MX379016B - Composiciones y metodos para tratar enfermedad de gaucher. - Google Patents

Composiciones y metodos para tratar enfermedad de gaucher.

Info

Publication number
MX379016B
MX379016B MX2017000266A MX2017000266A MX379016B MX 379016 B MX379016 B MX 379016B MX 2017000266 A MX2017000266 A MX 2017000266A MX 2017000266 A MX2017000266 A MX 2017000266A MX 379016 B MX379016 B MX 379016B
Authority
MX
Mexico
Prior art keywords
compositions
methods
disease
treating gaucher
treating
Prior art date
Application number
MX2017000266A
Other languages
English (en)
Inventor
Michael W Heartlein
Peter F Daniel
Original Assignee
Takeda Pharmaceuticals Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceuticals Co filed Critical Takeda Pharmaceuticals Co
Publication of MX379016B publication Critical patent/MX379016B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2434—Glucanases acting on beta-1,4-glucosidic bonds
    • C12N9/2442—Chitinase (3.2.1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/25—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving enzymes not classifiable in groups C12Q1/26 - C12Q1/66
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01014—Chitinase (3.2.1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01045—Glucosylceramidase (3.2.1.45), i.e. beta-glucocerebrosidase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/924—Hydrolases (3) acting on glycosyl compounds (3.2)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/044—Hyperlipemia or hypolipemia, e.g. dyslipidaemia, obesity

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Epidemiology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)

Abstract

La presente invención se refiere a un método para identificar a un sujeto como adecuado para el tratamiento con una enzima de glucocerebrosidasa alternativa, el método está caracterizado porque comprende; determinar si un anticuerpo neutralizante para una enzima de glucocerebrosidasa está presente en una muestra de un sujeto de está tomando actualmente o ha recibido anteriormente la enzima de glucocerebrosidasa para obtener un valor medio del anticuerpo, comparar el valor medido con un estándar, en donde si el valor medio es mayor que el estándar, el sujeto es identificado como haber dado positivo para la producción de los anticuerpos; y seleccionar a un sujeto para la enzima de glucocerebrosidasa alternativa con base en que el sujeto ha dado positivo para la producción de los anticuerpos.
MX2017000266A 2009-07-28 2010-07-28 Composiciones y metodos para tratar enfermedad de gaucher. MX379016B (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US22919509P 2009-07-28 2009-07-28
US30304410P 2010-02-10 2010-02-10
US31751310P 2010-03-25 2010-03-25
US33337210P 2010-05-11 2010-05-11
US35933810P 2010-06-28 2010-06-28
PCT/US2010/043586 WO2011017177A1 (en) 2009-07-28 2010-07-28 Compositions and methods for treating gaucher disease

Publications (1)

Publication Number Publication Date
MX379016B true MX379016B (es) 2025-03-10

Family

ID=43527246

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2017000266A MX379016B (es) 2009-07-28 2010-07-28 Composiciones y metodos para tratar enfermedad de gaucher.
MX2012001268A MX2012001268A (es) 2009-07-28 2010-07-28 Composiciones y metodos para tratar enfermedad de gaucher.
MX2015000528A MX344786B (es) 2009-07-28 2010-07-28 Composiciones y metodos para tratar enfermedad de gaucher.

Family Applications After (2)

Application Number Title Priority Date Filing Date
MX2012001268A MX2012001268A (es) 2009-07-28 2010-07-28 Composiciones y metodos para tratar enfermedad de gaucher.
MX2015000528A MX344786B (es) 2009-07-28 2010-07-28 Composiciones y metodos para tratar enfermedad de gaucher.

Country Status (15)

Country Link
US (2) US20110027254A1 (es)
EP (2) EP3354277B1 (es)
JP (5) JP5815521B2 (es)
CN (3) CN105126086B (es)
AU (3) AU2010281403B2 (es)
CA (2) CA3120503A1 (es)
CO (1) CO6660423A2 (es)
ES (2) ES2668079T3 (es)
IL (3) IL262668B2 (es)
MX (3) MX379016B (es)
NZ (3) NZ713967A (es)
PL (1) PL3354277T3 (es)
RU (2) RU2733466C2 (es)
WO (1) WO2011017177A1 (es)
ZA (2) ZA201200704B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7138262B1 (en) 2000-08-18 2006-11-21 Shire Human Genetic Therapies, Inc. High mannose proteins and methods of making high mannose proteins
AU2007212021B2 (en) 2006-02-07 2013-06-06 Takeda Pharmaceutical Company Limited Stabilized compositions of proteins having a free thiol moiety
DK3578195T5 (da) 2008-06-26 2024-06-10 Zevra Denmark As Anvendelse af Hsp70 som regulator af enzymatisk aktivitet
NZ713967A (en) 2009-07-28 2017-01-27 Shire Human Genetic Therapies Compositions and methods for treating gaucher disease
EP2595651B1 (en) * 2010-07-19 2017-03-29 Shire Human Genetic Therapies, Inc. Mannose receptor c type 1 (mrc1) codon optimized cell line and uses thereof
WO2012072082A1 (en) 2010-11-30 2012-06-07 Orphazyme Aps Methods for increasing intracellular activity of hsp70
US9387236B2 (en) * 2011-06-10 2016-07-12 Prothera Inc. Pharmaceutical compositions containing protease and methods for the treatment of lysosomal storage diseases
HUE037811T2 (hu) 2011-10-28 2018-09-28 Prothena Biosciences Ltd Alfa-szinukleint felismerõ humanizált antitestek
CN108517010A (zh) 2012-01-27 2018-09-11 普罗典娜生物科学有限公司 识别α-突触核蛋白的人源化抗体
US9623090B2 (en) * 2012-03-02 2017-04-18 Shire Human Genetic Therapies, Inc. Compositions and methods for treating type III gaucher disease
UA118441C2 (uk) 2012-10-08 2019-01-25 Протена Біосаєнсиз Лімітед Антитіло, що розпізнає альфа-синуклеїн
US10513555B2 (en) * 2013-07-04 2019-12-24 Prothena Biosciences Limited Antibody formulations and methods
HUE054957T2 (hu) 2014-09-15 2021-10-28 Orphazyme As Arimoklomol készítése
US20180296542A1 (en) * 2015-09-22 2018-10-18 Saint Louis University Iminosugars for improving bone mineral density in bone disease
WO2017178029A1 (en) 2016-04-13 2017-10-19 Orphazyme Aps Heat shock proteins and cholesterol homeostasis
CA3287846A1 (en) 2016-04-29 2025-11-29 Zevra Denmark A/S Arimoclomol for treating glucocerebrosidase associated disorders
EP3264092A1 (en) * 2016-07-01 2018-01-03 Centogene AG Use of lyso-gb1 as druggable target
AR113797A1 (es) * 2017-10-26 2020-06-10 Shire Human Genetic Therapies Formulaciones que comprenden glucocerebrosidasa e isofagomina
CN112512558A (zh) * 2018-05-27 2021-03-16 比奥阿赛斯技术有限公司 戈谢病的治疗
WO2020219874A1 (en) * 2019-04-25 2020-10-29 Shire Human Genetic Therapies, Inc. Isofagomine salts, methods of use and formulations
US11891588B2 (en) 2019-07-31 2024-02-06 Ecolab Usa Inc. Personal protective equipment free delimer compositions o
RU2759054C2 (ru) * 2019-11-27 2021-11-09 федеральное государственное бюджетное учреждение "Научно-исследовательский институт гриппа имени А.А. Смородинцева" Министерства здравоохранения Российской Федерации (ФГБУ "НИИ гриппа им. А.А. Смородинцева" Минздрава России) Рекомбинантный штамм вируса гриппа A/PR8-NS124-Luc и способ оценки поствакцинальных нейтрализующих антител с использованием биолюминесцентной детекции
CN115867644B (zh) * 2020-04-23 2025-10-10 上海药明生物技术有限公司 生产具有末端为甘露糖的n聚糖的重组糖蛋白的基因修饰细胞系
JP2023531750A (ja) * 2020-06-24 2023-07-25 ケムファーム デンマーク アー／エス ゴーシェ病を処置するためのアリモクロモル
CA3188000A1 (en) * 2020-07-13 2022-01-20 Genentech, Inc. Cell-based methods for predicting polypeptide immunogenicity
US20230384310A1 (en) * 2020-10-01 2023-11-30 Sangamo Therapeutics, Inc. Methods of detecting anti-aav antibodies
KR20230128462A (ko) 2020-11-19 2023-09-05 제브라 덴마크 에이/에스 아리모클로몰 시트레이트 및 이의 중간체를 제조하기 위한 공정

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5241093B2 (es) 1973-05-16 1977-10-17
US5272066A (en) * 1986-03-07 1993-12-21 Massachusetts Institute Of Technology Synthetic method for enhancing glycoprotein stability
US4925796A (en) * 1986-03-07 1990-05-15 Massachusetts Institute Of Technology Method for enhancing glycoprotein stability
WO1989005850A1 (en) 1987-12-23 1989-06-29 The United States Of America, As Represented By Th Cloned dna for synthesizing unique glucocerebrosidase
US5549892A (en) * 1988-12-23 1996-08-27 Genzyme Corporation Enhanced in vivo uptake of glucocerebrosidase
US5236838A (en) * 1988-12-23 1993-08-17 Genzyme Corporation Enzymatically active recombinant glucocerebrosidase
JPH03503721A (ja) 1988-12-23 1991-08-22 ジェンザイム　コーポレイション 酵素的に活性な組換えグルコセレブロシダーゼ
EP0401362B1 (en) 1988-12-23 1996-05-29 Genzyme Corporation Cho cells producing enzymatically active recombinant glucocerebrosidase
US5401650A (en) 1990-10-24 1995-03-28 The Mount Sinai School Of Medicine Of The City University Of New York Cloning and expression of biologically active α-galactosidase A
DE69213714T2 (de) 1991-01-21 1997-01-23 Genzyme Corp., Cambridge, Mass. Herstellung enzymatischer aktiver glukocerebrosidase von rekombinanten zellen
EP0604580A1 (en) 1991-09-19 1994-07-06 Genentech, Inc. EXPRESSION IN E. COLI OF ANTIBODY FRAGMENTS HAVING AT LEAST A CYSTEINE PRESENT AS A FREE THIOL, USE FOR THE PRODUCTION OF BIFUNCTIONAL F(ab') 2? ANTIBODIES
US5641670A (en) 1991-11-05 1997-06-24 Transkaryotic Therapies, Inc. Protein production and protein delivery
US6270989B1 (en) * 1991-11-05 2001-08-07 Transkaryotic Therapies, Inc. Protein production and delivery
US5911983A (en) 1992-06-26 1999-06-15 University Of Pittsburgh Gene therapy for Gaucher disease using retroviral vectors
WO1994013311A1 (en) 1992-12-10 1994-06-23 Enzon, Inc. Glycolipid enzyme-polymer conjugates
AU6809494A (en) 1992-12-21 1994-07-19 Enzon, Inc. Purification of proteinaceous material
DE69521074T2 (de) 1994-03-30 2001-09-13 Takara Shuzo Co., Ltd. Transglykosylierungsverfahren zur Herstellung eines Kohlenhydrats oder eines Glykokonjugates
JP3002113B2 (ja) 1994-03-30 2000-01-24 寳酒造株式会社 糖質又は複合糖質の製造方法
US5670132A (en) 1994-09-20 1997-09-23 Immunomedics, Inc. Modified radioantibody fragments for reduced renal uptake
PT1516628E (pt) 1995-07-27 2013-09-24 Genentech Inc Formulação de proteína liofilizada isotónica estável
ES2326705T3 (es) 1995-09-14 2009-10-16 Virginia Tech Intellectual Properties, Inc. Produccion de enzimas lisosomicas en sistemas de expresion basados en plantas.
JP2002504083A (ja) 1996-03-05 2002-02-05 オーケスト インコーポレイテッド ヒアルロン酸および増殖因子による骨の増殖を促進する方法
WO1998002161A1 (en) 1996-07-15 1998-01-22 Universiteit Van Amsterdam Deoxynojirimycin derivatives and their uses as glucosylceramidase inhibitors
HU227189B1 (en) 1996-09-13 2010-10-28 Transkaryotic Therapies Therapy for alpha-galactosidase a deficiency
IL155588A0 (en) 2003-04-27 2003-11-23 Metabogal Ltd Methods for expression of enzymatically active recombinant lysosomal enzymes in transgenic plant root cells and vectors used thereby
EP0852951A1 (de) 1996-11-19 1998-07-15 Roche Diagnostics GmbH Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern
JPH10273500A (ja) 1997-03-03 1998-10-13 Noguchi Inst 複合糖ペプチド及びその製造法
JPH10306099A (ja) 1997-03-04 1998-11-17 Noguchi Inst 新規複合糖ペプチドおよびその製法
TW542721B (en) 1997-08-06 2003-07-21 Melaleuca Inc Dietary supplements containing natural ingredients
DE69835308T2 (de) 1997-08-07 2007-08-09 University Of Utah Research Foundation, Salt Lake City Prodrugs und Konjugate von Selenoenthaltenden Verbindungen und ihre Verwendung
US5939279A (en) * 1997-09-18 1999-08-17 The Board Of Trustees Of The University Of Arkansas Inhibition of bacterial binding by high-mannose oligosaccharides
AU1905799A (en) 1997-12-22 1999-07-12 Human Genome Sciences, Inc. Keratinocyte growth factor-2 formulations
GB9802249D0 (en) 1998-02-03 1998-04-01 Ciba Geigy Ag Organic compounds
GB9807464D0 (en) 1998-04-07 1998-06-10 Pharming Bv Purification of human acid µ-glucosidase
EP0976838A1 (en) 1998-05-06 2000-02-02 Rhone-Poulenc Nutrition Animale Enzymes mixture
JPH11318441A (ja) 1998-05-14 1999-11-24 Nagase & Co Ltd 超耐熱耐酸性アミロプルラナーゼ
KR19990086271A (ko) 1998-05-27 1999-12-15 손경식 면역세포의 신규한 엔도뉴클레아제 및 이를 사용한 면역보조제
CA2330242A1 (fr) 1998-06-05 1999-12-16 Aventis Pharma S.A. Polypeptides possedant une activite de type beta-secretase
US6998267B1 (en) 1998-12-09 2006-02-14 The Dow Chemical Company Method for manufacturing glycoproteins having human-type glycosylation
GB9909066D0 (en) * 1999-04-20 1999-06-16 Oxford Glycosciences Uk Ltd Therapies
AU5483600A (en) * 1999-06-11 2001-01-02 Jean A. Chmielewski Pharmaceutical materials and methods for their preparation and use
AU6050600A (en) 1999-07-26 2001-02-13 G.D. Searle & Co. Use of long-chain n-alkyl derivates of deoxynojirimycin and a glucocerebrosidaseenzyme for the manufacture of medicament for the treatment of glycolipid storag e diseases
US6770468B1 (en) * 1999-09-14 2004-08-03 Genzyme Glycobiology Research Institute, Inc. Phosphodiester-α-GlcNAcase of the lysosomal targeting pathway
US6534300B1 (en) * 1999-09-14 2003-03-18 Genzyme Glycobiology Research Institute, Inc. Methods for producing highly phosphorylated lysosomal hydrolases
ATE464062T1 (de) 1999-10-04 2010-04-15 Novartis Vaccines & Diagnostic Stabilisierte flüssige pharmazeutische zusammensetzung enthaltend tfpi
AU2352201A (en) 1999-12-30 2001-07-16 Maxygen Aps Improved lysosomal enzymes and lysosomal enzyme activators
US20040204379A1 (en) * 2000-06-19 2004-10-14 Cheng Seng H. Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases
WO2001097829A2 (en) * 2000-06-19 2001-12-27 Genzyme Corporation Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases
US7138262B1 (en) 2000-08-18 2006-11-21 Shire Human Genetic Therapies, Inc. High mannose proteins and methods of making high mannose proteins
CN1156702C (zh) * 2001-07-11 2004-07-07 上海晶泰生物技术有限公司 采用标记链霉亲和素-生物素技术的蛋白质芯片
WO2003048357A1 (fr) 2001-12-04 2003-06-12 Mitsubishi Pharma Corporation Procede d'activation de proteine
WO2003068260A1 (fr) 2002-02-14 2003-08-21 Chugai Seiyaku Kabushiki Kaisha Produits pharmaceutiques en solution contenant des anticorps
US7429460B2 (en) * 2003-01-15 2008-09-30 Yeda Research And Development Co., Ltd. Methods of screening for inhibitors of phospholipid synthesis related to glycolipid-storage diseases
US20040202666A1 (en) 2003-01-24 2004-10-14 Immunomedics, Inc. Anti-cancer anthracycline drug-antibody conjugates
CN102586205A (zh) 2003-01-31 2012-07-18 纽约大学西奈山医学院 酶和酶的活性部位特异性陪伴分子的组合
US7951557B2 (en) 2003-04-27 2011-05-31 Protalix Ltd. Human lysosomal proteins from plant cell culture
EP1745288A2 (en) * 2004-04-16 2007-01-24 Genentech, Inc. Assay for antibodies
US20060008415A1 (en) 2004-06-25 2006-01-12 Protein Design Labs, Inc. Stable liquid and lyophilized formulation of proteins
MX2007007590A (es) 2004-12-22 2007-12-10 Ambrx Inc Composiciones que contienen, metodos que involucran y usos de aminoacidos no naturales y polipeptidos.
JP2009503105A (ja) 2005-08-03 2009-01-29 イミュノジェン・インコーポレーテッド 免疫複合体製剤
AU2007212021B2 (en) * 2006-02-07 2013-06-06 Takeda Pharmaceutical Company Limited Stabilized compositions of proteins having a free thiol moiety
EP2005166B1 (en) * 2006-03-17 2011-06-01 BioMarin Pharmaceutical Inc. Assays for detection of antibodies to lysosomal enzymes
NZ572225A (en) * 2006-04-18 2011-05-27 Ekr Therapeutics Inc Pre-mixed pharmaceutical compositions comprising nicardipine, a tonicity agent, and a buffer
DK1860101T3 (da) 2006-05-24 2011-07-25 Amicus Therapeutics Inc Tartrat salt af isofagomin og fremgangsmåder til anvendelse deraf
JP5303458B2 (ja) * 2006-06-23 2013-10-02 アミークス セラピューティックス インコーポレイテッド β−グルコセレブロシダーゼの活性増強による神経学的疾患の治療方法
DK3255141T3 (da) * 2006-07-13 2022-01-31 Wyeth Llc Fremstilling af antistoffer med forbedret glycosyleringsmønster
TWI489984B (zh) * 2006-08-04 2015-07-01 Wyeth Corp 用於非經腸道傳輸化合物之配方及其用途
NZ713967A (en) 2009-07-28 2017-01-27 Shire Human Genetic Therapies Compositions and methods for treating gaucher disease
US20130017169A1 (en) 2010-03-02 2013-01-17 Protalix Ltd. Multimeric forms of therapeutic proteins and uses thereof
EP2595651B1 (en) 2010-07-19 2017-03-29 Shire Human Genetic Therapies, Inc. Mannose receptor c type 1 (mrc1) codon optimized cell line and uses thereof

Also Published As

Publication number Publication date
CN105126086A (zh) 2015-12-09
IL217774A0 (en) 2012-03-29
JP2018077246A (ja) 2018-05-17
US11571466B2 (en) 2023-02-07
IL262668B1 (en) 2024-06-01
IL259413B (en) 2018-12-31
JP5815521B2 (ja) 2015-11-17
IL262668A (en) 2018-12-31
AU2010281403A1 (en) 2012-03-01
US20140242061A1 (en) 2014-08-28
JP6066503B2 (ja) 2017-01-25
JP6378257B2 (ja) 2018-08-22
CA2768999A1 (en) 2011-02-10
IL217774B (en) 2018-12-31
CN102686237A (zh) 2012-09-19
EP3354277B1 (en) 2021-06-30
AU2016200739B2 (en) 2018-02-15
AU2018203308B2 (en) 2020-04-23
CN105126086B (zh) 2019-05-14
CO6660423A2 (es) 2013-04-30
CN109172813A (zh) 2019-01-11
RU2015141669A3 (es) 2019-04-23
RU2733466C2 (ru) 2020-10-01
WO2011017177A1 (en) 2011-02-10
AU2010281403B2 (en) 2016-03-10
PL3354277T3 (pl) 2021-12-13
MX344786B (es) 2017-01-06
NZ623910A (en) 2016-06-24
RU2012107103A (ru) 2013-09-10
JP2016185980A (ja) 2016-10-27
CA2768999C (en) 2021-07-20
RU2568831C2 (ru) 2015-11-20
CN109172813B (zh) 2022-09-02
JP2013500976A (ja) 2013-01-10
MX2012001268A (es) 2012-09-12
JP2020033367A (ja) 2020-03-05
ZA201200704B (en) 2018-11-28
ZA201505556B (en) 2017-03-26
US20110027254A1 (en) 2011-02-03
RU2015141669A (ru) 2018-12-26
EP2459212B1 (en) 2018-03-14
JP2015127333A (ja) 2015-07-09
AU2016200739A1 (en) 2016-02-25
CA3120503A1 (en) 2011-02-10
NZ598156A (en) 2014-06-27
EP2459212A1 (en) 2012-06-06
ES2887552T3 (es) 2021-12-23
HK1258919A1 (en) 2019-11-22
CN102686237B (zh) 2018-10-19
IL262668B2 (en) 2024-10-01
NZ713967A (en) 2017-01-27
EP3354277A1 (en) 2018-08-01
AU2018203308A1 (en) 2018-05-31
EP2459212A4 (en) 2013-04-24
HK1217449A1 (zh) 2017-01-13
ES2668079T3 (es) 2018-05-16

Similar Documents

Publication Publication Date Title
MX379016B (es) Composiciones y metodos para tratar enfermedad de gaucher.
PH12021550756A1 (en) Compositions and methods for treating and/or preventing cardiovascular disease
BRPI0922122A2 (pt) composições e métodos para tratamento de doença celíaca.
BRPI1009920A2 (pt) composições bacterianas para profilaxina e tratamento de doença degenerativa.
BRPI0813725A2 (pt) Métodos e composições para tratamento de doenças
BR112012003092A2 (pt) composições e métodos para implantação de tecido adiposo processado e produtos de tecido adiposo processados.
BRPI0911757A2 (pt) composiÇÕes e mÉtodos para tratar distérbios digestivos.
MX2014010455A (es) Metodos y composiciones para tratar enfermedad de huntington.
BRPI1007929A2 (pt) "métodos e composições para o tratamento de neovascularização".
HUE036780T2 (hu) Új kompozíciók és eljárások immunológiai vonatkozású betegségek kezelésére
CR20120202A (es) Métodos y composiciones para tratar cáncer
BRPI0815841A2 (pt) Métodos e composições para melhoramento de traços preferidos.
BRPI0908087A2 (pt) Composições e métodos para implante de tecido adipose e produtos de tecido adiposo
BRPI1006141A2 (pt) composições de anticorpo modificado, métodos para preparar e usar as mesmas
BRPI0818732A2 (pt) Composições de análogo de prostaglandina e métodos para tratar condições relacionadas epiteliais.
BRPI1007477A2 (pt) método, e, composição de tratamento de poço
CR11731A (es) Composiciones y procedimientos para su preparación y uso
BRPI0822349A2 (pt) composições e métodos para tratar doenças lisossômicas
EP2608778A4 (en) COMPOSITIONS AND METHOD FOR THE TREATMENT OF BONE DEFECTS
EA201101521A1 (ru) Способы лечения онкологических заболеваний, использующие эпиметаболические переключатели, многоаспектные внутриклеточные молекулы или факторы влияния
BRPI0919238A2 (pt) métodos e composições para o tratamento de câncer
BRPI1006145A2 (pt) "composição e método para tratamento de diabetes".
BRPI0712607A8 (pt) métodos de tratamento de acidente vascular cerebral
BRPI1007972A2 (pt) composições de combinação e métodos para o tratamento de câncer
BRPI0911612A2 (pt) composições e métodos para o tratamento da esclerose múltipla.