MA35932B1 - Pyrazolopyrimidinyle inhibiteurs de l'enzyme d'activation de l'ubiquitine - Google Patents
Pyrazolopyrimidinyle inhibiteurs de l'enzyme d'activation de l'ubiquitineInfo
- Publication number
- MA35932B1 MA35932B1 MA37338A MA37338A MA35932B1 MA 35932 B1 MA35932 B1 MA 35932B1 MA 37338 A MA37338 A MA 37338A MA 37338 A MA37338 A MA 37338A MA 35932 B1 MA35932 B1 MA 35932B1
- Authority
- MA
- Morocco
- Prior art keywords
- activating enzyme
- chemical entities
- ubiquitin activating
- pyrazolopyrimidinyl
- inhibitors
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La présente invention concerne des entités chimiques inhibiteurs de l'enzyme d'activation de l'ubiquitine (uae), dont chacune est un composé de formule (i), ou un sel pharmaceutiquement acceptable de celles-ci, dans laquelle y est formule (2) et w, z, xy, ry1, ry2 et ry3 sont tels que définis dans la description; des compositions pharmaceutiques comportant les entités chimiques; et des procédés d'utilisation des entités chimiques. Ces entités chimiques sont utiles pour le traitement de troubles, en particulier des troubles de prolifération cellulaire, y compris des cancers.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261600070P | 2012-02-17 | 2012-02-17 | |
| PCT/US2013/026113 WO2013123169A1 (fr) | 2012-02-17 | 2013-02-14 | Pyrazolopyrimidinyle inhibiteurs de l'enzyme d'activation de l'ubiquitine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA35932B1 true MA35932B1 (fr) | 2014-12-01 |
Family
ID=48982730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA37338A MA35932B1 (fr) | 2012-02-17 | 2014-09-10 | Pyrazolopyrimidinyle inhibiteurs de l'enzyme d'activation de l'ubiquitine |
Country Status (30)
| Country | Link |
|---|---|
| US (4) | US9290500B2 (fr) |
| EP (3) | EP2814791A4 (fr) |
| JP (1) | JP6122877B2 (fr) |
| KR (1) | KR20140123104A (fr) |
| CN (1) | CN104136399B (fr) |
| AR (1) | AR092797A1 (fr) |
| BR (1) | BR112014020365B1 (fr) |
| CA (1) | CA2864672C (fr) |
| CL (1) | CL2014002181A1 (fr) |
| CO (1) | CO7071135A2 (fr) |
| CR (1) | CR20140380A (fr) |
| DO (1) | DOP2014000187A (fr) |
| EA (1) | EA035020B1 (fr) |
| EC (1) | ECSP14019113A (fr) |
| ES (1) | ES2739150T3 (fr) |
| GE (1) | GEP201706687B (fr) |
| HK (1) | HK1201817A1 (fr) |
| IL (1) | IL234016A0 (fr) |
| MA (1) | MA35932B1 (fr) |
| MX (1) | MX352963B (fr) |
| NZ (1) | NZ628969A (fr) |
| PE (1) | PE20142244A1 (fr) |
| PH (1) | PH12014501832A1 (fr) |
| SG (2) | SG10201606581RA (fr) |
| TN (1) | TN2014000351A1 (fr) |
| TW (1) | TWI593688B (fr) |
| UA (1) | UA116534C2 (fr) |
| UY (1) | UY34629A (fr) |
| WO (1) | WO2013123169A1 (fr) |
| ZA (1) | ZA201406103B (fr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8008307B2 (en) | 2006-08-08 | 2011-08-30 | Millennium Pharmaceuticals, Inc. | Heteroaryl compounds useful as inhibitors of E1 activating enzymes |
| BR112014020365B1 (pt) | 2012-02-17 | 2023-02-23 | Takeda Pharmaceutical Company Limited | Inibidores de pirazolopirimidinila de enzima de ativação de ubiquitina |
| CN104684559A (zh) | 2012-08-03 | 2015-06-03 | 米伦纽姆医药公司 | 针对Uba6的吲哚取代的吡咯并嘧啶基抑制剂 |
| US9695154B2 (en) | 2013-07-02 | 2017-07-04 | Millennium Pharmaceuticals, Inc. | Heteroaryl inhibitors of sumo activating enzyme |
| UY36198A (es) | 2014-07-01 | 2016-01-29 | Millennium Pharm Inc | Compuestos de heteroarilo útiles como inhibidores de enzima activadora de sumo |
| WO2016069392A1 (fr) | 2014-10-29 | 2016-05-06 | Millennium Pharmaceuticals, Inc. | Administration d'inhibiteur d'enzyme activant l'ubiquitine et agents chimiothérapeutiques |
| WO2016069393A1 (fr) | 2014-10-29 | 2016-05-06 | Millennium Pharmaceuticals, Inc. | Co-administration d'un inhibiteur d'enzyme activant l'ubiquitine et de rayons |
| MX2021004769A (es) | 2018-10-30 | 2021-08-24 | Kronos Bio Inc | Compuestos, composiciones, y metodos para modular la actividad cdk9. |
| WO2023021498A1 (fr) * | 2021-08-16 | 2023-02-23 | Moya Bio Ltd. | Analogues de nucléosides à base d'azole et de furane fusionnés et leurs utilisations |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003073989A2 (fr) | 2002-02-28 | 2003-09-12 | Biota, Inc. | Analogues de nucleoside 5'-monophosphate et leurs promedicaments |
| DE60313872T2 (de) | 2002-09-04 | 2008-01-17 | Schering Corp. | Pyrazoloä1,5-aüpyrimidine als hemmstoffe cyclin-abhängiger kinasen |
| ES2285164T3 (es) | 2002-09-04 | 2007-11-16 | Schering Corporation | Pirazolopirimidinas como inhibidores de quinasas dependientes de ciclina. |
| US7563798B2 (en) | 2002-09-04 | 2009-07-21 | Schering Corporation | Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors |
| US7196092B2 (en) | 2002-09-04 | 2007-03-27 | Schering Corporation | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| EP1608652A1 (fr) | 2003-03-31 | 2005-12-28 | Vernalis (Cambridge) Limited | Composes pyrazolopyrimidines et leur utilisation en medecine |
| JP2005008581A (ja) * | 2003-06-20 | 2005-01-13 | Kissei Pharmaceut Co Ltd | 新規なピラゾロ［１，５−ａ］ピリミジン誘導体、それを含有する医薬組成物およびそれらの用途 |
| WO2005037845A1 (fr) | 2003-10-17 | 2005-04-28 | Rigel Pharmaceuticals, Inc. | Compositions de benzothiazole et de thiazole'5,5-b!pyridine et leur utilisation comme inhibiteurs de l'ubiquitine ligase |
| EP1758873A1 (fr) | 2004-06-22 | 2007-03-07 | Rigel Pharmaceuticals, Inc. | Inhibiteurs de l'ubiquitine ligase |
| JP5048520B2 (ja) | 2005-02-04 | 2012-10-17 | ミレニアム ファーマシューティカルズ， インコーポレイテッド | Ｅ１活性化酵素の阻害剤 |
| WO2007044426A2 (fr) | 2005-10-06 | 2007-04-19 | Schering Corporation | Pyrazolopyrimidines utilisees comme inhibiteurs de proteines kinases |
| EP2402334B1 (fr) | 2006-02-02 | 2016-06-29 | Millennium Pharmaceuticals, Inc. | Inhibiteurs d'enzymes à activation E1 |
| EP1992008A1 (fr) * | 2006-02-28 | 2008-11-19 | Sez Ag | Dispositif et procede pour traitement liquide d'articles en forme de disque |
| MY157177A (en) | 2006-08-08 | 2016-05-13 | Millennium Pharm Inc | Heteroaryl compounds useful as inhibitors of e1 activating enzymes |
| US8008307B2 (en) | 2006-08-08 | 2011-08-30 | Millennium Pharmaceuticals, Inc. | Heteroaryl compounds useful as inhibitors of E1 activating enzymes |
| CN107021895A (zh) | 2007-06-12 | 2017-08-08 | 尔察祯有限公司 | 抗菌剂 |
| ES2758027T3 (es) * | 2007-08-02 | 2020-05-04 | Millennium Pharm Inc | Intermedios para la síntesis de inhibidores de enzimas activadoras de actividad E1 |
| US9216983B2 (en) | 2007-12-21 | 2015-12-22 | Board Of Regents, University Of Texas System | Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity |
| WO2010086040A1 (fr) | 2009-01-29 | 2010-08-05 | Biomarin Iga, Ltd. | Pyrazolo-pyrimidines pour traitement de la myopathie de duchenne |
| WO2010088518A2 (fr) | 2009-01-31 | 2010-08-05 | Kalypsys, Inc. | Modulateurs hétérocycliques du gpr119 pour le traitement de maladies |
| WO2010132110A1 (fr) | 2009-05-14 | 2010-11-18 | Millennium Pharmaceuticals, Inc. | Sel de chlorhydrate de ((1s,2s,4r)-4-{4-[(1s)-2,3-dihydro-1h-indèn-1-ylamino]-7h-pyrrolo [2,3-d] pyrimidin-7-yle}-2-hydroxycyclopentyle) méthylsulfamate |
| JP5879273B2 (ja) | 2010-03-01 | 2016-03-08 | ジーティーエックス・インコーポレイテッド | 癌を処置するための化合物 |
| US20120077814A1 (en) | 2010-09-10 | 2012-03-29 | Zhong Wang | Sulfonamide, sulfamate, and sulfamothioate derivatives |
| BR112014004239A2 (pt) | 2011-08-24 | 2017-03-21 | Millennium Pharm Inc | inibidores de enzima ativadora de nedd8 |
| BR112014020365B1 (pt) | 2012-02-17 | 2023-02-23 | Takeda Pharmaceutical Company Limited | Inibidores de pirazolopirimidinila de enzima de ativação de ubiquitina |
| CN104684559A (zh) | 2012-08-03 | 2015-06-03 | 米伦纽姆医药公司 | 针对Uba6的吲哚取代的吡咯并嘧啶基抑制剂 |
| US9695154B2 (en) | 2013-07-02 | 2017-07-04 | Millennium Pharmaceuticals, Inc. | Heteroaryl inhibitors of sumo activating enzyme |
| UY36198A (es) | 2014-07-01 | 2016-01-29 | Millennium Pharm Inc | Compuestos de heteroarilo útiles como inhibidores de enzima activadora de sumo |
-
2013
- 2013-02-14 BR BR112014020365-2A patent/BR112014020365B1/pt active IP Right Grant
- 2013-02-14 CN CN201380009784.8A patent/CN104136399B/zh active Active
- 2013-02-14 SG SG10201606581RA patent/SG10201606581RA/en unknown
- 2013-02-14 SG SG11201404757WA patent/SG11201404757WA/en unknown
- 2013-02-14 JP JP2014557765A patent/JP6122877B2/ja active Active
- 2013-02-14 EA EA201400831A patent/EA035020B1/ru not_active IP Right Cessation
- 2013-02-14 WO PCT/US2013/026113 patent/WO2013123169A1/fr active Application Filing
- 2013-02-14 EP EP13748707.0A patent/EP2814791A4/fr not_active Withdrawn
- 2013-02-14 EP EP16205139.5A patent/EP3173413B1/fr active Active
- 2013-02-14 UA UAA201409297A patent/UA116534C2/uk unknown
- 2013-02-14 KR KR1020147025556A patent/KR20140123104A/ko not_active Application Discontinuation
- 2013-02-14 MX MX2014009944A patent/MX352963B/es active IP Right Grant
- 2013-02-14 NZ NZ628969A patent/NZ628969A/en not_active IP Right Cessation
- 2013-02-14 ES ES16205139T patent/ES2739150T3/es active Active
- 2013-02-14 CA CA2864672A patent/CA2864672C/fr active Active
- 2013-02-14 GE GEAP201313560A patent/GEP201706687B/en unknown
- 2013-02-14 EP EP19170607.6A patent/EP3536692B1/fr active Active
- 2013-02-14 US US13/767,314 patent/US9290500B2/en active Active
- 2013-02-14 PE PE2014001278A patent/PE20142244A1/es active IP Right Grant
- 2013-02-15 UY UY0001034629A patent/UY34629A/es not_active Application Discontinuation
- 2013-02-15 AR ARP130100480A patent/AR092797A1/es unknown
- 2013-02-18 TW TW102105676A patent/TWI593688B/zh not_active IP Right Cessation
-
2014
- 2014-08-07 IL IL234016A patent/IL234016A0/en unknown
- 2014-08-11 TN TNP2014000351A patent/TN2014000351A1/fr unknown
- 2014-08-12 CR CR20140380A patent/CR20140380A/es unknown
- 2014-08-13 PH PH12014501832A patent/PH12014501832A1/en unknown
- 2014-08-14 CL CL2014002181A patent/CL2014002181A1/es unknown
- 2014-08-15 DO DO2014000187A patent/DOP2014000187A/es unknown
- 2014-08-20 ZA ZA2014/06103A patent/ZA201406103B/en unknown
- 2014-09-10 MA MA37338A patent/MA35932B1/fr unknown
- 2014-09-16 CO CO14205517A patent/CO7071135A2/es unknown
- 2014-09-17 EC ECIEPI201419113A patent/ECSP14019113A/es unknown
-
2015
- 2015-03-05 HK HK15102227.4A patent/HK1201817A1/xx unknown
-
2016
- 2016-02-19 US US15/048,007 patent/US9663525B2/en active Active
-
2017
- 2017-04-17 US US15/488,800 patent/US9796725B2/en active Active
- 2017-09-08 US US15/699,818 patent/US10202389B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MA35932B1 (fr) | Pyrazolopyrimidinyle inhibiteurs de l'enzyme d'activation de l'ubiquitine | |
| MA40225B1 (fr) | Composés dihydroisoquinolinone substitués | |
| MA45920A (fr) | Inhibiteurs de pyridopyrimidinone cdk2/4/6 | |
| MA39211A1 (fr) | Composés tricycliques comme agents anti-cancers | |
| MX2014000536A (es) | Compuestos de 4-piperidinilo para usarse como inhibidores de tanquirasa. | |
| MX2013004491A (es) | Boronatos como inhibidores de arginasa. | |
| MA37888B1 (fr) | Composition pharmaceutique enrobée contenant du régorafenib | |
| GEP20146146B (en) | Pyrrolopyrimidine compounds as inhibitors of cdk4/6 | |
| MA32903B1 (fr) | Inhibiteurs de proteine-kinases | |
| EA201201665A1 (ru) | Новые соединения | |
| MA34207B1 (fr) | Inhibiteurs de la pi3 kinase et/ou du mtor | |
| MA32035B1 (fr) | Composes tricycliques servant de modulateurs de synthese de tnf-alpha et d'inhibiteurs de pde4 | |
| MA33032B1 (fr) | Pyrimidines condensees | |
| UA107100C2 (xx) | Конденсовані гетероароматичні піролідинони як інгібітори syk | |
| MA35661B1 (fr) | Inhibiteurs de pak pour le traitement de troubles de prolifération cellulaire | |
| MA31419B1 (fr) | Derives de pyridine | |
| MA37866B1 (fr) | Dérivés de type aza-indazole ou diaza-indazole pour le traitement de la douleur | |
| TN2012000534A1 (en) | Pyrazole compounds as sigma receptor inhibitors | |
| MA34545B1 (fr) | Co-cristaux et sels d'inhibiteurs de ccr3 | |
| MA33533B1 (fr) | Compositions pharmaceutiques pour le traitement du cancer et d'autres maladies ou troubles | |
| MA32997B1 (fr) | Macrolide anti-inflammatoire | |
| MY152685A (en) | Imidazopyridazines as par1 inhibitors, production thereof, and use thereof as medicaments | |
| MA37879B1 (fr) | Forme amorphe stabilisée d'agomélatine, procédé pour sa préparation et compositions pharmaceutiques la contenant | |
| MY152040A (en) | Triazolopyridazines as par1 inhibitors, production thereof, and use as medicaments | |
| MA45867B1 (fr) | Modulateurs du récepteur des oestrogènes |