SG11202001050PA - Antibodies that bind egfr and cmet - Google Patents

Antibodies that bind egfr and cmet

Info

Publication number
SG11202001050PA
SG11202001050PA SG11202001050PA SG11202001050PA SG11202001050PA SG 11202001050P A SG11202001050P A SG 11202001050PA SG 11202001050P A SG11202001050P A SG 11202001050PA SG 11202001050P A SG11202001050P A SG 11202001050PA SG 11202001050P A SG11202001050P A SG 11202001050PA
Authority
SG
Singapore
Prior art keywords
cmet
antibodies
bind egfr
egfr
bind
Prior art date
Application number
SG11202001050PA
Inventor
Cecilia Geuijen
Robertus Roovers
Mark Throsby
Kruif Cornelis De
Ton Logtenberg
Original Assignee
Merus Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merus Nv filed Critical Merus Nv
Publication of SG11202001050PA publication Critical patent/SG11202001050PA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
SG11202001050PA 2017-08-09 2018-08-09 Antibodies that bind egfr and cmet SG11202001050PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17185572 2017-08-09
PCT/NL2018/050537 WO2019031965A1 (en) 2017-08-09 2018-08-09 Antibodies that bind egfr and cmet

Publications (1)

Publication Number Publication Date
SG11202001050PA true SG11202001050PA (en) 2020-03-30

Family

ID=59579503

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202001050PA SG11202001050PA (en) 2017-08-09 2018-08-09 Antibodies that bind egfr and cmet

Country Status (15)

Country Link
US (2) US11773170B2 (en)
EP (1) EP3665198A1 (en)
JP (2) JP2020530028A (en)
KR (1) KR20200042485A (en)
AU (2) AU2018312816B2 (en)
BR (1) BR112020002695A2 (en)
CA (1) CA3072404A1 (en)
EA (1) EA202090215A1 (en)
IL (1) IL272461A (en)
MA (1) MA49846A (en)
MX (1) MX2020001432A (en)
PH (1) PH12020550055A1 (en)
SG (1) SG11202001050PA (en)
TW (1) TW201910354A (en)
WO (1) WO2019031965A1 (en)

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CN108602888B (en) 2015-10-23 2022-10-04 美勒斯公司 Binding molecules that inhibit cancer growth
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AU2018246873B2 (en) 2017-03-31 2021-05-06 Merus N.V. ErbB-2 and ErbB3 binding bispecific antibodies for use in the treatment f cells that have an NRG1 fusion gene
AU2019243665B2 (en) * 2018-03-30 2023-06-01 Merus N.V. Multivalent antibody
US11254736B2 (en) * 2019-02-15 2022-02-22 Integral Molecular, Inc. Antibodies comprising a common light chain and uses thereof
CN114702587A (en) 2019-05-09 2022-07-05 美勒斯公司 Variant domains and their isolation for multimerizing proteins
AU2020349462A1 (en) 2019-09-16 2022-03-03 Regeneron Pharmaceuticals, Inc. Radiolabeled MET binding proteins for immuno-PET imaging
CN112898427B (en) * 2019-12-03 2023-06-30 同济大学苏州研究院 anti-c-Met single-arm antibody and preparation method and application thereof
EP4372001A1 (en) 2021-07-14 2024-05-22 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Antigen-binding molecule specifically binding to hgfr and egfr, and pharmaceutical use thereof
WO2023172133A1 (en) 2022-03-07 2023-09-14 Merus N.V. Combination therapy including antibodies that bind egfr and cmet
WO2023172134A1 (en) 2022-03-07 2023-09-14 Merus N.V. Treatment with an antibody that binds egfr and cmet.
WO2024002235A1 (en) * 2022-06-29 2024-01-04 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Anti-egfr/met antibodies and uses thereof

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Also Published As

Publication number Publication date
IL272461A (en) 2020-03-31
TW201910354A (en) 2019-03-16
AU2021202874A1 (en) 2021-06-03
BR112020002695A2 (en) 2020-08-25
CN111094351A (en) 2020-05-01
EP3665198A1 (en) 2020-06-17
US20240174756A1 (en) 2024-05-30
KR20200042485A (en) 2020-04-23
EA202090215A1 (en) 2020-07-01
MA49846A (en) 2020-06-17
US11773170B2 (en) 2023-10-03
PH12020550055A1 (en) 2020-10-19
WO2019031965A1 (en) 2019-02-14
AU2018312816A1 (en) 2020-02-27
MX2020001432A (en) 2020-03-20
JP2024029049A (en) 2024-03-05
JP2020530028A (en) 2020-10-15
US20200247892A1 (en) 2020-08-06
CA3072404A1 (en) 2019-02-14
AU2018312816B2 (en) 2021-05-27

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