CR20140380A - Inhibidores de pirazolopirimidinilo de enzima activadora de ubiquitina - Google Patents

Inhibidores de pirazolopirimidinilo de enzima activadora de ubiquitina

Info

Publication number
CR20140380A
CR20140380A CR20140380A CR20140380A CR20140380A CR 20140380 A CR20140380 A CR 20140380A CR 20140380 A CR20140380 A CR 20140380A CR 20140380 A CR20140380 A CR 20140380A CR 20140380 A CR20140380 A CR 20140380A
Authority
CR
Costa Rica
Prior art keywords
pirazolopirimidinyl
ubiquitine
inhibitors
activating enzyme
formula
Prior art date
Application number
CR20140380A
Other languages
English (en)
Inventor
Roushan Afroze
Indu T Bharathan
Jeffrey P Ciavarri
Paul E Fleming
Jeffrey L Gaulin
Mario Girard
Steven P Langston
Francois R Soucy
Tzu-Tshin Wong
Yingchun Ye
Original Assignee
Millennium Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc
Publication of CR20140380A publication Critical patent/CR20140380A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

Se describen entidades químicas que inhiben la enzima activadora de ubiquitina (UAE), cada una de las cuales es un compuesto de Fórmula (I) o una sal farmaceúticamente aceptable de este, donde Y es Fórmula (II).
CR20140380A 2012-02-17 2014-08-12 Inhibidores de pirazolopirimidinilo de enzima activadora de ubiquitina CR20140380A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261600070P 2012-02-17 2012-02-17
PCT/US2013/026113 WO2013123169A1 (en) 2012-02-17 2013-02-14 Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme

Publications (1)

Publication Number Publication Date
CR20140380A true CR20140380A (es) 2014-10-28

Family

ID=48982730

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20140380A CR20140380A (es) 2012-02-17 2014-08-12 Inhibidores de pirazolopirimidinilo de enzima activadora de ubiquitina

Country Status (30)

Country Link
US (4) US9290500B2 (es)
EP (3) EP3536692B1 (es)
JP (1) JP6122877B2 (es)
KR (1) KR20140123104A (es)
CN (1) CN104136399B (es)
AR (1) AR092797A1 (es)
BR (1) BR112014020365B1 (es)
CA (1) CA2864672C (es)
CL (1) CL2014002181A1 (es)
CO (1) CO7071135A2 (es)
CR (1) CR20140380A (es)
DO (1) DOP2014000187A (es)
EA (1) EA035020B1 (es)
EC (1) ECSP14019113A (es)
ES (1) ES2739150T3 (es)
GE (1) GEP201706687B (es)
HK (1) HK1201817A1 (es)
IL (1) IL234016A0 (es)
MA (1) MA35932B1 (es)
MX (1) MX352963B (es)
NZ (1) NZ628969A (es)
PE (1) PE20142244A1 (es)
PH (1) PH12014501832A1 (es)
SG (2) SG10201606581RA (es)
TN (1) TN2014000351A1 (es)
TW (1) TWI593688B (es)
UA (1) UA116534C2 (es)
UY (1) UY34629A (es)
WO (1) WO2013123169A1 (es)
ZA (1) ZA201406103B (es)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8008307B2 (en) 2006-08-08 2011-08-30 Millennium Pharmaceuticals, Inc. Heteroaryl compounds useful as inhibitors of E1 activating enzymes
SG10201606581RA (en) 2012-02-17 2016-09-29 Millennium Pharm Inc Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme
CA2880813A1 (en) 2012-08-03 2014-02-06 Millennium Pharmaceuticals, Inc. Indole-substituted pyrrolopyrimidinyl inhibitors of uba6
BR112015032902A8 (pt) 2013-07-02 2019-12-24 Millennium Pharm Inc compostos de heteroarila, seus usos e composições farmacêuticas
HUE045748T2 (hu) 2014-07-01 2020-01-28 Millennium Pharm Inc Heteroaril vegyületek mint SUMO aktiváló enzimek inhibitorai
EP3212650B1 (en) 2014-10-29 2021-02-17 Millennium Pharmaceuticals, Inc. Administration of ubiquitin-activating enzyme inhibitor and chemotherapeutic agents
TW201628621A (zh) 2014-10-29 2016-08-16 千禧製藥公司 泛素活化酶抑制劑及輻射之施用
KR20210068597A (ko) 2018-10-30 2021-06-09 크로노스 바이오, 인코포레이티드 Cdk9 활성을 조절하기 위한 화합물, 조성물 및 방법
WO2023021498A1 (en) * 2021-08-16 2023-02-23 Moya Bio Ltd. Fused azole and furan based nucleoside analogs and uses thereof

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AU2003298571B2 (en) 2002-09-04 2006-10-19 Merck Sharp & Dohme Corp. Pyrazolo[1,5-a]pyrimidines compounds as cyclin dependent kinase inhibitors
US7196092B2 (en) 2002-09-04 2007-03-27 Schering Corporation N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors
KR20050058507A (ko) 2002-09-04 2005-06-16 쉐링 코포레이션 사이클린 의존성 키나제 억제제로서의 피라졸로피리미딘
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US20050130974A1 (en) 2003-10-17 2005-06-16 Rigel Pharmaceuticals, Inc. Benzothiazole compositions and their use as ubiquitin ligase inhibitors
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CN101395698B (zh) * 2006-02-28 2010-06-09 兰姆研究股份公司 用于液体处理盘形物体的装置及方法
WO2008019124A1 (en) * 2006-08-08 2008-02-14 Millennium Pharmaceuticals, Inc. Heteroaryl compounds useful as inhibitors of e1 activating enzymes
US8008307B2 (en) 2006-08-08 2011-08-30 Millennium Pharmaceuticals, Inc. Heteroaryl compounds useful as inhibitors of E1 activating enzymes
JP5539864B2 (ja) 2007-06-12 2014-07-02 アカオゲン，インコーポレーテッド 抗菌剤
CN101868461B (zh) 2007-08-02 2013-09-25 米伦纽姆医药公司 合成e1活化酶抑制剂的方法
WO2009082691A1 (en) 2007-12-21 2009-07-02 Board Of Regents, University Of Texas System Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity
WO2010086040A1 (en) 2009-01-29 2010-08-05 Biomarin Iga, Ltd. Pyrazolo-pyrimidines for treatment of duchenne muscular dystrophy
WO2010088518A2 (en) 2009-01-31 2010-08-05 Kalypsys, Inc. Heterocyclic modulators of gpr119 for treatment of disease
PE20161222A1 (es) * 2009-05-14 2016-12-01 Millennium Pharm Inc Sal de clorhidrato de ((1s,2s,4r)-4-{4-[(1s)-2,3-dihidro-1h-inden-1-ilamino]-7h-pirrolo[2,3-d]pirimidin-7-il}-2-hidroxiciclopentil)metilsulfamato
EP2542081A4 (en) 2010-03-01 2013-07-31 Gtx Inc COMPOSITIONS FOR CANCER TREATMENT
US20120077814A1 (en) 2010-09-10 2012-03-29 Zhong Wang Sulfonamide, sulfamate, and sulfamothioate derivatives
SG10201601023UA (en) 2011-08-24 2016-03-30 Millennium Pharm Inc Inhibitors of nedd8-activating enzyme
SG10201606581RA (en) 2012-02-17 2016-09-29 Millennium Pharm Inc Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme
CA2880813A1 (en) 2012-08-03 2014-02-06 Millennium Pharmaceuticals, Inc. Indole-substituted pyrrolopyrimidinyl inhibitors of uba6
BR112015032902A8 (pt) 2013-07-02 2019-12-24 Millennium Pharm Inc compostos de heteroarila, seus usos e composições farmacêuticas
HUE045748T2 (hu) 2014-07-01 2020-01-28 Millennium Pharm Inc Heteroaril vegyületek mint SUMO aktiváló enzimek inhibitorai

Also Published As

Publication number Publication date
AR092797A1 (es) 2015-05-06
CL2014002181A1 (es) 2014-12-12
EP3536692A1 (en) 2019-09-11
ZA201406103B (en) 2017-11-29
CO7071135A2 (es) 2014-09-30
TW201345909A (zh) 2013-11-16
US9796725B2 (en) 2017-10-24
KR20140123104A (ko) 2014-10-21
US9663525B2 (en) 2017-05-30
JP2015508775A (ja) 2015-03-23
US10202389B2 (en) 2019-02-12
EA035020B1 (ru) 2020-04-17
NZ628969A (en) 2017-03-31
MA35932B1 (fr) 2014-12-01
US9290500B2 (en) 2016-03-22
JP6122877B2 (ja) 2017-04-26
US20140088096A9 (en) 2014-03-27
CA2864672A1 (en) 2013-08-22
PH12014501832A1 (en) 2014-11-17
CN104136399B (zh) 2018-08-07
TN2014000351A1 (en) 2015-12-21
ECSP14019113A (es) 2015-09-30
EP3173413B1 (en) 2019-05-01
WO2013123169A1 (en) 2013-08-22
US20170217968A1 (en) 2017-08-03
MX352963B (es) 2017-12-15
DOP2014000187A (es) 2014-10-15
ES2739150T3 (es) 2020-01-29
US20130217682A1 (en) 2013-08-22
GEP201706687B (en) 2017-06-26
EP3173413A1 (en) 2017-05-31
US20160244455A1 (en) 2016-08-25
SG11201404757WA (en) 2014-09-26
MX2014009944A (es) 2014-11-10
UA116534C2 (uk) 2018-04-10
PE20142244A1 (es) 2015-01-07
SG10201606581RA (en) 2016-09-29
IL234016A0 (en) 2014-09-30
CA2864672C (en) 2018-01-09
EP2814791A4 (en) 2015-08-19
TWI593688B (zh) 2017-08-01
UY34629A (es) 2013-09-02
CN104136399A (zh) 2014-11-05
US20170369499A1 (en) 2017-12-28
BR112014020365B1 (pt) 2023-02-23
EP3536692B1 (en) 2021-04-07
EA201400831A1 (ru) 2014-12-30
BR112014020365A2 (pt) 2020-12-22
HK1201817A1 (en) 2015-09-11
EP2814791A1 (en) 2014-12-24

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