CO7071135A2 - Inhibidores de pirazolopirimidinilo de enzima activadora de ubiquitina - Google Patents
Inhibidores de pirazolopirimidinilo de enzima activadora de ubiquitinaInfo
- Publication number
- CO7071135A2 CO7071135A2 CO14205517A CO14205517A CO7071135A2 CO 7071135 A2 CO7071135 A2 CO 7071135A2 CO 14205517 A CO14205517 A CO 14205517A CO 14205517 A CO14205517 A CO 14205517A CO 7071135 A2 CO7071135 A2 CO 7071135A2
- Authority
- CO
- Colombia
- Prior art keywords
- activating enzyme
- chemical entities
- ubiquitin activating
- pyrazolopyrimidinyl
- inhibitors
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Se describen entidades químicas que inhiben la enzima activadora de ubiquitina (UAE), cada una de las cuales es un compuesto de Fórmula (I) o una sal farmacéuticamente aceptable de este, donde Y es Fórmula (II) y W, Z, XY, RY1, RY2 y RY3 se definen en la presente; composiciones farmacéuticas que comprenden las entidades químicas; y métodos para usar las entidades químicas. Estas entidades químicas son útiles para tratar trastornos, particularmente trastornos de proliferación celular, incluyendo cánceres.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261600070P | 2012-02-17 | 2012-02-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO7071135A2 true CO7071135A2 (es) | 2014-09-30 |
Family
ID=48982730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO14205517A CO7071135A2 (es) | 2012-02-17 | 2014-09-16 | Inhibidores de pirazolopirimidinilo de enzima activadora de ubiquitina |
Country Status (30)
| Country | Link |
|---|---|
| US (4) | US9290500B2 (es) |
| EP (3) | EP2814791A4 (es) |
| JP (1) | JP6122877B2 (es) |
| KR (1) | KR20140123104A (es) |
| CN (1) | CN104136399B (es) |
| AR (1) | AR092797A1 (es) |
| BR (1) | BR112014020365B1 (es) |
| CA (1) | CA2864672C (es) |
| CL (1) | CL2014002181A1 (es) |
| CO (1) | CO7071135A2 (es) |
| CR (1) | CR20140380A (es) |
| DO (1) | DOP2014000187A (es) |
| EA (1) | EA035020B1 (es) |
| EC (1) | ECSP14019113A (es) |
| ES (1) | ES2739150T3 (es) |
| GE (1) | GEP201706687B (es) |
| HK (1) | HK1201817A1 (es) |
| IL (1) | IL234016A0 (es) |
| MA (1) | MA35932B1 (es) |
| MX (1) | MX352963B (es) |
| NZ (1) | NZ628969A (es) |
| PE (1) | PE20142244A1 (es) |
| PH (1) | PH12014501832A1 (es) |
| SG (2) | SG11201404757WA (es) |
| TN (1) | TN2014000351A1 (es) |
| TW (1) | TWI593688B (es) |
| UA (1) | UA116534C2 (es) |
| UY (1) | UY34629A (es) |
| WO (1) | WO2013123169A1 (es) |
| ZA (1) | ZA201406103B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8008307B2 (en) | 2006-08-08 | 2011-08-30 | Millennium Pharmaceuticals, Inc. | Heteroaryl compounds useful as inhibitors of E1 activating enzymes |
| KR20140123104A (ko) | 2012-02-17 | 2014-10-21 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | 유비퀴틴 활성화 효소의 피라졸로피리미디닐 억제제 |
| WO2014022744A1 (en) | 2012-08-03 | 2014-02-06 | Millennium Pharmaceuticals, Inc. | INDOLE-SUBSTITUTED PYRROLOPYRIMIDINYL INHIBITORS OF Uba6 |
| CA2916468C (en) | 2013-07-02 | 2019-07-23 | Millennium Pharmaceuticals, Inc. | Heteroaryl compounds useful as inhibitors of sumo activating enzyme |
| HUE045748T2 (hu) | 2014-07-01 | 2020-01-28 | Millennium Pharm Inc | Heteroaril vegyületek mint SUMO aktiváló enzimek inhibitorai |
| US10335411B2 (en) | 2014-10-29 | 2019-07-02 | Millennium Pharmaceuticals, Inc. | Administration of ubiquitin-activating enzyme inhibitor and radiation |
| EP3212650B1 (en) | 2014-10-29 | 2021-02-17 | Millennium Pharmaceuticals, Inc. | Administration of ubiquitin-activating enzyme inhibitor and chemotherapeutic agents |
| CN112996790B (zh) | 2018-10-30 | 2023-11-03 | 克洛诺斯生物公司 | 用于调节cdk9活性的化合物、组合物和方法 |
| WO2023021498A1 (en) * | 2021-08-16 | 2023-02-23 | Moya Bio Ltd. | Fused azole and furan based nucleoside analogs and uses thereof |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2477795A1 (en) | 2002-02-28 | 2003-09-12 | Kandasamy Sakthivel | Nucleoside 5'-monophosphate mimics and their prodrugs |
| US7563798B2 (en) | 2002-09-04 | 2009-07-21 | Schering Corporation | Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors |
| US7196092B2 (en) | 2002-09-04 | 2007-03-27 | Schering Corporation | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| EP1534712B1 (en) | 2002-09-04 | 2007-05-16 | Schering Corporation | Pyrazolo[1,5-a]pyrimidine compounds as cyclin dependent kinase inhibitors |
| WO2004022559A1 (en) | 2002-09-04 | 2004-03-18 | Schering Corporation | Pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| EP1608652A1 (en) | 2003-03-31 | 2005-12-28 | Vernalis (Cambridge) Limited | Pyrazolopyrimidine compounds and their use in medicine |
| JP2005008581A (ja) | 2003-06-20 | 2005-01-13 | Kissei Pharmaceut Co Ltd | 新規なピラゾロ［１，５−ａ］ピリミジン誘導体、それを含有する医薬組成物およびそれらの用途 |
| WO2005037845A1 (en) | 2003-10-17 | 2005-04-28 | Rigel Pharmaceuticals, Inc. | Benzothiazole and thiazole[5,5-b] pyridine compositions and their use as ubiquitin ligase inhibitors |
| US20050282818A1 (en) | 2004-06-22 | 2005-12-22 | Rigel Pharmaceuticals, Inc. | Ubiquitin ligase inhibitors |
| WO2006084281A1 (en) | 2005-02-04 | 2006-08-10 | Millennium Pharmaceuticals, Inc. | Inhibitors of e1 activating enzymes |
| AR055206A1 (es) | 2005-10-06 | 2007-08-08 | Schering Corp | Pirazolo[1, 5 - a]pirimidinas como inhibidoras de proteina quinasa, composiciones farmaceuticas y combinaciones con agentes citostaticos que las comprenden y su uso en la fabricacion de un medicamento para el tratamiento del cancer. |
| DK1989206T3 (da) | 2006-02-02 | 2012-10-08 | Millennium Pharm Inc | E1-aktiveringsenzymhæmmere |
| EP1992008A1 (en) * | 2006-02-28 | 2008-11-19 | Sez Ag | Device and method for liquid treating disc-like articles |
| US8008307B2 (en) | 2006-08-08 | 2011-08-30 | Millennium Pharmaceuticals, Inc. | Heteroaryl compounds useful as inhibitors of E1 activating enzymes |
| ME02789B (me) | 2006-08-08 | 2011-06-30 | Millennium Pharm Inc | Jedinjenja heteroarila korisna kao inhibitori e1 aktivirajućih enzima |
| EP2662353A3 (en) | 2007-06-12 | 2014-04-02 | Achaogen, Inc. | Antibacterial agents |
| CN106243111B (zh) * | 2007-08-02 | 2019-07-23 | 米伦纽姆医药公司 | 合成e1活化酶抑制剂的方法 |
| US9216983B2 (en) | 2007-12-21 | 2015-12-22 | Board Of Regents, University Of Texas System | Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity |
| WO2010086040A1 (en) | 2009-01-29 | 2010-08-05 | Biomarin Iga, Ltd. | Pyrazolo-pyrimidines for treatment of duchenne muscular dystrophy |
| WO2010088518A2 (en) | 2009-01-31 | 2010-08-05 | Kalypsys, Inc. | Heterocyclic modulators of gpr119 for treatment of disease |
| US9187482B2 (en) * | 2009-05-14 | 2015-11-17 | Millennium Pharmaceuticals, Inc. | Hydrochloride salt of((1S,2S,4R)-4-{4-[(1S)-2,3-dihydro-1H-inden-1-ylamino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl)methyl sulfamate |
| CN102883607B (zh) | 2010-03-01 | 2015-07-22 | Gtx公司 | 用于治疗癌的化合物 |
| US20120077814A1 (en) | 2010-09-10 | 2012-03-29 | Zhong Wang | Sulfonamide, sulfamate, and sulfamothioate derivatives |
| US8809356B2 (en) | 2011-08-24 | 2014-08-19 | Millennium Pharmaceuticals, Inc. | Inhibitors of NEDD8-activating enzyme |
| KR20140123104A (ko) | 2012-02-17 | 2014-10-21 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | 유비퀴틴 활성화 효소의 피라졸로피리미디닐 억제제 |
| WO2014022744A1 (en) | 2012-08-03 | 2014-02-06 | Millennium Pharmaceuticals, Inc. | INDOLE-SUBSTITUTED PYRROLOPYRIMIDINYL INHIBITORS OF Uba6 |
| CA2916468C (en) | 2013-07-02 | 2019-07-23 | Millennium Pharmaceuticals, Inc. | Heteroaryl compounds useful as inhibitors of sumo activating enzyme |
| HUE045748T2 (hu) | 2014-07-01 | 2020-01-28 | Millennium Pharm Inc | Heteroaril vegyületek mint SUMO aktiváló enzimek inhibitorai |
-
2013
- 2013-02-14 KR KR1020147025556A patent/KR20140123104A/ko not_active Application Discontinuation
- 2013-02-14 JP JP2014557765A patent/JP6122877B2/ja active Active
- 2013-02-14 PE PE2014001278A patent/PE20142244A1/es active IP Right Grant
- 2013-02-14 GE GEAP201313560A patent/GEP201706687B/en unknown
- 2013-02-14 EA EA201400831A patent/EA035020B1/ru not_active IP Right Cessation
- 2013-02-14 EP EP13748707.0A patent/EP2814791A4/en not_active Withdrawn
- 2013-02-14 CN CN201380009784.8A patent/CN104136399B/zh active Active
- 2013-02-14 BR BR112014020365-2A patent/BR112014020365B1/pt active IP Right Grant
- 2013-02-14 WO PCT/US2013/026113 patent/WO2013123169A1/en active Application Filing
- 2013-02-14 CA CA2864672A patent/CA2864672C/en active Active
- 2013-02-14 SG SG11201404757WA patent/SG11201404757WA/en unknown
- 2013-02-14 SG SG10201606581RA patent/SG10201606581RA/en unknown
- 2013-02-14 EP EP16205139.5A patent/EP3173413B1/en active Active
- 2013-02-14 ES ES16205139T patent/ES2739150T3/es active Active
- 2013-02-14 NZ NZ628969A patent/NZ628969A/en not_active IP Right Cessation
- 2013-02-14 MX MX2014009944A patent/MX352963B/es active IP Right Grant
- 2013-02-14 EP EP19170607.6A patent/EP3536692B1/en active Active
- 2013-02-14 UA UAA201409297A patent/UA116534C2/uk unknown
- 2013-02-14 US US13/767,314 patent/US9290500B2/en active Active
- 2013-02-15 UY UY0001034629A patent/UY34629A/es not_active Application Discontinuation
- 2013-02-15 AR ARP130100480A patent/AR092797A1/es unknown
- 2013-02-18 TW TW102105676A patent/TWI593688B/zh not_active IP Right Cessation
-
2014
- 2014-08-07 IL IL234016A patent/IL234016A0/en unknown
- 2014-08-11 TN TNP2014000351A patent/TN2014000351A1/fr unknown
- 2014-08-12 CR CR20140380A patent/CR20140380A/es unknown
- 2014-08-13 PH PH12014501832A patent/PH12014501832A1/en unknown
- 2014-08-14 CL CL2014002181A patent/CL2014002181A1/es unknown
- 2014-08-15 DO DO2014000187A patent/DOP2014000187A/es unknown
- 2014-08-20 ZA ZA2014/06103A patent/ZA201406103B/en unknown
- 2014-09-10 MA MA37338A patent/MA35932B1/fr unknown
- 2014-09-16 CO CO14205517A patent/CO7071135A2/es unknown
- 2014-09-17 EC ECIEPI201419113A patent/ECSP14019113A/es unknown
-
2015
- 2015-03-05 HK HK15102227.4A patent/HK1201817A1/xx unknown
-
2016
- 2016-02-19 US US15/048,007 patent/US9663525B2/en active Active
-
2017
- 2017-04-17 US US15/488,800 patent/US9796725B2/en active Active
- 2017-09-08 US US15/699,818 patent/US10202389B2/en active Active
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