SG10201800982QA - Humanized or chimeric cd3 antibodies - Google Patents

Humanized or chimeric cd3 antibodies

Info

Publication number
SG10201800982QA
SG10201800982QA SG10201800982QA SG10201800982QA SG10201800982QA SG 10201800982Q A SG10201800982Q A SG 10201800982QA SG 10201800982Q A SG10201800982Q A SG 10201800982QA SG 10201800982Q A SG10201800982Q A SG 10201800982QA SG 10201800982Q A SG10201800982Q A SG 10201800982QA
Authority
SG
Singapore
Prior art keywords
humanized
chimeric
antibodies
Prior art date
Application number
SG10201800982QA
Inventor
Den Brink Edward Van
Joost J Neijssen
Aran Frank Labrijn
Joyce Meesters
Janine Schuurman
Paul Parren
Original Assignee
Genmab As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2013/064330 external-priority patent/WO2014006217A1/en
Application filed by Genmab As filed Critical Genmab As
Publication of SG10201800982QA publication Critical patent/SG10201800982QA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/112—Retroviridae (F), e.g. leukemia viruses
    • C07K16/114—Lentivirus (G), e.g. human immunodeficiency virus [HIV], feline immunodeficiency virus [FIV] or simian immunodeficiency virus [SIV]
    • C07K16/1145—Env proteins, e.g. gp41, gp110/120, gp160, V3, principal neutralising domain [PND] or CD4-binding site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4241—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G01N33/686—Anti-idiotype
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/7051—T-cell receptor (TcR)-CD3 complex

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
SG10201800982QA 2013-07-05 2014-07-04 Humanized or chimeric cd3 antibodies SG10201800982QA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/EP2013/064330 WO2014006217A1 (en) 2012-07-06 2013-07-05 Dimeric protein with triple mutations
DKPA201400009 2014-01-09
PCT/EP2014/050340 WO2014108483A1 (en) 2013-01-10 2014-01-09 Inert format

Publications (1)

Publication Number Publication Date
SG10201800982QA true SG10201800982QA (en) 2018-03-28

Family

ID=52143134

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201800982QA SG10201800982QA (en) 2013-07-05 2014-07-04 Humanized or chimeric cd3 antibodies
SG11201510739TA SG11201510739TA (en) 2013-07-05 2014-07-04 Humanized or chimeric cd3 antibodies

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201510739TA SG11201510739TA (en) 2013-07-05 2014-07-04 Humanized or chimeric cd3 antibodies

Country Status (32)

Country Link
US (5) US10465006B2 (en)
EP (5) EP3693385A1 (en)
JP (7) JP6546162B2 (en)
KR (4) KR102531517B1 (en)
CN (5) CN105722529B (en)
AU (4) AU2014286116A1 (en)
BR (1) BR122023002590B1 (en)
CA (1) CA2915575A1 (en)
CY (1) CY1122840T1 (en)
DK (2) DK3016681T5 (en)
EA (1) EA201690167A1 (en)
ES (3) ES2776706T3 (en)
FI (2) FI4249515T3 (en)
FR (1) FR25C1054I1 (en)
HR (2) HRP20200382T1 (en)
HU (3) HUE048722T2 (en)
IL (4) IL290613B2 (en)
LT (3) LT3016681T (en)
ME (1) ME03675B (en)
MX (2) MX373245B (en)
NL (1) NL301352I2 (en)
NO (1) NO2025057I1 (en)
NZ (1) NZ715896A (en)
PL (2) PL3016681T3 (en)
PT (2) PT3016681T (en)
RS (2) RS60131B1 (en)
SG (2) SG10201800982QA (en)
SI (2) SI3016681T1 (en)
SM (2) SMT202000287T1 (en)
UA (1) UA119646C2 (en)
WO (2) WO2015001085A1 (en)
ZA (1) ZA201800385B (en)

Families Citing this family (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3434767T (en) 2010-11-30 2026-01-23 Chugai Pharmaceutical Co Ltd Cytotoxicity-inducing therapeutic agent
AU2013285355A1 (en) 2012-07-06 2015-01-29 Genmab B.V. Dimeric protein with triple mutations
JOP20200236A1 (en) 2012-09-21 2017-06-16 Regeneron Pharma Anti-cd3 antibodies, bispecific antigen-binding molecules that bind cd3 and cd20, and uses thereof
TWI635098B (en) 2013-02-01 2018-09-11 再生元醫藥公司 Antibody containing chimeric constant region
HUE048722T2 (en) 2013-07-05 2020-08-28 Genmab As Humanized or chimeric CD3 antibodies
DK3406633T3 (en) 2013-07-25 2022-03-28 Cytomx Therapeutics Inc MULTISPECIFIC ANTIBODIES, MULTISPECIFIC ACTIVABLE ANTIBODIES AND METHODS OF USING IT
TWI701042B (en) 2014-03-19 2020-08-11 美商再生元醫藥公司 Methods and antibody compositions for tumor treatment
ES2900898T3 (en) * 2014-04-07 2022-03-18 Chugai Pharmaceutical Co Ltd Bispecific immunoactivating antibodies
CA2947157A1 (en) 2014-05-13 2015-11-19 Chugai Seiyaku Kabushiki Kaisha T cell-redirected antigen-binding molecule for cells having immunosuppression function
AU2015292406B2 (en) 2014-07-25 2021-03-11 Cytomx Therapeutics, Inc Anti-CD3 antibodies, activatable anti-CD3 antibodies, multispecific anti-CD3 antibodies, multispecific activatable anti-CD3 antibodies, and methods of using the same
AU2015350075B2 (en) 2014-11-17 2021-06-03 Regeneron Pharmaceuticals, Inc. Methods for tumor treatment using CD3xCD20 bispecific antibody
BR112017010513A2 (en) 2014-11-20 2018-04-03 F. Hoffmann-La Roche Ag Common light chains and methods of use
RS61010B1 (en) 2014-11-20 2020-11-30 Hoffmann La Roche T cell activating bispecific antigen binding molecules against folr1 and cd3
UA120286C2 (en) 2015-01-08 2019-11-11 Ґенмаб А/С BISPECIFIC ANTIBODY AGAINST CD3 AND CD20
US10556952B2 (en) 2015-03-30 2020-02-11 Regeneron Pharmaceuticals, Inc. Heavy chain constant regions with reduced binding to Fc gamma receptors
PL3988117T3 (en) * 2015-04-13 2025-03-10 Pfizer Inc. Therapeutic antibodies and their uses
AU2016293073B2 (en) 2015-07-15 2022-12-22 Genmab A/S Humanized or chimeric CD3 antibodies
TWI784917B (en) 2015-09-23 2022-11-21 美商再生元醫藥公司 Optimized anti-cd3 bispecific antibodies and uses thereof
EP3371311B1 (en) 2015-11-06 2021-07-21 Orionis Biosciences BV Bi-functional chimeric proteins and uses thereof
WO2017086367A1 (en) 2015-11-18 2017-05-26 中外製薬株式会社 Combination therapy using t cell redirection antigen binding molecule against cell having immunosuppressing function
JP6925278B2 (en) 2015-11-18 2021-08-25 中外製薬株式会社 Method of enhancing humoral immune response
CN105296421B (en) * 2015-11-24 2019-01-29 高岱清 The T cell and preparation method of a kind of activation of bispecific antibody and application
ES2901794T3 (en) 2015-12-09 2022-03-23 Hoffmann La Roche Type II anti-CD20 antibody to reduce the formation of anti-drug antibodies
DK3411398T3 (en) 2016-02-05 2024-06-24 Orionis Biosciences BV TARGETED THERAPEUTICS AND THEIR USE
SG11201808085WA (en) * 2016-03-22 2018-10-30 Hoffmann La Roche Protease-activated t cell bispecific molecules
PL3433280T3 (en) * 2016-03-22 2023-07-31 F. Hoffmann-La Roche Ag Protease-activated t cell bispecific molecules
CA3059010A1 (en) 2016-06-02 2018-12-06 F. Hoffmann-La Roche Ag Type ii anti-cd20 antibody and anti-cd20/cd3 bispecific antibody for treatment of cancer
EP3252078A1 (en) 2016-06-02 2017-12-06 F. Hoffmann-La Roche AG Type ii anti-cd20 antibody and anti-cd20/cd3 bispecific antibody for treatment of cancer
TWI640536B (en) 2016-06-20 2018-11-11 克馬伯有限公司 antibody
CA3030636A1 (en) 2016-07-14 2018-01-18 Genmab A/S Multispecific antibodies against cd40 and cd137
CA3046489A1 (en) 2016-12-07 2018-06-14 Progenity Inc. Gastrointestinal tract detection methods, devices and systems
US10906985B2 (en) 2017-02-06 2021-02-02 Orionis Biosciences, Inc. Targeted engineered interferon and uses thereof
WO2018162749A1 (en) 2017-03-09 2018-09-13 Genmab A/S Antibodies against pd-l1
US20210138213A1 (en) 2017-03-30 2021-05-13 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with an immune modulatory agent released using an ingestible device
US11542330B2 (en) * 2017-05-08 2023-01-03 Adimab, Llc Anti-CD3-binding domains and antibodies comprising them, and methods for their generation and use
EP3409322A1 (en) 2017-06-01 2018-12-05 F. Hoffmann-La Roche AG Treatment method
US10882907B2 (en) 2017-06-21 2021-01-05 Gilead Sciences, Inc. Multispecific antibodies that target HIV GP120 and CD3
WO2019025545A1 (en) 2017-08-04 2019-02-07 Genmab A/S Binding agents binding to pd-l1 and cd137 and use thereof
EP3668898B1 (en) 2017-08-14 2023-07-05 MorphoSys AG Humanized antibodies for cd3
US20190100587A1 (en) * 2017-10-02 2019-04-04 Covagen Ag IgG1 Fc MUTANTS WITH ABLATED EFFECTOR FUNCTIONS
AU2018347607B2 (en) * 2017-10-14 2025-08-21 Cytomx Therapeutics, Inc. Antibodies, activatable antibodies, bispecific antibodies, and bispecific activatable antibodies and methods of use thereof
KR101973060B1 (en) * 2017-10-20 2019-04-26 주식회사 녹십자 Antibody against cd3 and pharmaceutical composition for treating cancer comprising the same
CN107860925B (en) * 2017-11-03 2019-07-12 合肥瀚科迈博生物技术有限公司 For detecting the ELISA detection kit of HuA21 antibody in serum
CN109971725B (en) 2017-12-28 2024-02-02 上海细胞治疗研究院 Antibody-modified chimeric antigen receptor-modified T cells and uses thereof
WO2019160904A1 (en) * 2018-02-15 2019-08-22 Macrogenics, Inc. Variant cd3-binding domains and their use in combination therapies for the treatment of disease
CN111971298B (en) 2018-03-12 2025-06-20 健玛保 Antibody
CA3093330A1 (en) * 2018-03-14 2019-09-19 Novimmune Sa Anti-cd3 epsilon antibodies and methods of use thereof
PL3797121T3 (en) * 2018-05-23 2024-09-23 Pfizer Inc. Antibodies specific for cd3 and uses thereof
MX420253B (en) * 2018-05-24 2025-02-10 Janssen Biotech Inc Anti-cd3 antibodies and uses thereof
WO2019246312A1 (en) 2018-06-20 2019-12-26 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with an immunomodulator
WO2019246317A1 (en) 2018-06-20 2019-12-26 Progenity, Inc. Treatment of a disease or condition in a tissue originating from the endoderm
IL280875B2 (en) 2018-08-31 2024-12-01 Regeneron Pharma Cytokine release syndrome-attenuating dosing strategy for bispecific antibodies to CD3 and CD20
WO2020076977A2 (en) 2018-10-11 2020-04-16 Inhibrx, Inc. Dll3 single domain antibodies and therapeutic compositions thereof
CA3115082A1 (en) 2018-10-11 2020-04-16 Inhibrx, Inc. B7h3 single domain antibodies and therapeutic compositions thereof
US20210340273A1 (en) 2018-10-11 2021-11-04 Inhlbrx, inc. 5t4 single domain antibodies and therapeutic compositions thereof
EP3864049A1 (en) 2018-10-11 2021-08-18 Inhibrx, Inc. Pd-1 single domain antibodies and therapeutic compositions thereof
CN116726361A (en) 2018-11-19 2023-09-12 比奥拉治疗股份有限公司 Methods and devices for treating diseases with biologic therapeutic agents
AU2019339582A1 (en) * 2018-12-04 2021-06-17 Novartis Ag Binding molecules against CD3 and uses thereof
TWI905099B (en) 2019-05-21 2025-11-21 瑞士商諾華公司 Cd19 binding molecules and uses thereof
WO2021048423A1 (en) 2019-09-12 2021-03-18 Genmab A/S Bispecific antibodies binding to 5t4 and cd3 for use in treatment of cancer
TWI841790B (en) * 2019-09-30 2024-05-11 大陸商和鉑醫藥（上海）有限責任公司 Antibodies targeting CD3, bispecific antibodies and their uses
WO2021119482A1 (en) 2019-12-13 2021-06-17 Progenity, Inc. Ingestible device for delivery of therapeutic agent to the gastrointestinal tract
AU2020411480B2 (en) 2019-12-23 2023-12-21 Denali Therapeutics Inc. Progranulin variants
US12545731B2 (en) 2020-01-06 2026-02-10 Cytomx Therapeutics, Inc. Single-and multi-chain polypeptides that bind specifically to CD3 epsilon
KR20220148175A (en) 2020-01-29 2022-11-04 인히브릭스, 인크. CD28 single domain antibody and multivalent and multispecific constructs thereof
US20230075244A1 (en) * 2020-02-20 2023-03-09 The Feinstein Institutes For Medical Research Agonist antibodies against endoglin and uses thereof
CA3168613A1 (en) 2020-03-18 2021-09-23 Genmab A/S Antibodies binding to b7h4
CN113563473A (en) * 2020-04-29 2021-10-29 三生国健药业（上海）股份有限公司 Tetravalent bispecific antibody, preparation method and application thereof
CA3176436A1 (en) * 2020-05-08 2021-11-11 Tahamtan Ahmadi Bispecific antibodies against cd3 and cd20
IL298444A (en) 2020-05-27 2023-01-01 Janssen Biotech Inc Proteins comprising cd3 antigen binding domains and uses thereof
MX2023002194A (en) 2020-08-25 2023-03-03 Gilead Sciences Inc Multi-specific antigen binding molecules targeting hiv and methods of use.
CN116472060A (en) 2020-09-02 2023-07-21 健玛保 Antibody therapy
US20240034812A1 (en) 2020-09-10 2024-02-01 Genmab A/S Bispecific antibody against cd3 and cd20 in combination therapy for treating diffuse large b-cell lymphoma
CN116406293A (en) 2020-09-10 2023-07-07 健玛保 Bispecific antibodies against CD3 and CD20 for use in combination therapy for the treatment of follicular lymphoma
JP2023542289A (en) 2020-09-10 2023-10-06 ジェンマブ エー／エス Bispecific antibodies against CD3 and CD20 in combination therapy to treat follicular lymphoma
JP2023541858A (en) 2020-09-10 2023-10-04 ジェンマブ エー／エス Bispecific antibodies against CD3 and CD20 for treating chronic lymphocytic leukemia
JP2023542291A (en) 2020-09-10 2023-10-06 ジェンマブ エー／エス Bispecific antibodies against CD3 and CD20 in combination therapy to treat diffuse large B-cell lymphoma
AU2021342343A1 (en) 2020-09-10 2023-04-13 Genmab A/S Bispecific antibody against cd3 and cd20 in combination therapy for treating diffuse large b-cell lymphoma
MX2023003749A (en) 2020-10-02 2023-04-24 Genmab As Antibodies capable of binding to ror2 and bispecific antibodies binding to ror2 and cd3.
KR102671734B1 (en) * 2021-04-13 2024-06-04 건국대학교 글로컬산학협력단 NOVEL CANINE CD3ε SPECIFIC ANTIBODY OR ANTIGEN-BINDING FRAGMENT THEREOF
AU2021443318A1 (en) 2021-04-30 2023-09-07 F. Hoffmann-La Roche Ag Dosing for combination treatment with anti-cd20/anti-cd3 bispecific antibody and anti-cd79b antibody drug conjugate
EP4329800A1 (en) 2021-04-30 2024-03-06 F. Hoffmann-La Roche AG Dosing for treatment with anti-cd20/anti-cd3 bispecific antibody
EP4334359A1 (en) 2021-05-07 2024-03-13 Genmab A/S Pharmaceutical compositions comprising bispecific antibodies binding to b7h4 and cd3
CN115558023A (en) * 2021-07-02 2023-01-03 安源医药科技（上海）有限公司 anti-CD 3 antibodies and uses thereof
US11814437B2 (en) 2021-10-08 2023-11-14 Genmab A/S Antibodies binding to CD30 and CD3
WO2023144290A1 (en) 2022-01-28 2023-08-03 Genmab A/S Bispecific antibody against cd3 and cd20 in combination therapy for treating diffuse large b-cell lymphoma
MX2024008832A (en) 2022-01-28 2024-07-25 Genmab As Bispecific antibody against cd3 and cd20 in combination therapy for treating diffuse large b-cell lymphoma.
MX2024011468A (en) 2022-03-23 2024-09-25 Hoffmann La Roche Combination treatment of an anti-cd20/anti-cd3 bispecific antibody and chemotherapy.
US20250304689A1 (en) 2022-04-13 2025-10-02 Genmab A/S Bispecific antibodies against cd3 and cd20
AU2023251832A1 (en) 2022-04-13 2024-10-17 F. Hoffmann-La Roche Ag Pharmaceutical compositions of anti-cd20/anti-cd3 bispecific antibodies and methods of use
CN119212716A (en) * 2022-05-09 2024-12-27 杭州微诺迈博生物科技有限公司 Therapeutic agents comprising multispecific antibodies and their use in tumor treatment
WO2024088987A1 (en) 2022-10-26 2024-05-02 F. Hoffmann-La Roche Ag Combination therapy for the treatment of cancer
JP2025537529A (en) 2022-11-02 2025-11-18 ジェンマブ エー／エス Bispecific antibodies against CD3 and CD20 for treating Richter's syndrome
WO2024102948A1 (en) 2022-11-11 2024-05-16 Celgene Corporation Fc receptor-homolog 5 (fcrh5) specific binding molecules and bispecific t-cell engaging antibodies including same and related methods
TW202506178A (en) 2023-04-05 2025-02-16 丹麥商珍美寶股份有限公司 Pharmaceutical compositions comprising antibodies binding to cd30 and cd3
US20240368297A1 (en) 2023-04-13 2024-11-07 Genmab A/S Methods of treating lymphoma with bispecific antibodies against cd3 and cd20
EP4695308A1 (en) * 2023-09-14 2026-02-18 Invitrogen BioServices India Private Limited Engineered antibodies and uses thereof
WO2025061993A1 (en) 2023-09-21 2025-03-27 Domain Therapeutics Anti-ccr8 monoclonal antibodies and their therapeutic use
WO2025061994A1 (en) 2023-09-21 2025-03-27 Domain Therapeutics Anti-ccr8 monoclonal antibodies and their therapeutic use
WO2025116732A1 (en) * 2023-12-01 2025-06-05 Rijksuniversiteit Groningen Methods and kits for detecting proliferating cells
WO2025199352A2 (en) 2024-03-20 2025-09-25 Juno Therapeutics, Inc. Antibodies specific for solute carrier family 34 member 2 (slc34a2)
WO2025240670A2 (en) 2024-05-15 2025-11-20 Abalytics Oncology, Inc. Anti-pd-1 antibodies and related binding molecules and methods and uses thereof

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4699880A (en) 1984-09-25 1987-10-13 Immunomedics, Inc. Method of producing monoclonal anti-idiotype antibody
US5776093A (en) 1985-07-05 1998-07-07 Immunomedics, Inc. Method for imaging and treating organs and tissues
US5057313A (en) 1986-02-25 1991-10-15 The Center For Molecular Medicine And Immunology Diagnostic and therapeutic antibody conjugates
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
EP0940468A1 (en) 1991-06-14 1999-09-08 Genentech, Inc. Humanized antibody variable domain
GB9203459D0 (en) 1992-02-19 1992-04-08 Scotgen Ltd Antibodies with germ-line variable regions
US6077835A (en) 1994-03-23 2000-06-20 Case Western Reserve University Delivery of compacted nucleic acid to cells
KR970029803A (en) 1995-11-03 1997-06-26 김광호 Precharge Circuit of Semiconductor Memory Device
DK0979281T3 (en) 1997-05-02 2005-11-21 Genentech Inc Process for the preparation of multispecific antibodies with heteromultimers and common components
DE60013773T2 (en) 1999-02-03 2005-11-10 Biosante Pharmaceuticals, Inc. Methods for the preparation of therapeutic calcium phosphate particles
US6281005B1 (en) 1999-05-14 2001-08-28 Copernicus Therapeutics, Inc. Automated nucleic acid compaction device
DE10043437A1 (en) 2000-09-04 2002-03-28 Horst Lindhofer Use of trifunctional bispecific and trispecific antibodies for the treatment of malignant ascites
PT2314629E (en) 2002-07-18 2014-01-22 Merus B V RECOMBINANT PRODUCTION OF ANTIBODY MIXTURES
PL216630B1 (en) * 2002-10-17 2014-04-30 Genmab As Human monoclonal antibodies against cd20
CN1942483B (en) 2004-04-13 2012-09-26 弗·哈夫曼-拉罗切有限公司 Anti-P-selectin antibodies
US7850962B2 (en) 2004-04-20 2010-12-14 Genmab A/S Human monoclonal antibodies against CD20
US7741568B2 (en) 2005-01-13 2010-06-22 The Wiremold Company Downward facing receptacle assembly for cable raceway
JP2008528668A (en) 2005-02-03 2008-07-31 アンチトープ リミテッド Human antibodies and proteins
EP1860120B1 (en) 2005-02-08 2018-01-24 The Chemo-Sero-Therapeutic Research Institute Method for improving antibody
TWI671403B (en) 2005-03-31 2019-09-11 中外製藥股份有限公司 Method for controlling controlled assembly of polypeptide
EP2500352A1 (en) 2005-08-19 2012-09-19 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
US7612181B2 (en) 2005-08-19 2009-11-03 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
EP1940881B1 (en) * 2005-10-11 2016-11-30 Amgen Research (Munich) GmbH Compositions comprising cross-species-specific antibodies and uses thereof
AU2006317242A1 (en) 2005-11-28 2007-05-31 Genmab A/S Recombinant monovalent antibodies and methods for production thereof
GEP20135917B (en) 2006-03-17 2013-09-10 Biogen Idec Inc Stabilized polypeptide compositions
ES2395969T3 (en) 2006-03-24 2013-02-18 Merck Patent Gmbh Genetically modified heterodimeric protein domains
AT503902B1 (en) 2006-07-05 2008-06-15 F Star Biotech Forsch & Entw METHOD FOR MANIPULATING IMMUNE LOBULINS
WO2008119567A2 (en) 2007-04-03 2008-10-09 Micromet Ag Cross-species-specific cd3-epsilon binding domain
AU2008234019B2 (en) * 2007-04-03 2014-05-29 Amgen Research (Munich) Gmbh Cross-species-specific bispecific binders
ES2702087T3 (en) 2007-06-21 2019-02-27 Macrogenics Inc Covalent diabodies and their uses
SI2235064T1 (en) 2008-01-07 2016-04-29 Amgen Inc. Method for making antibody fc-heterodimeric molecules using electrostatic steering effects
WO2010015792A1 (en) 2008-08-06 2010-02-11 Argenta Discovery Limited Nitrogen containing heterocyclic compounds useful as bifunctional modulators of m3 receptors and beta-2 receptors
DE102008039957A1 (en) 2008-08-27 2010-03-04 Continental Automotive Gmbh Method for determining an accident severity criterion by means of an acceleration signal and a structure-borne sound signal
JP5397668B2 (en) 2008-09-02 2014-01-22 ソニー株式会社 Storage element and storage device
FR2935974B1 (en) 2008-09-15 2010-10-08 Centre Nat Rech Scient DERIVATIVES OF METALLOPORPHYRINS, NANOPARTICLES COMPRISING THE SAME
AU2009299794B2 (en) * 2008-10-01 2015-08-13 Amgen Research (Munich) Gmbh Cross-species-specific single domain bispecific single chain antibody
WO2010045340A1 (en) 2008-10-14 2010-04-22 Centocor Ortho Biotech Inc. Methods of humanizing and affinity-maturing antibodies
SG172254A1 (en) 2008-12-19 2011-07-28 Macrogenics Inc Covalent diabodies and uses thereof
CN102459346B (en) 2009-04-27 2016-10-26 昂考梅德药品有限公司 The method manufacturing heteromultimers molecule
US9493578B2 (en) 2009-09-02 2016-11-15 Xencor, Inc. Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
PL2506871T3 (en) 2009-11-30 2017-03-31 Janssen Biotech, Inc ANTIBODY Fc MUTANTS WITH ABLATED EFFECTOR FUNCTIONS
US8786135B2 (en) 2010-03-25 2014-07-22 Mitsubishi Electric Research Laboratories, Inc. Wireless energy transfer with anisotropic metamaterials
TWI426920B (en) 2010-03-26 2014-02-21 Hoffmann La Roche Bispecific, bivalent anti-VEGF/anti-ANG-2 antibody
TWI653333B (en) * 2010-04-01 2019-03-11 安進研究（慕尼黑）有限責任公司 Cross-species specific PSMAxCD3 bispecific single chain antibody
PL2560993T3 (en) 2010-04-20 2024-11-04 Genmab A/S Heterodimeric proteins comprising an antibody FC region and methods of making the same
CA2797981C (en) 2010-05-14 2019-04-23 Rinat Neuroscience Corporation Heterodimeric proteins and methods for producing and purifying them
CA3051311A1 (en) 2010-05-27 2011-12-01 Genmab A/S Monoclonal antibodies against her2
BR112013000796B1 (en) 2010-07-14 2021-08-31 Merck Sharp & Dohme Corp Isolated antibody or antigen-binding fragment, pharmaceutical composition, methods to inhibit the assembly of ß-amyloid-derived diffusible ligands, to inhibit tau protein phosphorylation in ser202/thr205, to identify a putative therapeutic agent, to detect diffusible ligands ß-amyloid derivatives and for diagnosing a disease associated with ß-amyloid-derived diffusible ligands, and kit to detect ß-amyloid-derived diffusible ligands
TW201208703A (en) * 2010-08-17 2012-03-01 Roche Glycart Ag Combination therapy of an afucosylated CD20 antibody with an anti-VEGF antibody
RU2013110876A (en) 2010-08-24 2014-09-27 Рош Гликарт Аг ACTIVATED SPECIFIC ANTIBODIES
RU2013110875A (en) 2010-08-24 2014-09-27 Ф.Хоффманн-Ля Рош Аг SPECIFIC ANTIBODIES CONTAINING DISSULPHIDE-STABILIZED Fv Fragment
AU2011325833C1 (en) 2010-11-05 2017-07-13 Zymeworks Bc Inc. Stable heterodimeric antibody design with mutations in the Fc domain
PT3434767T (en) * 2010-11-30 2026-01-23 Chugai Pharmaceutical Co Ltd Cytotoxicity-inducing therapeutic agent
KR102003075B1 (en) 2011-02-23 2019-07-23 에프. 호프만-라 로슈 아게 Antibodies against human il33r and uses thereof
AU2012245116A1 (en) * 2011-04-20 2013-11-07 Genmab A/S Bispecific antibodies against HER2 and CD3
CN107827985A (en) 2011-05-21 2018-03-23 宏观基因有限公司 The CD3 binding molecules that can be combined with people and inhuman CD3
CN102250246A (en) 2011-06-10 2011-11-23 常州亚当生物技术有限公司 Bispecific antibody to VEGF/PDGFR beta and application thereof
HUE044633T2 (en) 2011-10-27 2019-11-28 Genmab As Production of heterodimeric proteins
CN108517010A (en) 2012-01-27 2018-09-11 普罗典娜生物科学有限公司 Identify the humanized antibody of alpha-synapse nucleoprotein
AU2013285355A1 (en) * 2012-07-06 2015-01-29 Genmab B.V. Dimeric protein with triple mutations
HUE048722T2 (en) 2013-07-05 2020-08-28 Genmab As Humanized or chimeric CD3 antibodies
US20160355588A1 (en) * 2013-07-12 2016-12-08 Zymeworks Inc. Bispecific CD3 and CD19 Antigen Binding Constructs
KR102225489B1 (en) * 2013-12-17 2021-03-10 제넨테크, 인크. Anti-cd3 antibodies and methods of use
UA120286C2 (en) * 2015-01-08 2019-11-11 Ґенмаб А/С BISPECIFIC ANTIBODY AGAINST CD3 AND CD20
AU2016293073B2 (en) 2015-07-15 2022-12-22 Genmab A/S Humanized or chimeric CD3 antibodies
CH713600A2 (en) 2017-03-21 2018-09-28 Digi Sens Ag Apparatus and method for measuring a load.
EP3668898B1 (en) * 2017-08-14 2023-07-05 MorphoSys AG Humanized antibodies for cd3
CN116406293A (en) * 2020-09-10 2023-07-07 健玛保 Bispecific antibodies against CD3 and CD20 for use in combination therapy for the treatment of follicular lymphoma
US20240034812A1 (en) * 2020-09-10 2024-02-01 Genmab A/S Bispecific antibody against cd3 and cd20 in combination therapy for treating diffuse large b-cell lymphoma
JP2023541858A (en) * 2020-09-10 2023-10-04 ジェンマブ エー／エス Bispecific antibodies against CD3 and CD20 for treating chronic lymphocytic leukemia
JP2023542291A (en) * 2020-09-10 2023-10-06 ジェンマブ エー／エス Bispecific antibodies against CD3 and CD20 in combination therapy to treat diffuse large B-cell lymphoma

Also Published As

Publication number Publication date
JP6546162B2 (en) 2019-07-17
AU2020202792A1 (en) 2020-05-21
IL276530A (en) 2020-09-30
HUS2500051I1 (en) 2025-12-28
AU2025256200A1 (en) 2025-11-13
LT4249515T (en) 2025-08-25
FR25C1054I1 (en) 2026-01-16
AU2020202792B2 (en) 2022-06-23
SI3016681T1 (en) 2020-04-30
SMT202500322T1 (en) 2025-11-10
EP3016681A1 (en) 2016-05-11
DK3016681T3 (en) 2020-03-09
ME03675B (en) 2020-10-20
UA119646C2 (en) 2019-07-25
JP2020005635A (en) 2020-01-16
WO2015104346A1 (en) 2015-07-16
BR122023002590B1 (en) 2023-12-05
JP2024026114A (en) 2024-02-28
JP7389833B2 (en) 2023-11-30
CN120365424A (en) 2025-07-25
HUE048722T2 (en) 2020-08-28
AU2022203851B2 (en) 2025-07-24
JP2017505121A (en) 2017-02-16
KR20230073341A (en) 2023-05-25
HK1231369A1 (en) 2017-12-22
SG11201510739TA (en) 2016-01-28
NL301352I2 (en) 2025-12-16
PL3016681T3 (en) 2020-06-15
US20230374131A1 (en) 2023-11-23
PT3016681T (en) 2020-03-26
US10465006B2 (en) 2019-11-05
KR20160027177A (en) 2016-03-09
JP7208129B2 (en) 2023-01-18
ES3038421T3 (en) 2025-10-13
IL290613B1 (en) 2024-07-01
RS67220B1 (en) 2025-10-31
FIC20250036I1 (en) 2025-12-09
NO2025057I1 (en) 2025-12-11
HUE072527T2 (en) 2025-11-28
EA201690167A1 (en) 2016-06-30
JP2022101539A (en) 2022-07-06
JP2022163009A (en) 2022-10-25
JP7757247B2 (en) 2025-10-21
JP6619342B2 (en) 2019-12-11
ES3052034T3 (en) 2025-12-30
AU2022203851A1 (en) 2022-06-23
CN105722529A (en) 2016-06-29
EP3016681B1 (en) 2019-12-18
MX373245B (en) 2020-05-11
IL311371A (en) 2024-04-01
CY1122840T1 (en) 2021-05-05
KR102363220B1 (en) 2022-02-15
US20160333095A1 (en) 2016-11-17
EP4249515A2 (en) 2023-09-27
RS60131B1 (en) 2020-05-29
AU2014286116A1 (en) 2016-02-04
PL4249515T3 (en) 2025-12-22
JP7104000B2 (en) 2022-07-20
US20200199229A1 (en) 2020-06-25
HRP20251127T1 (en) 2025-11-21
HRP20200382T1 (en) 2020-06-12
LTPA2025538I1 (en) 2025-12-29
AU2020202792B9 (en) 2022-07-07
JP2020048564A (en) 2020-04-02
WO2015001085A1 (en) 2015-01-08
NZ715896A (en) 2022-02-25
CN106255507B (en) 2025-05-02
SMT202000287T1 (en) 2020-07-08
MX2015017487A (en) 2016-03-21
EP4631978A3 (en) 2025-12-24
CN106255507A (en) 2016-12-21
IL311371B2 (en) 2024-09-01
SI4249515T1 (en) 2025-11-28
US10407501B2 (en) 2019-09-10
EP4249515A3 (en) 2023-11-15
IL243127B (en) 2020-08-31
KR102531517B1 (en) 2023-05-12
CN113248615A (en) 2021-08-13
JP2016529882A (en) 2016-09-29
US20200123255A1 (en) 2020-04-23
CA2915575A1 (en) 2015-01-08
CN118063621A (en) 2024-05-24
IL290613A (en) 2022-04-01
US11613575B2 (en) 2023-03-28
EP4249515B1 (en) 2025-06-18
LT3016681T (en) 2020-03-25
US20160168247A1 (en) 2016-06-16
BR112015032986A2 (en) 2017-08-22
MX2020004503A (en) 2020-08-13
ES2776706T3 (en) 2020-07-31
KR20250078622A (en) 2025-06-02
CN105722529B (en) 2021-06-08
EP3693385A1 (en) 2020-08-12
DK4249515T3 (en) 2025-09-15
DK3016681T5 (en) 2020-05-04
CN113248615B (en) 2025-07-04
PT4249515T (en) 2025-09-08
IL290613B2 (en) 2024-11-01
ZA201800385B (en) 2019-09-25
KR20220025210A (en) 2022-03-03
IL311371B1 (en) 2024-05-01
EP3091998A1 (en) 2016-11-16
IL276530B (en) 2022-03-01
EP3091998B1 (en) 2025-08-20
FI4249515T3 (en) 2025-09-02
EP4631978A2 (en) 2025-10-15
KR102813816B1 (en) 2025-05-29

Similar Documents

Publication Publication Date Title
IL311371A (en) Humanized or chimeric cd3 antibodies
SG11201509609SA (en) Chimeric antigen receptor-targeting monoclonal antibodies
ZA201504697B (en) Antibodies comprising chimeric constant domains
EP2931314A4 (en) Chimeric and humanized anti-histone antibodies
IL244784A0 (en) Chimeric antigen receptor
ZA201506568B (en) Anti-tnf-anti-il-17 bispecific antibodies
EP3083698A4 (en) Monoclonal anti-tk1 antibodies
IL256579A (en) Humanized antibodies
SMT202300409T1 (en) Antibodies against csf-1r
EP2970445A4 (en) Humanized anti-n2 antibodies
HK1255635A1 (en) Humanized or chimeric cd3 antibodies