DOP2014000187A - Inhibidores de pirazolopirimidinilo de enzima activadora de ubiquitina. - Google Patents

Inhibidores de pirazolopirimidinilo de enzima activadora de ubiquitina.

Info

Publication number
DOP2014000187A
DOP2014000187A DO2014000187A DO2014000187A DOP2014000187A DO P2014000187 A DOP2014000187 A DO P2014000187A DO 2014000187 A DO2014000187 A DO 2014000187A DO 2014000187 A DO2014000187 A DO 2014000187A DO P2014000187 A DOP2014000187 A DO P2014000187A
Authority
DO
Dominican Republic
Prior art keywords
activating enzyme
pyrazolopirimidinyl
ubiquitine
inhibitors
chemical entities
Prior art date
Application number
DO2014000187A
Other languages
English (en)
Inventor
Mario Girard
Paul E Fleming
Roushan Afroze
Indu T Bharathan
Jeffrey P Ciavarri
Jeffrey L Gaulin
Steven P Langston
Tzu-Tshin Wong
Yingchun Ye
Francois R Soucy
Original Assignee
Millennium Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc
Publication of DOP2014000187A publication Critical patent/DOP2014000187A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se describen entidades químicas que inhiben la enzima activadora de ubiquitina (UAE), cada una de las cuales es un compuesto de Fórmula (I) o una sal farmacéuticamente aceptable de este, donde Y es Fórmula (II) y W, Z, XY, RY1, RY2 y RY3 se definen en la presente; composiciones farmacéuticas que comprenden las entidades químicas; y métodos para usar las entidades químicas. Estas entidades químicas son útiles para tratar trastornos, particularmente trastornos de proliferación celular, incluyendo cánceres.
DO2014000187A 2012-02-17 2014-08-15 Inhibidores de pirazolopirimidinilo de enzima activadora de ubiquitina. DOP2014000187A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261600070P 2012-02-17 2012-02-17

Publications (1)

Publication Number Publication Date
DOP2014000187A true DOP2014000187A (es) 2014-10-15

Family

ID=48982730

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2014000187A DOP2014000187A (es) 2012-02-17 2014-08-15 Inhibidores de pirazolopirimidinilo de enzima activadora de ubiquitina.

Country Status (30)

Country Link
US (4) US9290500B2 (es)
EP (3) EP3536692B1 (es)
JP (1) JP6122877B2 (es)
KR (1) KR20140123104A (es)
CN (1) CN104136399B (es)
AR (1) AR092797A1 (es)
BR (1) BR112014020365B1 (es)
CA (1) CA2864672C (es)
CL (1) CL2014002181A1 (es)
CO (1) CO7071135A2 (es)
CR (1) CR20140380A (es)
DO (1) DOP2014000187A (es)
EA (1) EA035020B1 (es)
EC (1) ECSP14019113A (es)
ES (1) ES2739150T3 (es)
GE (1) GEP201706687B (es)
HK (1) HK1201817A1 (es)
IL (1) IL234016A0 (es)
MA (1) MA35932B1 (es)
MX (1) MX352963B (es)
NZ (1) NZ628969A (es)
PE (1) PE20142244A1 (es)
PH (1) PH12014501832A1 (es)
SG (2) SG11201404757WA (es)
TN (1) TN2014000351A1 (es)
TW (1) TWI593688B (es)
UA (1) UA116534C2 (es)
UY (1) UY34629A (es)
WO (1) WO2013123169A1 (es)
ZA (1) ZA201406103B (es)

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* Cited by examiner, † Cited by third party
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US8008307B2 (en) 2006-08-08 2011-08-30 Millennium Pharmaceuticals, Inc. Heteroaryl compounds useful as inhibitors of E1 activating enzymes
EP3536692B1 (en) 2012-02-17 2021-04-07 Millennium Pharmaceuticals, Inc. Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme
EP2879681A4 (en) 2012-08-03 2015-12-23 Millennium Pharm Inc INDOINDUBSTITUTED PYRROLOPYRIMIDINYL HIBITORS OF UBA6
CN105492429A (zh) 2013-07-02 2016-04-13 米伦纽姆医药公司 Sumo活化酶的杂芳基抑制剂
JP6603712B2 (ja) * 2014-07-01 2019-11-06 ミレニアム ファーマシューティカルズ， インコーポレイテッド Ｓｕｍｏ活性化酵素の阻害薬として有用なヘテロアリール化合物
WO2016069392A1 (en) 2014-10-29 2016-05-06 Millennium Pharmaceuticals, Inc. Administration of ubiquitin-activating enzyme inhibitor and chemotherapeutic agents
JP6697453B2 (ja) 2014-10-29 2020-05-20 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． ユビキチン活性化酵素阻害物質及び放射線の投与
CN112996790B (zh) 2018-10-30 2023-11-03 克洛诺斯生物公司 用于调节cdk9活性的化合物、组合物和方法
WO2023021498A1 (en) * 2021-08-16 2023-02-23 Moya Bio Ltd. Fused azole and furan based nucleoside analogs and uses thereof

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CN1310918C (zh) 2002-09-04 2007-04-18 先灵公司 作为细胞周期蛋白依赖激酶抑制剂的吡唑并嘧啶
US7196092B2 (en) 2002-09-04 2007-03-27 Schering Corporation N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors
ATE362474T1 (de) 2002-09-04 2007-06-15 Schering Corp Pyrazolo(1,5-a)pyrimidine als hemmstoffe cyclin- abhängiger kinasen
US7563798B2 (en) 2002-09-04 2009-07-21 Schering Corporation Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
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PL1848718T3 (pl) 2005-02-04 2012-12-31 Millennium Pharm Inc Inhibitory enzymów hamujących E1
EP1940847A2 (en) 2005-10-06 2008-07-09 Schering Corporation Pyrazolopyrimidines as protein kinase inhibitors
PT1989206E (pt) * 2006-02-02 2012-10-15 Millennium Pharm Inc Inibidores da enzima de ativação e1
WO2007099021A1 (en) * 2006-02-28 2007-09-07 Sez Ag Device and method for liquid treating disc-like articles
AU2007281993B2 (en) * 2006-08-08 2013-08-29 Millennium Pharmaceuticals, Inc. Heteroaryl compounds useful as inhibitors of E1 activating enzymes
US8008307B2 (en) 2006-08-08 2011-08-30 Millennium Pharmaceuticals, Inc. Heteroaryl compounds useful as inhibitors of E1 activating enzymes
TWI519508B (zh) 2007-06-12 2016-02-01 Achaogen Inc 抗菌劑
KR20100066475A (ko) * 2007-08-02 2010-06-17 밀레니엄 파머슈티컬스 인코퍼레이티드 Ｅ1 활성화 효소 억제제의 합성 방법
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EP3536692B1 (en) 2012-02-17 2021-04-07 Millennium Pharmaceuticals, Inc. Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme
EP2879681A4 (en) 2012-08-03 2015-12-23 Millennium Pharm Inc INDOINDUBSTITUTED PYRROLOPYRIMIDINYL HIBITORS OF UBA6
CN105492429A (zh) 2013-07-02 2016-04-13 米伦纽姆医药公司 Sumo活化酶的杂芳基抑制剂
JP6603712B2 (ja) 2014-07-01 2019-11-06 ミレニアム ファーマシューティカルズ， インコーポレイテッド Ｓｕｍｏ活性化酵素の阻害薬として有用なヘテロアリール化合物

Also Published As

Publication number Publication date
PH12014501832A1 (en) 2014-11-17
US20170369499A1 (en) 2017-12-28
US10202389B2 (en) 2019-02-12
WO2013123169A1 (en) 2013-08-22
EP3536692A1 (en) 2019-09-11
HK1201817A1 (en) 2015-09-11
BR112014020365A2 (pt) 2020-12-22
EP3173413B1 (en) 2019-05-01
TWI593688B (zh) 2017-08-01
US20170217968A1 (en) 2017-08-03
JP2015508775A (ja) 2015-03-23
MX352963B (es) 2017-12-15
EP3173413A1 (en) 2017-05-31
EP2814791A1 (en) 2014-12-24
UA116534C2 (uk) 2018-04-10
MA35932B1 (fr) 2014-12-01
CN104136399A (zh) 2014-11-05
ES2739150T3 (es) 2020-01-29
US9663525B2 (en) 2017-05-30
TN2014000351A1 (en) 2015-12-21
UY34629A (es) 2013-09-02
CN104136399B (zh) 2018-08-07
MX2014009944A (es) 2014-11-10
GEP201706687B (en) 2017-06-26
EA201400831A1 (ru) 2014-12-30
EA035020B1 (ru) 2020-04-17
CO7071135A2 (es) 2014-09-30
JP6122877B2 (ja) 2017-04-26
SG11201404757WA (en) 2014-09-26
US9796725B2 (en) 2017-10-24
CA2864672C (en) 2018-01-09
EP3536692B1 (en) 2021-04-07
CA2864672A1 (en) 2013-08-22
CR20140380A (es) 2014-10-28
BR112014020365B1 (pt) 2023-02-23
KR20140123104A (ko) 2014-10-21
NZ628969A (en) 2017-03-31
US20160244455A1 (en) 2016-08-25
US20130217682A1 (en) 2013-08-22
IL234016A0 (en) 2014-09-30
SG10201606581RA (en) 2016-09-29
US9290500B2 (en) 2016-03-22
ZA201406103B (en) 2017-11-29
ECSP14019113A (es) 2015-09-30
US20140088096A9 (en) 2014-03-27
AR092797A1 (es) 2015-05-06
PE20142244A1 (es) 2015-01-07
CL2014002181A1 (es) 2014-12-12
TW201345909A (zh) 2013-11-16
EP2814791A4 (en) 2015-08-19

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