ECSP14019113A - Inhibidores de pirazolopirimidinilo de enzima activadora de ubiquitina - Google Patents
Inhibidores de pirazolopirimidinilo de enzima activadora de ubiquitinaInfo
- Publication number
- ECSP14019113A ECSP14019113A ECIEPI201419113A ECPI201419113A ECSP14019113A EC SP14019113 A ECSP14019113 A EC SP14019113A EC IEPI201419113 A ECIEPI201419113 A EC IEPI201419113A EC PI201419113 A ECPI201419113 A EC PI201419113A EC SP14019113 A ECSP14019113 A EC SP14019113A
- Authority
- EC
- Ecuador
- Prior art keywords
- chemical entities
- activating enzyme
- ubiquitin activating
- pyrazolopyrimidinyl
- inhibitors
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Se describen entidades químicas que inhiben la enzima activadora de ubiquitina (UAE), cada una de las cuales es un compuesto de Fórmula (I) o una sal farmacéuticamente aceptable de este, donde Y es Fórmula (II) y W, Z, XY, RY1, RY2 y RY3 se definen en la presente; composiciones farmacéuticas que comprenden las entidades químicas; y métodos para usar las entidades químicas. Estas entidades químicas son útiles para tratar trastornos, particularmente trastornos de proliferación celular, incluyendo cánceres. (ver fórmulas en el archivo adjunto)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261600070P | 2012-02-17 | 2012-02-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP14019113A true ECSP14019113A (es) | 2015-09-30 |
Family
ID=48982730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECIEPI201419113A ECSP14019113A (es) | 2012-02-17 | 2014-09-17 | Inhibidores de pirazolopirimidinilo de enzima activadora de ubiquitina |
Country Status (30)
| Country | Link |
|---|---|
| US (4) | US9290500B2 (es) |
| EP (3) | EP2814791A4 (es) |
| JP (1) | JP6122877B2 (es) |
| KR (1) | KR20140123104A (es) |
| CN (1) | CN104136399B (es) |
| AR (1) | AR092797A1 (es) |
| BR (1) | BR112014020365B1 (es) |
| CA (1) | CA2864672C (es) |
| CL (1) | CL2014002181A1 (es) |
| CO (1) | CO7071135A2 (es) |
| CR (1) | CR20140380A (es) |
| DO (1) | DOP2014000187A (es) |
| EA (1) | EA035020B1 (es) |
| EC (1) | ECSP14019113A (es) |
| ES (1) | ES2739150T3 (es) |
| GE (1) | GEP201706687B (es) |
| HK (1) | HK1201817A1 (es) |
| IL (1) | IL234016A0 (es) |
| MA (1) | MA35932B1 (es) |
| MX (1) | MX352963B (es) |
| NZ (1) | NZ628969A (es) |
| PE (1) | PE20142244A1 (es) |
| PH (1) | PH12014501832A1 (es) |
| SG (2) | SG10201606581RA (es) |
| TN (1) | TN2014000351A1 (es) |
| TW (1) | TWI593688B (es) |
| UA (1) | UA116534C2 (es) |
| UY (1) | UY34629A (es) |
| WO (1) | WO2013123169A1 (es) |
| ZA (1) | ZA201406103B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8008307B2 (en) | 2006-08-08 | 2011-08-30 | Millennium Pharmaceuticals, Inc. | Heteroaryl compounds useful as inhibitors of E1 activating enzymes |
| BR112014020365B1 (pt) | 2012-02-17 | 2023-02-23 | Takeda Pharmaceutical Company Limited | Inibidores de pirazolopirimidinila de enzima de ativação de ubiquitina |
| CN104684559A (zh) | 2012-08-03 | 2015-06-03 | 米伦纽姆医药公司 | 针对Uba6的吲哚取代的吡咯并嘧啶基抑制剂 |
| US9695154B2 (en) | 2013-07-02 | 2017-07-04 | Millennium Pharmaceuticals, Inc. | Heteroaryl inhibitors of sumo activating enzyme |
| UY36198A (es) | 2014-07-01 | 2016-01-29 | Millennium Pharm Inc | Compuestos de heteroarilo útiles como inhibidores de enzima activadora de sumo |
| WO2016069392A1 (en) | 2014-10-29 | 2016-05-06 | Millennium Pharmaceuticals, Inc. | Administration of ubiquitin-activating enzyme inhibitor and chemotherapeutic agents |
| WO2016069393A1 (en) | 2014-10-29 | 2016-05-06 | Millennium Pharmaceuticals, Inc. | Administration of ubiquitin-activating enzyme inhibitor and radiation |
| MX2021004769A (es) | 2018-10-30 | 2021-08-24 | Kronos Bio Inc | Compuestos, composiciones, y metodos para modular la actividad cdk9. |
| WO2023021498A1 (en) * | 2021-08-16 | 2023-02-23 | Moya Bio Ltd. | Fused azole and furan based nucleoside analogs and uses thereof |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003073989A2 (en) | 2002-02-28 | 2003-09-12 | Biota, Inc. | Nucleoside 5'-monophosphate mimics and their prodrugs |
| DE60313872T2 (de) | 2002-09-04 | 2008-01-17 | Schering Corp. | Pyrazoloä1,5-aüpyrimidine als hemmstoffe cyclin-abhängiger kinasen |
| ES2285164T3 (es) | 2002-09-04 | 2007-11-16 | Schering Corporation | Pirazolopirimidinas como inhibidores de quinasas dependientes de ciclina. |
| US7563798B2 (en) | 2002-09-04 | 2009-07-21 | Schering Corporation | Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors |
| US7196092B2 (en) | 2002-09-04 | 2007-03-27 | Schering Corporation | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| EP1608652A1 (en) | 2003-03-31 | 2005-12-28 | Vernalis (Cambridge) Limited | Pyrazolopyrimidine compounds and their use in medicine |
| JP2005008581A (ja) * | 2003-06-20 | 2005-01-13 | Kissei Pharmaceut Co Ltd | 新規なピラゾロ［１，５−ａ］ピリミジン誘導体、それを含有する医薬組成物およびそれらの用途 |
| WO2005037845A1 (en) | 2003-10-17 | 2005-04-28 | Rigel Pharmaceuticals, Inc. | Benzothiazole and thiazole[5,5-b] pyridine compositions and their use as ubiquitin ligase inhibitors |
| EP1758873A1 (en) | 2004-06-22 | 2007-03-07 | Rigel Pharmaceuticals, Inc. | Ubiquitin ligase inhibitors |
| JP5048520B2 (ja) | 2005-02-04 | 2012-10-17 | ミレニアム ファーマシューティカルズ， インコーポレイテッド | Ｅ１活性化酵素の阻害剤 |
| WO2007044426A2 (en) | 2005-10-06 | 2007-04-19 | Schering Corporation | Pyrazolopyrimidines as protein kinase inhibitors |
| EP2402334B1 (en) | 2006-02-02 | 2016-06-29 | Millennium Pharmaceuticals, Inc. | Inhibitors of E1 Activating Enzymes |
| EP1992008A1 (en) * | 2006-02-28 | 2008-11-19 | Sez Ag | Device and method for liquid treating disc-like articles |
| MY157177A (en) | 2006-08-08 | 2016-05-13 | Millennium Pharm Inc | Heteroaryl compounds useful as inhibitors of e1 activating enzymes |
| US8008307B2 (en) | 2006-08-08 | 2011-08-30 | Millennium Pharmaceuticals, Inc. | Heteroaryl compounds useful as inhibitors of E1 activating enzymes |
| CN107021895A (zh) | 2007-06-12 | 2017-08-08 | 尔察祯有限公司 | 抗菌剂 |
| ES2758027T3 (es) * | 2007-08-02 | 2020-05-04 | Millennium Pharm Inc | Intermedios para la síntesis de inhibidores de enzimas activadoras de actividad E1 |
| US9216983B2 (en) | 2007-12-21 | 2015-12-22 | Board Of Regents, University Of Texas System | Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity |
| WO2010086040A1 (en) | 2009-01-29 | 2010-08-05 | Biomarin Iga, Ltd. | Pyrazolo-pyrimidines for treatment of duchenne muscular dystrophy |
| WO2010088518A2 (en) | 2009-01-31 | 2010-08-05 | Kalypsys, Inc. | Heterocyclic modulators of gpr119 for treatment of disease |
| WO2010132110A1 (en) | 2009-05-14 | 2010-11-18 | Millennium Pharmaceuticals, Inc. | Hydrochloride salt of ((1s,2s,4r)-4-{4-[(1s)-2,3-dihydro-1h-inden-1-ylamino]-7h-pyrrolo [2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl)methyl sulfamate |
| JP5879273B2 (ja) | 2010-03-01 | 2016-03-08 | ジーティーエックス・インコーポレイテッド | 癌を処置するための化合物 |
| US20120077814A1 (en) | 2010-09-10 | 2012-03-29 | Zhong Wang | Sulfonamide, sulfamate, and sulfamothioate derivatives |
| BR112014004239A2 (pt) | 2011-08-24 | 2017-03-21 | Millennium Pharm Inc | inibidores de enzima ativadora de nedd8 |
| BR112014020365B1 (pt) | 2012-02-17 | 2023-02-23 | Takeda Pharmaceutical Company Limited | Inibidores de pirazolopirimidinila de enzima de ativação de ubiquitina |
| CN104684559A (zh) | 2012-08-03 | 2015-06-03 | 米伦纽姆医药公司 | 针对Uba6的吲哚取代的吡咯并嘧啶基抑制剂 |
| US9695154B2 (en) | 2013-07-02 | 2017-07-04 | Millennium Pharmaceuticals, Inc. | Heteroaryl inhibitors of sumo activating enzyme |
| UY36198A (es) | 2014-07-01 | 2016-01-29 | Millennium Pharm Inc | Compuestos de heteroarilo útiles como inhibidores de enzima activadora de sumo |
-
2013
- 2013-02-14 BR BR112014020365-2A patent/BR112014020365B1/pt active IP Right Grant
- 2013-02-14 CN CN201380009784.8A patent/CN104136399B/zh active Active
- 2013-02-14 SG SG10201606581RA patent/SG10201606581RA/en unknown
- 2013-02-14 SG SG11201404757WA patent/SG11201404757WA/en unknown
- 2013-02-14 JP JP2014557765A patent/JP6122877B2/ja active Active
- 2013-02-14 EA EA201400831A patent/EA035020B1/ru not_active IP Right Cessation
- 2013-02-14 WO PCT/US2013/026113 patent/WO2013123169A1/en active Application Filing
- 2013-02-14 EP EP13748707.0A patent/EP2814791A4/en not_active Withdrawn
- 2013-02-14 EP EP16205139.5A patent/EP3173413B1/en active Active
- 2013-02-14 UA UAA201409297A patent/UA116534C2/uk unknown
- 2013-02-14 KR KR1020147025556A patent/KR20140123104A/ko not_active Application Discontinuation
- 2013-02-14 MX MX2014009944A patent/MX352963B/es active IP Right Grant
- 2013-02-14 NZ NZ628969A patent/NZ628969A/en not_active IP Right Cessation
- 2013-02-14 ES ES16205139T patent/ES2739150T3/es active Active
- 2013-02-14 CA CA2864672A patent/CA2864672C/en active Active
- 2013-02-14 GE GEAP201313560A patent/GEP201706687B/en unknown
- 2013-02-14 EP EP19170607.6A patent/EP3536692B1/en active Active
- 2013-02-14 US US13/767,314 patent/US9290500B2/en active Active
- 2013-02-14 PE PE2014001278A patent/PE20142244A1/es active IP Right Grant
- 2013-02-15 UY UY0001034629A patent/UY34629A/es not_active Application Discontinuation
- 2013-02-15 AR ARP130100480A patent/AR092797A1/es unknown
- 2013-02-18 TW TW102105676A patent/TWI593688B/zh not_active IP Right Cessation
-
2014
- 2014-08-07 IL IL234016A patent/IL234016A0/en unknown
- 2014-08-11 TN TNP2014000351A patent/TN2014000351A1/fr unknown
- 2014-08-12 CR CR20140380A patent/CR20140380A/es unknown
- 2014-08-13 PH PH12014501832A patent/PH12014501832A1/en unknown
- 2014-08-14 CL CL2014002181A patent/CL2014002181A1/es unknown
- 2014-08-15 DO DO2014000187A patent/DOP2014000187A/es unknown
- 2014-08-20 ZA ZA2014/06103A patent/ZA201406103B/en unknown
- 2014-09-10 MA MA37338A patent/MA35932B1/fr unknown
- 2014-09-16 CO CO14205517A patent/CO7071135A2/es unknown
- 2014-09-17 EC ECIEPI201419113A patent/ECSP14019113A/es unknown
-
2015
- 2015-03-05 HK HK15102227.4A patent/HK1201817A1/xx unknown
-
2016
- 2016-02-19 US US15/048,007 patent/US9663525B2/en active Active
-
2017
- 2017-04-17 US US15/488,800 patent/US9796725B2/en active Active
- 2017-09-08 US US15/699,818 patent/US10202389B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ECSP14019113A (es) | Inhibidores de pirazolopirimidinilo de enzima activadora de ubiquitina | |
| UY39630A (es) | Inhibidores de bromodominios | |
| PH12017502141A1 (en) | Compounds and their methods of use | |
| UA111382C2 (uk) | Інгібітори протеїнкінази | |
| DOP2014000062A (es) | Benzilindazoles sustituidos para uso como inhibidores de la quinasa bub1 en el tratamiento de enfermedades hiperproliferativas | |
| CR20150633A (es) | Derivados del bipirazol como inhibidores jak | |
| UY35243A (es) | Inhibidores de fosfatidilinositol 3-cinasa | |
| CL2014000746A1 (es) | Compuestos derivados de 3-pirimidin-4-il-oxazolidin-2-ona y sus sales, como inhibidores de las proteinas idh mutantes; composicion farmaceutica que los comprende, utiles para el tratamiento de trastornos de la proliferacion celular tal como el cancer. | |
| EA201391626A1 (ru) | Соединения для ингибирования клеточной пролиферации в egfr-стимулированных типах рака | |
| ECSP12012318A (es) | Inhibidores de pirazolil quinazolina cinasa | |
| EA201692506A2 (ru) | Ингибиторы репликации вирусов гриппа | |
| ECSP12012103A (es) | Inhibidores de virus flaviviridae. | |
| DOP2012000263A (es) | Compuestos quimicos | |
| MX2013008868A (es) | Nuevas azaindolifenil sulfonamidas como inhibidores de serina/treonina cinasa. | |
| EA201301209A1 (ru) | Производные пирролотриазинона в качестве ингибиторов p13k | |
| MX2013009873A (es) | Inhibidores triciclicos de cinasas. | |
| ECSP12012104A (es) | Inhibidores de virus flaviviridae | |
| UA111744C2 (uk) | ЗАМІЩЕНІ ПІРИДОПІРАЗИНИ ЯК ІНГІБІТОРИ Syk | |
| TN2014000016A1 (en) | 4 - piperidinyl compounds for use as tankyrase inhibitors | |
| EA201500426A1 (ru) | Производные пирролотриазинона в качестве ингибиторов pi3k | |
| ECSP11011258A (es) | Pirimidinas fusionadas | |
| CU24263B1 (es) | Derivados de imidazopiridazinas inhibidores de quinasa akt, útiles para el tratamiento del cáncer | |
| UY33305A (es) | Compuestos heterocíclicos inhibidores de DGAT1 | |
| EA201590656A1 (ru) | Азаиндолины | |
| EA201391586A1 (ru) | ИНГИБИТОРЫ 17α-ГИДРОКСИЛАЗЫ/C-ЛИАЗЫ |