EA201400831A1 - Пиразолопиримидиниловые ингибиторы убиквитин-активирующего фермента - Google Patents

Пиразолопиримидиниловые ингибиторы убиквитин-активирующего фермента

Info

Publication number
EA201400831A1
EA201400831A1 EA201400831A EA201400831A EA201400831A1 EA 201400831 A1 EA201400831 A1 EA 201400831A1 EA 201400831 A EA201400831 A EA 201400831A EA 201400831 A EA201400831 A EA 201400831A EA 201400831 A1 EA201400831 A1 EA 201400831A1
Authority
EA
Eurasian Patent Office
Prior art keywords
ubiquitin
structural units
chemical structural
activating enzyme
pyrazolopyrimidinyl
Prior art date
Application number
EA201400831A
Other languages
English (en)
Other versions
EA035020B1 (ru
Inventor
Роушан Афроуз
Инду Т. Бхаратхан
Джеффри П. Сиаварри
Пол Е. Флеминг
Джеффри Л. Голин
Марио Жирард
Стивен П. Лэнгстон
Франсуа Р. Суси
Цу-Чин Вонг
Йингчун Йе
Original Assignee
Миллениум Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Миллениум Фармасьютикалз, Инк. filed Critical Миллениум Фармасьютикалз, Инк.
Publication of EA201400831A1 publication Critical patent/EA201400831A1/ru
Publication of EA035020B1 publication Critical patent/EA035020B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Раскрыты химические структурные единицы, которые ингибируют убиквитин-активирующий фермент (UAE), каждая из которых представляет собой соединение формулы Iили его фармацевтически приемлемую соль, где Y представляет собой формулу IIи W, Z, X, R, Rи Rопределены в описании изобретения; фармацевтические композиции, содержащие химические структурные единицы, и способы применения химических структурных единиц. Эти химические структурные единицы применимы для лечения нарушений, в частности нарушений пролиферации клеток, включая виды рака.
EA201400831A 2012-02-17 2013-02-14 Пиразолопиримидиниловые ингибиторы убиквитин-активирующего фермента EA035020B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261600070P 2012-02-17 2012-02-17
PCT/US2013/026113 WO2013123169A1 (en) 2012-02-17 2013-02-14 Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme

Publications (2)

Publication Number Publication Date
EA201400831A1 true EA201400831A1 (ru) 2014-12-30
EA035020B1 EA035020B1 (ru) 2020-04-17

Family

ID=48982730

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201400831A EA035020B1 (ru) 2012-02-17 2013-02-14 Пиразолопиримидиниловые ингибиторы убиквитин-активирующего фермента

Country Status (30)

Country Link
US (4) US9290500B2 (ru)
EP (3) EP3536692B1 (ru)
JP (1) JP6122877B2 (ru)
KR (1) KR20140123104A (ru)
CN (1) CN104136399B (ru)
AR (1) AR092797A1 (ru)
BR (1) BR112014020365B1 (ru)
CA (1) CA2864672C (ru)
CL (1) CL2014002181A1 (ru)
CO (1) CO7071135A2 (ru)
CR (1) CR20140380A (ru)
DO (1) DOP2014000187A (ru)
EA (1) EA035020B1 (ru)
EC (1) ECSP14019113A (ru)
ES (1) ES2739150T3 (ru)
GE (1) GEP201706687B (ru)
HK (1) HK1201817A1 (ru)
IL (1) IL234016A0 (ru)
MA (1) MA35932B1 (ru)
MX (1) MX352963B (ru)
NZ (1) NZ628969A (ru)
PE (1) PE20142244A1 (ru)
PH (1) PH12014501832A1 (ru)
SG (2) SG11201404757WA (ru)
TN (1) TN2014000351A1 (ru)
TW (1) TWI593688B (ru)
UA (1) UA116534C2 (ru)
UY (1) UY34629A (ru)
WO (1) WO2013123169A1 (ru)
ZA (1) ZA201406103B (ru)

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US8008307B2 (en) 2006-08-08 2011-08-30 Millennium Pharmaceuticals, Inc. Heteroaryl compounds useful as inhibitors of E1 activating enzymes
EP3536692B1 (en) 2012-02-17 2021-04-07 Millennium Pharmaceuticals, Inc. Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme
EP2879681A4 (en) 2012-08-03 2015-12-23 Millennium Pharm Inc INDOINDUBSTITUTED PYRROLOPYRIMIDINYL HIBITORS OF UBA6
CN105492429A (zh) 2013-07-02 2016-04-13 米伦纽姆医药公司 Sumo活化酶的杂芳基抑制剂
JP6603712B2 (ja) * 2014-07-01 2019-11-06 ミレニアム ファーマシューティカルズ， インコーポレイテッド Ｓｕｍｏ活性化酵素の阻害薬として有用なヘテロアリール化合物
WO2016069392A1 (en) 2014-10-29 2016-05-06 Millennium Pharmaceuticals, Inc. Administration of ubiquitin-activating enzyme inhibitor and chemotherapeutic agents
JP6697453B2 (ja) 2014-10-29 2020-05-20 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． ユビキチン活性化酵素阻害物質及び放射線の投与
CN112996790B (zh) 2018-10-30 2023-11-03 克洛诺斯生物公司 用于调节cdk9活性的化合物、组合物和方法
WO2023021498A1 (en) * 2021-08-16 2023-02-23 Moya Bio Ltd. Fused azole and furan based nucleoside analogs and uses thereof

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CN1310918C (zh) 2002-09-04 2007-04-18 先灵公司 作为细胞周期蛋白依赖激酶抑制剂的吡唑并嘧啶
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EP3536692B1 (en) 2012-02-17 2021-04-07 Millennium Pharmaceuticals, Inc. Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme
EP2879681A4 (en) 2012-08-03 2015-12-23 Millennium Pharm Inc INDOINDUBSTITUTED PYRROLOPYRIMIDINYL HIBITORS OF UBA6
CN105492429A (zh) 2013-07-02 2016-04-13 米伦纽姆医药公司 Sumo活化酶的杂芳基抑制剂
JP6603712B2 (ja) 2014-07-01 2019-11-06 ミレニアム ファーマシューティカルズ， インコーポレイテッド Ｓｕｍｏ活性化酵素の阻害薬として有用なヘテロアリール化合物

Also Published As

Publication number Publication date
PH12014501832A1 (en) 2014-11-17
US20170369499A1 (en) 2017-12-28
US10202389B2 (en) 2019-02-12
WO2013123169A1 (en) 2013-08-22
EP3536692A1 (en) 2019-09-11
HK1201817A1 (en) 2015-09-11
BR112014020365A2 (pt) 2020-12-22
EP3173413B1 (en) 2019-05-01
TWI593688B (zh) 2017-08-01
US20170217968A1 (en) 2017-08-03
JP2015508775A (ja) 2015-03-23
MX352963B (es) 2017-12-15
EP3173413A1 (en) 2017-05-31
EP2814791A1 (en) 2014-12-24
UA116534C2 (uk) 2018-04-10
MA35932B1 (fr) 2014-12-01
CN104136399A (zh) 2014-11-05
ES2739150T3 (es) 2020-01-29
US9663525B2 (en) 2017-05-30
TN2014000351A1 (en) 2015-12-21
UY34629A (es) 2013-09-02
CN104136399B (zh) 2018-08-07
MX2014009944A (es) 2014-11-10
GEP201706687B (en) 2017-06-26
EA035020B1 (ru) 2020-04-17
CO7071135A2 (es) 2014-09-30
JP6122877B2 (ja) 2017-04-26
SG11201404757WA (en) 2014-09-26
US9796725B2 (en) 2017-10-24
CA2864672C (en) 2018-01-09
EP3536692B1 (en) 2021-04-07
CA2864672A1 (en) 2013-08-22
CR20140380A (es) 2014-10-28
BR112014020365B1 (pt) 2023-02-23
KR20140123104A (ko) 2014-10-21
NZ628969A (en) 2017-03-31
US20160244455A1 (en) 2016-08-25
US20130217682A1 (en) 2013-08-22
DOP2014000187A (es) 2014-10-15
IL234016A0 (en) 2014-09-30
SG10201606581RA (en) 2016-09-29
US9290500B2 (en) 2016-03-22
ZA201406103B (en) 2017-11-29
ECSP14019113A (es) 2015-09-30
US20140088096A9 (en) 2014-03-27
AR092797A1 (es) 2015-05-06
PE20142244A1 (es) 2015-01-07
CL2014002181A1 (es) 2014-12-12
TW201345909A (zh) 2013-11-16
EP2814791A4 (en) 2015-08-19

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Designated state(s): AM AZ BY KZ KG TJ TM

PC4A Registration of transfer of a eurasian patent by assignment