DOP2014000187A - Inhibidores de pirazolopirimidinilo de enzima activadora de ubiquitina. - Google Patents

Inhibidores de pirazolopirimidinilo de enzima activadora de ubiquitina.

Info

Publication number
DOP2014000187A
DOP2014000187A DO2014000187A DO2014000187A DOP2014000187A DO P2014000187 A DOP2014000187 A DO P2014000187A DO 2014000187 A DO2014000187 A DO 2014000187A DO 2014000187 A DO2014000187 A DO 2014000187A DO P2014000187 A DOP2014000187 A DO P2014000187A
Authority
DO
Dominican Republic
Prior art keywords
activating enzyme
pyrazolopirimidinyl
ubiquitine
inhibitors
chemical entities
Prior art date
Application number
DO2014000187A
Other languages
English (en)
Inventor
Mario Girard
Paul E Fleming
Roushan Afroze
Indu T Bharathan
Jeffrey P Ciavarri
Jeffrey L Gaulin
Steven P Langston
Tzu-Tshin Wong
Yingchun Ye
Francois R Soucy
Original Assignee
Millennium Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc
Publication of DOP2014000187A publication Critical patent/DOP2014000187A/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Se describen entidades químicas que inhiben la enzima activadora de ubiquitina (UAE), cada una de las cuales es un compuesto de Fórmula (I) o una sal farmacéuticamente aceptable de este, donde Y es Fórmula (II) y W, Z, XY, RY1, RY2 y RY3 se definen en la presente; composiciones farmacéuticas que comprenden las entidades químicas; y métodos para usar las entidades químicas. Estas entidades químicas son útiles para tratar trastornos, particularmente trastornos de proliferación celular, incluyendo cánceres.
DO2014000187A 2012-02-17 2014-08-15 Inhibidores de pirazolopirimidinilo de enzima activadora de ubiquitina. DOP2014000187A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261600070P 2012-02-17 2012-02-17

Publications (1)

Publication Number Publication Date
DOP2014000187A true DOP2014000187A (es) 2014-10-15

Family

ID=48982730

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2014000187A DOP2014000187A (es) 2012-02-17 2014-08-15 Inhibidores de pirazolopirimidinilo de enzima activadora de ubiquitina.

Country Status (30)

Country Link
US (4) US9290500B2 (es)
EP (3) EP3536692B1 (es)
JP (1) JP6122877B2 (es)
KR (1) KR20140123104A (es)
CN (1) CN104136399B (es)
AR (1) AR092797A1 (es)
BR (1) BR112014020365B1 (es)
CA (1) CA2864672C (es)
CL (1) CL2014002181A1 (es)
CO (1) CO7071135A2 (es)
CR (1) CR20140380A (es)
DO (1) DOP2014000187A (es)
EA (1) EA035020B1 (es)
EC (1) ECSP14019113A (es)
ES (1) ES2739150T3 (es)
GE (1) GEP201706687B (es)
HK (1) HK1201817A1 (es)
IL (1) IL234016A0 (es)
MA (1) MA35932B1 (es)
MX (1) MX352963B (es)
NZ (1) NZ628969A (es)
PE (1) PE20142244A1 (es)
PH (1) PH12014501832A1 (es)
SG (2) SG11201404757WA (es)
TN (1) TN2014000351A1 (es)
TW (1) TWI593688B (es)
UA (1) UA116534C2 (es)
UY (1) UY34629A (es)
WO (1) WO2013123169A1 (es)
ZA (1) ZA201406103B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8008307B2 (en) 2006-08-08 2011-08-30 Millennium Pharmaceuticals, Inc. Heteroaryl compounds useful as inhibitors of E1 activating enzymes
EP3536692B1 (en) 2012-02-17 2021-04-07 Millennium Pharmaceuticals, Inc. Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme
EP2879681A4 (en) 2012-08-03 2015-12-23 Millennium Pharm Inc INDOINDUBSTITUTED PYRROLOPYRIMIDINYL HIBITORS OF UBA6
CN105492429A (zh) 2013-07-02 2016-04-13 米伦纽姆医药公司 Sumo活化酶的杂芳基抑制剂
JP6603712B2 (ja) * 2014-07-01 2019-11-06 ミレニアム ファーマシューティカルズ, インコーポレイテッド Sumo活性化酵素の阻害薬として有用なヘテロアリール化合物
WO2016069392A1 (en) 2014-10-29 2016-05-06 Millennium Pharmaceuticals, Inc. Administration of ubiquitin-activating enzyme inhibitor and chemotherapeutic agents
JP6697453B2 (ja) 2014-10-29 2020-05-20 ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. ユビキチン活性化酵素阻害物質及び放射線の投与
CN112996790B (zh) 2018-10-30 2023-11-03 克洛诺斯生物公司 用于调节cdk9活性的化合物、组合物和方法
WO2023021498A1 (en) * 2021-08-16 2023-02-23 Moya Bio Ltd. Fused azole and furan based nucleoside analogs and uses thereof

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2477795A1 (en) 2002-02-28 2003-09-12 Kandasamy Sakthivel Nucleoside 5'-monophosphate mimics and their prodrugs
CN1310918C (zh) 2002-09-04 2007-04-18 先灵公司 作为细胞周期蛋白依赖激酶抑制剂的吡唑并嘧啶
US7196092B2 (en) 2002-09-04 2007-03-27 Schering Corporation N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors
ATE362474T1 (de) 2002-09-04 2007-06-15 Schering Corp Pyrazolo(1,5-a)pyrimidine als hemmstoffe cyclin- abhängiger kinasen
US7563798B2 (en) 2002-09-04 2009-07-21 Schering Corporation Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
WO2004087707A1 (en) 2003-03-31 2004-10-14 Vernalis (Cambridge) Limited Pyrazolopyrimidine compounds and their use in medicine
JP2005008581A (ja) * 2003-06-20 2005-01-13 Kissei Pharmaceut Co Ltd 新規なピラゾロ[1,5−a]ピリミジン誘導体、それを含有する医薬組成物およびそれらの用途
WO2005037845A1 (en) 2003-10-17 2005-04-28 Rigel Pharmaceuticals, Inc. Benzothiazole and thiazole[5,5-b] pyridine compositions and their use as ubiquitin ligase inhibitors
WO2006002284A1 (en) 2004-06-22 2006-01-05 Rigel Pharmaceuticals, Inc. Ubiquitin ligase inhibitors
PL1848718T3 (pl) 2005-02-04 2012-12-31 Millennium Pharm Inc Inhibitory enzymów hamujących E1
EP1940847A2 (en) 2005-10-06 2008-07-09 Schering Corporation Pyrazolopyrimidines as protein kinase inhibitors
PT1989206E (pt) * 2006-02-02 2012-10-15 Millennium Pharm Inc Inibidores da enzima de ativação e1
WO2007099021A1 (en) * 2006-02-28 2007-09-07 Sez Ag Device and method for liquid treating disc-like articles
AU2007281993B2 (en) * 2006-08-08 2013-08-29 Millennium Pharmaceuticals, Inc. Heteroaryl compounds useful as inhibitors of E1 activating enzymes
US8008307B2 (en) 2006-08-08 2011-08-30 Millennium Pharmaceuticals, Inc. Heteroaryl compounds useful as inhibitors of E1 activating enzymes
TWI519508B (zh) 2007-06-12 2016-02-01 Achaogen Inc 抗菌劑
KR20100066475A (ko) * 2007-08-02 2010-06-17 밀레니엄 파머슈티컬스 인코퍼레이티드 E1 활성화 효소 억제제의 합성 방법
US9216983B2 (en) 2007-12-21 2015-12-22 Board Of Regents, University Of Texas System Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity
WO2010086040A1 (en) 2009-01-29 2010-08-05 Biomarin Iga, Ltd. Pyrazolo-pyrimidines for treatment of duchenne muscular dystrophy
WO2010088518A2 (en) 2009-01-31 2010-08-05 Kalypsys, Inc. Heterocyclic modulators of gpr119 for treatment of disease
KR20120024715A (ko) * 2009-05-14 2012-03-14 밀레니엄 파머슈티컬스 인코퍼레이티드 ((1s,2s,4r)?4?{4?〔(1s)?2,3?디하이드로?1h?인덴?1?일아미노〕?7h?피롤로〔2,3?d〕피리미딘?7?일}?2?하이드록시사이클로펜틸)메틸 설파메이트의 하이드로클로라이드 염
EP3064204A1 (en) 2010-03-01 2016-09-07 GTx, Inc. Compounds for treatment of cancer
US20120077814A1 (en) 2010-09-10 2012-03-29 Zhong Wang Sulfonamide, sulfamate, and sulfamothioate derivatives
US8809356B2 (en) 2011-08-24 2014-08-19 Millennium Pharmaceuticals, Inc. Inhibitors of NEDD8-activating enzyme
EP3536692B1 (en) 2012-02-17 2021-04-07 Millennium Pharmaceuticals, Inc. Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme
EP2879681A4 (en) 2012-08-03 2015-12-23 Millennium Pharm Inc INDOINDUBSTITUTED PYRROLOPYRIMIDINYL HIBITORS OF UBA6
CN105492429A (zh) 2013-07-02 2016-04-13 米伦纽姆医药公司 Sumo活化酶的杂芳基抑制剂
JP6603712B2 (ja) 2014-07-01 2019-11-06 ミレニアム ファーマシューティカルズ, インコーポレイテッド Sumo活性化酵素の阻害薬として有用なヘテロアリール化合物

Also Published As

Publication number Publication date
PH12014501832A1 (en) 2014-11-17
US20170369499A1 (en) 2017-12-28
US10202389B2 (en) 2019-02-12
WO2013123169A1 (en) 2013-08-22
EP3536692A1 (en) 2019-09-11
HK1201817A1 (en) 2015-09-11
BR112014020365A2 (pt) 2020-12-22
EP3173413B1 (en) 2019-05-01
TWI593688B (zh) 2017-08-01
US20170217968A1 (en) 2017-08-03
JP2015508775A (ja) 2015-03-23
MX352963B (es) 2017-12-15
EP3173413A1 (en) 2017-05-31
EP2814791A1 (en) 2014-12-24
UA116534C2 (uk) 2018-04-10
MA35932B1 (fr) 2014-12-01
CN104136399A (zh) 2014-11-05
ES2739150T3 (es) 2020-01-29
US9663525B2 (en) 2017-05-30
TN2014000351A1 (en) 2015-12-21
UY34629A (es) 2013-09-02
CN104136399B (zh) 2018-08-07
MX2014009944A (es) 2014-11-10
GEP201706687B (en) 2017-06-26
EA201400831A1 (ru) 2014-12-30
EA035020B1 (ru) 2020-04-17
CO7071135A2 (es) 2014-09-30
JP6122877B2 (ja) 2017-04-26
SG11201404757WA (en) 2014-09-26
US9796725B2 (en) 2017-10-24
CA2864672C (en) 2018-01-09
EP3536692B1 (en) 2021-04-07
CA2864672A1 (en) 2013-08-22
CR20140380A (es) 2014-10-28
BR112014020365B1 (pt) 2023-02-23
KR20140123104A (ko) 2014-10-21
NZ628969A (en) 2017-03-31
US20160244455A1 (en) 2016-08-25
US20130217682A1 (en) 2013-08-22
IL234016A0 (en) 2014-09-30
SG10201606581RA (en) 2016-09-29
US9290500B2 (en) 2016-03-22
ZA201406103B (en) 2017-11-29
ECSP14019113A (es) 2015-09-30
US20140088096A9 (en) 2014-03-27
AR092797A1 (es) 2015-05-06
PE20142244A1 (es) 2015-01-07
CL2014002181A1 (es) 2014-12-12
TW201345909A (zh) 2013-11-16
EP2814791A4 (en) 2015-08-19

Similar Documents

Publication Publication Date Title
DOP2014000187A (es) Inhibidores de pirazolopirimidinilo de enzima activadora de ubiquitina.
PH12017502141A1 (en) Compounds and their methods of use
MX2013004491A (es) Boronatos como inhibidores de arginasa.
EA201301209A1 (ru) Производные пирролотриазинона в качестве ингибиторов p13k
UA111382C2 (uk) Інгібітори протеїнкінази
EA201692506A2 (ru) Ингибиторы репликации вирусов гриппа
DOP2014000062A (es) Benzilindazoles sustituidos para uso como inhibidores de la quinasa bub1 en el tratamiento de enfermedades hiperproliferativas
MX362550B (es) Inhibidores ciclicos de glutaminasa.
EA201391390A1 (ru) Циклопропиламины в качестве ингибиторов lsd
ECSP13013021A (es) Compuestos de benzotiazol y su uso farmacéutico
EA201490042A1 (ru) Азетидинил-фенил-, пиридил- или пиразинилкарбоксамидные производные как ингибиторы jak
MY165087A (en) Neprilysin inhibitors
CO6660497A2 (es) Derivados del ácido nft-2-ilacético para tratar el sida
MX2013008212A (es) Derivados de 7-azaindol.
EA201300211A1 (ru) N-ацилсульфонамидные промоторы апоптоза
MY191358A (en) Triazolopyrazines as brd4 inhibitors for use in the treatment of cancer
EA201201677A1 (ru) Производные гетероарилимидазолона в качестве ингибиторов jak
TN2014000016A1 (en) 4 - piperidinyl compounds for use as tankyrase inhibitors
EA201691032A1 (ru) Производные изохромена в качестве ингибиторов фосфоинозитид-3-киназ
UA111744C2 (uk) ЗАМІЩЕНІ ПІРИДОПІРАЗИНИ ЯК ІНГІБІТОРИ Syk
CU24263B1 (es) Derivados de imidazopiridazinas inhibidores de quinasa akt, útiles para el tratamiento del cáncer
MX348311B (es) Inhibidores nampt.
EA201590656A1 (ru) Азаиндолины
EA201270727A1 (ru) Пуриновые соединения
UA109932C2 (xx) Циклопропіламіни як інгібітори lsd1