DK3255141T3 - Fremstilling af antistoffer med forbedret glycosyleringsmønster - Google Patents
Fremstilling af antistoffer med forbedret glycosyleringsmønster Download PDFInfo
- Publication number
- DK3255141T3 DK3255141T3 DK17179340.9T DK17179340T DK3255141T3 DK 3255141 T3 DK3255141 T3 DK 3255141T3 DK 17179340 T DK17179340 T DK 17179340T DK 3255141 T3 DK3255141 T3 DK 3255141T3
- Authority
- DK
- Denmark
- Prior art keywords
- antibodies
- preparation
- glycosylation pattern
- improved glycosylation
- improved
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0037—Serum-free medium, which may still contain naturally-sourced components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83065806P | 2006-07-13 | 2006-07-13 | |
EP12164058.5A EP2495307B9 (en) | 2006-07-13 | 2007-07-11 | Production of coagulation factor IX with improved glycosylation pattern |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3255141T3 true DK3255141T3 (da) | 2022-01-31 |
Family
ID=38645762
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK17179340.9T DK3255141T3 (da) | 2006-07-13 | 2007-07-11 | Fremstilling af antistoffer med forbedret glycosyleringsmønster |
DK07796784T DK2041270T3 (da) | 2006-07-13 | 2007-07-11 | Fremstilling af glycoproteiner |
DK12164058.5T DK2495307T5 (da) | 2006-07-13 | 2007-07-11 | Fremstilling af koagulationsfaktor IX med forbedret glycosyleringsmønster |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK07796784T DK2041270T3 (da) | 2006-07-13 | 2007-07-11 | Fremstilling af glycoproteiner |
DK12164058.5T DK2495307T5 (da) | 2006-07-13 | 2007-07-11 | Fremstilling af koagulationsfaktor IX med forbedret glycosyleringsmønster |
Country Status (23)
Country | Link |
---|---|
US (1) | US8129145B2 (da) |
EP (3) | EP2495307B9 (da) |
JP (1) | JP5401310B2 (da) |
KR (1) | KR101495549B1 (da) |
CN (2) | CN104878064A (da) |
AR (1) | AR061976A1 (da) |
AU (1) | AU2007272957B2 (da) |
BR (1) | BRPI0714212B8 (da) |
CA (1) | CA2657248C (da) |
DK (3) | DK3255141T3 (da) |
ES (2) | ES2440487T3 (da) |
HK (1) | HK1214307A1 (da) |
HU (1) | HUE039128T2 (da) |
IL (1) | IL196252A (da) |
MX (1) | MX2009000349A (da) |
PE (1) | PE20081194A1 (da) |
PL (2) | PL2041270T3 (da) |
PT (2) | PT2041270E (da) |
RU (1) | RU2463345C2 (da) |
SI (1) | SI2495307T1 (da) |
TR (1) | TR201807021T4 (da) |
TW (1) | TW200812577A (da) |
WO (1) | WO2008008360A1 (da) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7138262B1 (en) | 2000-08-18 | 2006-11-21 | Shire Human Genetic Therapies, Inc. | High mannose proteins and methods of making high mannose proteins |
PL2041270T3 (pl) | 2006-07-13 | 2014-04-30 | Wyeth Llc | Wytwarzanie glikoprotein |
TWI548747B (zh) | 2006-09-13 | 2016-09-11 | 艾伯維有限公司 | 細胞培養改良 |
US8911964B2 (en) | 2006-09-13 | 2014-12-16 | Abbvie Inc. | Fed-batch method of making human anti-TNF-alpha antibody |
ES2541546T3 (es) * | 2006-11-03 | 2015-07-21 | Wyeth Llc | Sustancias que inhiben la glucólisis en cultivo celular |
CN101679941A (zh) * | 2007-03-02 | 2010-03-24 | 惠氏公司 | 在细胞培养物中使用铜和谷氨酸盐生产多肽 |
TW200902708A (en) * | 2007-04-23 | 2009-01-16 | Wyeth Corp | Methods of protein production using anti-senescence compounds |
US20090233334A1 (en) * | 2008-03-11 | 2009-09-17 | Excellgene Sa | Cell cultivation and production of recombinant proteins by means of an orbital shake bioreactor system with disposable bags at the 1,500 liter scale |
ES2535734T3 (es) | 2008-10-20 | 2015-05-14 | Abbvie Inc. | Aislamiento y purificación de anticuerpos mediante cromatografía de afinidad con la proteína A |
TW201028433A (en) | 2008-10-20 | 2010-08-01 | Abbott Lab | Viral inactivation during purification of antibodies |
WO2011011674A2 (en) * | 2009-07-24 | 2011-01-27 | Dr. Reddy's Laboratories Ltd. | Production of erythropoiesis stimulating protein using metal ions |
MX344786B (es) * | 2009-07-28 | 2017-01-06 | Shire Human Genetic Therapies | Composiciones y metodos para tratar enfermedad de gaucher. |
PT2563906T (pt) | 2010-04-26 | 2018-02-16 | Novartis Ag | Processo para cultivo de células cho |
BR112013018751B1 (pt) * | 2010-12-28 | 2021-01-05 | Chugai Seiyaku Kabushiki Kaisha (Chugai Pharmaceutical Co., Ltd.) | método para modular o nível de componentes de homogeneidade de uma proteína, método para produzir uma proteína desejada, medicamento e método para preparação do mesmo |
WO2012149197A2 (en) | 2011-04-27 | 2012-11-01 | Abbott Laboratories | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
DK2702164T3 (da) | 2011-04-29 | 2016-02-01 | Biocon Res Ltd | Fremgangsmåde til reduktion af heterogenitet af antistoffer og fremgangsmåde til fremstilling af disse antistoffer |
AU2012283858C1 (en) | 2011-07-20 | 2020-01-23 | Zepteon, Incorporated | Polypeptide separation methods |
EP2809773B1 (en) | 2012-01-30 | 2020-09-02 | Dr. Reddy's Laboratories Limited | Process of modulating man5 and/or afucosylation content of glycoprotein composition |
WO2013158273A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Methods to modulate c-terminal lysine variant distribution |
US9505833B2 (en) | 2012-04-20 | 2016-11-29 | Abbvie Inc. | Human antibodies that bind human TNF-alpha and methods of preparing the same |
WO2013158279A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Protein purification methods to reduce acidic species |
US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
US9249182B2 (en) | 2012-05-24 | 2016-02-02 | Abbvie, Inc. | Purification of antibodies using hydrophobic interaction chromatography |
US9206390B2 (en) | 2012-09-02 | 2015-12-08 | Abbvie, Inc. | Methods to control protein heterogeneity |
US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
US9499614B2 (en) | 2013-03-14 | 2016-11-22 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides |
US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
WO2014159579A1 (en) | 2013-03-14 | 2014-10-02 | Abbvie Inc. | MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE |
US9217168B2 (en) | 2013-03-14 | 2015-12-22 | Momenta Pharmaceuticals, Inc. | Methods of cell culture |
WO2014170866A2 (en) * | 2013-04-18 | 2014-10-23 | Dr. Reddy's Laboratories Limited | Process of obtaining glycoprotein composition with increased galactosylation content |
SG11201601262QA (en) * | 2013-08-20 | 2016-03-30 | Lek Pharmaceuticals | CELL CULTURE MEDIUM AND PROCESS FOR CONTROLLING α-AMIDATION AND/OR C-TERMINAL AMINO ACID CLEAVAGE OF POLYPEPTIDES |
WO2015051293A2 (en) | 2013-10-04 | 2015-04-09 | Abbvie, Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
WO2015073884A2 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
WO2015128795A1 (en) | 2014-02-25 | 2015-09-03 | Dr. Reddy's Laboratories Limited | Process for modifying galactosylation and g0f content of a glycoprotein composition by glutamine supplementation |
DK3110961T3 (da) * | 2014-02-27 | 2020-02-03 | Hoffmann La Roche | Modulering af cellevækst og glycosylering i rekombinant glycoproteinproduktion |
PT3227454T (pt) | 2014-12-01 | 2020-04-06 | Amgen Inc | Processo para a manipulação do nível do teor de glicano de uma glicoproteína |
KR102007930B1 (ko) * | 2014-12-31 | 2019-08-06 | 주식회사 엘지화학 | 재조합 당단백질의 글리코실화 조절 방법 |
EP3042952A1 (en) * | 2015-01-07 | 2016-07-13 | CEVEC Pharmaceuticals GmbH | O-glycan sialylated recombinant glycoproteins and cell lines for producing the same |
EP4089109A3 (en) | 2015-05-22 | 2023-03-01 | CSL Behring Lengnau AG | Methods for preparing modified von willebrand factor |
EP3303559A1 (en) | 2015-06-01 | 2018-04-11 | Biogen MA Inc. | Manganese supplementation for control of glycosylation in mammalian cell culture process |
CN104894055B (zh) * | 2015-06-15 | 2018-07-17 | 成都金凯生物技术有限公司 | 一种优化的细胞培养基、细胞培养方法及其在制备蛋白和抗体中的应用 |
KR101932137B1 (ko) * | 2017-01-02 | 2018-12-24 | 연세대학교 산학협력단 | 당화 증강용 조성물 및 당화 증강된 단백질의 제조방법 |
WO2018210771A1 (en) | 2017-05-17 | 2018-11-22 | Octapharma Ag | Method for the production of a recombinant target protein |
HUP1800376A2 (hu) * | 2018-11-07 | 2020-05-28 | Richter Gedeon Nyrt | Sejttenyészetben elõállított rekombináns glikoprotein glikozilációs-mintázatának megváltoztatására szolgáló módszer |
JP2020188737A (ja) * | 2019-05-23 | 2020-11-26 | 東ソー株式会社 | 抗体依存性細胞傷害活性が向上した抗体の製造方法 |
NZ781142A (en) | 2019-12-06 | 2023-05-26 | Regeneron Pharma | Anti-vegf protein compositions and methods for producing the same |
WO2022204120A1 (en) * | 2021-03-23 | 2022-09-29 | Biogen Ma Inc. | Reducing host cell impurities during recombinant protein production |
Family Cites Families (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
US4713339A (en) | 1983-01-19 | 1987-12-15 | Genentech, Inc. | Polycistronic expression vector construction |
AU2353384A (en) | 1983-01-19 | 1984-07-26 | Genentech Inc. | Amplification in eukaryotic host cells |
GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4767704A (en) * | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
US5078996A (en) | 1985-08-16 | 1992-01-07 | Immunex Corporation | Activation of macrophage tumoricidal activity by granulocyte-macrophage colony stimulating factor |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
NO162160C (no) * | 1987-01-09 | 1989-11-15 | Medi Cult As | Serumfritt vekstmedium, samt anvendelse derav. |
US5166320A (en) | 1987-04-22 | 1992-11-24 | University Of Connecticut | Carrier system and method for the introduction of genes into mammalian cells |
SU1587450A1 (ru) * | 1988-05-04 | 1990-08-23 | Институт биоорганической химии АН БССР | Способ разделени гликозилированной и негликозилированной форм пролактина биологического материала |
US6048728A (en) * | 1988-09-23 | 2000-04-11 | Chiron Corporation | Cell culture medium for enhanced cell growth, culture longevity, and product expression |
US5549892A (en) | 1988-12-23 | 1996-08-27 | Genzyme Corporation | Enhanced in vivo uptake of glucocerebrosidase |
JPH0396383A (ja) | 1989-09-08 | 1991-04-22 | Riso Kagaku Corp | 画像形成装置 |
EP0417563B1 (de) | 1989-09-12 | 2000-07-05 | F. Hoffmann-La Roche Ag | TNF-bindende Proteine |
US5156964A (en) * | 1990-08-16 | 1992-10-20 | Cetus Corporation | Methods for adapting cells for increased product production through exposure to ammonia |
US5122469A (en) * | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
GB9021679D0 (en) | 1990-10-05 | 1990-11-21 | Gorman Scott David | Antibody preparation |
GB9022545D0 (en) | 1990-10-17 | 1990-11-28 | Wellcome Found | Culture medium |
US5118816A (en) | 1990-12-26 | 1992-06-02 | American Cyanamid Company | 2-aryl-5-(trifluoromethyl)-2-pyrroline compounds useful in the manufacture of insecticidal, nematocidal and acaricidal arylpyrroles |
ES2335720T3 (es) | 1991-01-21 | 2010-03-31 | Elan Pharmaceuticals, Inc. | Ensayo y modelo para la enfermedad de alzheimer. |
US6765087B1 (en) | 1992-08-21 | 2004-07-20 | Vrije Universiteit Brussel | Immunoglobulins devoid of light chains |
US6005079A (en) | 1992-08-21 | 1999-12-21 | Vrije Universiteit Brussels | Immunoglobulins devoid of light chains |
PT1498427E (pt) | 1992-08-21 | 2010-03-22 | Univ Bruxelles | Imunoglobulinas desprovidas de cadeias leves |
US5981505A (en) | 1993-01-26 | 1999-11-09 | The Trustees Of The University Of Pennsylvania | Compositions and methods for delivery of genetic material |
US5593972A (en) | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
US5571515A (en) | 1994-04-18 | 1996-11-05 | The Wistar Institute Of Anatomy & Biology | Compositions and methods for use of IL-12 as an adjuvant |
US5705364A (en) * | 1995-06-06 | 1998-01-06 | Genentech, Inc. | Mammalian cell culture process |
WO1998017799A1 (en) | 1996-10-23 | 1998-04-30 | The Trustees Of The University Of Pennsylvania | Immunotherapy and improved vaccines |
US5980898A (en) | 1996-11-14 | 1999-11-09 | The United States Of America As Represented By The U.S. Army Medical Research & Material Command | Adjuvant for transcutaneous immunization |
US6217900B1 (en) | 1997-04-30 | 2001-04-17 | American Home Products Corporation | Vesicular complexes and methods of making and using the same |
WO1999035255A2 (en) | 1998-01-12 | 1999-07-15 | Betagene, Inc. | Compositions and methods for regulated secretion from neuroendocrine cell lines |
EP1078093B1 (en) | 1998-02-27 | 2011-06-08 | The Trustees of The University of Pennsylvania | Vaccines, immunotherapeutics and methods for using the same |
EP1117435B1 (en) | 1998-09-30 | 2007-11-14 | Wyeth Holdings Corporation | Mutant cholera holotoxin as an adjuvant |
ES2281342T3 (es) | 1999-04-26 | 2007-10-01 | Genentech, Inc. | Proceso de cultivo de celulas para la produccion de glicoproteinas. |
JP2001120262A (ja) * | 1999-10-26 | 2001-05-08 | Welfide Corp | 生理活性物質の産生増強方法 |
ES2254403T3 (es) | 2000-03-22 | 2006-06-16 | Octagene Gmbh | Produccion de muteinas recombinantes de factor de coagulacion sanguinea viii en lineas de celulas humanas. |
US20040001822A1 (en) * | 2000-12-29 | 2004-01-01 | Avigdor Levanon | Y1-isolated molecules comprising epitopes containing sulfated moieties, antibodies to such epitopes, and uses thereof |
JP2005508143A (ja) | 2001-06-07 | 2005-03-31 | ワイス・ホールデイングス・コーポレーシヨン | アジュバントとしてのコレラホロトキシンの突然変異形 |
EP1404368B1 (en) | 2001-06-07 | 2009-12-09 | Wyeth Holdings Corporation | Mutant forms of cholera holotoxin as an adjuvant |
ES2916174T3 (es) | 2002-05-02 | 2022-06-28 | Wyeth Holdings Llc | Conjugados de transportador derivado de caliqueamicina |
JP4510938B2 (ja) | 2002-07-15 | 2010-07-28 | イミュネックス・コーポレーション | 哺乳動物細胞により産生されるタンパク質のシアル酸付加を調節する方法および培地 |
TWI384069B (zh) * | 2004-08-27 | 2013-02-01 | Pfizer Ireland Pharmaceuticals | 多胜肽之製法 |
TWI364458B (en) * | 2004-08-27 | 2012-05-21 | Wyeth Res Ireland Ltd | Production of tnfr-lg |
TWI374935B (en) * | 2004-08-27 | 2012-10-21 | Pfizer Ireland Pharmaceuticals | Production of α-abeta |
EP1707634A1 (en) | 2005-03-29 | 2006-10-04 | Octapharma AG | Method for isolation of recombinantly produced proteins |
PE20070796A1 (es) | 2005-10-24 | 2007-08-15 | Wyeth Corp | Metodo de produccion proteica utilizando compuestos anti-senescencia |
AU2006312014A1 (en) | 2005-11-02 | 2007-05-18 | Wyeth | Methods for adapting mammalian cells |
WO2007070315A2 (en) * | 2005-12-08 | 2007-06-21 | Amgen Inc. | Improved production of glycoproteins using manganese |
PL2041270T3 (pl) | 2006-07-13 | 2014-04-30 | Wyeth Llc | Wytwarzanie glikoprotein |
-
2007
- 2007-07-11 PL PL07796784T patent/PL2041270T3/pl unknown
- 2007-07-11 CN CN201510345792.0A patent/CN104878064A/zh active Pending
- 2007-07-11 EP EP12164058.5A patent/EP2495307B9/en not_active Revoked
- 2007-07-11 PT PT07796784T patent/PT2041270E/pt unknown
- 2007-07-11 PE PE2007000892A patent/PE20081194A1/es not_active Application Discontinuation
- 2007-07-11 WO PCT/US2007/015767 patent/WO2008008360A1/en active Application Filing
- 2007-07-11 EP EP20070796784 patent/EP2041270B1/en not_active Revoked
- 2007-07-11 SI SI200732024T patent/SI2495307T1/en unknown
- 2007-07-11 MX MX2009000349A patent/MX2009000349A/es active IP Right Grant
- 2007-07-11 EP EP17179340.9A patent/EP3255141B1/en not_active Revoked
- 2007-07-11 PL PL12164058T patent/PL2495307T3/pl unknown
- 2007-07-11 TR TR2018/07021T patent/TR201807021T4/tr unknown
- 2007-07-11 ES ES07796784T patent/ES2440487T3/es active Active
- 2007-07-11 DK DK17179340.9T patent/DK3255141T3/da active
- 2007-07-11 BR BRPI0714212A patent/BRPI0714212B8/pt active IP Right Grant
- 2007-07-11 US US11/827,301 patent/US8129145B2/en active Active
- 2007-07-11 CN CNA2007800331125A patent/CN101541950A/zh active Pending
- 2007-07-11 ES ES12164058.5T patent/ES2668212T3/es active Active
- 2007-07-11 DK DK07796784T patent/DK2041270T3/da active
- 2007-07-11 HU HUE12164058A patent/HUE039128T2/hu unknown
- 2007-07-11 CA CA2657248A patent/CA2657248C/en active Active
- 2007-07-11 RU RU2008152449/10A patent/RU2463345C2/ru active
- 2007-07-11 AU AU2007272957A patent/AU2007272957B2/en not_active Ceased
- 2007-07-11 JP JP2009519501A patent/JP5401310B2/ja active Active
- 2007-07-11 KR KR20097003040A patent/KR101495549B1/ko active IP Right Grant
- 2007-07-11 PT PT121640585T patent/PT2495307T/pt unknown
- 2007-07-11 DK DK12164058.5T patent/DK2495307T5/da active
- 2007-07-12 AR ARP070103100 patent/AR061976A1/es unknown
- 2007-07-12 TW TW96125405A patent/TW200812577A/zh unknown
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2008
- 2008-12-29 IL IL196252A patent/IL196252A/en active IP Right Grant
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2016
- 2016-03-02 HK HK16102419.1A patent/HK1214307A1/zh unknown
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