EA201171155A1 - 5-β ПРОИЗВОДНЫЕ 14-β-АНДРОСТАНА ДЛЯ ЛЕЧЕНИЯ ПРОТЕИНУРИИ, ГЛОМЕРУЛОСКЛЕРОЗА И ПОЧЕЧНОЙ НЕДОСТАТОЧНОСТИ - Google Patents

5-β ПРОИЗВОДНЫЕ 14-β-АНДРОСТАНА ДЛЯ ЛЕЧЕНИЯ ПРОТЕИНУРИИ, ГЛОМЕРУЛОСКЛЕРОЗА И ПОЧЕЧНОЙ НЕДОСТАТОЧНОСТИ

Info

Publication number
EA201171155A1
EA201171155A1 EA201171155A EA201171155A EA201171155A1 EA 201171155 A1 EA201171155 A1 EA 201171155A1 EA 201171155 A EA201171155 A EA 201171155A EA 201171155 A EA201171155 A EA 201171155A EA 201171155 A1 EA201171155 A1 EA 201171155A1
Authority
EA
Eurasian Patent Office
Prior art keywords
glomerulosclerosis
proteinuria
renal failure
treatment
androstan
Prior art date
Application number
EA201171155A
Other languages
English (en)
Other versions
EA019929B1 (ru
Inventor
Патриция Феррари
Джузеппе Бьянки
Мара Ферранди
Original Assignee
Сигма-Тау Индустрие Фармасьютике Риуните С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сигма-Тау Индустрие Фармасьютике Риуните С.П.А. filed Critical Сигма-Тау Индустрие Фармасьютике Риуните С.П.А.
Publication of EA201171155A1 publication Critical patent/EA201171155A1/ru
Publication of EA019929B1 publication Critical patent/EA019929B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Соединение формулы (I), для которой значения символов раскрыто в тексте; для изготовления лекарственного средства для предотвращения и/или лечения протеинурии, гломерулосклероза или почечной недостаточности.
EA201171155A 2009-03-23 2010-03-18 5-β ПРОИЗВОДНЫЕ 14-β-АНДРОСТАНА ДЛЯ ЛЕЧЕНИЯ ПРОТЕИНУРИИ, ГЛОМЕРУЛОСКЛЕРОЗА И ПОЧЕЧНОЙ НЕДОСТАТОЧНОСТИ EA019929B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09155834 2009-03-23
PCT/EP2010/053571 WO2010108855A1 (en) 2009-03-23 2010-03-18 5-β, 14-β-ANDROSTANE DERIVATIVES USEFUL FOR THE TREATMENT OF PROTEINURIA, GLOMERULOSCLEROSIS AND RENAL FAILURE

Publications (2)

Publication Number Publication Date
EA201171155A1 true EA201171155A1 (ru) 2012-03-30
EA019929B1 EA019929B1 (ru) 2014-07-30

Family

ID=40622086

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201171155A EA019929B1 (ru) 2009-03-23 2010-03-18 5-β ПРОИЗВОДНЫЕ 14-β-АНДРОСТАНА ДЛЯ ЛЕЧЕНИЯ ПРОТЕИНУРИИ, ГЛОМЕРУЛОСКЛЕРОЗА И ПОЧЕЧНОЙ НЕДОСТАТОЧНОСТИ

Country Status (21)

Country Link
US (2) US20120028945A1 (ru)
EP (1) EP2411015B1 (ru)
JP (1) JP5738267B2 (ru)
KR (1) KR101656797B1 (ru)
CN (1) CN102361643B (ru)
AU (1) AU2010227644B2 (ru)
BR (1) BRPI1012240A2 (ru)
CA (1) CA2754642C (ru)
DK (1) DK2411015T3 (ru)
EA (1) EA019929B1 (ru)
ES (1) ES2559005T3 (ru)
HU (1) HUE027408T2 (ru)
IL (1) IL214477A (ru)
MX (1) MX2011009321A (ru)
NZ (1) NZ594412A (ru)
PL (1) PL2411015T3 (ru)
PT (1) PT2411015E (ru)
SG (2) SG2014010912A (ru)
UA (1) UA103664C2 (ru)
WO (1) WO2010108855A1 (ru)
ZA (1) ZA201107647B (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102053470B1 (ko) * 2009-10-19 2019-12-06 씨비에 테라퓨틱스 리미티드 심혈관 병폐의 약리유전학적 치료를 위한 방법들 및 시스템들
CN102940640A (zh) * 2012-12-06 2013-02-27 中国生命药物治疗有限公司 罗他夫辛在制备治疗基因缺陷型原发性高血压的药物中的用途
CN105078954A (zh) * 2015-08-20 2015-11-25 南京华宽信息咨询中心 一种治疗急性肾衰药物及其应用
CN108152432B (zh) * 2017-12-29 2020-11-20 兆科药业（合肥）有限公司 一种罗他夫辛片高效液相检测方法
US11337988B2 (en) 2018-09-27 2022-05-24 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Use of ouabain antagonists to inhibit viral infection
EP3805243B1 (en) * 2019-10-09 2023-11-15 Windtree Therapeutics, Inc. Androstane derivatives with activity as pure or predominantly pure stimulators of serca2a for the treatment of heart failure

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4227616C2 (de) * 1992-08-20 1995-04-13 Sigma Tau Ind Farmaceuti 17-(3-Furyl)-und 17-(4-Pyridazinyl)-5beta, 14beta-androstanderivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammemsetzungen
DE4232681C2 (de) 1992-09-29 1994-11-24 Sigma Tau Ind Farmaceuti 17-Phenyl- und 17-Furyl-14beta,5alpha-androstan- und androsten- Derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzung
DE4232638C2 (de) 1992-09-29 1994-11-17 Sigma Tau Ind Farmaceuti 17-Phenyl-5beta-14beta-androstanderivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
TWI389917B (zh) * 2006-04-13 2013-03-21 Sigma Tau Ind Farmaceuti 作為心血管疾病治療藥物的雄甾烷與雄甾烯之氮雜環烷基衍生物
TWI392682B (zh) * 2006-04-13 2013-04-11 Sigma Tau Ind Farmaceuti 作為心血管疾病的治療藥物之雄甾烷和雄甾烯的胺基衍生物
TWI372762B (en) * 2006-06-23 2012-09-21 Sigma Tau Ind Farmaceuti Amino derivatives of b-homoandrostanes and b-heteroandrostanes
BRPI0812775B8 (pt) * 2007-06-07 2021-05-25 Alfasigma Spa uso de 17 beta-(3-furil)-5 beta-androstano-3 beta, 14 beta, 17 alfa- triol na preparação de um medicamento para prevenção ou tratamento de doenças devidas à fibrose hepática

Also Published As

Publication number Publication date
IL214477A0 (en) 2011-09-27
CA2754642A1 (en) 2010-09-30
KR20110133027A (ko) 2011-12-09
EA019929B1 (ru) 2014-07-30
KR101656797B1 (ko) 2016-09-12
EP2411015B1 (en) 2015-12-23
PL2411015T3 (pl) 2016-05-31
HUE027408T2 (en) 2016-10-28
EP2411015A1 (en) 2012-02-01
MX2011009321A (es) 2011-10-03
JP5738267B2 (ja) 2015-06-24
WO2010108855A1 (en) 2010-09-30
AU2010227644A1 (en) 2011-09-01
NZ594412A (en) 2013-10-25
UA103664C2 (ru) 2013-11-11
US9868757B2 (en) 2018-01-16
SG2014010912A (en) 2014-06-27
PT2411015E (pt) 2016-02-26
AU2010227644B2 (en) 2016-05-19
US20160251392A1 (en) 2016-09-01
CN102361643B (zh) 2016-05-18
US20120028945A1 (en) 2012-02-02
ES2559005T3 (es) 2016-02-10
CA2754642C (en) 2016-11-08
CN102361643A (zh) 2012-02-22
SG174260A1 (en) 2011-10-28
BRPI1012240A2 (pt) 2018-06-12
IL214477A (en) 2017-04-30
DK2411015T3 (en) 2016-02-08
ZA201107647B (en) 2012-07-25
JP2012521383A (ja) 2012-09-13

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU