013-08-27 | 2022-03-17 | Gilead Pharmasset Llc | Formulación de combinación de dos compuestos antivirales |
PL3089971T3 (pl) | 2014-01-01 | 2021-01-25 | Medivation Technologies Llc | Związki i sposoby ich zastosowania |
EP3212188B1 (en) | 2014-10-29 | 2020-02-12 | King Abdullah University Of Science And Technology | 3-alkyl pyridinium compound from red sea sponge with potent antiviral activity |
WO2016107832A1 (en) * | 2014-12-30 | 2016-07-07 | F. Hoffmann-La Roche Ag | Novel tetrahydropyridopyrimidines and tetrahydropyridopyridines for the treatment and prophylaxis of hepatitis b virus infection |
EP3341372A1 (en) * | 2015-08-25 | 2018-07-04 | Bristol-Myers Squibb Company | Tgf beta receptor antagonists |
EP3356345B1 (en) | 2015-09-30 | 2023-11-08 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Heteroaryl derivatives as sepiapterin reductase inhibitors |
CR20180494A (es) * | 2016-04-01 | 2019-01-29 | Janssen Pharmaceuticals Inc | Derivados de compuestos de indol sustituidos como inhibidores de la replicación vírica del dengue |
JP6742452B2 (ja) * | 2016-06-29 | 2020-08-19 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Hbv感染の処置および予防のための新規のテトラヒドロピリドピリミジン |
CN111825674A (zh) * | 2019-04-22 | 2020-10-27 | 上海仕谱生物科技有限公司 | 嘧啶并五元杂环类化合物及其作为突变型idh2抑制剂的用途 |
RU2746423C2 (ru) * | 2019-09-02 | 2021-04-13 | Общество с ограниченной ответственностью "Научно-исследовательский институт ХимРар" (ООО "НИИ ХимРар") | Ингибитор вируса гепатита В (ВГВ) |
CN111548349A (zh) * | 2020-05-13 | 2020-08-18 | 厦门云凡医药科技有限公司 | 一种ret激酶抑制剂中间体及其制备方法 |
CN112724157B (zh) * | 2021-01-23 | 2022-04-19 | 中国科学院新疆理化技术研究所 | 二氢噁唑并[5,4-d]吡咯并[1,2-a]嘧啶-9(5H)-酮类衍生物及用途 |
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AR054122A1 (es) * | 2005-05-12 | 2007-06-06 | Tibotec Pharm Ltd | Pirido[2,3-d]pirimidas utiles como inhibidores de hcv, y metodos para la preparacion de las mismas |
AR056347A1 (es) * | 2005-05-12 | 2007-10-03 | Tibotec Pharm Ltd | Uso de compuestos de pteridina para fabricar medicamentos y composiciones farmaceuticas |
-
2005
- 2005-09-29 TW TW094133862A patent/TW200626157A/zh unknown
- 2005-09-29 KR KR1020077008247A patent/KR20070058602A/ko not_active Application Discontinuation
- 2005-09-29 AP AP2007003923A patent/AP2007003923A0/xx unknown
- 2005-09-29 CA CA2577745A patent/CA2577745C/en not_active Expired - Fee Related
- 2005-09-29 EP EP05789523A patent/EP1799218A1/en not_active Withdrawn
- 2005-09-29 WO PCT/EP2005/054912 patent/WO2006035061A1/en active Application Filing
- 2005-09-29 AU AU2005288858A patent/AU2005288858B2/en not_active Ceased
- 2005-09-29 CN CN200580033106A patent/CN100594903C/zh not_active Expired - Fee Related
- 2005-09-29 RU RU2007116176/15A patent/RU2380101C2/ru not_active IP Right Cessation
- 2005-09-29 AR ARP050104119A patent/AR052771A1/es not_active Application Discontinuation
- 2005-09-29 JP JP2007534024A patent/JP5046942B2/ja not_active Expired - Fee Related
- 2005-09-29 BR BRPI0516751-5A patent/BRPI0516751A/pt not_active IP Right Cessation
-
2007
- 2007-02-08 IL IL181226A patent/IL181226A/en not_active IP Right Cessation
- 2007-03-09 US US11/684,288 patent/US7977342B2/en not_active Expired - Fee Related
- 2007-04-30 NO NO20072235A patent/NO20072235L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU2005288858A1 (en) | 2006-04-06 |
JP2008514678A (ja) | 2008-05-08 |
CA2577745A1 (en) | 2006-04-06 |
RU2007116176A (ru) | 2008-11-10 |
WO2006035061A1 (en) | 2006-04-06 |
CN101031304A (zh) | 2007-09-05 |
AU2005288858B2 (en) | 2011-04-21 |
JP5046942B2 (ja) | 2012-10-10 |
US20070155716A1 (en) | 2007-07-05 |
AP2007003923A0 (en) | 2007-02-28 |
TW200626157A (en) | 2006-08-01 |
IL181226A (en) | 2015-03-31 |
CA2577745C (en) | 2012-11-27 |
CN100594903C (zh) | 2010-03-24 |
US7977342B2 (en) | 2011-07-12 |
NO20072235L (no) | 2007-06-28 |
KR20070058602A (ko) | 2007-06-08 |
IL181226A0 (en) | 2007-07-04 |
AR052771A1 (es) | 2007-04-04 |
RU2380101C2 (ru) | 2010-01-27 |
EP1799218A1 (en) | 2007-06-27 |
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