UY34216A - Nuevos compuestos que inhiben la actividad de la Lp-PLA2 - Google Patents

Nuevos compuestos que inhiben la actividad de la Lp-PLA2

Info

Publication number
UY34216A
UY34216A UY0001034216A UY34216A UY34216A UY 34216 A UY34216 A UY 34216A UY 0001034216 A UY0001034216 A UY 0001034216A UY 34216 A UY34216 A UY 34216A UY 34216 A UY34216 A UY 34216A
Authority
UY
Uruguay
Prior art keywords
pla2
inhibit
activity
new compounds
compounds
Prior art date
Application number
UY0001034216A
Other languages
English (en)
Inventor
Wan Zehong
Yu Haihua
Long Kai
Zhang Xiaomin
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of UY34216A publication Critical patent/UY34216A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

La presente invención se refiere a nuevos compuestos que inhiben la actividad de la Lp-PLA2, a procesos para su preparación, a composiciones que los contienen y a su uso en el tratamiento de enfermedades asociadas con la actividad de la Lp-PLA2, por ejemplo, aterosclerosis y enfermedad de Alzheimer.
UY0001034216A 2011-07-27 2012-07-25 Nuevos compuestos que inhiben la actividad de la Lp-PLA2 UY34216A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN2011077702 2011-07-27

Publications (1)

Publication Number Publication Date
UY34216A true UY34216A (es) 2013-02-28

Family

ID=46579034

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001034216A UY34216A (es) 2011-07-27 2012-07-25 Nuevos compuestos que inhiben la actividad de la Lp-PLA2

Country Status (12)

Country Link
US (2) US9273054B2 (es)
EP (1) EP2736908A1 (es)
JP (1) JP2014521625A (es)
KR (1) KR20140059204A (es)
AR (1) AR087309A1 (es)
AU (1) AU2012288865B2 (es)
BR (1) BR112014001634A2 (es)
CA (1) CA2843102A1 (es)
RU (1) RU2014107486A (es)
TW (1) TW201321382A (es)
UY (1) UY34216A (es)
WO (1) WO2013014185A1 (es)

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US20150307459A1 (en) 2012-11-27 2015-10-29 Basf Se Substituted 2-[phenoxy-phenyl]-1-[1,2,4]triazol-1-yl-ethanol Compounds and Their Use as Fungicides
EP2925732A1 (en) 2012-11-27 2015-10-07 Basf Se Substituted [1,2,4]triazole compounds
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CN105008365B (zh) 2013-01-25 2017-03-15 葛兰素史密斯克莱知识产权发展有限公司 化合物
US9630896B2 (en) 2013-11-22 2017-04-25 Tansna Therapeutics, Inc. 2,5-dialkyl-4-H/halo/ether-phenol compounds
WO2016012916A1 (en) 2014-07-22 2016-01-28 Glaxosmithkline Intellectual Property Development Limited 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
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WO2016012917A1 (en) 2014-07-22 2016-01-28 Glaxosmithkline Intellectual Property Development Limited 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
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CN106188063A (zh) * 2015-05-08 2016-12-07 中国科学院上海药物研究所 用作Lp-PLA2抑制剂的双环类化合物、其制备方法及医药用途
EP3344632A4 (en) * 2015-09-04 2019-03-20 Lysosomal Therapeutics Inc. Heterocyclic pyrimidine compounds and their use in the treatment of medical disorders
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CN112574221B (zh) * 2019-09-30 2022-03-04 上海纽思克生物科技有限公司 四环嘧啶酮类化合物、其制备方法、其组合物和用途
PE20230092A1 (es) 2019-11-09 2023-01-16 Shanghai Simr Biotechnology Co Ltd Derivado triciclico de dihidroimidazopirimidona, metodo de preparacion del mismo, composicion farmaceuticas y uso del mismo
CN115304620A (zh) 2021-05-07 2022-11-08 上海赛默罗生物科技有限公司 嘧啶酮衍生物、其制备方法、药物组合物和用途

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BR112014001634A2 (pt) * 2011-07-27 2017-02-14 Glaxo Group Ltd compostos bicíclicos de pirimidona

Also Published As

Publication number Publication date
KR20140059204A (ko) 2014-05-15
AU2012288865B2 (en) 2015-10-01
US20130030012A1 (en) 2013-01-31
AU2012288865A1 (en) 2014-02-13
JP2014521625A (ja) 2014-08-28
BR112014001634A2 (pt) 2017-02-14
US20140179716A1 (en) 2014-06-26
CA2843102A1 (en) 2013-01-31
AR087309A1 (es) 2014-03-12
WO2013014185A1 (en) 2013-01-31
EP2736908A1 (en) 2014-06-04
US9273054B2 (en) 2016-03-01
RU2014107486A (ru) 2015-09-10
TW201321382A (zh) 2013-06-01

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