DK1874821T3 - Kombination af antistoffer med glykokortikoider til behandling af kræft - Google Patents
Kombination af antistoffer med glykokortikoider til behandling af kræftInfo
- Publication number
- DK1874821T3 DK1874821T3 DK05738161.8T DK05738161T DK1874821T3 DK 1874821 T3 DK1874821 T3 DK 1874821T3 DK 05738161 T DK05738161 T DK 05738161T DK 1874821 T3 DK1874821 T3 DK 1874821T3
- Authority
- DK
- Denmark
- Prior art keywords
- glycocorticoids
- antibodies
- combination
- treat cancer
- cancer
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A61K39/001103—Receptors for growth factors
- A61K39/001106—Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ErbB4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A61K39/001111—Immunoglobulin superfamily
- A61K39/001112—CD19 or B4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A61K39/001111—Immunoglobulin superfamily
- A61K39/001113—CD22, BL-CAM, siglec-2 or sialic acid- binding Ig-related lectin 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A61K39/001124—CD20
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A61K39/001128—CD44 not IgG
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A61K39/001129—Molecules with a "CD" designation not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/00113—Growth factors
- A61K39/001135—Vascular endothelial growth factor [VEGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001166—Adhesion molecules, e.g. NRCAM, EpCAM or cadherins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001169—Tumor associated carbohydrates
- A61K39/001171—Gangliosides, e.g. GM2, GD2 or GD3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/00118—Cancer antigens from embryonic or fetal origin
- A61K39/001182—Carcinoembryonic antigen [CEA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001184—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
- A61K39/001186—MAGE
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Cell Biology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Vascular Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Developmental Biology & Embryology (AREA)
- Pregnancy & Childbirth (AREA)
- Reproductive Health (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP2005/004468 WO2006114115A1 (de) | 2005-04-26 | 2005-04-26 | Kombination von antikörpern mit glukokortikoiden zur behandlung von krebs |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1874821T3 true DK1874821T3 (da) | 2013-07-08 |
Family
ID=35431266
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK05738161.8T DK1874821T3 (da) | 2005-04-26 | 2005-04-26 | Kombination af antistoffer med glykokortikoider til behandling af kræft |
Country Status (8)
Country | Link |
---|---|
US (5) | US8709421B2 (da) |
EP (1) | EP1874821B1 (da) |
JP (1) | JP5129122B2 (da) |
CA (1) | CA2606081C (da) |
DK (1) | DK1874821T3 (da) |
ES (1) | ES2417065T3 (da) |
PL (1) | PL1874821T3 (da) |
WO (1) | WO2006114115A1 (da) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1874821B1 (de) | 2005-04-26 | 2013-04-17 | Trion Pharma Gmbh | Kombination von antikörpern mit glukokortikoiden zur behandlung von krebs |
AU2006326727A1 (en) | 2005-12-16 | 2007-06-21 | Amgen Research (Munich) Gmbh | Means and methods for the treatment of tumorous diseases |
GB0803076D0 (en) * | 2008-02-20 | 2008-03-26 | Univ Ghent | Mucosal Membrane Receptor and uses thereof |
IN2012DN03172A (da) * | 2009-09-18 | 2015-09-25 | Micromet Ag | |
US20110082091A1 (en) * | 2009-09-28 | 2011-04-07 | Theramab Gmbh | Method for Preclinical Testing of Immunomodulatory Drugs |
TW201302793A (zh) | 2010-09-03 | 2013-01-16 | Glaxo Group Ltd | 新穎之抗原結合蛋白 |
SI2632954T2 (sl) | 2010-10-27 | 2021-11-30 | Amgen Research (Munich) Gmbh | Sredstva in postopki za zdravljenje dlbcl |
US10130638B2 (en) | 2010-11-10 | 2018-11-20 | Amgen Research (Munich) Gmbh | Prevention of adverse effects caused by CD3 specific binding domains |
EP2668210B1 (en) | 2011-01-26 | 2020-06-17 | Celldex Therapeutics, Inc. | Anti-kit antibodies and uses thereof |
AU2012245260B2 (en) | 2011-04-22 | 2016-09-08 | Aptevo Research And Development Llc | Prostate-specific membrane antigen binding proteins and related compositions and methods |
CN107936121B (zh) | 2011-05-16 | 2022-01-14 | 埃泰美德(香港)有限公司 | 多特异性fab融合蛋白及其使用方法 |
RU2605390C2 (ru) | 2011-08-23 | 2016-12-20 | Рош Гликарт Аг | Биспецифические антитела, специфичные к антигенам, активирующим т-клетки, и опухолевому антигену, и способы их применения |
AU2012350429A1 (en) * | 2011-12-09 | 2013-07-11 | Amgen Research (Munich) Gmbh | Prevention of adverse effects caused by EpCAMxCD3 bispecific antibodies |
AU2013295848B2 (en) | 2012-07-25 | 2018-05-24 | Celldex Therapeutics, Inc. | Anti-KIT antibodies and uses thereof |
BR112015007120A2 (pt) | 2012-10-08 | 2017-12-12 | Roche Glycart Ag | anticorpo biespecífico, composição farmacêutica, uso, célula hospedeira e método de produção de um anticorpo |
RU2015140915A (ru) | 2013-02-26 | 2017-04-03 | Роше Гликарт Аг | Биспецифические антигенсвязывающие молекулы, активирующие т-клетки |
KR101833602B1 (ko) | 2013-02-26 | 2018-02-28 | 로슈 글리카트 아게 | 이중특이적 t 세포 활성화 항원 결합 분자 |
EP2994490A1 (en) * | 2013-05-10 | 2016-03-16 | Numab AG | Bispecific constructs and their use in the treatment of various diseases |
CN110156893B (zh) | 2013-12-17 | 2023-03-03 | 基因泰克公司 | 抗cd3抗体及使用方法 |
CN106659782B (zh) | 2014-05-23 | 2021-11-09 | 塞尔德克斯医疗公司 | 一种用于嗜酸性粒细胞或肥大细胞相关病症治疗的抗体 |
MA40510A (fr) | 2014-08-04 | 2017-06-14 | Hoffmann La Roche | Molécules bispécifiques de liaison à l'antigène activant les lymphocytes t |
WO2016019969A1 (en) * | 2014-08-08 | 2016-02-11 | Ludwig-Maximilians-Universität München | Subcutaneously administered bispecific antibodies for use in the treatment of cancer |
EP2990416B1 (en) | 2014-08-29 | 2018-06-20 | GEMoaB Monoclonals GmbH | Universal chimeric antigen receptor expressing immune cells for targeting of diverse multiple antigens and method of manufacturing the same and use of the same for treatment of cancer, infections and autoimmune disorders |
TW201617368A (zh) | 2014-09-05 | 2016-05-16 | 史坦森特瑞斯公司 | 新穎抗mfi2抗體及使用方法 |
EP3191520B1 (en) | 2014-09-12 | 2020-01-01 | Genentech, Inc. | Anti-cll-1 antibodies and immunoconjugates |
ES2835823T3 (es) | 2014-11-20 | 2021-06-23 | Hoffmann La Roche | Politerapia de moléculas de unión a antígeno biespecíficas activadoras de linfocitos T para CD3 y para el receptor de folato 1 (FolR1) y antagonistas de la unión al eje de PD-1 |
EP3227336B1 (en) | 2014-12-05 | 2019-07-03 | F.Hoffmann-La Roche Ag | Anti-cd79b antibodies and methods of use |
AR105026A1 (es) | 2015-06-16 | 2017-08-30 | Genentech Inc | ANTICUERPOS MADURADOS POR AFINIDAD Y HUMANIZADOS PARA FcRH5 Y MÉTODOS PARA SU USO |
TW201718647A (zh) | 2015-06-16 | 2017-06-01 | 建南德克公司 | 抗-cll-1抗體及使用方法 |
US11352426B2 (en) | 2015-09-21 | 2022-06-07 | Aptevo Research And Development Llc | CD3 binding polypeptides |
AR106188A1 (es) | 2015-10-01 | 2017-12-20 | Hoffmann La Roche | Anticuerpos anti-cd19 humano humanizados y métodos de utilización |
BR112018000835A2 (pt) | 2015-10-02 | 2018-09-11 | Hoffmann La Roche | molécula, um ou mais polinucleotídeos, um ou mais vetores, célula, método de produção da molécula, composição, uso da molécula, método de tratamento de uma doença e método para induzir a lise de uma célula-alvo |
PL3387015T3 (pl) | 2015-12-09 | 2022-02-14 | F. Hoffmann-La Roche Ag | Przeciwciało anty-CD20 typu II do ograniczania tworzenia przeciwciał przeciwlekowych |
CA3006529A1 (en) | 2016-01-08 | 2017-07-13 | F. Hoffmann-La Roche Ag | Methods of treating cea-positive cancers using pd-1 axis binding antagonists and anti-cea/anti-cd3 bispecific antibodies |
WO2017157305A1 (en) | 2016-03-15 | 2017-09-21 | Generon (Shanghai) Corporation Ltd. | Multispecific fab fusion proteins and use thereof |
PE20231511A1 (es) | 2016-03-22 | 2023-09-26 | Hoffmann La Roche | Moleculas biespecificas de celulas t activadas por proteasas que se unen especificamente al receptor 1 de folato (folr1) y cd3 |
ES2897217T3 (es) | 2016-09-30 | 2022-02-28 | Hoffmann La Roche | Anticuerpos biespecíficos frente a p95HER2 |
TWI791471B (zh) | 2016-11-15 | 2023-02-11 | 美商建南德克公司 | 用於用抗cd20/抗cd3雙特異性抗體進行治療之給藥 |
JP6748221B2 (ja) * | 2017-04-01 | 2020-08-26 | エーブイエム・バイオテクノロジー・エルエルシー | 細胞免疫療法前の細胞毒性プレコンディショニングの代替 |
EP3409322A1 (en) * | 2017-06-01 | 2018-12-05 | F. Hoffmann-La Roche AG | Treatment method |
CN108096255B (zh) * | 2017-12-28 | 2019-11-12 | 北京大学 | 地夫可特用于抑制或治疗胰腺癌的用途 |
AR115360A1 (es) | 2018-02-08 | 2021-01-13 | Genentech Inc | Moléculas de unión al antígeno y métodos de uso |
CN115916825A (zh) | 2020-06-19 | 2023-04-04 | 豪夫迈·罗氏有限公司 | 与cd3和cd19结合的抗体 |
WO2022036495A1 (en) | 2020-08-17 | 2022-02-24 | Utc Therapeutics Inc. | Lymphocytes-antigen presenting cells co-stimulators and uses thereof |
Family Cites Families (113)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6020145A (en) | 1989-06-30 | 2000-02-01 | Bristol-Myers Squibb Company | Methods for determining the presence of carcinoma using the antigen binding region of monoclonal antibody BR96 |
US5965132A (en) * | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
CA2092271C (en) * | 1993-03-09 | 2009-10-13 | Eddie Reed | Use of g-csf for treating taxol side-effects |
EP0702566B1 (en) * | 1993-05-17 | 2010-07-21 | Cytokine Pharmasciences, Inc | Inhibition of migration inhibitory factor in the treatment of diseases involving cytokine-mediated toxicity |
US6080407A (en) * | 1993-05-17 | 2000-06-27 | The Picower Institute For Medical Research | Diagnostic assays for MIF |
JPH07287008A (ja) * | 1994-04-18 | 1995-10-31 | Taisho Pharmaceut Co Ltd | 炎症性疾患治療薬の簡易試験法 |
US5945311A (en) | 1994-06-03 | 1999-08-31 | GSF--Forschungszentrumfur Umweltund Gesundheit | Method for producing heterologous bi-specific antibodies |
JPH08114588A (ja) * | 1994-10-19 | 1996-05-07 | Taisho Pharmaceut Co Ltd | サイトカイン産生抑制剤の簡易評価法 |
US5629194A (en) * | 1994-10-21 | 1997-05-13 | Diacrin, Inc. | Isolated porcine pancreatic cells for use in treatment of diseases characterized by insufficient insulin activity |
DE19531346A1 (de) | 1995-08-25 | 1997-02-27 | Gsf Forschungszentrum Umwelt | Arzneimittel zur Immuntherapie, enthaltend Antikörper, die spezifisch das MHCII-Antigen eines zu behandelnden Patienten erkennen |
FI105075B (fi) * | 1996-01-10 | 2000-06-15 | Suprakort Oy | Kombinaatioinjektiovalmisteen käyttö |
KR100214395B1 (ko) | 1996-07-05 | 1999-08-02 | 다이라 겐이찌로 | 미끄럼 방지 고무 시트 및 미끄럼 방지 고무 시트가 피복된 작업용 장갑 |
DE19634159C1 (de) | 1996-08-23 | 1997-09-25 | Gsf Forschungszentrum Umwelt | Induktion einer Tumorimmunität durch Injektion von Hybridzellen |
ES2169299T3 (es) | 1996-09-03 | 2002-07-01 | Gsf Forschungszentrum Umwelt | Procedimiento para la destruccion de celulas tumorales contaminantes en transplantes de celulas madre utilizando anticuerpos especificos. |
ES2176574T3 (es) * | 1996-09-03 | 2002-12-01 | Gsf Forschungszentrum Umwelt | Utilizacion de anticuerpos bi y triespecificos para la induccion de inmunidad tumoral. |
US6541212B2 (en) | 1997-03-10 | 2003-04-01 | The Regents Of The University Of California | Methods for detecting prostate stem cell antigen protein |
JP3988200B2 (ja) | 1997-03-14 | 2007-10-10 | 株式会社ジェイテクト | 衝撃吸収式ステアリング装置 |
US6306393B1 (en) | 1997-03-24 | 2001-10-23 | Immunomedics, Inc. | Immunotherapy of B-cell malignancies using anti-CD22 antibodies |
US6183744B1 (en) | 1997-03-24 | 2001-02-06 | Immunomedics, Inc. | Immunotherapy of B-cell malignancies using anti-CD22 antibodies |
DE19725586C2 (de) | 1997-06-17 | 1999-06-24 | Gsf Forschungszentrum Umwelt | Verfahren zur Herstellung von Zellpräparaten zur Immunisierung mittels heterologer intakter bispezifischer und/oder trispezifischer Antikörper |
US6172213B1 (en) | 1997-07-02 | 2001-01-09 | Genentech, Inc. | Anti-IgE antibodies and method of improving polypeptides |
US5994511A (en) | 1997-07-02 | 1999-11-30 | Genentech, Inc. | Anti-IgE antibodies and methods of improving polypeptides |
CN1129728C (zh) | 1997-07-22 | 2003-12-03 | 日本钢管株式会社 | 油井管 |
NZ507381A (en) | 1998-04-21 | 2003-12-19 | Micromet Ag | CD19xCD3 specific polypeptides and uses thereof |
US20030149531A1 (en) | 2000-12-06 | 2003-08-07 | Hubert Rene S. | Serpentine transmembrane antigens expressed in human cancers and uses thereof |
DE69942148D1 (de) | 1998-06-22 | 2010-04-29 | Immunomedics Inc | Gebrauch von bispezifischen antikörpern in diagnose und therapie |
US6962702B2 (en) | 1998-06-22 | 2005-11-08 | Immunomedics Inc. | Production and use of novel peptide-based agents for use with bi-specific antibodies |
DE19835633C1 (de) | 1998-08-06 | 1999-08-26 | Gsf Forschungszentrum Umwelt | Induktion einer Tumorimmunität durch Redirektion von Tumorzellen gegen Antigen-präsentierende Zellen |
US6994853B1 (en) | 1998-09-25 | 2006-02-07 | Trion Pharma Gmbh | Time-staggered utilization of tumor cells in combination with intact antibodies for immunization |
EP1854480A3 (en) * | 1999-03-19 | 2009-04-01 | Genentech, Inc. | Treatment of LFA-1 associated disorders with increasing doses of LFA-1 antagonist |
US7829064B2 (en) | 1999-05-10 | 2010-11-09 | Immunomedics, Inc. | Anti-CD74 immunoconjugates and methods |
US7074403B1 (en) | 1999-06-09 | 2006-07-11 | Immunomedics, Inc. | Immunotherapy of autoimmune disorders using antibodies which target B-cells |
US8383081B2 (en) | 1999-05-10 | 2013-02-26 | Immunomedics, Inc. | Anti-CD74 immunoconjugates and methods of use |
CA2374085C (en) * | 1999-05-14 | 2015-12-29 | Genentech, Inc. | Tumour treatment with anti-erbb2 antibodies |
US20030086924A1 (en) * | 1999-06-25 | 2003-05-08 | Genentech, Inc. | Treatment with anti-ErbB2 antibodies |
CN1407901A (zh) | 1999-11-08 | 2003-04-02 | Idec药物公司 | 使用抗cd40l抗体并联合抗cd20抗体和/或化疗剂和放疗治疗b细胞恶性瘤 |
US20020028178A1 (en) | 2000-07-12 | 2002-03-07 | Nabil Hanna | Treatment of B cell malignancies using combination of B cell depleting antibody and immune modulating antibody related applications |
US20020006404A1 (en) | 1999-11-08 | 2002-01-17 | Idec Pharmaceuticals Corporation | Treatment of cell malignancies using combination of B cell depleting antibody and immune modulating antibody related applications |
CN1169837C (zh) | 2000-03-02 | 2004-10-06 | 上海复旦张江生物医药股份有限公司 | 双特异性单克隆抗体、其制备方法和用其制成的溶血栓剂 |
JP2004500412A (ja) * | 2000-03-31 | 2004-01-08 | アイデック ファーマスーティカルズ コーポレイション | B細胞リンパ腫の治療のための抗サイトカイン抗体またはアンタゴニストおよび抗cd20の併用 |
EP2267026A1 (en) | 2000-04-12 | 2010-12-29 | Human Genome Sciences, Inc. | Albumin fusion proteins |
AU2001269688A1 (en) | 2000-06-30 | 2002-01-14 | Eli Lilly And Company | Combination containing an antifolate and methylmalonic acid lowering agent |
IL153764A0 (en) * | 2000-07-12 | 2003-07-06 | Idec Pharma Corp | Treatment of b cell malignancies using combination of b cell depleting antibody and immune modulating antibody related applications |
DE10043437A1 (de) | 2000-09-04 | 2002-03-28 | Horst Lindhofer | Verwendung von trifunktionellen bispezifischen und trispezifischen Antikörpern zur Behandlung von malignem Aszites |
DE60140461D1 (de) | 2000-09-11 | 2009-12-24 | Genzyme Corp | Muc1 extrazelluläre domäne und zusammensetzungen für krebsbehandlung, und davon abgeleitete verfahren |
US20020159996A1 (en) | 2001-01-31 | 2002-10-31 | Kandasamy Hariharan | Use of CD23 antagonists for the treatment of neoplastic disorders |
JP2005507635A (ja) * | 2001-02-12 | 2005-03-24 | メダレックス, インク. | Fcα受容体(CD89)に対するヒトモノクローナル抗体 |
EP1455820A2 (en) | 2001-03-09 | 2004-09-15 | William Herman | Targeted ligands |
WO2002074938A1 (en) | 2001-03-20 | 2002-09-26 | Trustees Of Amherst College | Methods for producing antibodies in mammals |
CA2444959C (en) | 2001-04-24 | 2014-07-08 | Dolores Baksh | Progenitor cell populations, expansion thereof, and growth of non-hematopoietic cell types and tissues therefrom |
CA2868614A1 (en) | 2001-06-08 | 2002-12-08 | Abbott Laboratories (Bermuda) Ltd. | Methods of administering anti-tnf.alpha. antibodies |
JP2005505271A (ja) | 2001-09-06 | 2005-02-24 | アジェンシス, インコーポレイテッド | 癌の処置および検出において有用なsteap−1と名称が与えられる核酸および対応するタンパク質 |
US7494646B2 (en) | 2001-09-06 | 2009-02-24 | Agensys, Inc. | Antibodies and molecules derived therefrom that bind to STEAP-1 proteins |
MXPA04003291A (es) * | 2001-10-12 | 2004-07-23 | Schering Corp | Uso de anticuerpos biespecificos para ragular respuestas inmunes. |
US20050215472A1 (en) | 2001-10-23 | 2005-09-29 | Psma Development Company, Llc | PSMA formulations and uses thereof |
AU2002356844C1 (en) | 2001-10-23 | 2010-03-04 | Amgen Fremont Inc. | PSMA antibodies and protein multimers |
CA2467242A1 (en) | 2001-11-20 | 2003-05-30 | Seattle Genetics, Inc. | Treatment of immunological disorders using anti-cd30 antibodies |
DE10209564A1 (de) | 2002-03-04 | 2003-09-18 | Heidelberg Pharma Holding Gmbh | Phospholipid-Derivate von Nucleosiden als antitumorale Arzneimittel |
DE10156910A1 (de) | 2001-11-21 | 2003-06-05 | Heidelberg Pharma Holding Gmbh | Phospholipid-Derivate von Nucleosiden als antitumorale Arzneimittel |
NZ533094A (en) | 2001-11-21 | 2006-01-27 | Heidelberg Pharma Gmbh | Phospholipid derivatives of nucleosides as antitumoral medicaments |
CA2397169A1 (en) | 2002-08-13 | 2004-02-13 | William Herman | Targeted ligands |
CA2402930A1 (en) | 2002-09-19 | 2004-03-19 | William Herman | Targeted ligands |
CN102174108B (zh) | 2002-03-01 | 2016-06-29 | 免疫医疗公司 | 内在化抗-cd74抗体和使用方法 |
US20030180292A1 (en) | 2002-03-14 | 2003-09-25 | Idec Pharmaceuticals | Treatment of B cell malignancies using anti-CD40L antibodies in combination with anti-CD20 antibodies and/or chemotherapeutics and radiotherapy |
US7538195B2 (en) | 2002-06-14 | 2009-05-26 | Immunogen Inc. | Anti-IGF-I receptor antibody |
JP2006506442A (ja) | 2002-07-09 | 2006-02-23 | ポイント セラピューティクス, インコーポレイテッド | ボロプロリン化合物併用療法 |
US7378386B2 (en) | 2002-07-15 | 2008-05-27 | Board Of Regents, The University Of Texas System | Anti-viral treatment methods using phosphatidylethanolamine-binding peptide derivatives |
US7625563B2 (en) | 2002-07-15 | 2009-12-01 | Board Of Regents, The University Of Texas System | Cancer treatment methods using selected immunoconjugates for binding to aminophospholipids |
US7714109B2 (en) | 2002-07-15 | 2010-05-11 | Board Of Regents, The University Of Texas System | Combinations and kits for cancer treatment using selected antibodies to aminophospholipids |
US7572448B2 (en) | 2002-07-15 | 2009-08-11 | Board Of Regents, The University Of Texas System | Combined cancer treatment methods using selected antibodies to aminophospholipids |
ES2358730T3 (es) | 2002-07-15 | 2011-05-13 | Board Of Regents, The University Of Texas System | Anticuerpos seleccionados y péptidos de duramicina que se enlazan a fosfolípidos aniónicos y aminofosfolípidos y sus usos en el tratamiento de infecciones virales y del cáncer. |
US7615223B2 (en) | 2002-07-15 | 2009-11-10 | Board Of Regents, The University Of Texas System | Selected immunoconjugates for binding to aminophospholipids |
CA2872136C (en) | 2002-07-18 | 2017-06-20 | Merus B.V. | Recombinant production of mixtures of antibodies |
US20050180972A1 (en) | 2002-07-31 | 2005-08-18 | Wahl Alan F. | Anti-CD20 antibody-drug conjugates for the treatment of cancer and immune disorders |
US8530627B2 (en) | 2002-08-14 | 2013-09-10 | Macrogenics, Inc. | FcγRIIB specific antibodies and methods of use thereof |
CA2495251C (en) | 2002-08-14 | 2018-03-06 | Macrogenics, Inc. | Fc.gamma.riib-specific antibodies and methods of use thereof |
KR101329843B1 (ko) | 2002-11-15 | 2013-11-14 | 젠맵 에이/에스 | Cd25에 대한 인간 모노클로날 항체 |
CA2414148A1 (en) | 2002-12-30 | 2004-06-30 | William Herman | Targeted ligands |
US7534427B2 (en) | 2002-12-31 | 2009-05-19 | Immunomedics, Inc. | Immunotherapy of B cell malignancies and autoimmune diseases using unconjugated antibodies and conjugated antibodies and antibody combinations and fusion proteins |
US7576101B2 (en) | 2003-01-24 | 2009-08-18 | Elan Pharmaceuticals, Inc. | Composition for and treatment of demyelinating diseases and paralysis by administration of remyelinating agents |
MXPA05008222A (es) | 2003-01-31 | 2005-10-05 | Immunomedics Inc | Metodos y composiciones para administrar agentes terapeuticos y de diagnostico. |
WO2004071404A2 (en) * | 2003-02-04 | 2004-08-26 | Centocor Inc. | Use of il-6 antagonists in combination with steroids to enhance apoptosis |
JP4869064B2 (ja) | 2003-04-04 | 2012-02-01 | ジェネンテック, インコーポレイテッド | 高濃度抗体及びタンパク質製剤 |
US20050003403A1 (en) | 2003-04-22 | 2005-01-06 | Rossi Edmund A. | Polyvalent protein complex |
US20050043233A1 (en) * | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
JP2007504273A (ja) * | 2003-05-30 | 2007-03-01 | エーアールシー ファーマシューティカルズ,インク. | 種々の作用剤を用いた、線維性癒着の抑制に関する医薬組成物及び方法 |
CA2523716C (en) | 2003-05-31 | 2014-11-25 | Micromet Ag | Human anti-human cd3 binding molecules |
AU2004242846A1 (en) | 2003-05-31 | 2004-12-09 | Micromet Ag | Pharmaceutical compositions comprising bispecific anti-CD3, anti-CD19 antibody constructs for the treatment of B-cell related disorders |
US7604799B2 (en) | 2003-06-06 | 2009-10-20 | Medimmune, Llc | EphA4 Antibodies |
EP1641826A2 (en) | 2003-06-27 | 2006-04-05 | Biogen Idec MA Inc. | Use of hydrophobic-interaction-chromatography or hinge-region modifications for the production of homogeneous antibody-solutions |
US7109304B2 (en) * | 2003-07-31 | 2006-09-19 | Immunomedics, Inc. | Humanized anti-CD19 antibodies |
JP4818917B2 (ja) | 2003-08-08 | 2011-11-16 | イミューノメディクス、インコーポレイテッド | 腫瘍および罹患細胞のアポトーシスを誘発するための二重特異性抗体 |
TW200522932A (en) * | 2003-09-15 | 2005-07-16 | Combinatorx Inc | Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines |
US8066989B2 (en) | 2004-11-30 | 2011-11-29 | Trion Pharma Gmbh | Method of treating tumor growth and metastasis by using trifunctional antibodies to reduce the risk for GvHD in allogeneic antitumor cell therapy |
CN105535967B (zh) | 2005-02-15 | 2022-05-03 | 杜克大学 | 抗cd19抗体及其在肿瘤学中的应用 |
CA2604032C (en) | 2005-04-06 | 2017-08-22 | Ibc Pharmaceuticals, Inc. | Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses |
EP1874821B1 (de) | 2005-04-26 | 2013-04-17 | Trion Pharma Gmbh | Kombination von antikörpern mit glukokortikoiden zur behandlung von krebs |
ES2391902T3 (es) | 2005-07-05 | 2012-11-30 | Glaxo Group Limited | Anticuerpos humanizados específicos para NOGO-A y sus usos farmacéuticos |
US20070116820A1 (en) | 2005-11-23 | 2007-05-24 | The Coca-Cola Company | Edible gel compositions comprising high-potency sweeteners |
AU2006326727A1 (en) | 2005-12-16 | 2007-06-21 | Amgen Research (Munich) Gmbh | Means and methods for the treatment of tumorous diseases |
CN101331151A (zh) | 2005-12-16 | 2008-12-24 | 麦克罗梅特股份公司 | 治疗肿瘤性疾病的方式和方法 |
EP1820513A1 (en) | 2006-02-15 | 2007-08-22 | Trion Pharma Gmbh | Destruction of tumor cells expressing low to medium levels of tumor associated target antigens by trifunctional bispecific antibodies |
US9399061B2 (en) | 2006-04-10 | 2016-07-26 | Abbvie Biotechnology Ltd | Methods for determining efficacy of TNF-α inhibitors for treatment of rheumatoid arthritis |
JP4692368B2 (ja) | 2006-04-19 | 2011-06-01 | 日本ビクター株式会社 | ブラウザ搭載装置 |
US20080088047A1 (en) | 2006-10-12 | 2008-04-17 | Mold-Masters Limited | Apparatus and method for a hot runner injection molding system |
EP2033657A1 (de) | 2007-09-04 | 2009-03-11 | Trion Pharma Gmbh | Intraoperative trifunktionale Antikörper-Applikation zur Prophylaxe intraperitonealer Tumorzelldissemination |
SI2632954T2 (sl) | 2010-10-27 | 2021-11-30 | Amgen Research (Munich) Gmbh | Sredstva in postopki za zdravljenje dlbcl |
US10130638B2 (en) | 2010-11-10 | 2018-11-20 | Amgen Research (Munich) Gmbh | Prevention of adverse effects caused by CD3 specific binding domains |
ES2703780T3 (es) | 2011-05-17 | 2019-03-12 | Trion Res Gmbh | Preparación de una vacuna que contiene anticuerpos trifuncionales con propiedades potenciadoras de la inmunogenicidad del antígeno |
EP2525222A1 (en) | 2011-05-17 | 2012-11-21 | Markus M. Heiss | Initial relative lymphocyte count as predictive biomarker |
EP2578230A1 (en) | 2011-10-04 | 2013-04-10 | Trion Pharma Gmbh | Removal of Tumor Cells from Intraoperative Autologous Blood Salvage |
AU2012350429A1 (en) | 2011-12-09 | 2013-07-11 | Amgen Research (Munich) Gmbh | Prevention of adverse effects caused by EpCAMxCD3 bispecific antibodies |
WO2016019969A1 (en) | 2014-08-08 | 2016-02-11 | Ludwig-Maximilians-Universität München | Subcutaneously administered bispecific antibodies for use in the treatment of cancer |
-
2005
- 2005-04-26 EP EP05738161.8A patent/EP1874821B1/de active Active
- 2005-04-26 PL PL05738161T patent/PL1874821T3/pl unknown
- 2005-04-26 DK DK05738161.8T patent/DK1874821T3/da active
- 2005-04-26 WO PCT/EP2005/004468 patent/WO2006114115A1/de active Search and Examination
- 2005-04-26 CA CA2606081A patent/CA2606081C/en active Active
- 2005-04-26 ES ES05738161T patent/ES2417065T3/es active Active
- 2005-04-26 JP JP2008508080A patent/JP5129122B2/ja active Active
-
2007
- 2007-10-26 US US11/977,856 patent/US8709421B2/en active Active
-
2014
- 2014-04-07 US US14/247,029 patent/US10071158B2/en active Active
-
2018
- 2018-03-23 US US15/934,403 patent/US10576149B2/en active Active
-
2020
- 2020-02-06 US US16/783,500 patent/US20210015917A1/en not_active Abandoned
-
2023
- 2023-01-30 US US18/102,922 patent/US20230310597A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2006114115A1 (de) | 2006-11-02 |
US20210015917A1 (en) | 2021-01-21 |
JP5129122B2 (ja) | 2013-01-23 |
JP2008539177A (ja) | 2008-11-13 |
PL1874821T3 (pl) | 2013-09-30 |
US20230310597A1 (en) | 2023-10-05 |
CA2606081A1 (en) | 2006-11-02 |
EP1874821B1 (de) | 2013-04-17 |
US10576149B2 (en) | 2020-03-03 |
US10071158B2 (en) | 2018-09-11 |
US20150086550A1 (en) | 2015-03-26 |
US20180236067A1 (en) | 2018-08-23 |
EP1874821A1 (de) | 2008-01-09 |
US20090191201A1 (en) | 2009-07-30 |
ES2417065T3 (es) | 2013-08-05 |
CA2606081C (en) | 2013-09-17 |
US8709421B2 (en) | 2014-04-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK1874821T3 (da) | Kombination af antistoffer med glykokortikoider til behandling af kræft | |
CY2019004I2 (el) | Τροποποιημενα αντισωματα αντι-ιl-23ρ19 | |
DK2076540T3 (da) | Hidtil ukendte anti-cd38-antistoffer til behandling af cancer | |
DK2195015T3 (da) | Sammensætning til behandling af prostatacancer | |
LTC2152290I2 (lt) | Anti-il-5 antikūnų skyrimo būdai | |
DK2068874T3 (da) | Fremgangsmåder til behandling af multiple myelom med anvendelse af kombinationsterapier baseret på anti-cs1 antistoffer | |
DK2478907T3 (da) | Sammensætninger til behandling af kræft | |
DK3289876T3 (da) | Forbindelser til behandling af cancer | |
DK2781593T3 (da) | Fremgangsmåde til behandling af methanemissioner | |
DK3517534T3 (da) | Forbindelser, der er anvendelige til behandling af cancer | |
CY2013046I1 (el) | Καινοτομος χρηση των αντισωματων αντι il-1bhta | |
BRPI0820407A2 (pt) | Uso de anticorpos anti-cd40 | |
DK2155188T3 (da) | Fremgangsmåder og sammensætninger til behandling af tilbagevendende kræft | |
DK2480574T3 (da) | Anti-cd33-antistoffer og deres anvendelse til immunotargeting i behandlingen af cd33-associerede sygdomme | |
DK2177537T3 (da) | Antistoffer til MAdCAM | |
ATE528296T1 (de) | Polymorphe form von 4-ä3-(4- cyclopropancarbonylpiperazin-1-carbonyl)-4- fluorbenzylü-2h-phthalazin-1-on | |
DK1874781T3 (da) | Dihydrothienopyrimidiner til behandling af inflammatoriske sygdomme | |
DK1942938T3 (da) | Anvendelse af oligouronater til behandling af slim-hyperviskositet | |
BRPI0819205A2 (pt) | Anticorpos humanizados contra tl1a | |
DK2086944T3 (da) | Fremgangsmåde til fremstilling af difluormethylpyrazolylcarboxylater | |
BRPI0716456A2 (pt) | Navegação eficiente de resultados de pesquisa | |
ATE483732T1 (de) | Madcam-antikörper | |
DK1893586T3 (da) | Fremgangsmåde til fremstilling af 1-alkyl-3-phenyluraciler | |
DK2219469T3 (da) | Modificering af enzymatisk disponerede proteiner | |
FR2918570B1 (fr) | DIGLYCATION DES AGEs. |