ECSP066794A - Nuevos compuestos como inhibidores de serina proteasa ns3 del virus de la hepatitis c - Google Patents
Nuevos compuestos como inhibidores de serina proteasa ns3 del virus de la hepatitis cInfo
- Publication number
- ECSP066794A ECSP066794A EC2006006794A ECSP066794A ECSP066794A EC SP066794 A ECSP066794 A EC SP066794A EC 2006006794 A EC2006006794 A EC 2006006794A EC SP066794 A ECSP066794 A EC SP066794A EC SP066794 A ECSP066794 A EC SP066794A
- Authority
- EC
- Ecuador
- Prior art keywords
- hepatitis
- virus
- inhibitors
- new compounds
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
La presente invención describe nuevos compuestos que tienen actividad inhibidora de la proteasa de HCV, así como también métodos para preparar dichos compuestos. En otra realización, la invención describe composiciones farmacéuticas que comprenden dichos compuestos así como también métodos de uso de los mismos para tratar desórdenes asociados con la proteasa de HCV.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US54853504P | 2004-02-27 | 2004-02-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP066794A true ECSP066794A (es) | 2006-11-16 |
Family
ID=34962125
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2006006794A ECSP066794A (es) | 2004-02-27 | 2006-08-25 | Nuevos compuestos como inhibidores de serina proteasa ns3 del virus de la hepatitis c |
Country Status (20)
Country | Link |
---|---|
US (2) | US7186747B2 (es) |
EP (2) | EP1737881B1 (es) |
JP (1) | JP2007525511A (es) |
KR (1) | KR20060124729A (es) |
CN (1) | CN1972956A (es) |
AR (1) | AR047903A1 (es) |
AT (2) | ATE478889T1 (es) |
AU (1) | AU2005222056A1 (es) |
BR (1) | BRPI0508186A (es) |
CA (1) | CA2557249A1 (es) |
DE (2) | DE602005023224D1 (es) |
EC (1) | ECSP066794A (es) |
ES (2) | ES2349328T3 (es) |
HK (2) | HK1095837A1 (es) |
IL (1) | IL177627A0 (es) |
NO (1) | NO20064357L (es) |
RU (1) | RU2006134002A (es) |
TW (1) | TW200529823A (es) |
WO (1) | WO2005087725A2 (es) |
ZA (1) | ZA200607053B (es) |
Families Citing this family (59)
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US20060275366A1 (en) * | 2005-06-02 | 2006-12-07 | Schering Corporation | Controlled-release formulation |
US20060276404A1 (en) * | 2005-06-02 | 2006-12-07 | Anima Ghosal | Medicaments and methods combining a HCV protease inhibitor and an AKR competitor |
WO2006130607A2 (en) * | 2005-06-02 | 2006-12-07 | Schering Corporation | Controlled-release formulation useful for treating disorders associated with hepatitis c virus |
US20060276406A1 (en) * | 2005-06-02 | 2006-12-07 | Schering Corporation | Methods of treating hepatitis C virus |
US20070021351A1 (en) * | 2005-06-02 | 2007-01-25 | Schering Corporation | Liver/plasma concentration ratio for dosing hepatitis C virus protease inhibitor |
NZ563365A (en) * | 2005-06-02 | 2011-02-25 | Schering Corp | Combination of HCV protease inhibitors with a surfactant |
US8119602B2 (en) | 2005-06-02 | 2012-02-21 | Schering Corporation | Administration of HCV protease inhibitors in combination with food to improve bioavailability |
WO2006130554A2 (en) * | 2005-06-02 | 2006-12-07 | Schering Corporation | Methods of treating hepatitis c virus |
JP5249028B2 (ja) * | 2005-07-25 | 2013-07-31 | インターミューン・インコーポレーテッド | C型肝炎ウイルス複製の新規大環状阻害剤 |
AR055395A1 (es) | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
DE602006019323D1 (de) | 2005-10-11 | 2011-02-10 | Intermune Inc | Verbindungen und verfahren zur inhibierung der replikation des hepatitis-c-virus |
US7705138B2 (en) * | 2005-11-11 | 2010-04-27 | Vertex Pharmaceuticals Incorporated | Hepatitis C virus variants |
EP1951748B1 (en) | 2005-11-11 | 2013-07-24 | Vertex Pharmaceuticals, Inc. | Hepatitis c virus variants |
US7816348B2 (en) | 2006-02-03 | 2010-10-19 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
WO2007094296A1 (ja) | 2006-02-14 | 2007-08-23 | Matsushita Electric Industrial Co., Ltd. | プラズマディスプレイパネルの駆動方法およびプラズマディスプレイ装置 |
KR20090024834A (ko) * | 2006-07-05 | 2009-03-09 | 인터뮨, 인크. | C형 간염 바이러스 복제의 신규 억제제 |
US20090098085A1 (en) * | 2006-08-11 | 2009-04-16 | Ying Sun | Tetrazolyl acyclic hepatitis c serine protease inhibitors |
RU2009109355A (ru) | 2006-08-17 | 2010-09-27 | БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) | Ингибиторы вырусной полимеразы |
RU2009113664A (ru) * | 2006-09-13 | 2010-10-20 | Новартис АГ (CH) | Макроциклические ингибиторы hcv и их применения |
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US8242140B2 (en) | 2007-08-03 | 2012-08-14 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
US8419332B2 (en) * | 2007-10-19 | 2013-04-16 | Atlas Bolt & Screw Company Llc | Non-dimpling fastener |
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US9254292B2 (en) | 2010-09-29 | 2016-02-09 | Merck Sharp & Dohme Corp. | Fused tetracycle derivatives and methods of use thereof for the treatment of viral diseases |
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AR112412A1 (es) | 2017-08-17 | 2019-10-23 | Gilead Sciences Inc | Formas de sal de colina de un inhibidor de la cápside del vih |
AR112413A1 (es) | 2017-08-17 | 2019-10-23 | Gilead Sciences Inc | Formas sólidas de un inhibidor de la cápside del vih |
CA3089590C (en) | 2018-02-15 | 2022-12-06 | Gilead Sciences, Inc. | Pyridine derivatives and their use for treating hiv infection |
AR114631A1 (es) | 2018-02-16 | 2020-09-30 | Gilead Sciences Inc | Métodos e intermedios para preparar compuestos de piridina |
KR20210033492A (ko) | 2018-07-16 | 2021-03-26 | 길리애드 사이언시즈, 인코포레이티드 | Hiv의 치료를 위한 캡시드 억제제 |
JP2023502530A (ja) | 2019-11-26 | 2023-01-24 | ギリアード サイエンシーズ, インコーポレイテッド | Hiv予防のためのカプシド阻害剤 |
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US11351149B2 (en) | 2020-09-03 | 2022-06-07 | Pfizer Inc. | Nitrile-containing antiviral compounds |
US11787825B2 (en) | 2021-12-03 | 2023-10-17 | Gilead Sciences, Inc. | Therapeutic compounds for HIV virus infection |
CN114133350B (zh) * | 2021-12-16 | 2023-05-23 | 浙江乐普药业股份有限公司 | 一种抗新冠药物Paxlovid中间体的制备方法 |
WO2023151188A1 (zh) * | 2022-02-08 | 2023-08-17 | 上海皓元医药股份有限公司 | 一种抗病毒药物中间体的绿色合成方法 |
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AR029851A1 (es) | 2000-07-21 | 2003-07-16 | Dendreon Corp | Nuevos peptidos como inhibidores de ns3-serina proteasa del virus de hepatitis c |
US7012066B2 (en) * | 2000-07-21 | 2006-03-14 | Schering Corporation | Peptides as NS3-serine protease inhibitors of hepatitis C virus |
US7244721B2 (en) | 2000-07-21 | 2007-07-17 | Schering Corporation | Peptides as NS3-serine protease inhibitors of hepatitis C virus |
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-
2005
- 2005-02-24 RU RU2006134002/04A patent/RU2006134002A/ru not_active Application Discontinuation
- 2005-02-24 EP EP05723590A patent/EP1737881B1/en active Active
- 2005-02-24 EP EP08102711A patent/EP1939213B1/en active Active
- 2005-02-24 DE DE602005023224T patent/DE602005023224D1/de active Active
- 2005-02-24 CN CNA2005800126954A patent/CN1972956A/zh active Pending
- 2005-02-24 BR BRPI0508186-6A patent/BRPI0508186A/pt not_active IP Right Cessation
- 2005-02-24 US US11/065,531 patent/US7186747B2/en active Active
- 2005-02-24 AT AT08102711T patent/ATE478889T1/de not_active IP Right Cessation
- 2005-02-24 AU AU2005222056A patent/AU2005222056A1/en not_active Abandoned
- 2005-02-24 ES ES08102711T patent/ES2349328T3/es active Active
- 2005-02-24 CA CA002557249A patent/CA2557249A1/en not_active Abandoned
- 2005-02-24 TW TW094105642A patent/TW200529823A/zh unknown
- 2005-02-24 JP JP2007500947A patent/JP2007525511A/ja not_active Ceased
- 2005-02-24 KR KR1020067017296A patent/KR20060124729A/ko not_active Application Discontinuation
- 2005-02-24 AT AT05723590T patent/ATE434621T1/de not_active IP Right Cessation
- 2005-02-24 WO PCT/US2005/005773 patent/WO2005087725A2/en active Application Filing
- 2005-02-24 DE DE602005015093T patent/DE602005015093D1/de active Active
- 2005-02-24 ES ES05723590T patent/ES2327544T3/es active Active
- 2005-02-25 AR ARP050100721A patent/AR047903A1/es unknown
-
2006
- 2006-08-22 IL IL177627A patent/IL177627A0/en unknown
- 2006-08-23 ZA ZA200606953A patent/ZA200607053B/xx unknown
- 2006-08-25 EC EC2006006794A patent/ECSP066794A/es unknown
- 2006-09-26 NO NO20064357A patent/NO20064357L/no not_active Application Discontinuation
- 2006-12-21 US US11/644,708 patent/US7425576B2/en active Active
-
2007
- 2007-03-19 HK HK07102949.1A patent/HK1095837A1/xx not_active IP Right Cessation
-
2008
- 2008-08-19 HK HK08109243.8A patent/HK1118066A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NO20064357L (no) | 2006-11-24 |
AU2005222056A1 (en) | 2005-09-22 |
EP1939213A1 (en) | 2008-07-02 |
CA2557249A1 (en) | 2005-09-22 |
ES2349328T3 (es) | 2010-12-30 |
US7425576B2 (en) | 2008-09-16 |
IL177627A0 (en) | 2006-12-31 |
ATE478889T1 (de) | 2010-09-15 |
HK1118066A1 (en) | 2009-01-30 |
RU2006134002A (ru) | 2008-04-10 |
WO2005087725A2 (en) | 2005-09-22 |
EP1737881B1 (en) | 2009-06-24 |
HK1095837A1 (en) | 2007-05-18 |
DE602005023224D1 (de) | 2010-10-07 |
ATE434621T1 (de) | 2009-07-15 |
WO2005087725A3 (en) | 2005-10-27 |
EP1939213B1 (en) | 2010-08-25 |
BRPI0508186A (pt) | 2007-08-14 |
US7186747B2 (en) | 2007-03-06 |
KR20060124729A (ko) | 2006-12-05 |
TW200529823A (en) | 2005-09-16 |
JP2007525511A (ja) | 2007-09-06 |
US20050245458A1 (en) | 2005-11-03 |
EP1737881A2 (en) | 2007-01-03 |
ES2327544T3 (es) | 2009-10-30 |
AR047903A1 (es) | 2006-03-01 |
ZA200607053B (en) | 2009-02-25 |
CN1972956A (zh) | 2007-05-30 |
DE602005015093D1 (de) | 2009-08-06 |
US20070142300A1 (en) | 2007-06-21 |
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