SG11201601262QA - CELL CULTURE MEDIUM AND PROCESS FOR CONTROLLING α-AMIDATION AND/OR C-TERMINAL AMINO ACID CLEAVAGE OF POLYPEPTIDES - Google Patents
CELL CULTURE MEDIUM AND PROCESS FOR CONTROLLING α-AMIDATION AND/OR C-TERMINAL AMINO ACID CLEAVAGE OF POLYPEPTIDESInfo
- Publication number
- SG11201601262QA SG11201601262QA SG11201601262QA SG11201601262QA SG11201601262QA SG 11201601262Q A SG11201601262Q A SG 11201601262QA SG 11201601262Q A SG11201601262Q A SG 11201601262QA SG 11201601262Q A SG11201601262Q A SG 11201601262QA SG 11201601262Q A SG11201601262Q A SG 11201601262QA
- Authority
- SG
- Singapore
- Prior art keywords
- amidation
- polypeptides
- controlling
- amino acid
- culture medium
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/22—Zinc; Zn chelators
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13181027 | 2013-08-20 | ||
| PCT/EP2014/067762 WO2015024977A1 (en) | 2013-08-20 | 2014-08-20 | CELL CULTURE MEDIUM AND PROCESS FOR CONTROLLING α-AMIDATION AND/OR C-TERMINAL AMINO ACID CLEAVAGE OF POLYPEPTIDES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201601262QA true SG11201601262QA (en) | 2016-03-30 |
Family
ID=48986049
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201601262QA SG11201601262QA (en) | 2013-08-20 | 2014-08-20 | CELL CULTURE MEDIUM AND PROCESS FOR CONTROLLING α-AMIDATION AND/OR C-TERMINAL AMINO ACID CLEAVAGE OF POLYPEPTIDES |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US10196601B2 (en) |
| EP (1) | EP3036254A1 (en) |
| JP (1) | JP2016527911A (en) |
| KR (1) | KR102118240B1 (en) |
| CN (1) | CN105473614B (en) |
| AU (1) | AU2014310555B2 (en) |
| BR (1) | BR112016002622B1 (en) |
| CA (1) | CA2915948A1 (en) |
| SG (1) | SG11201601262QA (en) |
| WO (1) | WO2015024977A1 (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9062106B2 (en) | 2011-04-27 | 2015-06-23 | Abbvie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| WO2013158279A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Protein purification methods to reduce acidic species |
| WO2013158273A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Methods to modulate c-terminal lysine variant distribution |
| US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
| WO2014151878A2 (en) | 2013-03-14 | 2014-09-25 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides |
| WO2015051293A2 (en) | 2013-10-04 | 2015-04-09 | Abbvie, Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| US20150139988A1 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| AR104050A1 (en) | 2015-03-26 | 2017-06-21 | Chugai Pharmaceutical Co Ltd | PRODUCTION PROCESS WITH CONTROLLED COPPER IONS |
| TW201923069A (en) * | 2017-10-02 | 2019-06-16 | 美商拜耳保健有限責任公司 | Methods for preventing disulfide bond reduction in cell culture harvest with selenite |
| CN117018164B (en) * | 2023-06-19 | 2024-06-07 | 广东源心再生医学有限公司 | CPON application |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ210501A (en) | 1983-12-13 | 1991-08-27 | Kirin Amgen Inc | Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence |
| GB2220938B (en) | 1988-07-20 | 1992-01-29 | Erba Carlo Spa | Use of pam enzyme in solid phase peptide synthesis |
| GB8916289D0 (en) | 1989-07-17 | 1989-08-31 | Erba Carlo Spa | Cofactor for the pam enzyme |
| GB2233978B (en) * | 1989-07-17 | 1993-03-03 | Erba Carlo Spa | Cofactors for enzymatic amidation |
| DE69034135T3 (en) | 1989-12-22 | 2012-08-23 | Laboratoires Serono S.A. | DNA constructs to activate and alter the expression of endogenous genes |
| PT101031B (en) | 1991-11-05 | 2002-07-31 | Transkaryotic Therapies Inc | PROCESS FOR THE SUPPLY OF PROTEINS BY GENETIC THERAPY |
| US5723765A (en) | 1994-08-01 | 1998-03-03 | Delta And Pine Land Co. | Control of plant gene expression |
| KR100302100B1 (en) | 1999-05-03 | 2001-11-22 | 박찬구 | Recombinant Microorganisms Expressing Small Rubber Particle-Associated Protein |
| CN1114619C (en) * | 1999-06-25 | 2003-07-16 | 中国科学院上海细胞生物学研究所 | Liver cancer murine monoclone antibody without endogenous immunoglobulin and its preparation and application |
| US8227241B2 (en) | 2004-03-12 | 2012-07-24 | Unigene Laboratories, Inc. | Bacterial host cell for the direct expression of peptides |
| EP1776461A2 (en) | 2004-04-16 | 2007-04-25 | DSMIP Assets B.V. | Fungal promoters for expressing a gene in a fungal cell |
| US20050287666A1 (en) * | 2004-06-29 | 2005-12-29 | Invitrogen Corporation | Cell culture medium comprising transition metals or trace elements |
| ES2668212T3 (en) * | 2006-07-13 | 2018-05-17 | Wyeth Llc | Production of coagulation factor IX with improved glycosylation pattern |
| RU2009132986A (en) | 2007-03-02 | 2011-04-10 | Уайт (Us) | APPLICATION OF COPPER AND GLUTAMATE IN CULTURE OF CELLS FOR THE PRODUCTION OF POLYPEPTIDES |
| CN100482786C (en) * | 2007-12-28 | 2009-04-29 | 天津百若克医药生物技术有限责任公司 | Human embryo kidney 293 cell amplifying protein-free medium |
| EP2304022A1 (en) * | 2008-06-09 | 2011-04-06 | As Vähiuuringute Tehnoloogia Arenduskeskus | THE USE OF EXTRACT OF SELENIUM ENRICHED YEAST (Se-YE) IN MAMMALIAN CELL CULTURE MEDIA FORMULATIONS |
| KR101030978B1 (en) | 2008-07-10 | 2011-04-28 | (주) 에이프로젠 | Recombinant Expression Vectors for Animal Cells |
| US9376394B2 (en) | 2009-12-23 | 2016-06-28 | Dr. Reddy's Laboratories Ltd. | Preparation of bendamustine and its salts |
| CA2797016A1 (en) | 2010-04-22 | 2011-10-27 | Senesco Technologies, Inc. | Transgenic algae with enhanced oil expression |
| PL2563904T3 (en) | 2010-04-26 | 2015-06-30 | Novartis Ag | Improved cell culture medium |
| EP2450375A1 (en) | 2010-11-09 | 2012-05-09 | Sandoz Gmbh | Cell culture medium and process for protein expression, said medium and process comprising a PAM inhibitor |
| CA2864466C (en) | 2012-04-16 | 2021-03-02 | Lek Pharmaceuticals D.D. | Reduction of formation of amidated amino acids in cell lines for protein expression |
| WO2013158273A1 (en) * | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Methods to modulate c-terminal lysine variant distribution |
| SI2970980T1 (en) | 2013-03-15 | 2018-11-30 | Janssen Biotech, Inc. | Manufacturing methods to control c-terminal lysine, galactose and sialic acid content in recombinant proteins |
-
2014
- 2014-08-20 US US14/913,312 patent/US10196601B2/en active Active
- 2014-08-20 CN CN201480046012.6A patent/CN105473614B/en active Active
- 2014-08-20 AU AU2014310555A patent/AU2014310555B2/en active Active
- 2014-08-20 JP JP2016535474A patent/JP2016527911A/en active Pending
- 2014-08-20 BR BR112016002622-5A patent/BR112016002622B1/en active IP Right Grant
- 2014-08-20 EP EP14752892.1A patent/EP3036254A1/en not_active Withdrawn
- 2014-08-20 WO PCT/EP2014/067762 patent/WO2015024977A1/en active Application Filing
- 2014-08-20 KR KR1020167005093A patent/KR102118240B1/en active IP Right Grant
- 2014-08-20 CA CA2915948A patent/CA2915948A1/en not_active Abandoned
- 2014-08-20 SG SG11201601262QA patent/SG11201601262QA/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3036254A1 (en) | 2016-06-29 |
| AU2014310555B2 (en) | 2018-01-18 |
| JP2016527911A (en) | 2016-09-15 |
| WO2015024977A1 (en) | 2015-02-26 |
| BR112016002622A2 (en) | 2017-08-01 |
| CA2915948A1 (en) | 2015-02-26 |
| BR112016002622B1 (en) | 2023-04-11 |
| CN105473614B (en) | 2019-11-01 |
| KR20160036612A (en) | 2016-04-04 |
| KR102118240B1 (en) | 2020-06-03 |
| US10196601B2 (en) | 2019-02-05 |
| AU2014310555A1 (en) | 2016-03-10 |
| US20160201028A1 (en) | 2016-07-14 |
| CN105473614A (en) | 2016-04-06 |
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